C M Morshead

Summary

Affiliation: University of Toronto
Country: Canada

Publications

  1. ncbi request reprint Distinct populations of forebrain neural stem and progenitor cells can be isolated using side-population analysis
    Mina Kim
    Department of Surgery, University of Toronto, Toronto, Ontario, Canada M5S 1A8
    J Neurosci 23:10703-9. 2003
  2. ncbi request reprint True monolayer cell culture in a confined 3D microenvironment enables lineage informatics
    John Ramunas
    Department of Chemical Engineering, University of Waterloo, Waterloo, Ontario N2L 3G1, Canada
    Cytometry A 69:1202-11. 2006
  3. pmc Adult subependymal neural precursors, but not differentiated cells, undergo rapid cathodal migration in the presence of direct current electric fields
    Robart Babona-Pilipos
    Institute for Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada
    PLoS ONE 6:e23808. 2011
  4. ncbi request reprint Induced pluripotent stem cells for the treatment of stroke: the potential and the pitfalls
    Fenggang Yu
    Department of Otolaryngology, Yong Loo Lin School of Medicine, National University of Singapore, 1E Kent Ridge Road, Singapore 119228
    Curr Stem Cell Res Ther 8:407-14. 2013
  5. ncbi request reprint A cell-survival factor (N-acetyl-L-cysteine) alters the in vivo fate of constitutively proliferating subependymal cells in the adult forebrain
    C M Morshead
    University of Toronto, Department of Anatomy and Cell Biology, 1 King s College Circle, Toronto, Ontario, Canada M5S 1A8
    J Neurobiol 42:338-46. 2000
  6. ncbi request reprint Hematopoietic competence is a rare property of neural stem cells that may depend on genetic and epigenetic alterations
    Cindi M Morshead
    Department of Surgery, University of Toronto, Toronto, Ontario, Canada
    Nat Med 8:268-73. 2002
  7. ncbi request reprint Disguising adult neural stem cells
    Cindi M Morshead
    Department of Surgery, Division of Anatomy, 1 King s College Circle Room 1182, Toronto, Ontario M5S 1A8, Canada
    Curr Opin Neurobiol 14:125-31. 2004
  8. ncbi request reprint Adult neural stem cells: attempting to solve the identity crisis
    Cindi M Morshead
    Department of Surgery, University of Toronto, Toronto, Canada
    Dev Neurosci 26:93-100. 2004
  9. ncbi request reprint In vivo clonal analyses reveal the properties of endogenous neural stem cell proliferation in the adult mammalian forebrain
    C M Morshead
    Neurobiology Research Group, Department of Anatomy and Cell Biology, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    Development 125:2251-61. 1998
  10. ncbi request reprint Transforming growth factor-alpha null and senescent mice show decreased neural progenitor cell proliferation in the forebrain subependyma
    V Tropepe
    Neurobiology Research Group, Department of Anatomy and Cell Biology, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    J Neurosci 17:7850-9. 1997

Collaborators

Detail Information

Publications22

  1. ncbi request reprint Distinct populations of forebrain neural stem and progenitor cells can be isolated using side-population analysis
    Mina Kim
    Department of Surgery, University of Toronto, Toronto, Ontario, Canada M5S 1A8
    J Neurosci 23:10703-9. 2003
    ....
  2. ncbi request reprint True monolayer cell culture in a confined 3D microenvironment enables lineage informatics
    John Ramunas
    Department of Chemical Engineering, University of Waterloo, Waterloo, Ontario N2L 3G1, Canada
    Cytometry A 69:1202-11. 2006
    ..Herein, we present a novel imaging culture chamber that facilitates "lineage informatics," a lineage-centric approach to cytomics...
  3. pmc Adult subependymal neural precursors, but not differentiated cells, undergo rapid cathodal migration in the presence of direct current electric fields
    Robart Babona-Pilipos
    Institute for Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada
    PLoS ONE 6:e23808. 2011
    ..The administration of growth factors and immunomodulatory agents following injury augments this activation and has been shown to result in behavioural functional recovery following stroke...
  4. ncbi request reprint Induced pluripotent stem cells for the treatment of stroke: the potential and the pitfalls
    Fenggang Yu
    Department of Otolaryngology, Yong Loo Lin School of Medicine, National University of Singapore, 1E Kent Ridge Road, Singapore 119228
    Curr Stem Cell Res Ther 8:407-14. 2013
    ..Finally, we will consider future directions and areas of exploration which may promote the realization of iPSC-based cell replacement strategies for the treatment of stroke. ..
  5. ncbi request reprint A cell-survival factor (N-acetyl-L-cysteine) alters the in vivo fate of constitutively proliferating subependymal cells in the adult forebrain
    C M Morshead
    University of Toronto, Department of Anatomy and Cell Biology, 1 King s College Circle, Toronto, Ontario, Canada M5S 1A8
    J Neurobiol 42:338-46. 2000
    ..These data suggest that preventing cell death is not sufficient to keep all of the progeny of these cells in a proliferative mode...
  6. ncbi request reprint Hematopoietic competence is a rare property of neural stem cells that may depend on genetic and epigenetic alterations
    Cindi M Morshead
    Department of Surgery, University of Toronto, Toronto, Ontario, Canada
    Nat Med 8:268-73. 2002
    ....
  7. ncbi request reprint Disguising adult neural stem cells
    Cindi M Morshead
    Department of Surgery, Division of Anatomy, 1 King s College Circle Room 1182, Toronto, Ontario M5S 1A8, Canada
    Curr Opin Neurobiol 14:125-31. 2004
    ..We highlight and compare the experimental paradigms that have led to our current state of knowledge and conclude that there is no reason at present to abandon the prevailing view of adult neural stem cell identity...
  8. ncbi request reprint Adult neural stem cells: attempting to solve the identity crisis
    Cindi M Morshead
    Department of Surgery, University of Toronto, Toronto, Canada
    Dev Neurosci 26:93-100. 2004
    ..This review will discuss the in vivo characterization of neural stem cells in the embryonic and adult CNS and some recent discrepancies and limitations between in vivo and in vitro assays used to identify neural stem cells...
  9. ncbi request reprint In vivo clonal analyses reveal the properties of endogenous neural stem cell proliferation in the adult mammalian forebrain
    C M Morshead
    Neurobiology Research Group, Department of Anatomy and Cell Biology, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    Development 125:2251-61. 1998
    ..There were calculated to be 1200-1300 cells between the rostral corpus callosum and rostral anterior commissure; these data support a lineage model similar to those based on stem cell behavior in other tissue types...
  10. ncbi request reprint Transforming growth factor-alpha null and senescent mice show decreased neural progenitor cell proliferation in the forebrain subependyma
    V Tropepe
    Neurobiology Research Group, Department of Anatomy and Cell Biology, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    J Neurosci 17:7850-9. 1997
    ..These results suggest that endogenous TGFalpha and the effects of senescence may regulate the proliferation of progenitor cells in the adult subependyma, but that the number of neural stem cells is maintained throughout life...
  11. doi request reprint Cyclosporin A has direct effects on adult neural precursor cells
    Jessica Hunt
    Department of Surgery, Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario, Canada
    J Neurosci 30:2888-96. 2010
    ..Together, our findings establish that cyclosporin A has direct effects on NPCs both in vitro and in vivo, making it a promising candidate molecule for developing clinically relevant strategies to stimulate NPCs for brain repair...
  12. doi request reprint Neurogenic potential of isolated precursor cells from early post-gastrula somitic tissue
    Vincent Tropepe
    Department of Cell and Systems Biology, Centre for the Analysis of Genome Evolution and Function, University of Toronto, Toronto, ON M5S 3G5, Canada
    Stem Cells Dev 18:1533-42. 2009
    ....
  13. ncbi request reprint The ablation of glial fibrillary acidic protein-positive cells from the adult central nervous system results in the loss of forebrain neural stem cells but not retinal stem cells
    Cindi M Morshead
    Department of Surgery, University of Toronto, 1 King s College Circle, Toronto, Ontario M5S 1A8, Canada
    Eur J Neurosci 18:76-84. 2003
    ..Exposure to GCV in vitro has no effect on adult retinal stem cells hence, we conclude that adult forebrain NSCs comprise a subpopulation of the GFAP-positive cells within the subependyma...
  14. pmc Embryonic cortical neural stem cells migrate ventrally and persist as postnatal striatal stem cells
    Sandrine Willaime-Morawek
    Department of Medical Genetics and Microbiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    J Cell Biol 175:159-68. 2006
    ..This demonstrates the existence of a novel dorsal-to-ventral migration of neural stem cells in the perinatal forebrain...
  15. doi request reprint Don't look: growing clonal versus nonclonal neural stem cell colonies
    Brenda L K Coles-Takabe
    Departments of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada
    Stem Cells 26:2938-44. 2008
    ..Disclosure of potential conflicts of interest is found at the end of this article...
  16. ncbi request reprint Delayed transplantation of adult neural precursor cells promotes remyelination and functional neurological recovery after spinal cord injury
    Soheila Karimi-Abdolrezaee
    Division of Cell and Molecular Biology, Toronto Western Research Institute, Krembil Neuroscience Center, Toronto, Ontario, M5T 2S8, Canada
    J Neurosci 26:3377-89. 2006
    ..Our data provide strong evidence in support of the feasibility of adult NPCs for cell-based remyelination after SCI...
  17. doi request reprint Extramedullary chitosan channels promote survival of transplanted neural stem and progenitor cells and create a tissue bridge after complete spinal cord transection
    Hiroshi Nomura
    Toronto Western Research Institute, Toronto Western Hospital, Toronto, Ontario, Canada
    Tissue Eng Part A 14:649-65. 2008
    ..Thus, implantation of chitosan channels seeded with NSPCs after SCT created a tissue bridge containing many surviving transplanted cells and host axons, although there was no functional improvement...
  18. doi request reprint Potential and pitfalls of stem cell therapy in old age
    David Piccin
    Department of Surgery, Institute of Medical Science, Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario, Canada
    Dis Model Mech 3:421-5. 2010
    ....
  19. doi request reprint Endogenous radial glial cells support regenerating axons after spinal cord transection
    Hiroshi Nomura
    Toronto Western Research Institute, Toronto Western Hospital, Toronto, Ontario, Canada
    Neuroreport 21:871-6. 2010
    ..We suggest that radial glial cells can guide regenerating axons across the bridge in the channel after spinal cord transection...
  20. ncbi request reprint Adult stem cells and bioengineering strategies for the treatment of cerebral ischemic stroke
    Fenggang Yu
    Department of Otolaryngology, Yong Loo Lin School of Medicine, National University of Singapore
    Curr Stem Cell Res Ther 6:190-207. 2011
    ....
  21. ncbi request reprint Exploiting the properties of adult stem cells for the treatment of disease
    Anna Erlandsson
    Karolinska Institute, Department of Clinical Neuroscience, Center for Hearing and Communication Research, Building M1, Stockholm, Sweden
    Curr Opin Mol Ther 8:331-7. 2006
    ....
  22. ncbi request reprint Incorporation of protein-eluting microspheres into biodegradable nerve guidance channels for controlled release
    Alex Goraltchouk
    Department of Chemical Engineering and Applied Chemistry, University of Toronto 200 College Street, Toronto, ON, Canada M5S 3E5
    J Control Release 110:400-7. 2006
    ..Released EGF was found to be bioactive for at least 14 days as assessed by a neurosphere forming bioassay...