Manuela Neuman

Summary

Affiliation: University of Toronto
Country: Canada

Publications

  1. ncbi request reprint Kinetics of serum cytokines reflect changes in the severity of chronic hepatitis C presenting minimal fibrosis
    Manuela G Neuman
    Division of Clinical Pharmacology, Sunnybrook and Women s College Health Sciences Centre, University of Toronto, 2075 Bayview Avenue, Toronto, Ontario, M4N 3M5, Canada
    J Viral Hepat 9:134-40. 2002
  2. ncbi request reprint Cytokine--chemokine and apoptotic signatures in patients with hepatitis C
    Manuela G Neuman
    In Vitro Drug Safety and Biotechnology, MaRS Discovery Center, 101 College Street, Lab 351, Toronto, Ontario, M5G 1L7 Canada
    Transl Res 149:126-36. 2007
  3. ncbi request reprint Mechanisms of alcoholic liver disease: cytokines
    M G Neuman
    Sunnybrook and Women s College Health Sciences Centre, University of Toronto, Ontario, Canada
    Alcohol Clin Exp Res 25:251S-253S. 2001
  4. ncbi request reprint Monitoring adverse drug reactions to sulfonamide antibiotics in human immunodeficiency virus-infected individuals
    Manuela G Neuman
    Department of Pharmacology, University of Toronto, Canada
    Ther Drug Monit 24:728-36. 2002
  5. ncbi request reprint An electron microscopic and morphometric study of ursodeoxycholic effect in primary biliary cirrhosis
    Manuela G Neuman
    Division of Clinical Pharmacology, Sunnybrook and Women s Health Sciences Centre, Toronto, Ontario, Canada
    Liver 22:235-44. 2002
  6. ncbi request reprint Ethanol signals for apoptosis in cultured skin cells
    Manuela G Neuman
    Departments of Clinical Pharmacology, Dermatology, Medicine, and Laboratory Medicine, University of Toronto, M5S 1A1, Toronto, Ontario, Canada
    Alcohol 26:179-90. 2002
  7. ncbi request reprint Tumor necrosis factor-alpha and transforming growth factor-beta reflect severity of liver damage in primary biliary cirrhosis
    Manuela Neuman
    Division of Clinical Pharmacology, Sunnybrook and Women s Health Sciences Center, University of Toronto, Toronto, Ontario, Canada
    J Gastroenterol Hepatol 17:196-202. 2002
  8. ncbi request reprint Serum tumour necrosis factor-alpha and transforming growth factor-beta levels in chronic hepatitis C patients are immunomodulated by therapy
    Manuela G Neuman
    Division of Clinical Pharmacology, E 240, Sunnybrook and Women s College Health Sciences Centre, 2075 Bayview Avenue, Toronto, Ontario, M4N 3M5, Canada
    Cytokine 17:108-17. 2002
  9. ncbi request reprint CYP2E1-mediated modulation of valproic acid-induced hepatocytotoxicity
    M G Neuman
    Division of Clinical Pharmacology, Sunnybrook and Women s College Health Sciences Centre and Department of Pathology, Toronto Health Network, Canada
    Clin Biochem 34:211-8. 2001
  10. ncbi request reprint Cytokine network in nonresponding chronic hepatitis C patients with genotype 1: role of triple therapy with interferon alpha, ribavirin, and ursodeoxycholate
    M G Neuman
    Division of Clinical Pharmacology, E 240, Sunnybrook and Women s College Health Sciences Centre, Department of Pharmacology and Medicine, University of Toronto, 2075 Bayview Avenue, Toronto, Ontario, M4N 3M5, Canada
    Clin Biochem 34:183-8. 2001

Detail Information

Publications16

  1. ncbi request reprint Kinetics of serum cytokines reflect changes in the severity of chronic hepatitis C presenting minimal fibrosis
    Manuela G Neuman
    Division of Clinical Pharmacology, Sunnybrook and Women s College Health Sciences Centre, University of Toronto, 2075 Bayview Avenue, Toronto, Ontario, M4N 3M5, Canada
    J Viral Hepat 9:134-40. 2002
    ..In conclusion, serum TNF-alpha reflects the progression of inflammation as seen in liver biopsies and TGF-beta reflects the degree of fibrosis in HCV patients...
  2. ncbi request reprint Cytokine--chemokine and apoptotic signatures in patients with hepatitis C
    Manuela G Neuman
    In Vitro Drug Safety and Biotechnology, MaRS Discovery Center, 101 College Street, Lab 351, Toronto, Ontario, M5G 1L7 Canada
    Transl Res 149:126-36. 2007
    ..In conclusion, cytokines, chemokines and apoptosis levels reflect the progression of inflammation and fibrosis in hepatitis C infected patients, but their signatures differ...
  3. ncbi request reprint Mechanisms of alcoholic liver disease: cytokines
    M G Neuman
    Sunnybrook and Women s College Health Sciences Centre, University of Toronto, Ontario, Canada
    Alcohol Clin Exp Res 25:251S-253S. 2001
    ..Maeyama, T. Uchikoshi, and G. Toda; and (8) Increased levels of macrophage migration inhibitory factor in sera from patients with alcoholic liver diseases, by T. Kumagi, S. M. F. Akbar, M. Abe, K. Michitaka, N. Horiike, and M. Onji...
  4. ncbi request reprint Monitoring adverse drug reactions to sulfonamide antibiotics in human immunodeficiency virus-infected individuals
    Manuela G Neuman
    Department of Pharmacology, University of Toronto, Canada
    Ther Drug Monit 24:728-36. 2002
    ..Larger patient populations, as well as in vitro studies are needed to further address the reasons for elevated results in immunocompromised patients and to validate the usefulness of the test...
  5. ncbi request reprint An electron microscopic and morphometric study of ursodeoxycholic effect in primary biliary cirrhosis
    Manuela G Neuman
    Division of Clinical Pharmacology, Sunnybrook and Women s Health Sciences Centre, Toronto, Ontario, Canada
    Liver 22:235-44. 2002
    ..The study attempted to quantify perisinusoidal collagenization and the number of apoptotic bodies in PBC liver biopsies from patients in a randomized control trial treated with UDCA compared to those who received placebo...
  6. ncbi request reprint Ethanol signals for apoptosis in cultured skin cells
    Manuela G Neuman
    Departments of Clinical Pharmacology, Dermatology, Medicine, and Laboratory Medicine, University of Toronto, M5S 1A1, Toronto, Ontario, Canada
    Alcohol 26:179-90. 2002
    ..Therefore, even at low concentrations, ethanol may induce apoptosis in skin cells by enhancing the effects of TNF-alpha...
  7. ncbi request reprint Tumor necrosis factor-alpha and transforming growth factor-beta reflect severity of liver damage in primary biliary cirrhosis
    Manuela Neuman
    Division of Clinical Pharmacology, Sunnybrook and Women s Health Sciences Center, University of Toronto, Toronto, Ontario, Canada
    J Gastroenterol Hepatol 17:196-202. 2002
    ..Our aims were to determine: (i) the relationship between serum levels of TNF-alpha and TGF-beta and the severity of PBC; and (ii) the effects of UDCA therapy on TNF-alpha and TGF-beta levels in patients with PBC...
  8. ncbi request reprint Serum tumour necrosis factor-alpha and transforming growth factor-beta levels in chronic hepatitis C patients are immunomodulated by therapy
    Manuela G Neuman
    Division of Clinical Pharmacology, E 240, Sunnybrook and Women s College Health Sciences Centre, 2075 Bayview Avenue, Toronto, Ontario, M4N 3M5, Canada
    Cytokine 17:108-17. 2002
    ....
  9. ncbi request reprint CYP2E1-mediated modulation of valproic acid-induced hepatocytotoxicity
    M G Neuman
    Division of Clinical Pharmacology, Sunnybrook and Women s College Health Sciences Centre and Department of Pathology, Toronto Health Network, Canada
    Clin Biochem 34:211-8. 2001
    ..To determine the cytotoxicity of valproic acid (VPA) and its metabolite, 4-ene-valproic acid (4-ene-VPA) in human hepatoblastoma cells (Hep G2), and to study the modulatory effect of cytochrome P450 2E1 induction in this model...
  10. ncbi request reprint Cytokine network in nonresponding chronic hepatitis C patients with genotype 1: role of triple therapy with interferon alpha, ribavirin, and ursodeoxycholate
    M G Neuman
    Division of Clinical Pharmacology, E 240, Sunnybrook and Women s College Health Sciences Centre, Department of Pharmacology and Medicine, University of Toronto, 2075 Bayview Avenue, Toronto, Ontario, M4N 3M5, Canada
    Clin Biochem 34:183-8. 2001
    ....
  11. ncbi request reprint Cytokines as predictors for sustained response and as markers for immunomodulation in patients with chronic hepatitis C
    M G Neuman
    Division of Clinical Pharmacology, E 240, Sunnybrook and Women s Health Sciences Centre, Department of Pharmacology, University of Toronto, 2075 Bayview Avenue, Toronto, M4N 3M5, Canada
    Clin Biochem 34:173-82. 2001
    ....
  12. ncbi request reprint Apoptosis in ibuprofen-induced Stevens-Johnson syndrome
    Manuela Neuman
    In Vitro Drug Safety and Biotechnology Laboratory, University of Toronto, Toronto, Ontario, Canada
    Transl Res 149:254-9. 2007
    ..The same is the case with the apoptotic markers Fas, caspase activity, and M30. T-cell cytokines control the pathogenesis of SJS/TEN contributing to apoptotic processes in the liver and in the skin...
  13. doi request reprint Causal considerations on alcohol and HIV/AIDS--a systematic review
    Paul A Shuper
    Centre for Addiction and Mental Health, 33 Russell Street, Room T 518, Toronto, Ontario, Canada M5S 2S1
    Alcohol Alcohol 45:159-66. 2010
    ..The study aimed to explore the possible causal nature of the association between alcohol consumption and HIV/AIDS...
  14. pmc The splenic microenvironment is a source of proangiogenesis/inflammatory mediators accelerating the expansion of murine erythroleukemic cells
    Yuval Shaked
    Department of Molecular and Cellular Biology, Sunnybrook and Women s College Health Sciences Centre, Toronto, ON, Canada
    Blood 105:4500-7. 2005
    ..These findings suggest that VEGF-A and MCP-5 are potentially pivotal paracrine mediators occurring within the diseased splenic microenvironment capable of promoting disease acceleration and expansion of erythroleukemic blasts...
  15. ncbi request reprint Molecular pathology and clinical aspects of alcohol-induced tissue injury
    Patricia E Molina
    Alcohol Research Center and Department of Physiology at Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
    Alcohol Clin Exp Res 26:120-8. 2002
    ..Molina and Manuela Neuman. The presentations were (1) Mechanisms of alcohol-induced cell injury by Craig McClain; (2) Cytokines in ..
  16. pmc Methionine deficiency and hepatic injury in a dietary steatohepatitis model
    Helieh S Oz
    Center for the Oral Health Research, Department of Internal Medicine, University of Kentucky Medical Center, Lexington, KY 40536, USA
    Dig Dis Sci 53:767-76. 2008
    ..These data support a pivotal role for methionine in the pathogenesis of the dietary model of Meth-choline-deficient (MCD) steatohepatitis (NASH)...