Leigh Murphy

Summary

Affiliation: University of Manitoba
Country: Canada

Publications

  1. ncbi Altered expression of estrogen receptor coregulators during human breast tumorigenesis
    L C Murphy
    Department of Biochemistry and Medical Genetics, University of Manitoba, Faculty of Medicine, Winnipeg, Manitoba, Canada
    Cancer Res 60:6266-71. 2000
  2. ncbi Estrogen receptor-beta regulates psoriasin (S100A7) in human breast cancer
    George P Skliris
    Department of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, Canada
    Breast Cancer Res Treat 104:75-85. 2007
  3. pmc Expression of oestrogen receptor-beta in oestrogen receptor-alpha negative human breast tumours
    G P Skliris
    Department of Biochemistry and Medical Genetics, Manitoba Institute of Cell Biology, University of Manitoba, Winnipeg, Manitoba, Canada R3E OV9
    Br J Cancer 95:616-26. 2006
  4. pmc Claudin 1 expression in basal-like breast cancer is related to patient age
    Anne A Blanchard
    Department of Pathology, University of Manitoba, Winnipeg, Manitoba, Canada
    BMC Cancer 13:268. 2013
  5. doi The role of estrogen receptor-β in breast cancer
    Leigh C Murphy
    Department of Biochemistry and Medical Genetics and the Manitoba Institute of Cell Biology, University of Manitoba and CancerCare Manitoba, Winnipeg, Manitoba, Canada
    Semin Reprod Med 30:5-13. 2012
  6. pmc Steroid Receptor RNA Activator Protein (SRAP): a potential new prognostic marker for estrogen receptor-positive/node-negative/younger breast cancer patients
    Yi Yan
    Manitoba Institute of Cell Biology, 675 McDermot Avenue, R3E0V9, Winnipeg, Manitoba, Canada
    Breast Cancer Res 11:R67. 2009
  7. pmc S100A7 (psoriasin) expression is associated with aggressive features and alteration of Jab1 in ductal carcinoma in situ of the breast
    Ethan D Emberley
    Manitoba Institute of Cell Biology and Department of Pathology, University of Manitoba, Faculty of Medicine, Winnipeg, Manitoba, Canada
    Breast Cancer Res 6:R308-15. 2004
  8. pmc S100A7 and the progression of breast cancer
    Ethan D Emberley
    Manitoba Institute of Cell Biology, University of Manitoba, Winnipeg, Canada
    Breast Cancer Res 6:153-9. 2004
  9. pmc RanBPM interacts with psoriasin in vitro and their expression correlates with specific clinical features in vivo in breast cancer
    Ethan D Emberley
    Department of Pathology, University of Manitoba, Winnipeg Manitoba, Canada, R3E OW3
    BMC Cancer 2:28. 2002
  10. pmc Expression analysis of the mouse S100A7/psoriasin gene in skin inflammation and mammary tumorigenesis
    Meghan Webb
    Manitoba Institute of Cell Biology, University of Manitoba, Winnipeg, Canada
    BMC Cancer 5:17. 2005

Collaborators

Detail Information

Publications53

  1. ncbi Altered expression of estrogen receptor coregulators during human breast tumorigenesis
    L C Murphy
    Department of Biochemistry and Medical Genetics, University of Manitoba, Faculty of Medicine, Winnipeg, Manitoba, Canada
    Cancer Res 60:6266-71. 2000
    ..Although our study is small, these data are consistent with the above hypothesis and suggest that such alterations may have a role in the altered estrogen action occurring during breast tumorigenesis...
  2. ncbi Estrogen receptor-beta regulates psoriasin (S100A7) in human breast cancer
    George P Skliris
    Department of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, Canada
    Breast Cancer Res Treat 104:75-85. 2007
    ..These data support the hypothesis that psoriasin/S100A7 is specifically regulated by ERbeta activity and could be useful to guide future therapies targeting ERbeta in certain phenotypic subsets of breast cancers in-vivo...
  3. pmc Expression of oestrogen receptor-beta in oestrogen receptor-alpha negative human breast tumours
    G P Skliris
    Department of Biochemistry and Medical Genetics, Manitoba Institute of Cell Biology, University of Manitoba, Winnipeg, Manitoba, Canada R3E OV9
    Br J Cancer 95:616-26. 2006
    ..Based on our in vivo observations, ERbeta may have the potential to become a therapeutic target in the specific subcohort of ERalpha-negative breast cancers...
  4. pmc Claudin 1 expression in basal-like breast cancer is related to patient age
    Anne A Blanchard
    Department of Pathology, University of Manitoba, Winnipeg, Manitoba, Canada
    BMC Cancer 13:268. 2013
    ..In these tumors, the claudin 1 protein, usually localized in the cell membrane, is often mislocalized to the cytoplasm...
  5. doi The role of estrogen receptor-β in breast cancer
    Leigh C Murphy
    Department of Biochemistry and Medical Genetics and the Manitoba Institute of Cell Biology, University of Manitoba and CancerCare Manitoba, Winnipeg, Manitoba, Canada
    Semin Reprod Med 30:5-13. 2012
    ..This supports continued efforts to understand the nature and function of ERβ in breast cancer, but it also suggests that ER status may need to be redefined to include an assessment of ERβ isoforms in addition to ERα...
  6. pmc Steroid Receptor RNA Activator Protein (SRAP): a potential new prognostic marker for estrogen receptor-positive/node-negative/younger breast cancer patients
    Yi Yan
    Manitoba Institute of Cell Biology, 675 McDermot Avenue, R3E0V9, Winnipeg, Manitoba, Canada
    Breast Cancer Res 11:R67. 2009
    ..Our aim was to assess, in a large breast cancer cohort, whether levels of this protein could be associated with outcome or established clinical parameters...
  7. pmc S100A7 (psoriasin) expression is associated with aggressive features and alteration of Jab1 in ductal carcinoma in situ of the breast
    Ethan D Emberley
    Manitoba Institute of Cell Biology and Department of Pathology, University of Manitoba, Faculty of Medicine, Winnipeg, Manitoba, Canada
    Breast Cancer Res 6:R308-15. 2004
    ..Persistent S100A7 expression in invasive carcinoma is associated with a worse prognosis, and this effect may be mediated in part through interaction with the multifunctional cell signaling protein Jab1...
  8. pmc S100A7 and the progression of breast cancer
    Ethan D Emberley
    Manitoba Institute of Cell Biology, University of Manitoba, Winnipeg, Canada
    Breast Cancer Res 6:153-9. 2004
    ..The present review outlines what is known about S100A7 in breast cancer and summarizes the need to better understand the importance of this protein in breast cancer...
  9. pmc RanBPM interacts with psoriasin in vitro and their expression correlates with specific clinical features in vivo in breast cancer
    Ethan D Emberley
    Department of Pathology, University of Manitoba, Winnipeg Manitoba, Canada, R3E OW3
    BMC Cancer 2:28. 2002
    ..However the protein is found in the nucleus, cytoplasm as well as extracellularly. In the present study we have sought to identify potential psoriasin-binding proteins and to describe their expression profile in breast tumors...
  10. pmc Expression analysis of the mouse S100A7/psoriasin gene in skin inflammation and mammary tumorigenesis
    Meghan Webb
    Manitoba Institute of Cell Biology, University of Manitoba, Winnipeg, Canada
    BMC Cancer 5:17. 2005
    ..In this study we have cloned the cDNA and characterized the expression of the potential murine ortholog of human S100A7/psoriasin in skin inflammation and mammary tumorigenesis...
  11. ncbi Is oestrogen receptor-beta a predictor of endocrine therapy responsiveness in human breast cancer?
    Leigh C Murphy
    Manitoba Institute of Cell Biology, Department of Biochemistry and Medical Genetics, University of Manitoba, and Cancer Care Manitoba Winnipeg, Canada R3E 0V9
    Endocr Relat Cancer 13:327-34. 2006
    ....
  12. ncbi Phospho-serine-118 estrogen receptor-alpha detection in human breast tumors in vivo
    Leigh Murphy
    Manitoba Institute of Cell Biology, Department of Biochemistry, University of Manitoba, Winnipeg, Manitoba, Canada
    Clin Cancer Res 10:1354-9. 2004
    ..IHC was used to determine the relationship of P-Ser(118)-ERalpha to known prognostic markers and active mitogen-activated protein kinase (MAPK; erk1/2) expression...
  13. ncbi Phospho-serine-118 estrogen receptor-alpha expression is associated with better disease outcome in women treated with tamoxifen
    Leigh C Murphy
    Manitoba Institute of Cell Biology, Department of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, Manitoba, Canada
    Clin Cancer Res 10:5902-6. 2004
    ....
  14. ncbi Potential role of estrogen receptor alpha (ERalpha) phosphorylated at Serine118 in human breast cancer in vivo
    Leigh C Murphy
    Manitoba Institute of Cell Biology, University of Manitoba, Winnipeg, Man R3E 0V9, Canada
    J Steroid Biochem Mol Biol 102:139-46. 2006
    ..However, the in vivo data are somewhat contradictory and limited by the small cohorts used and the lack of standard well-characterized reagents and protocols...
  15. doi The relevance of phosphorylated forms of estrogen receptor in human breast cancer in vivo
    Leigh C Murphy
    Manitoba Institute of Cell Biology, University of Manitoba, Winnipeg, Manitoba, Canada
    J Steroid Biochem Mol Biol 114:90-5. 2009
    ..Profiling of phosphorylated ERalpha may provide better biomarkers of endocrine therapy response over and above those currently available...
  16. ncbi Inducible upregulation of oestrogen receptor-beta1 affects oestrogen and tamoxifen responsiveness in MCF7 human breast cancer cells
    L C Murphy
    Department of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, Manitoba, Canada
    J Mol Endocrinol 34:553-66. 2005
    ..These models are relevant and will be useful for dissecting the role of ERbeta1 expression in ER-positive breast cancer...
  17. ncbi New insights into estrogen receptor function in human breast cancer
    Leigh Murphy
    Manitoba Institute of Cell Biology, Department of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, Manitoba, Canada R3E 0V9
    Ann Med 35:614-31. 2003
    ..Such knowledge is necessary to have a significant impact on better prevention and treatment strategies for human breast cancer...
  18. ncbi Oestrogen receptor variants and mutations in human breast cancer
    L C Murphy
    Department of Biochemistry and Molecular Biology, University of Manitoba, Winnipeg, Canada
    Ann Med 29:221-34. 1997
    ....
  19. ncbi Estrogen receptor variants and mutations
    L C Murphy
    Department of Biochemistry and Molecular Biology, University of Manitoba, Winnipeg, Canada
    J Steroid Biochem Mol Biol 62:363-72. 1997
    ....
  20. ncbi Mechanisms of hormone independence in human breast cancer
    L C Murphy
    Department of Biochemistry and Molecular Biology University of Manitoba, Winnipeg, Canada
    In Vivo 12:95-106. 1998
    ..These include variant or mutated estrogen receptor-alpha, ligant independent activation of estrogen receptor-alpha, altered expression of down-stream estrogen target genes, post receptor and pharmacological alterations...
  21. ncbi The pathophysiological role of estrogen receptor variants in human breast cancer
    L C Murphy
    Department of Biochemistry and Molecular Biology, University of Manitoba, Winnipeg, Canada
    J Steroid Biochem Mol Biol 65:175-80. 1998
    ....
  22. ncbi Steroid receptors in human breast tumorigenesis and breast cancer progression
    L C Murphy
    Manitoba Institute of Cell Biology, Dept of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, Canada
    Biomed Pharmacother 56:65-77. 2002
    ....
  23. pmc Relationship of coregulator and oestrogen receptor isoform expression to de novo tamoxifen resistance in human breast cancer
    L C Murphy
    Manitoba Institute of Cell Biology, University of Manitoba, Faculty of Medicine, Winnipeg, Manitoba, Canada, R3E OW3
    Br J Cancer 87:1411-6. 2002
    ..However, our data provide preliminary evidence that the expression of oestrogen receptor beta protein isoforms may differ in primary tumours of breast cancer patients who prove to have differential sensitivity to tamoxifen therapy...
  24. doi Clinical significance of estrogen receptor phosphorylation
    Leigh C Murphy
    Department of Biochemistry and Medical Genetics, Faculty of Medicine Manitoba Institute of Cell Biology, University of Manitoba, 675 McDermot Avenue, Winnipeg, Manitoba, Canada
    Endocr Relat Cancer 18:R1-14. 2011
    ..This suggests the hypothesis that phospho-profiling of ERα in human breast tumors to establish an 'ERα phosphorylation code', may be a more accurate marker of prognosis and/or response to endocrine therapy in human breast cancer...
  25. ncbi The S100A7-c-Jun activation domain binding protein 1 pathway enhances prosurvival pathways in breast cancer
    Ethan D Emberley
    Department of Biochemistry and Medical Genetics, University of Manitoba, Canada
    Cancer Res 65:5696-702. 2005
    ..We conclude that the S100A7-Jab1 pathway acts to enhance survival under conditions of cellular stress, such as anoikis, which may promote progression of breast cancer...
  26. ncbi A phosphorylation code for oestrogen receptor-alpha predicts clinical outcome to endocrine therapy in breast cancer
    Georgios P Skliris
    Department of Biochemistry and Medical Genetics, Faculty of Medicine Manitoba Institute of Cell Biology, University of Manitoba, 675 McDermot Avenue, Winnipeg, Manitoba, Canada R3E 0V9
    Endocr Relat Cancer 17:589-97. 2010
    ....
  27. ncbi Reactive oxygen species induce phosphorylation of serine 118 and 167 on estrogen receptor alpha
    Gregory E Weitsman
    Manitoba Institute of Cell Biology, University of Manitoba, 675 McDermot Ave, Winnipeg, MB, Canada R3E 0V9
    Breast Cancer Res Treat 118:269-79. 2009
    ..Both the phosphorylation and consequent down-regulation of ERalpha may be a mechanism associated with development of endocrine therapy resistance...
  28. ncbi Psoriasin interacts with Jab1 and influences breast cancer progression
    Ethan D Emberley
    Department of Pathology, University of Manitoba, Winnipeg, Manitoba R3E 0W3, Canada
    Cancer Res 63:1954-61. 2003
    ..We conclude that intracellular psoriasin influences breast cancer progression and that this may occur through stimulation of Jab1 activity...
  29. ncbi Psoriasin (S100A7) expression is associated with poor outcome in estrogen receptor-negative invasive breast cancer
    Ethan D Emberley
    Departments of Pathology, University of Manitoba, Faculty of Medicine, Winnipeg, Manitoba, R3E OW3 Canada
    Clin Cancer Res 9:2627-31. 2003
    ..This study explores the clinical significance of psoriasin in relation to patient survival in invasive breast cancer...
  30. ncbi S100A7 (psoriasin) influences immune response genes in human breast cancer
    Soma Mandal
    Department of Pathology, University of Manitoba, Winnipeg, Manitoba, Canada
    Exp Cell Res 313:3016-25. 2007
    ..042, n=149). These results are consistent with a role for S100A7 in modulating the immune response which may be a factor in early breast tumor progression...
  31. doi Estrogen receptor alpha negative breast cancer patients: estrogen receptor beta as a therapeutic target
    George P Skliris
    Manitoba Institute of Cell Biology, Department of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, Manitoba, Canada R3E OV9
    J Steroid Biochem Mol Biol 109:1-10. 2008
    ....
  32. ncbi Analysis of gene expression in ductal carcinoma in situ of the breast
    Adewale Adeyinka
    Department of Pathology, University of Manitoba, Faculty of Medicine, Winnipeg, Manitoba, R3E OW3 Canada
    Clin Cancer Res 8:3788-95. 2002
    ..Our purpose was to identify molecular alterations underlying progression of DCIS...
  33. ncbi Relationship between mammaglobin expression and estrogen receptor status in breast tumors
    Xiao feng Guan
    Departments of Biochemistry and Medical Genetics, University of Manitoba, Faculty of Medicine, Winnipeg, Manitoba, Canada, R3EOW3
    Endocrine 21:245-50. 2003
    ..As estrogen and antiestrogen treatment of estrogen-positive breast cancer cell lines does not modify SCGB2A2 expression we suggest that SCGB2A2 may be a new independent breast cancer prognostic marker...
  34. ncbi Intermittent hypoxia induces proteasome-dependent down-regulation of estrogen receptor alpha in human breast carcinoma
    Charlton Cooper
    Manitoba Institute of Cell Biology and Department of Pathology, University of Manitoba, Faculty of Medicine, Winnipeg, Manitoba, Canada
    Clin Cancer Res 10:8720-7. 2004
    ..However, the effect of intermittent hypoxia, which is likely more prevalent in breast cancers, remains to be determined...
  35. pmc Increasing the relative expression of endogenous non-coding Steroid Receptor RNA Activator (SRA) in human breast cancer cells using modified oligonucleotides
    Charlton Cooper
    Department of Biochemistry and Medical Genetics, Manitoba Institute of Cell Biology, University of Manitoba, Winnipeg, Manitoba R3E0W3, Canada
    Nucleic Acids Res 37:4518-31. 2009
    ....
  36. ncbi Identification of new human coding steroid receptor RNA activator isoforms
    Ethan Emberley
    Department of Biochemistry and Medical Genetics, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada R3EOW3
    Biochem Biophys Res Commun 301:509-15. 2003
    ..Our results demonstrate that full-length SRA-RNAs likely to encode stable proteins are widely expressed in breast cancer cell lines...
  37. ncbi Estrogen receptors inhibit Smad3 transcriptional activity through Ap-1 transcription factors
    Tracy Cherlet
    Manitoba Institute of Cell Biology, Department of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, MB, Canada R3E 0V9
    Mol Cell Biochem 306:33-42. 2007
    ..Based on these results, a model is proposed whereby c-Jun is limiting in its ability to act as a Smad3 co-activator in the presence of E(2)-bound ER, possibly due to ER sequestering c-Jun away from the Smad3 responsive promoter...
  38. ncbi Estrogen receptor-alpha phosphorylated at Ser118 is present at the promoters of estrogen-regulated genes and is not altered due to HER-2 overexpression
    Gregory E Weitsman
    Department of Biochemistry and Medical Genetics and Department of Pathology, Manitoba Institute of Cell Biology, University of Manitoba, Winnipeg, Manitoba, Canada
    Cancer Res 66:10162-70. 2006
    ....
  39. doi Claudins 1, 3, and 4 protein expression in ER negative breast cancer correlates with markers of the basal phenotype
    Anne A Blanchard
    Department of Pathology, University of Manitoba, 770 Bannatyne Avenue, Winnipeg, Manitoba, Canada R3E0W3
    Virchows Arch 454:647-56. 2009
    ..Our data also suggests that increased expression of claudins 1 and 4 was associated with the basal-like subtype of breast cancers, a subtype generally linked to poor outcome...
  40. pmc Post-translational modifications of nuclear receptors and human disease
    Muralidharan Anbalagan
    Department of Structural and Cellular Biology, Tulane University School of Medicine, New Orleans, Louisiana, USA
    Nucl Recept Signal 10:e001. 2012
    ..NR PTMs provide an additional measure of NR function that can be used as both biomarkers of disease progression, and predictive markers for patient response to NR-directed treatments...
  41. ncbi Reduced expression of the small leucine-rich proteoglycans, lumican, and decorin is associated with poor outcome in node-negative invasive breast cancer
    Sandra Troup
    Department of Pathology, University of Manitoba, Faculty of Medicine, Winnipeg, Manitoba, R3E OW3 Canada
    Clin Cancer Res 9:207-14. 2003
    ..To examine the prognostic significance of lumican and decorin, two abundant small leucine-rich proteoglycans in breast tissue stroma...
  42. ncbi Activated mitogen-activated protein kinase expression during human breast tumorigenesis and breast cancer progression
    Adewale Adeyinka
    Department of Biochemistry and Medical Genetics, Faculty of Medicine, University of Manitoba, 675 McDermot Avenue, Winnipeg, Manitoba, R3E 0W3 Canada
    Clin Cancer Res 8:1747-53. 2002
    ....
  43. pmc Immunohistochemical validation of multiple phospho-specific epitopes for estrogen receptor alpha (ERalpha) in tissue microarrays of ERalpha positive human breast carcinomas
    George P Skliris
    Department of Biochemistry and Medical Genetics, Faculty of Medicine, University of Manitoba, 675 McDermot Avenue, Winnipeg, MB, R3E 0V9, Canada
    Breast Cancer Res Treat 118:443-53. 2009
    ....
  44. ncbi Assessment of multiple different estrogen receptor-beta antibodies for their ability to immunoprecipitate under chromatin immunoprecipitation conditions
    Gregory E Weitsman
    Manitoba Institute of Cell Biology, Department of Biochemistry and Medical Genetics, University of Manitoba, 675 McDermot Avenue, R3E 0V9 Winnipeg, Manitoba, Canada
    Breast Cancer Res Treat 100:23-31. 2006
    ....
  45. ncbi S100 proteins and their influence on pro-survival pathways in cancer
    Ethan D Emberley
    Manitoba Institute of Cell Biology, Winnipeg, Canada
    Biochem Cell Biol 82:508-15. 2004
    ..Others suggest that, many S100s may also promote cancer progression through specific roles in cell survival and apoptosis pathways. This review summarizes these findings and their implications...
  46. doi Differential role of estrogen receptor beta in early versus metastatic non-small cell lung cancer
    Sri Navaratnam
    Department of Internal Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
    Horm Cancer 3:93-100. 2012
    ..01–3.75 P=0.047). These results suggest a differential impact of ER-beta 1 expression on clinical outcome by disease stage, that needs to be explored further and may explain contradictory observations reported in the literature...
  47. doi Targeted production of proprotein convertase PC1 enhances mammary development and tumorigenesis in transgenic mice
    Anne Blanchard
    Department of Physiology, University of Manitoba, Winnipeg, MB R3E 0W3, Canada
    Can J Physiol Pharmacol 87:831-8. 2009
    ..The present study therefore shows that PC1 expression can promote normal and neoplastic mammary development and growth and suggests that proprotein convertases may be important etiological factors in human breast neoplasia...
  48. doi Estrogen receptor alpha phosphorylated at tyrosine 537 is associated with poor clinical outcome in breast cancer patients treated with tamoxifen
    Georgios P Skliris
    Department of Biochemistry and Medical Genetics, Faculty of Medicine, University of Manitoba, Winnipeg, R3E 0V9, MB, Canada
    Horm Cancer 1:215-21. 2010
    ..These data support the relevance of phosphorylation at p-Y537-ERα in human breast cancers and add further support to the presence of a phosphorylation code for ERα in human breast cancer in vivo...
  49. ncbi Targeting the EGFR pathway for cancer therapy
    James B Johnston
    Department of Internal Medicine, Manitoba Institute of Cell Biology, ON6010 675 McDermot Ave, University of Manitoba, Winnipeg, MB, R3E 0V9, Canada
    Curr Med Chem 13:3483-92. 2006
    ....
  50. ncbi Differential expression and comparative subcellular localization of estrogen receptor beta isoforms in virally transformed and normal cultured human lens epithelial cells
    Patrick R Cammarata
    Department of Cell Biology and Genetics, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
    Exp Eye Res 81:165-75. 2005
    ..The differential subcellular partitioning of ERbeta-1 to the mitochondria and ERbeta-2 to the nucleus suggests a new aspect of regulation and function of the estrogen signalling system...
  51. ncbi Identification of a novel breast- and salivary gland-specific, mucin-like gene strongly expressed in normal and tumor human mammary epithelium
    Richard J Miksicek
    Department of Physiology, Michigan State University, East Lansing, MI 48824, USA
    Cancer Res 62:2736-40. 2002
    ..The SBEM gene is predicted to code for a putative low molecular weight, secreted sialoglycoprotein, potentially useful for the diagnosis of metastatic breast cancer...
  52. ncbi The Prohibitins: emerging roles in diverse functions
    Suresh Mishra
    Department of Physiology, University of Manitoba, Winnipeg, Canada
    J Cell Mol Med 10:353-63. 2006
    ..This review presents some of the recent developments in prohibitin research and focuses on the similarities in the structure and function of these interesting proteins...
  53. ncbi Prohibitin: a potential target for new therapeutics
    Suresh Mishra
    Department of Physiology, University of Manitoba, Winnipeg, Manitoba R3E 3P4, Canada
    Trends Mol Med 11:192-7. 2005
    ....