William Wiley Navarre

Summary

Affiliation: University of Toronto
Country: Canada

Publications

  1. pmc PoxA, yjeK, and elongation factor P coordinately modulate virulence and drug resistance in Salmonella enterica
    William Wiley Navarre
    Department of Molecular Genetics, University of Toronto, Toronto, Ontario, M5S 1A8, Canada
    Mol Cell 39:209-21. 2010
  2. pmc Divergent protein motifs direct elongation factor P-mediated translational regulation in Salmonella enterica and Escherichia coli
    Steven J Hersch
    Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada
    MBio 4:e00180-13. 2013
  3. pmc Loss of elongation factor P disrupts bacterial outer membrane integrity
    S Betty Zou
    Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada
    J Bacteriol 194:413-25. 2012
  4. pmc Molecular evolution of protein-RNA mimicry as a mechanism for translational control
    Assaf Katz
    Department of Microbiology, Ohio State University, Columbus, OH 43210, USA, Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada and Ohio State Biochemistry Program, Center for RNA Biology, Ohio State University, Columbus, OH 43210, USA
    Nucleic Acids Res 42:3261-71. 2014
  5. pmc Elongation factor P mediates a novel post-transcriptional regulatory pathway critical for bacterial virulence
    S Betty Zou
    Department of Molecular Genetics, University of Toronto, ON, Canada
    Virulence 2:147-51. 2011
  6. doi Silencing of foreign DNA in bacteria
    Sabrina S Ali
    Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada
    Curr Opin Microbiol 15:175-81. 2012
  7. pmc Structural insights into the regulation of foreign genes in Salmonella by the Hha/H-NS complex
    Sabrina S Ali
    Departments of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    J Biol Chem 288:13356-69. 2013
  8. pmc Translation initiation rate determines the impact of ribosome stalling on bacterial protein synthesis
    Steven J Hersch
    From the Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada and
    J Biol Chem 289:28160-71. 2014
  9. pmc Silencing by H-NS potentiated the evolution of Salmonella
    Sabrina S Ali
    Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada
    PLoS Pathog 10:e1004500. 2014
  10. pmc The 5.5 protein of phage T7 inhibits H-NS through interactions with the central oligomerization domain
    Sabrina S Ali
    Department of Molecular Genetics, University of Toronto, Toronto, Ontario, M5S 1A8 Canada
    J Bacteriol 193:4881-92. 2011

Collaborators

  • HervĂ© Roy
  • Andrea S Leung
  • Jun Liu
  • Leonard J Foster
  • Alexei Savchenko
  • Bin Xia
  • Sabrina S Ali
  • S Betty Zou
  • Steven J Hersch
  • Michael Ibba
  • Blair R G Gordon
  • Assaf Katz
  • Chitong Rao
  • Alexander W Ensminger
  • Sara Elgamal
  • Lindsey Solden
  • Jeremy Soo
  • David Hon Man Ngai
  • James Stevenson
  • John C Whitney
  • Mengchi Wang
  • P Lynne Howell
  • Kyung Mee Moon
  • Howard Robinson
  • J Brad Wiggers
  • Jinglin Lucy Xie
  • Stephen Buranyi
  • Kiley Dare
  • Atina CotĂ©
  • Sandy Jeehoon Bae
  • Matthew T Weirauch
  • Yifei Li
  • Emily Beckett
  • Pengfei Ding
  • Timothy R Hughes
  • Linru Wang
  • Robin Imperial

Detail Information

Publications12

  1. pmc PoxA, yjeK, and elongation factor P coordinately modulate virulence and drug resistance in Salmonella enterica
    William Wiley Navarre
    Department of Molecular Genetics, University of Toronto, Toronto, Ontario, M5S 1A8, Canada
    Mol Cell 39:209-21. 2010
    ..The modification of EF-P is a mechanism of regulation whereby PoxA acts as an aminoacyl-tRNA synthetase that attaches an amino acid to a protein resembling tRNA rather than to a tRNA...
  2. pmc Divergent protein motifs direct elongation factor P-mediated translational regulation in Salmonella enterica and Escherichia coli
    Steven J Hersch
    Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada
    MBio 4:e00180-13. 2013
    ..This work expands the known repertoire of EF-P target motifs and implicates factors beyond polyproline motifs that are required for EF-P-mediated regulation...
  3. pmc Loss of elongation factor P disrupts bacterial outer membrane integrity
    S Betty Zou
    Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada
    J Bacteriol 194:413-25. 2012
    ..Our data support a role for EF-P in the translational regulation of a limited number of proteins that, when perturbed, renders the cell susceptible to stress by the adventitious overexpression of an outer membrane porin...
  4. pmc Molecular evolution of protein-RNA mimicry as a mechanism for translational control
    Assaf Katz
    Department of Microbiology, Ohio State University, Columbus, OH 43210, USA, Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada and Ohio State Biochemistry Program, Center for RNA Biology, Ohio State University, Columbus, OH 43210, USA
    Nucleic Acids Res 42:3261-71. 2014
    ..This suggests EF-P first evolved tRNA mimicry to optimize interactions with the ribosome, with PoxA-catalyzed aminoacylation evolving later as a secondary mechanism to further improve ribosome binding and translation control. ..
  5. pmc Elongation factor P mediates a novel post-transcriptional regulatory pathway critical for bacterial virulence
    S Betty Zou
    Department of Molecular Genetics, University of Toronto, ON, Canada
    Virulence 2:147-51. 2011
    ..Other observations suggest that the eukaryotic homolog of EF-P, eIF5A, may illicit similar changes in the translation machinery during stress adaptation, indicating that the role of these factors in physiology may be broadly conserved...
  6. doi Silencing of foreign DNA in bacteria
    Sabrina S Ali
    Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada
    Curr Opin Microbiol 15:175-81. 2012
    ..Here we discuss the mechanisms that underlie the ability of these proteins to selectively target AT-rich DNA and the contradictory data regarding the mode by which H-NS forms nucleoprotein complexes...
  7. pmc Structural insights into the regulation of foreign genes in Salmonella by the Hha/H-NS complex
    Sabrina S Ali
    Departments of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    J Biol Chem 288:13356-69. 2013
    ..Hha facilitates H-NS-mediated silencing of foreign genes in bacteria...
  8. pmc Translation initiation rate determines the impact of ribosome stalling on bacterial protein synthesis
    Steven J Hersch
    From the Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada and
    J Biol Chem 289:28160-71. 2014
    ..This model can be generalized to explain why sequences that induce pauses in translation elongation to, for example, facilitate folding do not necessarily exact a penalty on the overall production of the protein. ..
  9. pmc Silencing by H-NS potentiated the evolution of Salmonella
    Sabrina S Ali
    Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada
    PLoS Pathog 10:e1004500. 2014
    ..These findings indicate that H-NS was central to the evolution of the Salmonellae by buffering the negative fitness consequences caused by the secretion system that is the defining characteristic of the species. ..
  10. pmc The 5.5 protein of phage T7 inhibits H-NS through interactions with the central oligomerization domain
    Sabrina S Ali
    Department of Molecular Genetics, University of Toronto, Toronto, Ontario, M5S 1A8 Canada
    J Bacteriol 193:4881-92. 2011
    ..The 5.5 proteins utilize a previously undescribed mechanism of H-NS antagonism that further highlights the critical importance that higher-order oligomerization plays in H-NS-mediated gene repression...
  11. pmc Structural basis for recognition of AT-rich DNA by unrelated xenogeneic silencing proteins
    Blair R G Gordon
    Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada M5S 1A8
    Proc Natl Acad Sci U S A 108:10690-5. 2011
    ..Our findings also suggest that structural information contained within the DNA minor groove is deciphered by xenogeneic silencing proteins to distinguish genetic material that is self from nonself...
  12. pmc Lsr2 of Mycobacterium represents a novel class of H-NS-like proteins
    Blair R G Gordon
    Department of Molecular Genetics, University of Toronto, 1 King s College Circle, Toronto ON M5S 1A8, Canada
    J Bacteriol 190:7052-9. 2008
    ..Taken together, our results demonstrate unequivocally that Lsr2 is an H-NS-like protein...