R K Nam

Summary

Affiliation: University of Toronto
Country: Canada

Publications

  1. ncbi request reprint The use of genetic markers to determine risk for prostate cancer at prostate biopsy
    Robert K Nam
    Division of Urology and Department of Pathology, Sunnybrook and Women s College Health Sciences Centre, Ontario, Canada
    Clin Cancer Res 11:8391-7. 2005
  2. ncbi request reprint Correlation of the primary Gleason pattern on prostate needle biopsy with clinico-pathological factors in Gleason 7 tumors
    Ethan D Grober
    Division of Urology, Department of Surgery and Pathology, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Can J Urol 11:2157-62. 2004
  3. ncbi request reprint Assessing individual risk for prostate cancer
    Robert K Nam
    Division of Urology, Department of Radiation Oncology, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
    J Clin Oncol 25:3582-8. 2007
  4. doi request reprint Incidence of complications other than urinary incontinence or erectile dysfunction after radical prostatectomy or radiotherapy for prostate cancer: a population-based cohort study
    Robert K Nam
    Division of Urology, Sunnybrook Health Sciences Centre, Sunnybrook Research Institute, University of Toronto, Toronto, ON, Canada Electronic address
    Lancet Oncol 15:223-31. 2014
  5. doi request reprint Increasing hospital admission rates for urological complications after transrectal ultrasound guided prostate biopsy
    Robert K Nam
    Division of Urology, Sunnybrook Research Institute, Toronto, Ontario, Canada
    J Urol 189:S12-7; discussion S17-8. 2013
  6. doi request reprint Population based study of long-term rates of surgery for urinary incontinence after radical prostatectomy for prostate cancer
    Robert K Nam
    Division of Urology, Sunnybrook Health Sciences Centre, Sunnybrook Research Institute, Toronto, Ontario, Canada
    J Urol 188:502-6. 2012
  7. doi request reprint Association between germline HOXB13 G84E mutation and risk of prostate cancer
    Mohammad R Akbari
    Women s College Research Institute, Women s College Hospital, Toronto, ON, Canada
    J Natl Cancer Inst 104:1260-2. 2012
  8. pmc New variants at 10q26 and 15q21 are associated with aggressive prostate cancer in a genome-wide association study from a prostate biopsy screening cohort
    Robert K Nam
    Division of Urology, Sunnybrook Research Institute, University of Toronto, ON, Canada
    Cancer Biol Ther 12:997-1004. 2011
  9. pmc Serial personal digital assistant data capture of health-related quality of life: a randomized controlled trial in a prostate cancer clinic
    Andrew G Matthew
    Department of Surgical Oncology, University Health Network, Toronto, Ontario, Canada
    Health Qual Life Outcomes 5:38. 2007
  10. ncbi request reprint A genome-wide association screen identifies regions on chromosomes 1q25 and 7p21 as risk loci for sporadic prostate cancer
    R K Nam
    Division of Urology, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
    Prostate Cancer Prostatic Dis 11:241-6. 2008

Collaborators

Detail Information

Publications36

  1. ncbi request reprint The use of genetic markers to determine risk for prostate cancer at prostate biopsy
    Robert K Nam
    Division of Urology and Department of Pathology, Sunnybrook and Women s College Health Sciences Centre, Ontario, Canada
    Clin Cancer Res 11:8391-7. 2005
    ..We examined a panel of 13 polymorphisms in 13 different genes to determine whether specific genotypes can help predict prostate cancer at the time of biopsy among men prescreened with prostate-specific antigen and digital rectal exam...
  2. ncbi request reprint Correlation of the primary Gleason pattern on prostate needle biopsy with clinico-pathological factors in Gleason 7 tumors
    Ethan D Grober
    Division of Urology, Department of Surgery and Pathology, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Can J Urol 11:2157-62. 2004
    ..To correlate the primary Gleason pattern among patients with biopsy-derived Gleason 7 tumors with the radical prostatectomy specimen Gleason grading and other clinical and pathologic outcomes...
  3. ncbi request reprint Assessing individual risk for prostate cancer
    Robert K Nam
    Division of Urology, Department of Radiation Oncology, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
    J Clin Oncol 25:3582-8. 2007
    ..To construct a clinical nomogram instrument to estimate individual risk for having prostate cancer (PC) for patients undergoing prostate specific antigen (PSA) screening, using all risk factors known for PC...
  4. doi request reprint Incidence of complications other than urinary incontinence or erectile dysfunction after radical prostatectomy or radiotherapy for prostate cancer: a population-based cohort study
    Robert K Nam
    Division of Urology, Sunnybrook Health Sciences Centre, Sunnybrook Research Institute, University of Toronto, Toronto, ON, Canada Electronic address
    Lancet Oncol 15:223-31. 2014
    ..We aimed to assess other important complications associated with these treatments for prostate cancer...
  5. doi request reprint Increasing hospital admission rates for urological complications after transrectal ultrasound guided prostate biopsy
    Robert K Nam
    Division of Urology, Sunnybrook Research Institute, Toronto, Ontario, Canada
    J Urol 189:S12-7; discussion S17-8. 2013
    ..Transrectal ultrasound guided prostate biopsy is widely used to confirm the diagnosis of prostate cancer. The technique has been associated with significant morbidity in a small proportion of patients...
  6. doi request reprint Population based study of long-term rates of surgery for urinary incontinence after radical prostatectomy for prostate cancer
    Robert K Nam
    Division of Urology, Sunnybrook Health Sciences Centre, Sunnybrook Research Institute, Toronto, Ontario, Canada
    J Urol 188:502-6. 2012
    ..We examined the long-term rate of post-prostatectomy incontinence surgery and factors influencing it...
  7. doi request reprint Association between germline HOXB13 G84E mutation and risk of prostate cancer
    Mohammad R Akbari
    Women s College Research Institute, Women s College Hospital, Toronto, ON, Canada
    J Natl Cancer Inst 104:1260-2. 2012
    ..7%] vs 2 of 1757 [0.1%], P = .01) and was associated with an increased risk of prostate cancer (unadjusted odds ratio = 5.8, 95% confidence interval = 1.3 to 26.5, P = .01)...
  8. pmc New variants at 10q26 and 15q21 are associated with aggressive prostate cancer in a genome-wide association study from a prostate biopsy screening cohort
    Robert K Nam
    Division of Urology, Sunnybrook Research Institute, University of Toronto, ON, Canada
    Cancer Biol Ther 12:997-1004. 2011
    ..To identify and examine polymorphisms of genes associated with aggressive and clinical significant forms of prostate cancer among a screening cohort...
  9. pmc Serial personal digital assistant data capture of health-related quality of life: a randomized controlled trial in a prostate cancer clinic
    Andrew G Matthew
    Department of Surgical Oncology, University Health Network, Toronto, Ontario, Canada
    Health Qual Life Outcomes 5:38. 2007
    ....
  10. ncbi request reprint A genome-wide association screen identifies regions on chromosomes 1q25 and 7p21 as risk loci for sporadic prostate cancer
    R K Nam
    Division of Urology, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
    Prostate Cancer Prostatic Dis 11:241-6. 2008
    ....
  11. pmc Expression of the TMPRSS2:ERG fusion gene predicts cancer recurrence after surgery for localised prostate cancer
    R K Nam
    Division of Urology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Canada
    Br J Cancer 97:1690-5. 2007
    ..0001) compared to patients without the fusion protein. Among prostate cancer patients treated with surgery, the expression of TMPRSS2:ERG fusion gene is a strong prognostic factor and is independent of grade, stage and PSA level...
  12. doi request reprint Utility of incorporating genetic variants for the early detection of prostate cancer
    Robert K Nam
    Division of Urology, Sunnybrook Research Institute, Department of Radiation Oncology, Sunnybrook Health Sciences, University of Toronto, Toronto, Ontario, Canada
    Clin Cancer Res 15:1787-93. 2009
    ..Several single nucleotide polymorphisms (SNP) have been associated with the risk of prostate cancer. The clinical utility of using SNPs in the early detection of prostate cancer has not been evaluated...
  13. doi request reprint Increasing hospital admission rates for urological complications after transrectal ultrasound guided prostate biopsy
    Robert K Nam
    Division of Urology, Sunnybrook Research Institute, Toronto, Ontario, Canada
    J Urol 183:963-8. 2010
    ..Transrectal ultrasound guided prostate biopsy is widely used to confirm the diagnosis of prostate cancer. The technique has been associated with significant morbidity in a small proportion of patients...
  14. doi request reprint Prospective multi-institutional study evaluating the performance of prostate cancer risk calculators
    Robert K Nam
    Sunnybrook Health Sciences Centre, 2075 Bayview Ave, Room MG 406, Toronto, Ontario, Canada
    J Clin Oncol 29:2959-64. 2011
    ..Prostate cancer risk calculators incorporate many factors to evaluate an individual's risk for prostate cancer. We validated two common North American-based, prostate cancer risk calculators...
  15. ncbi request reprint Variants of the hK2 protein gene (KLK2) are associated with serum hK2 levels and predict the presence of prostate cancer at biopsy
    Robert K Nam
    Division of Urology Department of Pathology, Sunnybrook Health Sciences Centre, University Health Network, Mount Sinai Hospital, University of Toronto, Ontario, Canada
    Clin Cancer Res 12:6452-8. 2006
    ..We examined five variants of the KLK2 gene to further define its relevance to prostate cancer susceptibility and hK2 levels...
  16. ncbi request reprint Variation in patterns of practice in diagnosing screen-detected prostate cancer
    Robert K Nam
    Division of Urology, Sunnybrook and Women s College Health Sciences Centre, University of Toronto, Toronto, Canada
    BJU Int 94:1239-44. 2004
    ....
  17. ncbi request reprint Comprehensive assessment of candidate genes and serological markers for the detection of prostate cancer
    Robert K Nam
    Division of Urology, Sunnybrook and Women s College Health Sciences Centre, University of Toronto, Ontario, Canada
    Cancer Epidemiol Biomarkers Prev 12:1429-37. 2003
    ..The GST-T1 and IGF-I polymorphisms demonstrated modest associations with prostate cancer risk. IGF-I levels were not helpful in identifying patients with prostate cancer at the time of biopsy...
  18. ncbi request reprint Single nucleotide polymorphism of the human kallikrein-2 gene highly correlates with serum human kallikrein-2 levels and in combination enhances prostate cancer detection
    Robert K Nam
    Division of Urology, 2075 Bayview Ave, MG 406, Toronto, Ontario, Canada, M4N 3M5
    J Clin Oncol 21:2312-9. 2003
    ..We examined the relationship between a mutant (T) for wild-type (C) allele substitution of the human kallikrein-2 gene (KLK2), circulating human kallikrein-2 (hK2) levels and prostate cancer risk...
  19. ncbi request reprint A novel serum marker, total prostate secretory protein of 94 amino acids, improves prostate cancer detection and helps identify high grade cancers at diagnosis
    Robert K Nam
    Division of Urology, Sunnybrook and Women s College Health Sciences Centre and University Health Network, Toronto, Ontario, Canada
    J Urol 175:1291-7. 2006
    ..New biomarkers for prostate cancer are needed. We determined whether a novel serum marker, total PSP94 can be used to accomplish these goals...
  20. ncbi request reprint Making sense of prostate specific antigen: improving its predictive value in patients undergoing prostate biopsy
    Robert K Nam
    Division of Urology, Sunnybrook and Women s College Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada
    J Urol 175:489-94. 2006
    ..The clinical usefulness of PSA for prostate cancer screening is unclear, although the test remains in common use. New methods to interpret PSA are needed...
  21. ncbi request reprint Serum insulin-like growth factor-I levels and prostatic intraepithelial neoplasia: a clue to the relationship between IGF-I physiology and prostate cancer risk
    Robert K Nam
    Sunnybrook and Women s College Health Sciences Centre, 2075 Bayview Avenue, MG 406 Toronto, Ontario, Canada, M4N 3M5
    Cancer Epidemiol Biomarkers Prev 14:1270-3. 2005
    ..Larger studies will be required to confirm this relationship...
  22. pmc HPC2 variants and screen-detected prostate cancer
    D Vesprini
    Department of Public Health Sciences, University of Toronto, Toronto, Ontario, Canada
    Am J Hum Genet 68:912-7. 2001
    ..8%), and healthy women (6.3%) (P = .83). We conclude that HPC2 genotyping is unlikely to be a useful adjunct to PSA in the prediction of the presence of biopsy-detected prostate cancer in asymptomatic men...
  23. ncbi request reprint V89L polymorphism of type-2, 5-alpha reductase enzyme gene predicts prostate cancer presence and progression
    R K Nam
    Division of Urology, Princess Margaret Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Urology 57:199-204. 2001
    ..We examined whether this polymorphism predicts the presence of prostate cancer in 320 men without cancer who underwent biopsy and cancer progression in 318 men who underwent radical prostatectomy...
  24. pmc Radical prostatectomy as treatment for prostate cancer
    Michael A S Jewett
    Uro Oncology Program, Division of Urology, University of Toronto
    CMAJ 168:44-5. 2003
  25. pmc miR-221 Is down-regulated in TMPRSS2:ERG fusion-positive prostate cancer
    Aida Gordanpour
    Department of Laboratory Medicine and Pathobiology, University of Toronto, and Sunnybrook Research Institute, Toronto, Canada
    Anticancer Res 31:403-10. 2011
    ..Herein we report that in a large and diverse cohort of prostate carcinoma samples, miR-221 is down-regulated in patients with tumours bearing TMPRSS2:ERG fusion transcripts, thus providing a link between miRNA and gene fusion expression...
  26. ncbi request reprint Nomogram prediction for prostate cancer and aggressive prostate cancer at time of biopsy: utilizing all risk factors and tumor markers for prostate cancer
    Robert K Nam
    Division of Urology, Sunnybrook and Women s College Health Sciences Centre, Toronto, Ontario, Canada
    Can J Urol 13:2-10. 2006
    ..There is a large amount of confusion in interpreting prostate specific antigen (PSA) values for prostate cancer. More precise risk assessments for prostate cancer detection are needed for men faced with an abnormal PSA...
  27. doi request reprint MicroRNAs in prostate cancer: from biomarkers to molecularly-based therapeutics
    A Gordanpour
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
    Prostate Cancer Prostatic Dis 15:314-9. 2012
    ....
  28. ncbi request reprint Expression of TMPRSS2:ERG gene fusion in prostate cancer cells is an important prognostic factor for cancer progression
    Robert K Nam
    Division of Urology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Canada
    Cancer Biol Ther 6:40-5. 2007
    ..Our study indicates that the expression of TMPRSS2:ERG fusion gene among prostate cancer patients treated with surgery is a strong prognostic factor for disease relapse, and may have important clinical implications...
  29. doi request reprint Indications and timing for prostate biopsy, diagnosis of early stage prostate cancer and its definitive treatment: a clinical conundrum in the PSA era
    Sanoj Punnen
    Division of Urology, Sunnybrook Health Sciences Centre, University of Toronto, Ontario, Canada M4N 3M5
    Surg Oncol 18:192-9. 2009
    ..Finally, discovery of a new molecular marker independent of the PSA level will be very important in the diagnosis and prognosis of prostate cancer...
  30. ncbi request reprint Delay in surgical therapy for clinically localized prostate cancer and biochemical recurrence after radical prostatectomy
    Robert K Nam
    Division of Urology, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Can J Urol 10:1891-8. 2003
    ..We examined whether delay from diagnosis for patients undergoing surgery for clinically localized prostate cancer affects cancer cure rates...
  31. doi request reprint Lymph node assessment and lymphadenectomy in prostate cancer
    Michael Ordon
    Division of Urology, Sunnybrook Health Sciences Centre, Department of Health Policy, Management and Evaluation, University of Toronto, Toronto, Canada
    J Surg Oncol 99:215-24. 2009
    ..The status of pelvic lymph nodes is also being used to guide further treatments after surgery. Also, recent data has shown possible therapeutic benefit of lymphadenectomy in improving cancer specific survival...
  32. ncbi request reprint Active surveillance with selective delayed intervention for favorable risk prostate cancer: clinical experience and a 'number needed to treat' analysis
    Laurence H Klotz
    Division of Urology, University of Toronto, Sunnybrook and Women s College Health Sciences Centre, Toronto, Ontario, Canada
    Can J Urol 13:48-55. 2006
    ....
  33. pmc Micronutrients attenuate progression of prostate cancer by elevating the endogenous inhibitor of angiogenesis, platelet factor-4
    David Cervi
    1Department of Molecular and Cellular Biology, Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Toronto, Ontario, M4N 3M5, Canada
    BMC Cancer 10:258. 2010
    ..The purpose herein was to discover, validate and characterize functional biomarkers of dietary supplementation capable of suppressing the course of prostate cancer in vivo...
  34. ncbi request reprint Urolith masquerading as severe acute radiation toxicity: case report
    Daniel Toguri
    Clinical Clerk, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, Ontario, Canada
    Can J Urol 17:5040-3. 2010
    ..We describe an unusual case of a patient experiencing severe, culture negative urinary symptoms early in a course of salvage radiotherapy...
  35. doi request reprint A combination of micronutrients is beneficial in reducing the incidence of prostate cancer and increasing survival in the Lady transgenic model
    Vasundara Venkateswaran
    Division of Urology, S 118B, Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Toronto, Ontario, Canada
    Cancer Prev Res (Phila) 2:473-83. 2009
    ..These observations provide support for their chemopreventive effect and some clues about their mechanism of action. These key findings will be complementary to the outcome from the Selenium and Vitamin E Chemoprevention Trial...
  36. ncbi request reprint Prostate sparing radical cystectomy--not for all, but an option for some
    Jehonathan H Pinthus
    Department of Surgery, Division of Urology, McMaster University, Hamilton, Ontario, Canada
    Can J Urol 13:81-7. 2006
    ..The objective of this review is to address some of the concerns related to the potential compromise of oncological outcome compared to radical cystoprostatectomy (RCP)-the gold standard procedure...