Research Topics
Genomes and GenesSpecies | R K NamSummaryAffiliation: University of Toronto Country: Canada Publications
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Detail Information
Publications
The use of genetic markers to determine risk for prostate cancer at prostate biopsyRobert K Nam
Division of Urology and Department of Pathology, Sunnybrook and Women's College Health Sciences Centre, Ontario, Canada
Clin Cancer Res 11:8391-7. 2005..Future studies are required to confirm these results...- Correlation of the primary Gleason pattern on prostate needle biopsy with clinico-pathological factors in Gleason 7 tumorsEthan D Grober
Division of Urology, Department of Surgery and Pathology, University Health Network, University of Toronto, Toronto, Ontario, Canada
Can J Urol 11:2157-62. 2004..The utility of distinguishing a primary Gleason pattern on needle biopsy among patients with Gleason 7 tumors remains unclear given the limited and conflicting literature addressing this issue... - Assessing individual risk for prostate cancerRobert K Nam
Division of Urology, Department of Radiation Oncology, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
J Clin Oncol 25:3582-8. 2007..To construct a clinical nomogram instrument to estimate individual risk for having prostate cancer (PC) for patients undergoing prostate specific antigen (PSA) screening, using all risk factors known for PC... 
Increasing hospital admission rates for urological complications after transrectal ultrasound guided prostate biopsyRobert K Nam
Division of Urology, Sunnybrook Research Institute, Toronto, Ontario, Canada
J Urol 189:S12-7; discussion S17-8. 2013..Transrectal ultrasound guided prostate biopsy is widely used to confirm the diagnosis of prostate cancer. The technique has been associated with significant morbidity in a small proportion of patients...- Population based study of long-term rates of surgery for urinary incontinence after radical prostatectomy for prostate cancerRobert K Nam
Division of Urology, Sunnybrook Health Sciences Centre, Sunnybrook Research Institute, Toronto, Ontario, Canada
J Urol 188:502-6. 2012..We examined the long-term rate of post-prostatectomy incontinence surgery and factors influencing it... - Association between germline HOXB13 G84E mutation and risk of prostate cancerMohammad R Akbari
Women s College Research Institute, Women s College Hospital, Toronto, ON, Canada
J Natl Cancer Inst 104:1260-2. 2012..7%] vs 2 of 1757 [0.1%], P = .01) and was associated with an increased risk of prostate cancer (unadjusted odds ratio = 5.8, 95% confidence interval = 1.3 to 26.5, P = .01)... 
New variants at 10q26 and 15q21 are associated with aggressive prostate cancer in a genome-wide association study from a prostate biopsy screening cohortRobert K Nam
Division of Urology, Sunnybrook Research Institute, University of Toronto, ON, Canada
Cancer Biol Ther 12:997-1004. 2011..To identify and examine polymorphisms of genes associated with aggressive and clinical significant forms of prostate cancer among a screening cohort...
Serial personal digital assistant data capture of health-related quality of life: a randomized controlled trial in a prostate cancer clinicAndrew G Matthew
Department of Surgical Oncology, University Health Network, Toronto, Ontario, Canada
Health Qual Life Outcomes 5:38. 2007....- Comprehensive assessment of candidate genes and serological markers for the detection of prostate cancerRobert K Nam
Division of Urology, Sunnybrook and Women s College Health Sciences Centre, University of Toronto, Ontario, Canada
Cancer Epidemiol Biomarkers Prev 12:1429-37. 2003..The GST-T1 and IGF-I polymorphisms demonstrated modest associations with prostate cancer risk. IGF-I levels were not helpful in identifying patients with prostate cancer at the time of biopsy... - Single nucleotide polymorphism of the human kallikrein-2 gene highly correlates with serum human kallikrein-2 levels and in combination enhances prostate cancer detectionRobert K Nam
Division of Urology, 2075 Bayview Ave, MG 406, Toronto, Ontario, Canada, M4N 3M5
J Clin Oncol 21:2312-9. 2003..We examined the relationship between a mutant (T) for wild-type (C) allele substitution of the human kallikrein-2 gene (KLK2), circulating human kallikrein-2 (hK2) levels and prostate cancer risk... - Prospective multi-institutional study evaluating the performance of prostate cancer risk calculatorsRobert K Nam
Sunnybrook Health Sciences Centre, 2075 Bayview Ave, Room MG 406, Toronto, Ontario, Canada
J Clin Oncol 29:2959-64. 2011..Prostate cancer risk calculators incorporate many factors to evaluate an individual's risk for prostate cancer. We validated two common North American-based, prostate cancer risk calculators... - Increasing hospital admission rates for urological complications after transrectal ultrasound guided prostate biopsyRobert K Nam
Division of Urology, Sunnybrook Research Institute, Toronto, Ontario, Canada
J Urol 183:963-8. 2010..Transrectal ultrasound guided prostate biopsy is widely used to confirm the diagnosis of prostate cancer. The technique has been associated with significant morbidity in a small proportion of patients... - Utility of incorporating genetic variants for the early detection of prostate cancerRobert K Nam
Division of Urology, Sunnybrook Research Institute, Department of Radiation Oncology, Sunnybrook Health Sciences, University of Toronto, Toronto, Ontario, Canada
Clin Cancer Res 15:1787-93. 2009..Several single nucleotide polymorphisms (SNP) have been associated with the risk of prostate cancer. The clinical utility of using SNPs in the early detection of prostate cancer has not been evaluated... - Expression of the TMPRSS2:ERG fusion gene predicts cancer recurrence after surgery for localised prostate cancerR K Nam
Division of Urology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Canada
Br J Cancer 97:1690-5. 2007..0001) compared to patients without the fusion protein. Among prostate cancer patients treated with surgery, the expression of TMPRSS2:ERG fusion gene is a strong prognostic factor and is independent of grade, stage and PSA level... - A genome-wide association screen identifies regions on chromosomes 1q25 and 7p21 as risk loci for sporadic prostate cancerR K Nam
Division of Urology, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
Prostate Cancer Prostatic Dis 11:241-6. 2008.... - Variants of the hK2 protein gene (KLK2) are associated with serum hK2 levels and predict the presence of prostate cancer at biopsyRobert K Nam
Division of Urology Department of Pathology, Sunnybrook Health Sciences Centre, University Health Network, Mount Sinai Hospital, University of Toronto, Ontario, Canada
Clin Cancer Res 12:6452-8. 2006..We examined five variants of the KLK2 gene to further define its relevance to prostate cancer susceptibility and hK2 levels... - Serum insulin-like growth factor-I levels and prostatic intraepithelial neoplasia: a clue to the relationship between IGF-I physiology and prostate cancer riskRobert K Nam
Sunnybrook and Women s College Health Sciences Centre, 2075 Bayview Avenue, MG 406 Toronto, Ontario, Canada, M4N 3M5
Cancer Epidemiol Biomarkers Prev 14:1270-3. 2005..Larger studies will be required to confirm this relationship... - Making sense of prostate specific antigen: improving its predictive value in patients undergoing prostate biopsyRobert K Nam
Division of Urology, Sunnybrook and Women s College Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada
J Urol 175:489-94. 2006..The clinical usefulness of PSA for prostate cancer screening is unclear, although the test remains in common use. New methods to interpret PSA are needed... - A novel serum marker, total prostate secretory protein of 94 amino acids, improves prostate cancer detection and helps identify high grade cancers at diagnosisRobert K Nam
Division of Urology, Sunnybrook and Women s College Health Sciences Centre and University Health Network, Toronto, Ontario, Canada
J Urol 175:1291-7. 2006..New biomarkers for prostate cancer are needed. We determined whether a novel serum marker, total PSP94 can be used to accomplish these goals... - Variation in patterns of practice in diagnosing screen-detected prostate cancerRobert K Nam
Division of Urology, Sunnybrook and Women s College Health Sciences Centre, University of Toronto, Toronto, Canada
BJU Int 94:1239-44. 2004.... - HPC2 variants and screen-detected prostate cancerD Vesprini
Department of Public Health Sciences, University of Toronto, Toronto, Ontario, Canada
Am J Hum Genet 68:912-7. 2001..8%), and healthy women (6.3%) (P = .83). We conclude that HPC2 genotyping is unlikely to be a useful adjunct to PSA in the prediction of the presence of biopsy-detected prostate cancer in asymptomatic men... - V89L polymorphism of type-2, 5-alpha reductase enzyme gene predicts prostate cancer presence and progressionR K Nam
Division of Urology, Princess Margaret Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada
Urology 57:199-204. 2001..We examined whether this polymorphism predicts the presence of prostate cancer in 320 men without cancer who underwent biopsy and cancer progression in 318 men who underwent radical prostatectomy... - Radical prostatectomy as treatment for prostate cancerMichael A S Jewett
Uro-Oncology Program, Division of Urology, University of Toronto
CMAJ 168:44-5. 2003 - miR-221 Is down-regulated in TMPRSS2:ERG fusion-positive prostate cancerAida Gordanpour
Department of Laboratory Medicine and Pathobiology, University of Toronto, and Sunnybrook Research Institute, Toronto, Canada
Anticancer Res 31:403-10. 2011..Herein we report that in a large and diverse cohort of prostate carcinoma samples, miR-221 is down-regulated in patients with tumours bearing TMPRSS2:ERG fusion transcripts, thus providing a link between miRNA and gene fusion expression... - Nomogram prediction for prostate cancer and aggressive prostate cancer at time of biopsy: utilizing all risk factors and tumor markers for prostate cancerRobert K Nam
Division of Urology, Sunnybrook and Women's College Health Sciences Centre, Toronto, Ontario, Canada
Can J Urol 13:2-10. 2006..This tool will aid physicians and patients in determining the need for prostate biopsy... - Indications and timing for prostate biopsy, diagnosis of early stage prostate cancer and its definitive treatment: a clinical conundrum in the PSA eraSanoj Punnen
Division of Urology, Sunnybrook Health Sciences Centre, University of Toronto, Ontario, Canada M4N 3M5
Surg Oncol 18:192-9. 2009..Finally, discovery of a new molecular marker independent of the PSA level will be very important in the diagnosis and prognosis of prostate cancer... - Expression of TMPRSS2:ERG gene fusion in prostate cancer cells is an important prognostic factor for cancer progressionRobert K Nam
Division of Urology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Canada
Cancer Biol Ther 6:40-5. 2007..Our study indicates that the expression of TMPRSS2:ERG fusion gene among prostate cancer patients treated with surgery is a strong prognostic factor for disease relapse, and may have important clinical implications... - Delay in surgical therapy for clinically localized prostate cancer and biochemical recurrence after radical prostatectomyRobert K Nam
Division of Urology, University Health Network, University of Toronto, Toronto, Ontario, Canada
Can J Urol 10:1891-8. 2003..These findings may have many biases that could not be properly accounted in this retrospective analysis and larger cohort analyses will be required to confirm these findings... - Lymph node assessment and lymphadenectomy in prostate cancerMichael Ordon
Division of Urology, Sunnybrook Health Sciences Centre, Department of Health Policy, Management and Evaluation, University of Toronto, Toronto, Canada
J Surg Oncol 99:215-24. 2009..The status of pelvic lymph nodes is also being used to guide further treatments after surgery. Also, recent data has shown possible therapeutic benefit of lymphadenectomy in improving cancer specific survival... - MicroRNAs in prostate cancer: from biomarkers to molecularly-based therapeuticsA Gordanpour
Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
Prostate Cancer Prostatic Dis 15:314-9. 2012.... - Active surveillance with selective delayed intervention for favorable risk prostate cancer: clinical experience and a 'number needed to treat' analysisLaurence H Klotz
Division of Urology, University of Toronto, Sunnybrook and Women's College Health Sciences Centre, Toronto, Ontario, Canada
Can J Urol 13:48-55. 2006.... - Micronutrients attenuate progression of prostate cancer by elevating the endogenous inhibitor of angiogenesis, platelet factor-4David Cervi
1Department of Molecular and Cellular Biology, Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Toronto, Ontario, M4N 3M5, Canada
BMC Cancer 10:258. 2010..The purpose herein was to discover, validate and characterize functional biomarkers of dietary supplementation capable of suppressing the course of prostate cancer in vivo... - Urolith masquerading as severe acute radiation toxicity: case reportDaniel Toguri
Clinical Clerk, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, Ontario, Canada
Can J Urol 17:5040-3. 2010..We describe an unusual case of a patient experiencing severe, culture negative urinary symptoms early in a course of salvage radiotherapy... - Prostate sparing radical cystectomy--not for all, but an option for someJehonathan H Pinthus
Department of Surgery, Division of Urology, McMaster University, Hamilton, Ontario, Canada
Can J Urol 13:81-7. 2006..However, with proper patient screening and selection the short-term results appear promising... - A combination of micronutrients is beneficial in reducing the incidence of prostate cancer and increasing survival in the Lady transgenic modelVasundara Venkateswaran
Division of Urology, S 118B, Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Toronto, Ontario, Canada
Cancer Prev Res (Phila) 2:473-83. 2009..These observations provide support for their chemopreventive effect and some clues about their mechanism of action. These key findings will be complementary to the outcome from the Selenium and Vitamin E Chemoprevention Trial...