Devki Nandan

Summary

Affiliation: University of British Columbia
Country: Canada

Publications

  1. ncbi request reprint Leishmania EF-1alpha activates the Src homology 2 domain containing tyrosine phosphatase SHP-1 leading to macrophage deactivation
    Devki Nandan
    Department of Medicine, Division of Infectious Diseases, The University of British Columbia, Research Institute of the Vancouver Hospital and Health Sciences Center, Vancouver, British Columbia V5Z 3J5, Canada
    J Biol Chem 277:50190-7. 2002
  2. ncbi request reprint Molecular cloning, biochemical and structural analysis of elongation factor-1 alpha from Leishmania donovani: comparison with the mammalian homologue
    Devki Nandan
    Department of Medicine, Division of Infectious Diseases, Faculty of Medicine, The Research Institute of the Vancouver Hospital and Health Sciences Center, The University of British Columbia, Vancouver, BC, Canada V5Z 3J5
    Biochem Biophys Res Commun 302:646-52. 2003
  3. ncbi request reprint Leishmania donovani engages in regulatory interference by targeting macrophage protein tyrosine phosphatase SHP-1
    Devki Nandan
    Division of Infectious Diseases, Department of Medicine, Vancouver Coastal Health Research Institute VCHRI, The University of British Columbia, Room 452D, 2733 Heather Street, Vancouver, BC, Canada, V5Z 3J5
    Clin Immunol 114:266-77. 2005
  4. ncbi request reprint Indel-based targeting of essential proteins in human pathogens that have close host orthologue(s): discovery of selective inhibitors for Leishmania donovani elongation factor-1alpha
    Devki Nandan
    Division of Infectious Diseases, Department of Medicine, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada
    Proteins 67:53-64. 2007
  5. ncbi request reprint Identification of leishmania fructose-1,6-bisphosphate aldolase as a novel activator of host macrophage Src homology 2 domain containing protein tyrosine phosphatase SHP-1
    Devki Nandan
    Department of Medicine, Division of Infectious Diseases, 2733 Heather Street, Heather Pavilion East, Room 452 D, Vancouver, BC, Canada V5Z 3J5
    Biochem Biophys Res Commun 364:601-7. 2007
  6. ncbi request reprint Molecular architecture of leishmania EF-1alpha reveals a novel site that may modulate protein translation: a possible target for drug development
    Martin Lopez
    Department of Medicine Division of Infectious Diseases, University of British Columbia, Faculties of Medicine and Science, 2733 Heather Street, Heather Pavilion East, Room 452 D, Vancouver, BC, Canada V5Z 3J5
    Biochem Biophys Res Commun 356:886-92. 2007
  7. doi request reprint Myeloid cell IL-10 production in response to leishmania involves inactivation of glycogen synthase kinase-3β downstream of phosphatidylinositol-3 kinase
    Devki Nandan
    Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada
    J Immunol 188:367-78. 2012
  8. ncbi request reprint Large-scale survey for potentially targetable indels in bacterial and protozoan proteins
    Artem Cherkasov
    Division of Infectious Diseases, Department of Medicine, University of British Columbia, Faculty of Medicine, Vancouver Coastal Health Research Institute, Vancouver, British Columbia, Canada
    Proteins 62:371-80. 2006
  9. pmc Proteomic analysis of the secretome of Leishmania donovani
    J Maxwell Silverman
    Department of Medicine Division of Infectious Diseases, University of British Columbia, Faculty of Medicine, 2733 Heather St, Vancouver, British Columbia, V5Z 3J5, Canada
    Genome Biol 9:R35. 2008
  10. doi request reprint Secreted virulence factors and immune evasion in visceral leishmaniasis
    Ulrike Lambertz
    Department of Medicine Division of Infectious Diseases and the Experimental Medicine Program, University of British Columbia, Vancouver, Canada
    J Leukoc Biol 91:887-99. 2012

Collaborators

Detail Information

Publications17

  1. ncbi request reprint Leishmania EF-1alpha activates the Src homology 2 domain containing tyrosine phosphatase SHP-1 leading to macrophage deactivation
    Devki Nandan
    Department of Medicine, Division of Infectious Diseases, The University of British Columbia, Research Institute of the Vancouver Hospital and Health Sciences Center, Vancouver, British Columbia V5Z 3J5, Canada
    J Biol Chem 277:50190-7. 2002
    ..Thus, Leishmania EF-1alpha is identified as a novel SHP-1-binding and activating protein that recapitulates the deactivated phenotype of infected macrophages...
  2. ncbi request reprint Molecular cloning, biochemical and structural analysis of elongation factor-1 alpha from Leishmania donovani: comparison with the mammalian homologue
    Devki Nandan
    Department of Medicine, Division of Infectious Diseases, Faculty of Medicine, The Research Institute of the Vancouver Hospital and Health Sciences Center, The University of British Columbia, Vancouver, BC, Canada V5Z 3J5
    Biochem Biophys Res Commun 302:646-52. 2003
    ..Since EF-1 alpha is essential for survival, the distinct biochemical and structural properties of Leishmania EF-1 alpha may provide a novel target for drug development...
  3. ncbi request reprint Leishmania donovani engages in regulatory interference by targeting macrophage protein tyrosine phosphatase SHP-1
    Devki Nandan
    Division of Infectious Diseases, Department of Medicine, Vancouver Coastal Health Research Institute VCHRI, The University of British Columbia, Room 452D, 2733 Heather Street, Vancouver, BC, Canada, V5Z 3J5
    Clin Immunol 114:266-77. 2005
    ..The role of leishmania EF-1alpha as an SHP-1 activator and its contribution to pathogenesis are reviewed with particular attention to the properties that distinguish it from host EF-1alpha...
  4. ncbi request reprint Indel-based targeting of essential proteins in human pathogens that have close host orthologue(s): discovery of selective inhibitors for Leishmania donovani elongation factor-1alpha
    Devki Nandan
    Division of Infectious Diseases, Department of Medicine, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada
    Proteins 67:53-64. 2007
    ..We anticipate that such indel-directed targeting of essential proteins in microbial pathogens may help address the growing problem of antibiotic resistance...
  5. ncbi request reprint Identification of leishmania fructose-1,6-bisphosphate aldolase as a novel activator of host macrophage Src homology 2 domain containing protein tyrosine phosphatase SHP-1
    Devki Nandan
    Department of Medicine, Division of Infectious Diseases, 2733 Heather Street, Heather Pavilion East, Room 452 D, Vancouver, BC, Canada V5Z 3J5
    Biochem Biophys Res Commun 364:601-7. 2007
    ..Collectively, these data show that leishmania aldolase is a novel SHP-1 binding and activating protein that contributes to macrophage dysfunction...
  6. ncbi request reprint Molecular architecture of leishmania EF-1alpha reveals a novel site that may modulate protein translation: a possible target for drug development
    Martin Lopez
    Department of Medicine Division of Infectious Diseases, University of British Columbia, Faculties of Medicine and Science, 2733 Heather Street, Heather Pavilion East, Room 452 D, Vancouver, BC, Canada V5Z 3J5
    Biochem Biophys Res Commun 356:886-92. 2007
    ..Taken together, these findings identify a novel, exposed region in leishmania EF-1alpha that may be involved in protein synthesis and a potential site for drug targeting...
  7. doi request reprint Myeloid cell IL-10 production in response to leishmania involves inactivation of glycogen synthase kinase-3β downstream of phosphatidylinositol-3 kinase
    Devki Nandan
    Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada
    J Immunol 188:367-78. 2012
    ..Thus, GSK-3β negatively regulates myeloid cell IL-10 production in response to leishmania. Switching off GSK-3β promotes disease pathogenesis...
  8. ncbi request reprint Large-scale survey for potentially targetable indels in bacterial and protozoan proteins
    Artem Cherkasov
    Division of Infectious Diseases, Department of Medicine, University of British Columbia, Faculty of Medicine, Vancouver Coastal Health Research Institute, Vancouver, British Columbia, Canada
    Proteins 62:371-80. 2006
    ..The finding suggested that the occurrence of sequence indels may be involved in the evolution of pathogenic mechanisms in these protozoa...
  9. pmc Proteomic analysis of the secretome of Leishmania donovani
    J Maxwell Silverman
    Department of Medicine Division of Infectious Diseases, University of British Columbia, Faculty of Medicine, 2733 Heather St, Vancouver, British Columbia, V5Z 3J5, Canada
    Genome Biol 9:R35. 2008
    ....
  10. doi request reprint Secreted virulence factors and immune evasion in visceral leishmaniasis
    Ulrike Lambertz
    Department of Medicine Division of Infectious Diseases and the Experimental Medicine Program, University of British Columbia, Vancouver, Canada
    J Leukoc Biol 91:887-99. 2012
    ..In addition to representing a novel mechanism for trafficking of virulence factors across membranes, recent findings indicate that leishmania exosomes may have potential as vaccine candidates...
  11. ncbi request reprint 1alpha,25-dihydroxycholecalciferol activates binding of CREB to a CRE site in the CD14 promoter and drives promoter activity in a phosphatidylinositol-3 kinase-dependent manner
    Alireza Moeenrezakhanlou
    Department of Medicine, University of British Columbia, Rm 452D, 2733 Heather St, Vancouver, BC, Canada, V5Z 3J5
    J Leukoc Biol 81:1311-21. 2007
    ..Mutation of the CRE within the 19-mer abolished this activity. Taken together, these results show that calcitriol signaling, leading to activation of the CD14 promoter, involves CREB activation downstream of PI-3K...
  12. ncbi request reprint Selective targeting of indel-inferred differences in spatial structures of highly homologous proteins
    Artem Cherkasov
    Department of Medicine, Division of Infectious Diseases, University of British Columbia, Vancouver, British Columbia, Canada
    Proteins 58:950-4. 2005
    ..These findings may establish a new strategy for the development of antagonists directed against certain pathogenic targets having close human homologues...
  13. ncbi request reprint Differential regulation of CD44 expression by lipopolysaccharide (LPS) and TNF-alpha in human monocytic cells: distinct involvement of c-Jun N-terminal kinase in LPS-induced CD44 expression
    Katrina Gee
    Department of Pediatrics, Research Institute, Children s Hospital of Eastern Ontario, University of Ottawa, 401 Smyth Road, Ottawa, Ontario, Canada, K1H 8L1
    J Immunol 169:5660-72. 2002
    ..Taken together, these results suggest a predominant role of JNK in LPS-induced CD44 expression in monocytic cells...
  14. ncbi request reprint Annexin V associates with the IFN-gamma receptor and regulates IFN-gamma signaling
    Carlos Leon
    Department of Medicine, Division of Infectious Diseases, Faculties of Medicine and Science, University of British Columbia, 2733 Heather Street, Vancouver, BC, Canada
    J Immunol 176:5934-42. 2006
    ..Taken together, these results suggest that through an inducible association with the R2 subunit of the IFN-gammaR, AxV modulates cellular responses to IFN-gamma by modulating signaling through the Jak-Stat1 pathway...
  15. doi request reprint Echinacea and trypanasomatid parasite interactions: growth-inhibitory and anti-inflammatory effects of Echinacea
    Judith Canlas
    Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada
    Pharm Biol 48:1047-52. 2010
    ..Herbal preparations derived from various species and parts of Echinacea (Asteraceae) have been advocated for various medical applications, as a result of the many antimicrobial and immunomodulatory activities attributed to them...
  16. ncbi request reprint Cyclosporin A and FK506 inhibit IL-12p40 production through the calmodulin/calmodulin-dependent protein kinase-activated phosphoinositide 3-kinase in lipopolysaccharide-stimulated human monocytic cells
    Wei Ma
    Department of Pathology and Laboratory Medicine, and Biochemistry, University of Ottawa, Ottawa, Ontario K1H 8L1, Canada
    J Biol Chem 282:13351-62. 2007
    ..Importantly, both CyA and FK506 down-regulated LPS-induced IL-12p40 transcription by inhibiting CaM/CaMK-II-activated PI3K and their downstream transcription factors NFkappaB and AP-1 independent of the JNK pathway...
  17. ncbi request reprint Distinct role of p38 and c-Jun N-terminal kinases in IL-10-dependent and IL-10-independent regulation of the costimulatory molecule B7.2 in lipopolysaccharide-stimulated human monocytic cells
    Wilfred Lim
    Department of Pediatrics, University of Ottawa, Ottawa, Ontario, Canada
    J Immunol 168:1759-69. 2002
    ..2 expression. Taken together, our results reveal the distinct involvement of p38 in IL-10-dependent, and JNK in IL-10-independent regulation of B7.2 expression in LPS-stimulated monocytic cells...