Nicholas Mrosovsky


Affiliation: University of Toronto
Country: Canada


  1. Mrosovsky N, Hampton R. Spatial responses to light in mice with severe retinal degeneration. Neurosci Lett. 1997;222:204-6 pubmed
    ..This was true of mutant mice over a year old, when retinal degeneration is very severe, and also of a transgenic strain of mice whose rods are destroyed as they begin to develop in the first few weeks after birth. ..
  2. Mrosovsky N. Masking: history, definitions, and measurement. Chronobiol Int. 1999;16:415-29 pubmed
    ..This paper discusses the origin and definition of terminology (positive and negative masking, paradoxical masking) and methods of quantifying masking. How masking is scored can greatly influence the interpretation of results. ..
  3. Mrosovsky N. Beyond the suprachiasmatic nucleus. Chronobiol Int. 2003;20:1-8 pubmed
    ..Yet extensive temporal restructuring of behavior can occur without participation of the suprachiasmatic nucleus. This raises questions about current thinking about how to cope with jet lag and shift work. ..
  4. Mrosovsky N, Foster R, Salmon P. Thresholds for masking responses to light in three strains of retinally degenerate mice. J Comp Physiol A. 1999;184:423-8 pubmed
    ..With very dim light pulses, mutants did not change their activity, but wildtypes actually became more active (positive masking). Positive and negative masking appear to depend on different sensory and central processes. ..
  5. Mrosovsky N, Salmon P, Foster R, McCall M. Responses to light after retinal degeneration. Vision Res. 2000;40:575-8 pubmed
    ..Enhanced inhibition of activity around twilight may be adaptive for mice in some circumstances and so help maintain genes for retinal degeneration in natural populations. ..
  6. Mrosovsky N. Further characterization of the phenotype of mCry1/mCry2-deficient mice. Chronobiol Int. 2001;18:613-25 pubmed
    ..One possible explanation of such predark activity is that some damped endogenous process is spared in mCry1/mCry2 double-knockout mice. ..
  7. Mrosovsky N. Contribution of classic photoreceptors to entrainment. J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2003;189:69-73 pubmed
    ..Thresholds for entrainment appear to be a more sensitive test of deficits in entrainment than phase shifts in response to light pulses. ..
  8. Mrosovsky N, Hattar S. Impaired masking responses to light in melanopsin-knockout mice. Chronobiol Int. 2003;20:989-99 pubmed
    ..This suggests that melanopsin in retinal ganglion cells is involved in masking, as it is in pupil contraction and phase shifts. Melanopsin is especially important in maintaining masking responses over long periods. ..
  9. Mrosovsky N, Redlin U, Roberts R, Threadgill D. Masking in waved-2 mice: EGF receptor control of locomotion questioned. Chronobiol Int. 2005;22:963-74 pubmed
    ..No evidence suggested that normal functioning of epidermal growth factor receptors was required, or even involved, in masking. ..

More Information


  1. Mrosovsky N, Thompson S. Negative and positive masking responses to light in retinal degenerate slow (rds/rds) mice during aging. Vision Res. 2008;48:1270-3 pubmed publisher