FRANCIS NANO

Summary

Affiliation: University of Victoria
Country: Canada

Publications

  1. pmc The Francisella pathogenicity island protein IglA localizes to the bacterial cytoplasm and is needed for intracellular growth
    Olle M de Bruin
    The Department of Biochemistry and Microbiology, University of Victoria, Victoria, BC, Canada
    BMC Microbiol 7:1. 2007
  2. ncbi request reprint The Francisella pathogenicity island
    Francis E Nano
    Department of Biochemistry and Microbiology, PO Box 3055 STN CSC, University of Victoria, Victoria B C V8W 3P6 Canada
    Ann N Y Acad Sci 1105:122-37. 2007
  3. pmc A Francisella tularensis pathogenicity island required for intramacrophage growth
    Francis E Nano
    Department of Biochemistry and Microbiology, University of Victoria, Victoria, British Columbia, Canada
    J Bacteriol 186:6430-6. 2004
  4. ncbi request reprint The identification of five genetic loci of Francisella novicida associated with intracellular growth
    Catherine G Gray
    Department of Biochemistry and Microbiology, University of Victoria, P O Box 3055 STN CSC, Victoria, BC, Canada V8W 3P6
    FEMS Microbiol Lett 215:53-6. 2002
  5. pmc The Francisella pathogenicity island protein PdpD is required for full virulence and associates with homologues of the type VI secretion system
    Jagjit S Ludu
    Department of Biochemistry and Microbiology, University of Victoria, Victoria, BC V8W 3P6, Canada
    J Bacteriol 190:4584-95. 2008
  6. pmc A Francisella novicida pdpA mutant exhibits limited intracellular replication and remains associated with the lysosomal marker LAMP-1
    Crystal L Schmerk
    Department of Biochemistry and Microbiology, University of Victoria, Victoria, BC, Canada
    Microbiology 155:1498-504. 2009
  7. pmc Characterization of the pathogenicity island protein PdpA and its role in the virulence of Francisella novicida
    Crystal L Schmerk
    Department of Biochemistry and Microbiology, University of Victoria, Victoria, BC, Canada
    Microbiology 155:1489-97. 2009
  8. pmc Essential genes from Arctic bacteria used to construct stable, temperature-sensitive bacterial vaccines
    Barry N Duplantis
    Department of Biochemistry and Microbiology, University of Victoria, Victoria, BC, V8W 3P6, Canada
    Proc Natl Acad Sci U S A 107:13456-60. 2010
  9. pmc Virulence of Francisella spp. in chicken embryos
    Eli B Nix
    Department of Biochemistry and Microbiology, PO Box 3055 STN CSC, University of Victoria, Victoria, British Columbia, V8W 3P6, Canada
    Infect Immun 74:4809-16. 2006
  10. ncbi request reprint Genetic elements for selection, deletion mutagenesis and complementation in Francisella spp
    Jagjit S Ludu
    Department of Biochemistry and Microbiology, University of Victoria, Victoria, BC, Canada
    FEMS Microbiol Lett 278:86-93. 2008

Research Grants

  1. A. Francisella tularensis pathogenicity island
    FRANCIS NANO; Fiscal Year: 2007

Collaborators

Detail Information

Publications15

  1. pmc The Francisella pathogenicity island protein IglA localizes to the bacterial cytoplasm and is needed for intracellular growth
    Olle M de Bruin
    The Department of Biochemistry and Microbiology, University of Victoria, Victoria, BC, Canada
    BMC Microbiol 7:1. 2007
    ..tularensis but has low virulence for humans while being highly virulent in mice. IglA is a 21 kDa protein encoded by a gene that is part of an iglABCD operon located on the Francisella pathogenicity island (FPI)...
  2. ncbi request reprint The Francisella pathogenicity island
    Francis E Nano
    Department of Biochemistry and Microbiology, PO Box 3055 STN CSC, University of Victoria, Victoria B C V8W 3P6 Canada
    Ann N Y Acad Sci 1105:122-37. 2007
    ..However, bioinformatics analysis suggests that some of the FPI-encoded proteins are part of a type VI secretion system...
  3. pmc A Francisella tularensis pathogenicity island required for intramacrophage growth
    Francis E Nano
    Department of Biochemistry and Microbiology, University of Victoria, Victoria, British Columbia, Canada
    J Bacteriol 186:6430-6. 2004
    ..7-kb stretch of the FPI is 26.6%, which is 6.6% below the average G+C content of the F. tularensis genome. This extremely low G+C content suggests that the DNA was imported from a microbe with a very low G+C-containing chromosome...
  4. ncbi request reprint The identification of five genetic loci of Francisella novicida associated with intracellular growth
    Catherine G Gray
    Department of Biochemistry and Microbiology, University of Victoria, P O Box 3055 STN CSC, Victoria, BC, Canada V8W 3P6
    FEMS Microbiol Lett 215:53-6. 2002
    ....
  5. pmc The Francisella pathogenicity island protein PdpD is required for full virulence and associates with homologues of the type VI secretion system
    Jagjit S Ludu
    Department of Biochemistry and Microbiology, University of Victoria, Victoria, BC V8W 3P6, Canada
    J Bacteriol 190:4584-95. 2008
    ..Finally, deletions of FPI genes encoding proteins that are homologues of known components of type VI secretion systems abolished the altered distribution of IglC and the outer membrane localization of PdpD...
  6. pmc A Francisella novicida pdpA mutant exhibits limited intracellular replication and remains associated with the lysosomal marker LAMP-1
    Crystal L Schmerk
    Department of Biochemistry and Microbiology, University of Victoria, Victoria, BC, Canada
    Microbiology 155:1498-504. 2009
    ..novicida. The transcriptional response of the host macrophage indicates that PdpA functions directly or indirectly to suppress macrophage ability to signal via growth factors, cytokines and adhesion ligands...
  7. pmc Characterization of the pathogenicity island protein PdpA and its role in the virulence of Francisella novicida
    Crystal L Schmerk
    Department of Biochemistry and Microbiology, University of Victoria, Victoria, BC, Canada
    Microbiology 155:1489-97. 2009
    ..Deletion of pdpA resulted in a strain that was highly attenuated for virulence in chicken embryos and mice...
  8. pmc Essential genes from Arctic bacteria used to construct stable, temperature-sensitive bacterial vaccines
    Barry N Duplantis
    Department of Biochemistry and Microbiology, University of Victoria, Victoria, BC, V8W 3P6, Canada
    Proc Natl Acad Sci U S A 107:13456-60. 2010
    ..These results show that psychrophilic essential genes can be used to create a unique class of bacterial temperature-sensitive vaccines for important human pathogens, such as S. enterica and Mycobacterium tuberculosis...
  9. pmc Virulence of Francisella spp. in chicken embryos
    Eli B Nix
    Department of Biochemistry and Microbiology, PO Box 3055 STN CSC, University of Victoria, Victoria, British Columbia, V8W 3P6, Canada
    Infect Immun 74:4809-16. 2006
    ..tularensis appeared to be growing intracellularly. These results demonstrate that infection of 7-day-old chicken embryos can be used to evaluate the virulence of attenuated F. tularensis strains...
  10. ncbi request reprint Genetic elements for selection, deletion mutagenesis and complementation in Francisella spp
    Jagjit S Ludu
    Department of Biochemistry and Microbiology, University of Victoria, Victoria, BC, Canada
    FEMS Microbiol Lett 278:86-93. 2008
    ..Two general approaches to deletion mutagenesis in F. novicida is also described...
  11. pmc MglA regulates transcription of virulence factors necessary for Francisella tularensis intraamoebae and intramacrophage survival
    Crystal M Lauriano
    Department of Microbiology and Immunology, University of Texas Health Science Center, San Antonio, TX 78229 3900, USA
    Proc Natl Acad Sci U S A 101:4246-9. 2004
    ..Thus, MglA regulates the transcription of virulence factors of F. tularensis that contribute to intramacrophage and intraamoebae survival...
  12. ncbi request reprint Francisella novicida LPS has greater immunobiological activity in mice than F. tularensis LPS, and contributes to F. novicida murine pathogenesis
    Tara L Kieffer
    Laboratory of Mycobacterial Diseases and Cellular Immunity, Division of Bacterial and Parasitic Products, CBER FDA, 1401 Rockville Pike, HFM 431, Bethesda, Rockville, MD 20852, USA
    Microbes Infect 5:397-403. 2003
    ..novicida LPS to stimulate the production of proinflammatory cytokines including TNF-alpha likely contributes to the increased virulence for mice of F. novicida compared to F. tularensis LVS...
  13. ncbi request reprint Allelic exchange in Francisella tularensis using PCR products
    Crystal M Lauriano
    Department of Microbiology and Immunology, University of Texas Health Science Center, San Antonio, TX 78229 3900, USA
    FEMS Microbiol Lett 229:195-202. 2003
    ..Interestingly, the bla mutant maintained resistance to ampicillin, indicating the presence of multiple ampicillin resistance genes in F. tularensis...
  14. pmc Construction and characterization of a highly efficient Francisella shuttle plasmid
    Tamara M Maier
    Department of Microbiology and Molecular Genetics, The Medical College of Wisconsin, 8701 Watertown Plank Rd, P O Box 26509, Milwaukee, WI 53226 0509, USA
    Appl Environ Microbiol 70:7511-9. 2004
    ..This new tool should significantly enhance genetic manipulation and characterization of F. tularensis and other Francisella biotypes...
  15. ncbi request reprint Biosafety and selectable markers
    Richard W Titball
    Defence Science and Technology Laboratory, Porton Down, Salisbury, SP4 0JQ, United Kingdom
    Ann N Y Acad Sci 1105:405-17. 2007
    ..Because antibiotic therapy is central to the treatment of human tularemia, antibiotic resistance markers for use in genetic manipulation studies should be carefully selected...

Research Grants4

  1. A. Francisella tularensis pathogenicity island
    FRANCIS NANO; Fiscal Year: 2007
    ..tularensis. ..