Anthony C Nichols

Summary

Affiliation: University of Western Ontario
Country: Canada

Publications

  1. ncbi Exploiting high-throughput cell line drug screening studies to identify candidate therapeutic agents in head and neck cancer
    Anthony C Nichols
    Department of Otolaryngology Head and Neck Surgery, Western University, London, Ontario, Canada
    BMC Pharmacol Toxicol 15:66. 2014
  2. pmc The role of transoral robotic surgery in the management of oropharyngeal cancer: a review of the literature
    Samuel A Dowthwaite
    Department of Otolaryngology Head and Neck Surgery, The University of Western ON, London, ON, Canada N6A 3K7
    ISRN Oncol 2012:945162. 2012
  3. pmc A Pilot Study Comparing HPV-Positive and HPV-Negative Head and Neck Squamous Cell Carcinomas by Whole Exome Sequencing
    Anthony C Nichols
    Department of Otolaryngology Head and Neck Surgery, Western University, Victoria Hospital, London Health Science Centre, Room B3 431A, 800 Commissioners Road East, London, ON, Canada N6A 5W9 London Regional Cancer Program, London, ON, Canada N6A 4L6 Lawson Health Research Institute, London, ON, Canada N6C 2R5 Department of Oncology, Western University, London, ON, Canada N6A 4L6 Department of Pathology, Western University, London, ON, Canada N6A 5C1
    ISRN Oncol 2012:809370. 2012
  4. ncbi Detection of circulating tumor cells in advanced head and neck cancer using the CellSearch system
    Anthony C Nichols
    Department of Otolaryngology Head and Neck Surgery, The University of Western Ontario, London, Ontario, Canada
    Head Neck 34:1440-4. 2012
  5. ncbi Ki-67 expression predicts radiotherapy failure in early glottic cancer
    Anthony C Nichols
    Department of Otolaryngology Head and Neck Surgery, The University of Western Ontario, London, ON N6A 5W9
    J Otolaryngol Head Neck Surg 41:124-30. 2012
  6. ncbi Frequent mutations in TP53 and CDKN2A found by next-generation sequencing of head and neck cancer cell lines
    Anthony C Nichols
    Departmentof Otolaryngology Head and Neck Surgery, VictoriaHospital, London Health Science Centre, Room B3 431A, 800 Commissioners Rd E, London, ONN6A 5W9, Canada
    Arch Otolaryngol Head Neck Surg 138:732-9. 2012
  7. pmc Development of a transoral robotic surgery program in Canada
    Anthony C Nichols
    Department of Otolaryngology Head and Neck Surgery, Western University, London, ON, Canada
    J Otolaryngol Head Neck Surg 42:8. 2013
  8. pmc Does HPV type affect outcome in oropharyngeal cancer?
    Anthony C Nichols
    Department of Otolaryngology, Head and Neck Surgery, The University of Western Ontario, Room B3 431A, 800 Commissioners Road East, London, N6A 5W9, Ontario, Canada
    J Otolaryngol Head Neck Surg 42:9. 2013
  9. ncbi The control of anaplastic thyroid carcinoma cell lines by oncolytic poxviruses
    Neil Mundi
    Department of Otolaryngology Head and Neck Surgery, Western University, London, ON, Canada
    Virus Res 190:53-9. 2014
  10. ncbi Transoral robotic total laryngectomy: report of 3 cases
    Samuel Dowthwaite
    Department of Otolaryngology Head and Neck Surgery, Western University, London, Ontario, Canada
    Head Neck 35:E338-42. 2013

Collaborators

Detail Information

Publications19

  1. ncbi Exploiting high-throughput cell line drug screening studies to identify candidate therapeutic agents in head and neck cancer
    Anthony C Nichols
    Department of Otolaryngology Head and Neck Surgery, Western University, London, Ontario, Canada
    BMC Pharmacol Toxicol 15:66. 2014
    ..We have exploited data from two large-scale cell line projects to clearly describe the mutational and copy number status of HNSCC cell lines and identify candidate drugs with elevated efficacy in HNSCC...
  2. pmc The role of transoral robotic surgery in the management of oropharyngeal cancer: a review of the literature
    Samuel A Dowthwaite
    Department of Otolaryngology Head and Neck Surgery, The University of Western ON, London, ON, Canada N6A 3K7
    ISRN Oncol 2012:945162. 2012
    ..Potential exists for treatment deintensification, particularly in patients who are HPV positive...
  3. pmc A Pilot Study Comparing HPV-Positive and HPV-Negative Head and Neck Squamous Cell Carcinomas by Whole Exome Sequencing
    Anthony C Nichols
    Department of Otolaryngology Head and Neck Surgery, Western University, Victoria Hospital, London Health Science Centre, Room B3 431A, 800 Commissioners Road East, London, ON, Canada N6A 5W9 London Regional Cancer Program, London, ON, Canada N6A 4L6 Lawson Health Research Institute, London, ON, Canada N6C 2R5 Department of Oncology, Western University, London, ON, Canada N6A 4L6 Department of Pathology, Western University, London, ON, Canada N6A 5C1
    ISRN Oncol 2012:809370. 2012
    ..Next-generation sequencing has the potential to identify novel therapeutic targets and biomarkers in HNSCC...
  4. ncbi Detection of circulating tumor cells in advanced head and neck cancer using the CellSearch system
    Anthony C Nichols
    Department of Otolaryngology Head and Neck Surgery, The University of Western Ontario, London, Ontario, Canada
    Head Neck 34:1440-4. 2012
    ..Early detection of circulating tumor cells (CTCs) offers the possibility of improved outcome for patients with head and neck squamous cell cancer (HNSCC)...
  5. ncbi Ki-67 expression predicts radiotherapy failure in early glottic cancer
    Anthony C Nichols
    Department of Otolaryngology Head and Neck Surgery, The University of Western Ontario, London, ON N6A 5W9
    J Otolaryngol Head Neck Surg 41:124-30. 2012
    ..Although cure rates are high, radiation failures often require total laryngectomy for salvage. Biomarkers that can predict tumour radioresistance may be useful in modifying the treatment approach for individual patients...
  6. ncbi Frequent mutations in TP53 and CDKN2A found by next-generation sequencing of head and neck cancer cell lines
    Anthony C Nichols
    Departmentof Otolaryngology Head and Neck Surgery, VictoriaHospital, London Health Science Centre, Room B3 431A, 800 Commissioners Rd E, London, ONN6A 5W9, Canada
    Arch Otolaryngol Head Neck Surg 138:732-9. 2012
    ..Established cell lines are valuable tools to study cancer in vitro. Similar high-throughput mutational analysis of head and neck cancer cell lines is necessary to confirm their mutational profile...
  7. pmc Development of a transoral robotic surgery program in Canada
    Anthony C Nichols
    Department of Otolaryngology Head and Neck Surgery, Western University, London, ON, Canada
    J Otolaryngol Head Neck Surg 42:8. 2013
    ..This experience can potentially be used as a roadmap for other Canadian institutions pursuing a TORS program...
  8. pmc Does HPV type affect outcome in oropharyngeal cancer?
    Anthony C Nichols
    Department of Otolaryngology, Head and Neck Surgery, The University of Western Ontario, Room B3 431A, 800 Commissioners Road East, London, N6A 5W9, Ontario, Canada
    J Otolaryngol Head Neck Surg 42:9. 2013
    ..The purpose of this study was to determine the rate of HPV-positive oropharyngeal cancer in Southwestern Ontario, Canada...
  9. ncbi The control of anaplastic thyroid carcinoma cell lines by oncolytic poxviruses
    Neil Mundi
    Department of Otolaryngology Head and Neck Surgery, Western University, London, ON, Canada
    Virus Res 190:53-9. 2014
    ..Oncolytic viral therapy is a potential strategy to improve outcomes for patients suffering with this disease...
  10. ncbi Transoral robotic total laryngectomy: report of 3 cases
    Samuel Dowthwaite
    Department of Otolaryngology Head and Neck Surgery, Western University, London, Ontario, Canada
    Head Neck 35:E338-42. 2013
    ..One such technique is transoral robotic surgery (TORS). We aim to discuss the potential role of TORS in patients requiring total laryngectomy (TL)...
  11. ncbi Vaccinia virus outperforms a panel of other poxviruses as a potent oncolytic agent for the control of head and neck squamous cell carcinoma cell lines
    Anthony C Nichols
    Department of Otolaryngology Head and Neck Surgery, Western University, London, Ont, Canada
    Intervirology 57:17-22. 2014
    ..New treatment strategies are needed to improve outcomes for patients suffering with this disease and oncolytic viruses represent a promising approach...
  12. ncbi High frequency of activating PIK3CA mutations in human papillomavirus-positive oropharyngeal cancer
    Anthony C Nichols
    Victoria Hospital, London Health Science Centre, Department of Otolaryngology Head and Neck Surgery, Room B3 431A, 800 Commissioners Rd E, London, ON N6A 5W9, Canada
    JAMA Otolaryngol Head Neck Surg 139:617-22. 2013
    ..We set out to test this prediction in oropharyngeal patient samples from our institution...
  13. pmc Early-stage squamous cell carcinoma of the oropharynx: radiotherapy vs. trans-oral robotic surgery (ORATOR)--study protocol for a randomized phase II trial
    Anthony C Nichols
    Department of Otolaryngology Head and Neck Surgery, London Health Sciences Centre and Western University, London, Ontario, Canada
    BMC Cancer 13:133. 2013
    ..The goal of this randomized phase II study is to compare QOL, functional outcomes, toxicity profiles, and survival following primary RT (± chemotherapy) vs. TORS (± adjuvant [chemo] RT) in patients with OPSCC...
  14. ncbi Variable expression of the forgotten oncogene E5 in HPV-positive oropharyngeal cancer
    Sung Ho Um
    Department of Otolaryngology Head and Neck Surgery, The University of Western Ontario, London, Ontario, Canada
    J Clin Virol 61:94-100. 2014
    ..Studies in cervical cancer indicate that E5 increases epidermal growth factor receptor (EGFR) recycling to the cell surface and enhances growth factor signal transduction...
  15. pmc The human papillomavirus E7 proteins associate with p190RhoGAP and alter its function
    Biljana Todorovic
    Department of Microbiology and Immunology, The University of Western Ontario, London, Ontario, Canada
    J Virol 88:3653-63. 2014
    ..We also found that this interaction negatively regulates cell spreading on a fibronectin substrate and therefore likely contributes to important aspects of the HPV life cycle or HPV-induced tumorigenesis...
  16. ncbi Temporal changes in the efficacy of chemotherapy for recurrent or metastatic squamous cell carcinoma of the head and neck: a systematic review and meta-analysis
    Eric Winquist
    London Health Sciences Centre, London, Ontario, Canada Department of Oncology, Western University, London, Ontario, Canada Electronic address
    Cancer Treat Rev 40:1073-9. 2014
    ....
  17. pmc Viral retasking of hBre1/RNF20 to recruit hPaf1 for transcriptional activation
    Gregory J Fonseca
    Department of Microbiology and Immunology, University of Western Ontario, London, Ontario, Canada
    PLoS Pathog 9:e1003411. 2013
    ....
  18. ncbi Surgical salvage of the oropharynx after failure of organ-sparing therapy
    Anthony C Nichols
    Department of Otolaryngology Head and Neck Surgery, University of Western Ontario, London, Ontario, Canada
    Head Neck 33:516-24. 2011
    ..The purpose of this study was to evaluate the efficacy of salvage surgery for local recurrences of oropharyngeal squamous cell carcinoma (OPSCC) and identify predictors of survival...