Research Topics
| Elena MoroSummaryAffiliation: University of Toronto Country: Canada Publications
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Publications
Firing rates of pallidal neurons are similar in Huntington's and Parkinson's disease patientsJoyce K H Tang
Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada, M5S 1A8
Exp Brain Res 166:230-6. 2005..Furthermore, the findings did reveal a difference between firing patterns in the HD and PD groups, thereby supporting the role of altered firing patterns in the pathophysiology of these diseases...
Subthalamic nucleus stimulation: improvements in outcome with reprogrammingElena Moro
Movement Disorders Center and Department of Neurosurgery, Toronto Western Hospital, University Health Network, University of Toronto, 399 Bathurst Street, Toronto, Ontario
Arch Neurol 63:1266-72. 2006..Even when the electrode is well positioned in the target, the optimization of clinical results depends on careful programming of electrical parameters and changes in antiparkinsonian drug dosages...
Criteria for deep-brain stimulation in Parkinson's disease: review and analysisElena Moro
University of Toronto, Department of Medicine, Movement Disorders Center, 399 Bathurst Street, McL7 402, Canada
Expert Rev Neurother 6:1695-705. 2006..The recent observation that deep-brain stimulation of the pedunculopontine nucleus improves axial signs, possibly even in those less responsive to levodopa, brings new hope to the management of advanced Parkinson's disease...
Changes in cortical and pallidal oscillatory activity during the execution of a sensory trick in patients with cervical dystoniaJoyce K H Tang
Department of Physiology, Med Sci Bldg 3302, 1 King s College Circle, University of Toronto, Toronto, Ontario, Canada M5S 1A8
Exp Neurol 204:845-8. 2007..These preliminary findings suggest a role for 4-8 Hz frequency synchronization in the pathophysiology of dystonia...
Neuronal firing rates and patterns in the globus pallidus internus of patients with cervical dystonia differ from those with Parkinson's diseaseJoyce K H Tang
Department of Physiology, University of Toronto, Toronto, ON, Canada
J Neurophysiol 98:720-9. 2007..These findings suggest that alterations in both firing rate and firing pattern may underlie the differing motor symptoms associated with these two movement disorders...
Pallidal stimulation in cervical dystonia: clinical implications of acute changes in stimulation parametersE Moro
Movement Disorders Center, Toronto Western Hospital, University of Toronto, University Health Network, Toronto, ON, Canada
Eur J Neurol 16:506-12. 2009..We studied the clinical effects of acute changes of different parameters of GPi-DBS in cervical dystonia (CD)...
Unilateral subdural motor cortex stimulation improves essential tremor but not Parkinson's diseaseElena Moro
Movement Disorders Centre, Division of Neurology, Department of Medicine, University of Toronto, Toronto Western Hospital, University Health Network, Toronto, ON M5T2S8, Canada
Brain 134:2096-105. 2011..These findings suggest that unilateral subdural motor cortex stimulation may be useful for contralateral hand tremor in selected patients with essential tremor but was not effective in improving parkinsonian signs in our series...
Bilateral pallidal stimulation for x-linked dystonia parkinsonismPettarusp M Wadia
Movement Disorders Centre, Toronto Western Hospital, 399 Bathurst St, McL7 402, Toronto, Ontario, Canada, M5T 2S8
Arch Neurol 67:1012-5. 2010..To report the clinical benefits of bilateral deep brain stimulation (DBS) of the globus pallidus internus (GPi) in a patient with X-linked dystonia parkinsonism (XDP)...
Bilateral globus pallidus stimulation for Huntington's diseaseElena Moro
Movement Disorders Center, Toronto Western Hospital, Toronto, Ontario, Canada
Ann Neurol 56:290-4. 2004..Adjustment of stimulation parameters in GPi DBS may have the potential to optimize the motor response in HD, improving chorea without aggravating bradykinesia...
Ten-year outcome of subthalamic stimulation in Parkinson disease: a blinded evaluationAnna Castrioto
Clinica Neurologica, Universita degli Studi di Perugia, Perugia, Italy
Arch Neurol 68:1550-6. 2011..To assess the 10-year motor outcome of deep brain stimulation of the subthalamic nucleus (STN-DBS) in patients with Parkinson disease (PD)...
Long-term results of a multicenter study on subthalamic and pallidal stimulation in Parkinson's diseaseElena Moro
Toronto Western Hospital, Movement Disorders Center, University of Toronto and University Health Network, Toronto, Ontario, Canada
Mov Disord 25:578-86. 2010..Although the surgical targets were not randomized, there was a trend to a better outcome of motor signs in the STN-DBS patients and fewer adverse events in the GPi-DBS group...
A decision tool to support appropriate referral for deep brain stimulation in Parkinson's diseaseElena Moro
Movement Disorders Center, University of Toronto, UHN, Toronto Western Hospital, 399 Bathurst Street, 7MCL 7 402, Toronto ON M5T 2S8, Canada
J Neurol 256:83-8. 2009..We developed an electronic decision tool that can assist neurologists in deciding which PD patients should be referred for DBS consideration...
Stimulation of the subthalamic nucleus and impulsivity: release your horsesBenedicte Ballanger
Division of Brain, Imaging and Behaviour Systems Neuroscience, Toronto Western Research Institute, University Health Network, University of Toronto, Toronto, Ontario, Canada
Ann Neurol 66:817-24. 2009....
Movement related potentials and oscillatory activities in the human internal globus pallidus during voluntary movementsEric W Tsang
Division of Brain Imaging and Behaviour Systems Neuroscience, Toronto Western Research Institute, University Health Network, Toronto, Canada
J Neurol Neurosurg Psychiatry 83:91-7. 2012..To study internal globus pallidus (GPi) activities and the interactions among the bilateral GPi and motor cortical areas during voluntary movements...
Pedunculopontine nucleus microelectrode recordings in movement disorder patientsMoran Weinberger
Department of Physiology, University of Toronto, Med Sci Bldg 3302, 1 King s College Circle, M5S 1A8, Toronto, ON, Canada
Exp Brain Res 188:165-74. 2008..It remains to be seen to what extent the physiological characteristics of the neurons and the stimulation-evoked effects will permit reliable identification of PPN and determination of the optimal target for DBS therapy...
Cerebral blood flow changes induced by pedunculopontine nucleus stimulation in patients with advanced Parkinson's disease: a [(15)O] H2O PET studyBenedicte Ballanger
Toronto Western Research Institute Division of Brain, Imaging and Behaviour Systems Neuroscience, UHN, University of Toronto, Toronto, Ontario, Canada
Hum Brain Mapp 30:3901-9. 2009..Whether these findings are associated with the DBS-PPN clinical effect remains to be proven. However, they suggest that PPN modulation may induce functional changes in neural networks associated with the control of lower limb movements...
Levodopa response in long-term bilateral subthalamic stimulation for Parkinson's diseasePanida Piboolnurak
Movement Disorders Center, Division of Neurology, University of Toronto, Toronto Western Hospital, Toronto, Ontario, Canada
Mov Disord 22:990-7. 2007..1% at 3 years and 19.2% at 5 years). Anti-PD drugs were significantly reduced by 47.9% at 3 years and 39.8% at 5 years. However, the magnitude of the preoperative response to levodopa did not predict DBS benefit at 3 and 5 years...
Selective enhancement of rapid eye movement sleep by deep brain stimulation of the human ponsAndrew S Lim
Division of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada
Ann Neurol 66:110-4. 2009..This represents the first demonstration that DBS can selectively modulate human sleep, and it supports an important role for the pedunculopontine nucleus region in modulating human REM sleep. Ann Neurol 2009;66:110-114...
Beta oscillatory activity in the subthalamic nucleus and its relation to dopaminergic response in Parkinson's diseaseMoran Weinberger
Department of Physiology, Med Sci Building 3302, 1 King's College Circle, University of Toronto, Toronto, Ontario M5S 1A8, Canada
J Neurophysiol 96:3248-56. 2006..The study also suggests that LFP beta oscillatory activity is generated largely within the dorsal portion of the STN and can produce synchronous oscillatory activity of the local neuronal population...
Subdural motor cortex stimulation in Parkinson's disease does not modify movement-related rCBF patternAntonio P Strafella
Movement Disorders Center, Division of Neurology, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada
Mov Disord 22:2113-6. 2007..We conclude that while MCS may be a simpler and safer surgical procedure than DBS of STN, it failed to provide evidence of clear effect on motor performance and movement-related activation pattern in patients with advanced PD...
Oscillatory activity in the globus pallidus internus: comparison between Parkinson's disease and dystoniaMoran Weinberger
Department of Physiology, University of Toronto, Toronto, ON, Canada
Clin Neurophysiol 123:358-68. 2012....
rCBF changes associated with PPN stimulation in a patient with Parkinson's disease: a PET studyAntonio P Strafella
Movement Disorders Center, Toronto Western Hospital, Division of Neurology, University of Toronto, Toronto, Ontario, Canada
Mov Disord 23:1051-4. 2008....
The nature and time course of cortical activation following subthalamic stimulation in Parkinson's diseaseRenju Kuriakose
Division of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada M5T 2S8
Cereb Cortex 20:1926-36. 2010..Cortical activation may be related to the clinical effects of STN DBS in PD...
Somatosensory evoked potentials recorded from the human pedunculopontine nucleus regionI Jin Yeh
Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada
Mov Disord 25:2076-83. 2010..Among the 10 recordings with HFOs, only 1 had possible phase reversal in the bipolar derivation. Our results suggest that there are direct somatosensory inputs to the PPNR. The slow components and HFOs of the SEP have different origins...
Involvement of the basal ganglia and cerebellar motor pathways in the preparation of self-initiated and externally triggered movements in humansJamie Purzner
The Krembil Neuroscience Centre and Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada M5T 2S8
J Neurosci 27:6029-36. 2007..The CTC pathway is involved in the preparation of self-paced but not externally cued movements, although the pathway may still be involved in the execution of these movements...
Long-term effect of unilateral pallidotomy on levodopa-induced dyskinesiaGalit Kleiner-Fisman
Morton and Gloria Shulman Movement Disorders Center, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada
Mov Disord 25:1496-8. 2010..Though sample size was small, there was a trend towards a reduction in LID lasting up to 12 years suggesting that posteroventral pallidotomy may provide sustained benefit in reducing LID...
Unilateral pedunculopontine stimulation improves falls in Parkinson's diseaseElena Moro
Division of Neurosurgery, 4 447 Toronto Western Hospital, 399 Bathurst Street, Toronto, ON, M5T 2S8 Canada
Brain 133:215-24. 2010..Our results suggest that pedunculopontine nucleus deep-brain stimulation may be effective in preventing falls in patients with advanced Parkinson's disease but that further evaluation of this procedure is required...
Psychiatric symptoms following surgery for Parkinson's disease with an emphasis on subthalamic stimulationValerie Voon
Department of Psychiatry, Toronto Western Hospital, UHN, Toronto, Canada
Adv Neurol 96:130-47. 2005..The paucity of the literature underscores the need for well-designed studies on psychiatric issues investigating both pathophysiology and clinical outcomes...
Clinicopathological study in progressive supranuclear palsy with pedunculopontine stimulationLili Naz Hazrati
Department of Pathology, University of Toronto, University Health Network, Toronto, Ontario, Canada
Mov Disord 27:1304-7. 2012..However, targeting this nucleus can be challenging. We report on the first neuropathological analyses after PPN-DBS surgery in advanced progressive supranuclear palsy (PSP)...
The dominant-STN phenomenon in bilateral STN DBS for Parkinson's diseaseAnna Castrioto
Movement Disorders Center, Toronto Western Hospital, University of Toronto, University Health Network, Toronto, ON, Canada
Neurobiol Dis 41:131-7. 2011..In our sample 50% of the patients presented with a dominant-STN, suggesting that a non-negligible part of PD patients might not need bilateral STN-DBS surgery...
Location of active contacts in patients with primary dystonia treated with globus pallidus deep brain stimulationClement Hamani
Division of Neurosurgery, Toronto Western Hospital, University of Toronto, University Health Network, Toronto, Canada
Neurosurgery 62:217-23; discussion 223-5. 2008..We compared the location of the contacts being used for stimulation (active contacts) in patients with cervical dystonia, generalized dystonia, and Parkinson's disease and correlated the results with clinical outcome...
Deep brain stimulation of the ventral intermediate nucleus of the thalamus for tremor in patients with multiple sclerosisCristina V Torres
Division of Neurosurgery, Department of Surgery, Toronto Western Hospital, University of Toronto, University Health Network, Toronto, Ontario, Canada
Neurosurgery 67:646-51; discussion 651. 2010..Tremor is an important cause of disability in patients with multiple sclerosis (MS). Deep brain stimulation (DBS) in the ventral intermediate nucleus (VIM) of the thalamus is said to be beneficial for MS tremor...
Unilateral pallidal deep brain stimulation in a patient with cervical dystonia and tremorCristina V Torres
Division of Neurosurgery, Department of Surgery, Movement Disorders Center, Toronto Western Hospital, University of Toronto, University Health Network, Toronto, Ontario, Canada
J Neurosurg 113:1230-3. 2010..The authors report on a case of unilateral GPi implantation that resulted in sustained benefit with marked improvement in pain and dystonia...
The pedunculopontine nucleus as a target for deep brain stimulationClement Hamani
Division of Neurosurgery, Department of Surgery, Toronto Western Hospital, University Health Network, University of Toronto, 399 Bathurst Street WW 4 447, Toronto, ON, M5T2S8, Canada
J Neural Transm 118:1461-8. 2011..In this article, we review some of the basic aspects of the PPN as a target and the outcome of the recently published clinical trials...
Characterization of REM-sleep associated ponto-geniculo-occipital waves in the human ponsAndrew S Lim
Division of Neurology, Department of Medicine, University of Toronto, Ontario, Canada
Sleep 30:823-7. 2007..We sought to identify and characterize human PGO waves...
Psychiatric symptoms in patients with Parkinson disease presenting for deep brain stimulation surgeryValerie Voon
Department of Psychiatry, Toronto Western Hospital, University Health Network, University of Toronto, Ontario, Canada
J Neurosurg 103:246-51. 2005..In the present study, preoperative psychiatric symptoms were systematically assessed in patients with PD presenting for routine preoperative psychiatric assessment...
Modulation of Beta oscillations in the subthalamic nucleus with prosaccades and antisaccades in Parkinson's diseaseAkihiro Yugeta
Division of Neurology, Toronto Western Research Institute, and the Edmond J Safra Program in Parkinson s Disease, Division of Neurosurgery, and Toronto Western Research Institute, and Department of Physiology, University of Toronto, Toronto, Ontario M5T 2S8, Canada
J Neurosci 33:6895-904. 2013..Beta-band desynchronization in the STN may reflect the additional processes associated with suppression of reflexive responses and volitional execution of saccades in the opposite direction...
Deep brain stimulation: preoperative issuesAnthony E Lang
Department of Neurology, Toronto Western Hospital, Toronto, Ontario, Canada
Mov Disord 21:S171-96. 2006..It outlines answers to a series of questions developed to address all aspects of deep brain stimulation preoperative decision-making...
Randomized controlled trial of intraputamenal glial cell line-derived neurotrophic factor infusion in Parkinson diseaseAnthony E Lang
Toronto Western Hospital, University of Toronto, Ontario, Canada
Ann Neurol 59:459-66. 2006..This randomized controlled clinical trial was designed to confirm initial clinical benefits observed in a small, open-label trial using intraputamenal (Ipu) infusion of recombinant human GDNF (liatermin)...
Pallidal deep brain stimulation influences both reflexive and voluntary saccades in Huntington's diseaseAdrian P Fawcett
Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
Mov Disord 20:371-7. 2005..Our data demonstrate a task-specific improvement of oculomotor deficits in this HD patient with pallidal DBS, supporting a role of GPi in oculomotor control...
A survey on the impact of the menstrual cycle on movement disorders severityAnna Castrioto
Movement Disorders Centre, Toronto Western Hospital, Faculty of Medicine, University Health Network, University of Toronto, Ontario, Canada
Can J Neurol Sci 37:478-81. 2010..We designed a survey to quantify how frequently female patients with various movement disorders are affected by this phenomenon and its impact on symptom severity...
Surgery for other movement disorders: dystonia, ticsClement Hamani
Division of Neurosurgery, Toronto Western Hospital, UHN, Toronto, Ontario, Canada
Curr Opin Neurol 20:470-6. 2007..We review the neurosurgical treatment of dystonias and tics, focusing mainly on the surgical aspects and outcome of deep brain stimulation...
Amantadine improves gait in PD patients with STN stimulationHiu Fai Chan
Movement Disorders Center, Division of Neurology, TWH, University of Toronto, UHN, Toronto, Ontario, Canada
Parkinsonism Relat Disord 19:316-9. 2013..2%) patients reported improvement in gait and balance. In conclusion, our data suggest that amantadine may have new beneficial effects on axial symptoms in PD patients with STN-DBS...
Clinical features of dopamine agonist withdrawal syndrome in a movement disorders clinicMargarita Pondal
Movement Disorders Centre, Toronto Western Hospital, University of Toronto, Canada
J Neurol Neurosurg Psychiatry 84:130-5. 2013....
Neuromodulation: a more comprehensive concept beyond deep brain stimulationClement Hamani
Behavioural Neurobiology Laboratory, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
Int Rev Neurobiol 107:1-3. 2012..As the number of indications and studies increases, so does research in associated fields. This chapter provides a brief introduction and discusses the overall contents of this volume of the International Review of Neurobiology...
Acute psychotropic effects of bilateral subthalamic nucleus stimulation and levodopa in Parkinson's diseaseAurélie Funkiewiez
Department of Clinical and Biological Neurosciences, Joseph Fourier University, Grenoble, France
Mov Disord 18:524-30. 2003....
Response to levodopa in parkinsonian patients with bilateral subthalamic nucleus stimulationElena Moro
Department of Clinical and Biological Neurosciences and INSERM U318, Joseph Fourier University, CHU de Grenoble, Grenoble, France
Brain 125:2408-17. 2002..In addition, the persistence of levodopa intake after surgery might hinder this beneficial process...
Intraoperative micro- and macrostimulation of the subthalamic nucleus in Parkinson's diseasePierre Pollak
Department of Clinical and Biological Neurosciences, Service de Neurologie, Centre Hospitalier Universitaire de Grenoble, Grenoble, France
Mov Disord 17:S155-61. 2002..New skills are needed to assess all stimulation-induced effects and interpret them in anatomo-functional terms...
Treatment results: Parkinson's diseasePierre Pollak
Department of Clinical and Biological Neurosciences, Service de Neurologie, Centre Hospitalier Universitaire de Grenoble, France
Mov Disord 17:S75-83. 2002..Intracranial electrode implantation can induce a hematoma or contusion. Most authors agree that the benefit to risk ratio of DBS is favorable...
How many parkinsonian patients are suitable candidates for deep brain stimulation of subthalamic nucleus? Results of a questionnaireLetterio Morgante
Dipartimento di Neuroscienze, Scienze Psichiatriche ed Anestesiologiche, Universita di Messina, Italy
Parkinsonism Relat Disord 13:528-31. 2007..Items related to disease severity were responsible for the largest number of exclusions. This knowledge will help make decisions on resource allocation in centres wishing to start DBS surgery...
Pathological gambling in Parkinson's disease improves on chronic subthalamic nucleus stimulationClaire Ardouin
, CHU Grenoble, INSERM U318, , Grenoble, France
Mov Disord 21:1941-6. 2006....
Basic algorithms for the programming of deep brain stimulation in Parkinson's diseaseJens Volkmann
Department of Neurology, Christian Albrechts Universitat Kiel, Kiel, Germany
Mov Disord 21:S284-9. 2006..The basic programming algorithms for thalamic, subthalamic, and pallidal stimulation in PD are explained and summarized in flowcharts...
Fixed dystonia unresponsive to pallidal stimulation improved by motor cortex stimulationAlberto J Espay
Neurology 69:1062-3; author reply 1063. 2007
GDNF in treatment of Parkinson's disease: response to editorialAnthony E Lang
Lancet Neurol 5:200-2. 2006
