Research Topics
Species | T R MosmannSummaryAffiliation: University of Alberta Country: Canada Publications
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Publications
The expanding universe of T-cell subsets: Th1, Th2 and moreT R Mosmann
Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Canada
Immunol Today 17:138-46. 1996....
Cytokine-induced differentiation of precursor mouse CD8+ T cells into cytotoxic CD8+ T cells secreting Th1 or Th2 cytokinesS Sad
Department of Immunology, University of Alberta, Edmonton, Canada
Immunity 2:271-9. 1995..We propose the names TC1 and TC2 for cytotoxic CD8+ T cells secreting Th1-like and Th2-like cytokines, respectively...
Cytokine-deficient CD8+ Tc1 cells induced by IL-4: retained inflammation and perforin and Fas cytotoxicity but compromised long term killing of tumor cellsS Sad
Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Canada
J Immunol 159:606-13. 1997..These results suggest that IL-4 synthesis in vivo would not affect immediate effector functions of differentiated Tc1 cells, but would compromise immunity by reducing their long term functional capability...
Synthesis of T helper 2-type cytokines at the maternal-fetal interfaceH Lin
Department of Immunology, University of Alberta, Canada
J Immunol 151:4562-73. 1993..The continuous presence of IL-4, IL-5, and IL-10, with early and transient expression of IFN-gamma, can provide a molecular basis for the antibody/Th2-like bias of the maternal immune response during pregnancy...
IL-10 inhibits cytokine production, vascular leakage, and swelling during T helper 1 cell-induced delayed-type hypersensitivityL Li
Department of Immunology, University of Alberta, Edmonton, Canada
J Immunol 153:3967-78. 1994..The correlation between the inhibition of footpad swelling and cytokine production suggested that the effect of IL-10 on DTH may be mediated through suppression of cytokine synthesis...
