William Wiley Navarre

Summary

Affiliation: University of Toronto
Country: Canada

Publications

  1. pmc Divergent protein motifs direct elongation factor P-mediated translational regulation in Salmonella enterica and Escherichia coli
    Steven J Hersch
    Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada
    MBio 4:e00180-13. 2013
  2. pmc PoxA, yjeK, and elongation factor P coordinately modulate virulence and drug resistance in Salmonella enterica
    William Wiley Navarre
    Department of Molecular Genetics, University of Toronto, Toronto, Ontario, M5S 1A8, Canada
    Mol Cell 39:209-21. 2010
  3. pmc Loss of elongation factor P disrupts bacterial outer membrane integrity
    S Betty Zou
    Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada
    J Bacteriol 194:413-25. 2012
  4. pmc Structural insights into the regulation of foreign genes in Salmonella by the Hha/H-NS complex
    Sabrina S Ali
    Departments of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    J Biol Chem 288:13356-69. 2013
  5. doi Silencing of foreign DNA in bacteria
    Sabrina S Ali
    Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada
    Curr Opin Microbiol 15:175-81. 2012
  6. pmc Elongation factor P mediates a novel post-transcriptional regulatory pathway critical for bacterial virulence
    S Betty Zou
    Department of Molecular Genetics, University of Toronto, ON, Canada
    Virulence 2:147-51. 2011
  7. doi Molecular evolution of protein-RNA mimicry as a mechanism for translational control
    Assaf Katz
    Department of Microbiology, Ohio State University, Columbus, OH 43210, USA, Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada and Ohio State Biochemistry Program, Center for RNA Biology, Ohio State University, Columbus, OH 43210, USA
    Nucleic Acids Res 42:3261-71. 2014
  8. pmc The 5.5 protein of phage T7 inhibits H-NS through interactions with the central oligomerization domain
    Sabrina S Ali
    Department of Molecular Genetics, University of Toronto, Toronto, Ontario, M5S 1A8 Canada
    J Bacteriol 193:4881-92. 2011
  9. pmc Structural basis for recognition of AT-rich DNA by unrelated xenogeneic silencing proteins
    Blair R G Gordon
    Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada M5S 1A8
    Proc Natl Acad Sci U S A 108:10690-5. 2011
  10. pmc Lsr2 of Mycobacterium represents a novel class of H-NS-like proteins
    Blair R G Gordon
    Department of Molecular Genetics, University of Toronto, 1 King s College Circle, Toronto ON M5S 1A8, Canada
    J Bacteriol 190:7052-9. 2008

Collaborators

  • HervĂ© Roy
  • Jun Liu
  • Leonard J Foster
  • Alexei Savchenko
  • Andrea S Leung
  • Bin Xia
  • S Betty Zou
  • Sabrina S Ali
  • Michael Ibba
  • Blair R G Gordon
  • Steven J Hersch
  • Assaf Katz
  • Lindsey Solden
  • John C Whitney
  • Mengchi Wang
  • P Lynne Howell
  • Howard Robinson
  • James Stevenson
  • Kyung Mee Moon
  • Stephen Buranyi
  • Jinglin Lucy Xie
  • Kiley Dare
  • J Brad Wiggers
  • Matthew T Weirauch
  • Pengfei Ding
  • Timothy R Hughes
  • Emily Beckett
  • Atina CotĂ©
  • Yifei Li
  • Sandy Jeehoon Bae
  • Linru Wang
  • Robin Imperial

Detail Information

Publications10

  1. pmc Divergent protein motifs direct elongation factor P-mediated translational regulation in Salmonella enterica and Escherichia coli
    Steven J Hersch
    Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada
    MBio 4:e00180-13. 2013
    ..This work expands the known repertoire of EF-P target motifs and implicates factors beyond polyproline motifs that are required for EF-P-mediated regulation...
  2. pmc PoxA, yjeK, and elongation factor P coordinately modulate virulence and drug resistance in Salmonella enterica
    William Wiley Navarre
    Department of Molecular Genetics, University of Toronto, Toronto, Ontario, M5S 1A8, Canada
    Mol Cell 39:209-21. 2010
    ..The modification of EF-P is a mechanism of regulation whereby PoxA acts as an aminoacyl-tRNA synthetase that attaches an amino acid to a protein resembling tRNA rather than to a tRNA...
  3. pmc Loss of elongation factor P disrupts bacterial outer membrane integrity
    S Betty Zou
    Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada
    J Bacteriol 194:413-25. 2012
    ..Our data support a role for EF-P in the translational regulation of a limited number of proteins that, when perturbed, renders the cell susceptible to stress by the adventitious overexpression of an outer membrane porin...
  4. pmc Structural insights into the regulation of foreign genes in Salmonella by the Hha/H-NS complex
    Sabrina S Ali
    Departments of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    J Biol Chem 288:13356-69. 2013
    ..Hha facilitates H-NS-mediated silencing of foreign genes in bacteria...
  5. doi Silencing of foreign DNA in bacteria
    Sabrina S Ali
    Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada
    Curr Opin Microbiol 15:175-81. 2012
    ..Here we discuss the mechanisms that underlie the ability of these proteins to selectively target AT-rich DNA and the contradictory data regarding the mode by which H-NS forms nucleoprotein complexes...
  6. pmc Elongation factor P mediates a novel post-transcriptional regulatory pathway critical for bacterial virulence
    S Betty Zou
    Department of Molecular Genetics, University of Toronto, ON, Canada
    Virulence 2:147-51. 2011
    ..Other observations suggest that the eukaryotic homolog of EF-P, eIF5A, may illicit similar changes in the translation machinery during stress adaptation, indicating that the role of these factors in physiology may be broadly conserved...
  7. doi Molecular evolution of protein-RNA mimicry as a mechanism for translational control
    Assaf Katz
    Department of Microbiology, Ohio State University, Columbus, OH 43210, USA, Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada and Ohio State Biochemistry Program, Center for RNA Biology, Ohio State University, Columbus, OH 43210, USA
    Nucleic Acids Res 42:3261-71. 2014
    ..This suggests EF-P first evolved tRNA mimicry to optimize interactions with the ribosome, with PoxA-catalyzed aminoacylation evolving later as a secondary mechanism to further improve ribosome binding and translation control. ..
  8. pmc The 5.5 protein of phage T7 inhibits H-NS through interactions with the central oligomerization domain
    Sabrina S Ali
    Department of Molecular Genetics, University of Toronto, Toronto, Ontario, M5S 1A8 Canada
    J Bacteriol 193:4881-92. 2011
    ..The 5.5 proteins utilize a previously undescribed mechanism of H-NS antagonism that further highlights the critical importance that higher-order oligomerization plays in H-NS-mediated gene repression...
  9. pmc Structural basis for recognition of AT-rich DNA by unrelated xenogeneic silencing proteins
    Blair R G Gordon
    Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada M5S 1A8
    Proc Natl Acad Sci U S A 108:10690-5. 2011
    ..Our findings also suggest that structural information contained within the DNA minor groove is deciphered by xenogeneic silencing proteins to distinguish genetic material that is self from nonself...
  10. pmc Lsr2 of Mycobacterium represents a novel class of H-NS-like proteins
    Blair R G Gordon
    Department of Molecular Genetics, University of Toronto, 1 King s College Circle, Toronto ON M5S 1A8, Canada
    J Bacteriol 190:7052-9. 2008
    ..Taken together, our results demonstrate unequivocally that Lsr2 is an H-NS-like protein...