Research Topics
| Gary NaglieSummaryAffiliation: University of Toronto Country: Canada Publications
| Collaborators
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Detail Information
Publications
Predictors of family caregiver ratings of patient quality of life in Alzheimer disease: cross-sectional results from the Canadian Alzheimer's Disease Quality of Life StudyGary Naglie
Division of General Internal Medicine, University Health Network, Toronto, Ontario, Canada
Am J Geriatr Psychiatry 19:891-901. 2011..To assess whether the core symptoms of Alzheimer disease (AD) and caregiver factors consistently predict family caregiver ratings of patient quality of life (QOL) as assessed by a variety of QOL measures in a large national sample...- Predictors of patient self-ratings of quality of life in Alzheimer disease: cross-sectional results from the Canadian Alzheimer's Disease Quality of Life StudyGary Naglie
Division of General Internal Medicine GN, MK, University Health Network, Toronto, Ontario, Canada
Am J Geriatr Psychiatry 19:881-90. 2011..To assess whether the core symptoms of Alzheimer disease (AD) consistently predict patient self-rated quality of life (QOL) as assessed by a variety of QOL measures in a large national sample of AD patients... 
Utility-based Quality of Life measures in Alzheimer's diseaseGary Naglie
Division of General Internal Medicine and Clinical Epidemiology, University Health Network, Toronto, Ontario, Canada
Qual Life Res 15:631-43. 2006....- 30-day mortality and major complications after radical prostatectomy: influence of age and comorbidityShabbir M H Alibhai
Division of General Internal Medicine and Clinical Epidemiology, University Health Network, Toronto, Canada
J Natl Cancer Inst 97:1525-32. 2005..Prior studies have suggested an increased risk of short-term complications among older men who underwent radical prostatectomy, but these studies did not adjust for comorbidity... 
Impact of androgen-deprivation therapy on physical function and quality of life in men with nonmetastatic prostate cancerShabbir M H Alibhai
University Health Network, Toronto, Ontario, Canada
J Clin Oncol 28:5038-45. 2010..This prospective longitudinal study evaluated the effect of androgen deprivation therapy (ADT) on objective and self-reported physical function...- Predictors of time to requiring dopaminergic treatment in 2 Parkinson's disease cohortsConnie Marras
Morton and Gloria Shulman Movement Disorders Centre, Toronto Western Hospital, Toronto, Ontario, Canada
Mov Disord 26:608-13. 2011..We suspect that individuals employed full time may have a lower threshold for requiring dopaminergic therapy because of occupational demands... - Healthcare costs associated with prostate cancer: estimates from a population-based studyMurray D Krahn
Department of Medicine, University of Toronto, Toronto, Canada
BJU Int 105:338-46. 2010..Study Type - Health Economic (multiway sensitivity analyses) Level of Evidence 2b... - Predictors of deterioration in health-related quality of life in Parkinson's disease: results from the DATATOP trialConnie Marras
Division of Neurology, Toronto Western Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada
Mov Disord 23:653-9; quiz 776. 2008..Our focus in clinical care needs to be broadened beyond assessing and treating Parkinsonism, recognizing the impact of mood, cognition and function on HRQOL... - Is there an optimal comorbidity index for prostate cancer?Shabbir M H Alibhai
Division of General Internal Medicine and Clinical Epidemiology, University Health Network, Toronto, Ontario, Canada
Cancer 112:1043-50. 2008..Comorbidity is an important consideration in oncology practice, particularly among older patients. Although a variety of comorbidity indices have been employed in research studies, it is unclear whether any one index is preferred... - Impact of androgen-deprivation therapy on cognitive function in men with nonmetastatic prostate cancerShabbir M H Alibhai
University Health Network, Toronto, Ontario, Canada
J Clin Oncol 28:5030-7. 2010..To evaluate the effects of androgen-deprivation therapy (ADT) on cognitive function in men with nonmetastatic prostate cancer (PC)... - Responsiveness of disease-specific and generic utility instruments in prostate cancer patientsMurray Krahn
Department of Medicine, University of Toronto, Toronto, Ontario, Canada
Qual Life Res 16:509-22. 2007..Preferences (utilities) for health outcomes have an important role in decisions about prostate cancer screening and treatment. The responsiveness of utility instruments has not been evaluated... - An unadjusted NNT was a moderately good predictor of health benefitChristopher A K Y Chong
Department of Medicine, University of Toronto, Toronto, Ontario, Canada
J Clin Epidemiol 59:224-33. 2006..5 QALYs), an NNT <or=5 had a specificity of 77%. CONCLUSION: Using NNT thresholds of <or=5 and >15 to rule in and out therapies with large QALY gains may provide general guidance regarding the magnitude of health benefit... - Geriatric comorbidities, such as falls, confer an independent mortality risk to elderly dialysis patientsMarilyn Li
Department of Medicine, Toronto General Research Institute, University of Toronto, Toronto, Ontario, Canada
Nephrol Dial Transplant 23:1396-400. 2008..The objective of this study was to assess whether falls remained predictive of increased mortality risk even after controlling for age, comorbidity, dialysis vintage and laboratory variables... - Validation of the triage risk stratification tool to identify older persons at risk for hospital admission and returning to the emergency departmentJacques S Lee
Sunnybrook Research Institute, University of Toronto, Toronto, Ontario, Canada
J Am Geriatr Soc 56:2112-7. 2008..To assess the predictive validity of the Triage Risk Stratification Tool (TRST) to identify return to the emergency department (ED) or hospitalization in a multicenter patient sample... - Cyclo-oxygenase-2 inhibitors versus non-selective non-steroidal anti-inflammatory drugs and congestive heart failure outcomes in elderly patients: a population-based cohort studyMuhammad Mamdani
Institute for Clinical Evaluative Sciences, Toronto, ON M4N 3M5, Canada
Lancet 363:1751-6. 2004..We aimed to compare rates of admission for congestive heart failure in elderly patients who were newly dispensed COX-2 inhibitors or non-selective NSAIDs... - Is there age bias in the treatment of localized prostate carcinoma?Shabbir M H Alibhai
Division of General Internal Medicine and Clinical Epidemiology, University Health Network, Toronto, Ontario, Canada
Cancer 100:72-81. 2004..Previous studies have evaluated the influence of age and comorbidity, but to the authors' knowledge not RLE, on actual treatment decisions... - Exercise program to enhance physical performance and quality of life of older hemodialysis patients: a feasibility studyMika L Nonoyama
Toronto Rehabilitation Institute, 550 University Avenue, Toronto, ON, M5G 2A2, Canada
Int Urol Nephrol 42:1125-30. 2010..Evaluate the feasibility of implementing a combined in-hospital and home-based exercise program in older hemodialysis (HD) patients... - Development and validation of a utility weighting function for the patient-oriented prostate utility scale (PORPUS)George Tomlinson
Department of Medicine, University of Toronto, Toronto, Ontario, Canada
Med Decis Making 32:11-30. 2012..In this study, we developed a scoring system to allow indirect calculation of utilities from the PORPUS... - The association between patient age and prostate cancer stage and grade at diagnosisShabbir M H Alibhai
Division of General Internal Medicine and Clinical Epidemiology, University Health Network, 200 Elizabeth Street, Toronto, Ontario M50 2C4, Canada
BJU Int 94:303-6. 2004..To investigate the association of age with prostate cancer stage and grade, as the latter factors at the time of diagnosis influence management and prognosis, with some studies suggesting that they may change as a function of patient age... - Case selection for statins was similar in two Canadian provinces: BC and OntarioJ Michael Paterson
Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
J Clin Epidemiol 60:73-8. 2007..We aimed to assess whether new statin users in BC and Ontario differ in terms of their risk for future coronary heart disease (CHD) events... - Quality of life in dementiaGary Naglie
Division of General Internal Medicine, University Health Network, Canada
Can J Neurol Sci 34:S57-61. 2007..However, to date, QOL has rarely been included as an outcome measure in clinical trials of pharmacotherapy for dementia. This manuscript reviews the current state of knowledge about QOL assessment in dementia... - Rethinking 30-day mortality risk after radical prostatectomyShabbir M H Alibhai
Division of General Internal Medicine and Clinical Epidemiology, University Health Network, Toronto, Ontario, Canada
Urology 68:1057-60. 2006..Although radical prostatectomy (RP) is associated with greater 30-day mortality in older men, the magnitude of the excess risk in older age groups compared with younger ones has not been well characterized... - The feasibility of six-minute and two-minute walk tests in in-patient geriatric rehabilitationDina Brooks
Graduate Department of Rehabilitation Science, University of Toronto, Toronto, Ontario
Can J Aging 26:159-62. 2007..To evaluate the feasibility of the 6-minute and 2-minute walk tests in frail older persons... - Continued undertreatment of older men with localized prostate cancerKevin L Schwartz
University of Toronto, School of Medicine, Toronto, Ontario, Canada
Urology 62:860-5. 2003..Many of these patients with at least moderate-grade disease may benefit from potentially curative therapy (radical prostatectomy or radiotherapy)... - Observational study of upper gastrointestinal haemorrhage in elderly patients given selective cyclo-oxygenase-2 inhibitors or conventional non-steroidal anti-inflammatory drugsMuhammad Mamdani
Institute for Clinical Evaluative Sciences, 2075 Bayview Avenue G215, Toronto, Ontario, Canada
BMJ 325:624. 2002..To compare rates of upper gastrointestinal haemorrhage among elderly patients given selective cyclo-oxygenase-2 (COX 2) inhibitors and non-selective non-steroidal anti-inflammatory drugs (NSAIDs)... - Decision analysis in aerospace medicine: costs and benefits of a hyperbaric facility in spaceAva John-Baptiste
Department of Medicine, University of Toronto, Toronto, Ontario, Canada
Aviat Space Environ Med 77:434-42; discussion 442-3. 2006..We illustrate the use of decision analysis to compare a hyperbaric oxygen (HBO) chamber to currently available therapy for DCS treatment on the ISS... - The cost effectiveness of rofecoxib and celecoxib in patients with osteoarthritis or rheumatoid arthritisAndreas Maetzel
University Health Network, Toronto, Ontario, Canada
Arthritis Rheum 49:283-92. 2003..To evaluate the cost effectiveness of the cyclooxygenase 2 (COX-2) selective nonsteroidal antiinflammatory drug (NSAID) rofecoxib compared with naproxen and the COX-2 NSAID celecoxib compared with ibuprofen and diclofenac... - Effect of selective cyclooxygenase 2 inhibitors and naproxen on short-term risk of acute myocardial infarction in the elderlyMuhammad Mamdani
Institute for Clinical Evaluative Sciences, 2075 Bayview Ave G215, Toronto, Ontario, Canada M4N 3M5
Arch Intern Med 163:481-6. 2003..We compared the rates of acute myocardial infarction (AMI) among elderly patients dispensed selective cyclooxygenase 2 inhibitors, naproxen, and nonselective nonnaproxen nonsteroidal anti-inflammatory drugs (NSAIDs)... - An inpatient rehabilitation model of care targeting patients with cognitive impairmentKatherine S McGilton
Department of Research, Toronto Rehabilitation Institute, EW Bickle Centre for Continuing Care, 130 Dunn Avenue, Toronto, ON M6K 2R7, Canada
BMC Geriatr 12:21. 2012.... - Do older men benefit from curative therapy of localized prostate cancer?Shabbir M H Alibhai
University Health Network, Room ENG 233, 200 Elizabeth St, Toronto, Ontario, Canada M5G 2C4
J Clin Oncol 21:3318-27. 2003..We estimated life expectancy (LE) and quality-adjusted life expectancy (QALE) associated with available treatments for localized prostate cancer in men aged >/= 65 years, adjusting for Gleason score, patient preferences, and comorbidity... - Risk factors for harm in cognitively impaired seniors who live alone: a prospective studyMary C Tierney
Geriatric Research Unit, Sunnybrook and Women s College Health Sciences Center, Toronto, Ontario, Canada
J Am Geriatr Soc 52:1435-41. 2004..To identify risk factors for harm due to self-neglect or behaviors related to disorientation in cognitively impaired seniors who live alone that can be used in primary care... - Reliability and validity of the PORPUS, a combined psychometric and utility-based quality-of-life instrument for prostate cancerPaul Ritvo
York University, and Cancer Care Ontario, Division of Preventive Oncology, 620 University Ave, 1236, Toronto, Ontario M5G, Canada
J Clin Epidemiol 58:466-74. 2005..In this study we developed and tested these two forms of quality-of-life instruments, both based on a single, validated, health classification system... - Factors influencing exercise participation by older adults requiring chronic hemodialysis: a qualitative studyPia C Kontos
Toronto Rehabilitation Institute, 11035 550 University Ave, Toronto, ON, Canada, M5G 2A2
Int Urol Nephrol 39:1303-11. 2007..A shift is required in the culture of ESRD treatment programs towards a wellness perspective that includes expectations of exercise encouragement by the health care team and participation by patients... - Management of decreased bone mineral density in men starting androgen-deprivation therapy for prostate cancerAbbas H Panju
Department of Medicine, University Health Network, Toronto, Ontario, Canada
BJU Int 103:753-7. 2009.... - Health-state utilities and quality of life in hepatitis C patientsChristopher A K Y Chong
Faculty of Medicine, University of Toronto, Ontario, Canada
Am J Gastroenterol 98:630-8. 2003.... - A prescribing cascade involving cholinesterase inhibitors and anticholinergic drugsSudeep S Gill
Institute for Clinical Evaluative Sciences, Toronto, Ontario
Arch Intern Med 165:808-13. 2005..We present a new example of the prescribing cascade involving cholinesterase inhibitors and anticholinergic drugs used to manage urinary incontinence... - A phase I trial of deep brain stimulation of memory circuits in Alzheimer's diseaseAdrian W Laxton
Division of Neurosurgery, University of Toronto, Toronto, Ontario, Canada
Ann Neurol 68:521-34. 2010..We hypothesized that fornix/hypothalamus deep brain stimulation (DBS) could modulate neurophysiological activity in these pathological circuits and possibly produce clinical benefits... - The effect of English language proficiency on length of stay and in-hospital mortalityAva John-Baptiste
Division of General Internal Medicine, Department of Medicine, University Health Network, University of Toronto, Toronto, Ontario, Canada
J Gen Intern Med 19:221-8. 2004..The effect of communication barriers on outcomes of care in the inpatient setting requires further exploration, particularly for selected conditions in which length of stay is significantly prolonged... - Clinical pharmacy services in the home: Canadian case studiesLinda D MacKeigan
Faculty of Pharmacy and Home Care Evaluation and Research Centre, University of Toronto, Ontario, Canada
J Am Pharm Assoc (Wash) 42:735-42. 2002..Design: Home care practices in Canada were identified using key informant and snowball sampling methods. Case descriptions of each pharmacy were composed using data obtained via a faxed questionnaire and a follow-up telephone interview... - Risk factors for medication nonadherence in older adults with cognitive impairment who live aloneThulasi Thiruchselvam
Primary Care Research Unit, Sunnybrook Health Sciences Centre, Toronto, Canada
Int J Geriatr Psychiatry 27:1275-82. 2012..The aim of this study was to prospectively examine the influence of cognitive, medical, behavioral, and social risk factors on medication nonadherence in community-dwelling older adults with cognitive impairment... - Quality of life in early Parkinson's disease: impact of dyskinesias and motor fluctuationsConnie Marras
Division of Neurology, Toronto Western Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada
Mov Disord 19:22-8. 2004..We conclude that motor complications that occur within the first 4 years of treatment of PD do not have a significant negative effect on quality of life as measured by a visual analogue scale for most patients... - Validity of 3 physical performance measures in inpatient geriatric rehabilitationDina Brooks
Graduate Department of Rehabilitation Science, University of Toronto, Toronto, Ontario, Canada
Arch Phys Med Rehabil 87:105-10. 2006..To evaluate the construct validity and the responsiveness of 3 measures of physical performance measures as outcome measures for frail older persons... - Family physicians' attitudes and practices regarding assessments of medical fitness to drive in older personsRaymond W Jang
Department of Medicine, University of Toronto, Toronto, ON, Canada
J Gen Intern Med 22:531-43. 2007..Higher crash rates per mile driven in older drivers have focused attention on the assessment of older drivers... - The next step in guideline development: incorporating patient preferencesMurray Krahn
Toronto Health Economics and Technology Assessment Collaborative, Toronto General Research Institute, and University of Toronto, Toronto, Ontario, Canada
JAMA 300:436-8. 2008 - The proportion of variation in perioperative transfusion decisions in Canada attributable to the hospitalNadine Shehata
Division of Hematology, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
Can J Anaesth 54:902-7. 2007..The objective of this report was to quantify hospital variation in red cell transfusion decisions perioperatively for patients undergoing coronary artery bypass surgery (CABG)... - Content validity for dementia of three generic preference based health related quality of life instrumentsMichel Silberfeld
Department of Psychiatry, Baycrest Centre for Geriatric Care, University of Toronto, Ontario, Canada
Qual Life Res 11:71-9. 2002..Compared to the respondent generated attributes all three utility-based quality of life instruments have important shortcomings in content validity... - Development and validation of diagnostic criteria for carpal tunnel syndromeBrent Graham
University Health Network, Hospital for Sick Children, Toronto Rehabilitation Institute, Toronto, Ontario, Canada
J Hand Surg Am 31:919-24. 2006..To develop clinical diagnostic criteria for carpal tunnel syndrome (CTS) that modeled the clinical diagnostic practices of experts... - The cost effectiveness of ACE inhibitors as first-line antihypertensive therapyAlain J Nordmann
The Programme in Clinical Epidemiology and Health Care Research, University of Toronto, Toronto, Ontario, Canada
Pharmacoeconomics 21:573-85. 2003..Current hypertension guidelines differ in their recommendations for first-line antihypertensive therapy... - Concordance between discharge prescriptions and insurance claims in post-myocardial infarction patientsCynthia A Jackevicius
University Health Network, Toronto, ON, Canada
Pharmacoepidemiol Drug Saf 16:207-15. 2007..To assess the degree of concordance between the information (drug quantity, days' supply, and daily dose) recorded on hospital discharge prescriptions and what appears in a public drug insurance electronic claims database... - Expressions of personhood in Alzheimer's disease: an evaluation of research-based theatre as a pedagogical toolPia C Kontos
Toronto Rehabilitation Institute, Toronto, Canada
Qual Health Res 17:799-811. 2007.... - ABO-identical versus nonidentical platelet transfusion: a systematic reviewNadine Shehata
Department of Medicine, University of Toronto, Division of Hematology, St Michael s Hospital, Toronto, Ontario, Canada
Transfusion 49:2442-53. 2009..The primary objective of this report is to assess whether ABO-identical PLT transfusion is associated with improved mortality and/or morbidity for patients with hematologic/oncologic disorders... - Validating diagnostic information on the Minimum Data Set in Ontario Hospital-based long-term careWalter P Wodchis
Department of Health Policy Management and Evaluation, University of Toronto, Toronto, Ontario, Canada
Med Care 46:882-7. 2008..A full assessment of the quality of the diagnostic information recorded on the MDS is lacking... - Kidney transplantation in the elderly: a decision analysisSarbjit V Jassal
Division of Nephrology, University Health Network, Toronto, Ontario, Canada
J Am Soc Nephrol 14:187-96. 2003..Prolonged waiting times dramatically decrease the clinical benefits and economic attractiveness of transplantation, suggesting that living donor transplantation may be of particular benefit in this population... - The ten-year rule revisited: accuracy of clinicians' estimates of life expectancy in patients with localized prostate cancerMurray D Krahn
Department of Medicine, University of Toronto School of Medicine, Toronto, Ontario, Canada
Urology 60:258-63. 2002..quot; Life expectancy estimates are strongly associated with treatment choice. The appropriateness of the 10-year rule remains to be determined... - Affective correlates of fear of falling in elderly personsNadine Gagnon
Department of Psychiatry, University of Toronto, Ontario, M5G 2C4, Canada
Am J Geriatr Psychiatry 13:7-14. 2005..Further research is needed to determine whether similar findings occur in a community-based sample of older people...