David Moher

Summary

Affiliation: University of Ottawa
Country: Canada

Publications

  1. pmc Following 411 Cochrane protocols to completion: a retrospective cohort study
    Andrea C Tricco
    Chalmers Research Group, Children s Hospital of Eastern Ontario Research Institute, Ottawa, Ontario, Canada
    PLoS ONE 3:e3684. 2008
  2. pmc Randomized trials published in some Chinese journals: how many are randomized?
    Taixiang Wu
    Chinese Cochrane Centre, Chinese Evidence Based Medicine Centre, International Clinical Epidemiology Network INCLEN, West China Hospital, Sichuan University, Chengdu, PR China
    Trials 10:46. 2009
  3. pmc Identifying null meta-analyses that are ripe for updating
    Nicholas J Barrowman
    Chalmers Research Group, Children s Hospital of Eastern Ontario Research Institute, Ottawa, Canada
    BMC Med Res Methodol 3:13. 2003
  4. pmc Development of AMSTAR: a measurement tool to assess the methodological quality of systematic reviews
    Beverley J Shea
    EMGO Institute, VU University Medical Center, Amsterdam, The Netherlands
    BMC Med Res Methodol 7:10. 2007
  5. pmc Instruments to assess the perception of physicians in the decision-making process of specific clinical encounters: a systematic review
    France Legare
    Research Centre of the Centre Hospitalier Universitaire de Québec, Quebec, Canada
    BMC Med Inform Decis Mak 7:30. 2007
  6. pmc Helping editors, peer reviewers and authors improve the clarity, completeness and transparency of reporting health research
    David Moher
    BMC Med 6:13. 2008
  7. pmc How effective is tetracaine 4% gel, before a peripherally inserted central catheter, in reducing procedural pain in infants: a randomized double-blind placebo controlled trial [ISRCTN75884221]
    Brigitte Lemyre
    Department of Pediatrics, Children s Hospital of Eastern Ontario, Ottawa, Ontario, Canada
    BMC Med 4:11. 2006
  8. pmc Transparent and accurate reporting increases reliability, utility, and impact of your research: reporting guidelines and the EQUATOR Network
    Iveta Simera
    Centre for Statistics in Medicine, University of Oxford, Oxford, UK
    BMC Med 8:24. 2010
  9. pmc Shorter courses of parenteral antibiotic therapy do not appear to influence response rates for children with acute hematogenous osteomyelitis: a systematic review
    Nicole Le Saux
    Department of Pediatrics, University of Ottawa, Ontario, Canada
    BMC Infect Dis 2:16. 2002
  10. pmc Assessing the quality of reports of systematic reviews in pediatric complementary and alternative medicine
    David Moher
    Thomas C Chalmers Centre for Systematic Reviews, Children s Hospital of Eastern Ontario Research Institute Canada
    BMC Pediatr 2:3. 2002

Collaborators

Detail Information

Publications137 found, 100 shown here

  1. pmc Following 411 Cochrane protocols to completion: a retrospective cohort study
    Andrea C Tricco
    Chalmers Research Group, Children s Hospital of Eastern Ontario Research Institute, Ottawa, Ontario, Canada
    PLoS ONE 3:e3684. 2008
    ..g., funding) are being published, this may lead to inaccurate decisions. We examined the frequency of published and unpublished Cochrane reviews and protocol factors that predict the publication of Cochrane reviews...
  2. pmc Randomized trials published in some Chinese journals: how many are randomized?
    Taixiang Wu
    Chinese Cochrane Centre, Chinese Evidence Based Medicine Centre, International Clinical Epidemiology Network INCLEN, West China Hospital, Sichuan University, Chengdu, PR China
    Trials 10:46. 2009
    ..We investigated the adequacy of randomization of clinical trials published in recent years in China to determine how many of them met acceptable standards for allocating participants to treatment groups...
  3. pmc Identifying null meta-analyses that are ripe for updating
    Nicholas J Barrowman
    Chalmers Research Group, Children s Hospital of Eastern Ontario Research Institute, Ottawa, Canada
    BMC Med Res Methodol 3:13. 2003
    ..As an increasingly large number of meta-analyses are published, quantitative methods are needed to help clinicians and systematic review teams determine when meta-analyses are not up to date...
  4. pmc Development of AMSTAR: a measurement tool to assess the methodological quality of systematic reviews
    Beverley J Shea
    EMGO Institute, VU University Medical Center, Amsterdam, The Netherlands
    BMC Med Res Methodol 7:10. 2007
    ..Our objective was to develop an instrument to assess the methodological quality of systematic reviews, building upon previous tools, empirical evidence and expert consensus...
  5. pmc Instruments to assess the perception of physicians in the decision-making process of specific clinical encounters: a systematic review
    France Legare
    Research Centre of the Centre Hospitalier Universitaire de Québec, Quebec, Canada
    BMC Med Inform Decis Mak 7:30. 2007
    ..A systematic review was conducted to identify instruments that assess the perception physicians have of the decision-making process within specific clinical encounters...
  6. pmc Helping editors, peer reviewers and authors improve the clarity, completeness and transparency of reporting health research
    David Moher
    BMC Med 6:13. 2008
    ..As such, they are not able to judge the merits of the results and interpret them. The EQUATOR Network is a new initiative aimed at improving the clarity and transparency of reporting health research...
  7. pmc How effective is tetracaine 4% gel, before a peripherally inserted central catheter, in reducing procedural pain in infants: a randomized double-blind placebo controlled trial [ISRCTN75884221]
    Brigitte Lemyre
    Department of Pediatrics, Children s Hospital of Eastern Ontario, Ottawa, Ontario, Canada
    BMC Med 4:11. 2006
    ..The objective of this trial was to assess the safety and efficacy of tetracaine gel on the pain response of very low birth weight (VLBW) infants during insertion of a PICC...
  8. pmc Transparent and accurate reporting increases reliability, utility, and impact of your research: reporting guidelines and the EQUATOR Network
    Iveta Simera
    Centre for Statistics in Medicine, University of Oxford, Oxford, UK
    BMC Med 8:24. 2010
    ..This paper outlines EQUATOR's goals and activities and offers suggestions for organizations and individuals involved in health research on how to strengthen research reporting...
  9. pmc Shorter courses of parenteral antibiotic therapy do not appear to influence response rates for children with acute hematogenous osteomyelitis: a systematic review
    Nicole Le Saux
    Department of Pediatrics, University of Ottawa, Ontario, Canada
    BMC Infect Dis 2:16. 2002
    ..Currently, there is no consensus on the route and duration of antimicrobial therapy to treat AHO...
  10. pmc Assessing the quality of reports of systematic reviews in pediatric complementary and alternative medicine
    David Moher
    Thomas C Chalmers Centre for Systematic Reviews, Children s Hospital of Eastern Ontario Research Institute Canada
    BMC Pediatr 2:3. 2002
    ..We also examined whether there were differences in the quality of reports of a subset of CAM reviews compared to reviews using conventional interventions...
  11. pmc Potential solutions to the problem of conducting systematic reviews of new health technologies
    David Moher
    Thomas C Chalmers Centre for Systematic Reviews, Children s Hospital of Eastern Ontario Research Institute, and Department of Pediatrics, University of Ottawa
    CMAJ 166:1674-5. 2002
  12. ncbi request reprint [Improving the quality of reports of meta-analyses of randomized controlled trials: the QUOROM Statement]
    D Moher
    Universidad de Ottawa
    Rev Esp Salud Publica 74:107-18. 2000
    ..The Quality of Reporting of Meta-analyses (QUOROM) Conference was convened to address standards for improving the quality of reporting of meta-analyses of clinical randomised controlled trials (RCTs)...
  13. pmc Registering CIHR-funded randomized controlled trials: a global public good
    David Moher
    Department of Pediatrics, Children s Hospital of Eastern Ontario Research Institute, and the Faculty of Medicine, University of Ottawa, Ottawa, Ont
    CMAJ 171:750-1. 2004
  14. ncbi request reprint Systematic reviews: when is an update an update?
    David Moher
    Chalmers Research Group, Children s Hospital of Eastern Ontario Research Institute, Ottawa K1H 8L1, Ontario, Canada
    Lancet 367:881-3. 2006
  15. ncbi request reprint Issues related to the conduct of systematic reviews: a focus on the nutrition field
    David Moher
    Children s Hospital of Eastern Ontario Research Institute, Ottawa, Canada
    Am J Clin Nutr 88:1191-9. 2008
    ..Recommendations are then provided, such as developing a capacity-building program, searching the primary literature for research gaps, and extending reporting tools such as the QUOROM Statement to the field of nutrition...
  16. ncbi request reprint A systematic review identified few methods and strategies describing when and how to update systematic reviews
    David Moher
    Chalmers Research Group, Children s Hospital of Eastern Ontario Research Institute, Ottawa, Ontario, Canada
    J Clin Epidemiol 60:1095-1104. 2007
    ..SRs are most helpful if they are current; however, most of them are not being updated. This SR summarizes strategies and methods describing when and how to update SRs...
  17. pmc Epidemiology and reporting characteristics of systematic reviews
    David Moher
    Chalmers Research Group, Children s Hospital of Eastern Ontario Research Institute, Ottawa, Canada
    PLoS Med 4:e78. 2007
    ..We set out to capture a representative cross-sectional sample of published SRs and examine them in terms of a broad range of epidemiological, descriptive, and reporting characteristics, including emerging aspects not previously examined...
  18. pmc Opportunities and challenges for improving the quality of reporting clinical research: CONSORT and beyond
    David Moher
    Chalmers Research Group, Children s Hospital of Eastern Ontario Research Institute, 401 Smyth Road, Ottawa, Ontario K1H 8L1, Canada
    CMAJ 171:349-50. 2004
  19. ncbi request reprint Improving the quality of reports of meta-analyses of randomised controlled trials: the QUOROM statement. Quality of Reporting of Meta-analyses
    D Moher
    University of Ottawa, Thomas C Chalmers Centre for Systematic Reviews, Ontario, Canada
    Lancet 354:1896-900. 1999
    ..The Quality of Reporting of Meta-analyses (QUOROM) conference was convened to address standards for improving the quality of reporting of meta-analyses of clinical randomised controlled trials (RCTs)...
  20. ncbi request reprint Improving the quality of reports of meta-analyses of randomised controlled trials: the QUOROM statement. QUOROM Group
    D Moher
    University of Ottawa, Thomas C Chalmers Centre for Systematic Reviews, Ontario, Canada
    Br J Surg 87:1448-54. 2000
    ..The Quality of Reporting of Meta-analyses (QUOROM) conference was convened to address standards for improving the quality of reporting of meta-analyses of clinical randomised controlled trials (RCTs)...
  21. pmc The CONSORT statement: revised recommendations for improving the quality of reports of parallel group randomized trials
    D Moher
    University of Ottawa, Thomas C, Chalmers Centre for Systematic Reviews, Ottawa, Canada
    BMC Med Res Methodol 1:2. 2001
    ..In sum, the CONSORT statement is intended to improve the reporting of an RCT, enabling readers to understand a trial's conduct and to assess the validity of its results...
  22. pmc Assessing the quality of reports of randomized trials in pediatric complementary and alternative medicine
    David Moher
    Thomas C Chalmers Centre for Systematic Reviews, Children s Hospital of Eastern Ontario Research Institute, Canada
    BMC Pediatr 2:2. 2002
    ..To evaluate the quality of reports of complementary and alternative medicine (CAM) randomized controlled trials (RCTs) in the pediatric population. We also examined whether there was a change in the quality of reporting over time...
  23. ncbi request reprint What contributions do languages other than English make on the results of meta-analyses?
    D Moher
    Thomas C Chalmers Center for Systematic Reviews, Children s Hospital of Eastern Ontario Research Institute, Ontario, Ottawa, Canada
    J Clin Epidemiol 53:964-72. 2000
    ..We encourage others to replicate this study using different sampling frames, clinical topics and interventions...
  24. ncbi request reprint Pharmacological management of intermittent claudication: a meta-analysis of randomised trials
    D Moher
    Thomas C Chalmers Centre for Systematic Reviews, CHEO Research Institute, Ottawa, Ontario, Canada
    Drugs 59:1057-70. 2000
    ..There is a need for uniformity in research design and reporting of trials. A future trial comparing medical therapy with physical therapy is indicated...
  25. pmc An alternative to the hand searching gold standard: validating methodological search filters using relative recall
    Margaret Sampson
    Chalmers Research Group, Children s Hospital of Eastern Ontario Research Institute, Canada
    BMC Med Res Methodol 6:33. 2006
    ..We demonstrate the feasibility of using relative recall of included studies from multiple systematic reviews to validate methodological search filters as an alternative to validation against a gold standard formed through hand searching...
  26. ncbi request reprint STrengthening the REporting of Genetic Association Studies (STREGA)--an extension of the STROBE statement
    Julian Little
    Department of Epidemiology and Community Medicine, University of Ottawa, Ottawa, Ontario, Canada
    Genet Epidemiol 33:581-98. 2009
    ..The STREGA recommendations do not prescribe or dictate how a genetic association study should be designed but seek to enhance the transparency of its reporting, regardless of choices made during design, conduct, or analysis...
  27. doi request reprint Strengthening the reporting of genetic association studies (STREGA): an extension of the strengthening the reporting of observational studies in epidemiology (STROBE) statement
    Julian Little
    Department of Epidemiology and Community Medicine, University of Ottawa, Ottawa, Ontario, Canada
    J Clin Epidemiol 62:597-608.e4. 2009
    ..The STREGA recommendations do not prescribe or dictate how a genetic association study should be designed, but seek to enhance the transparency of its reporting, regardless of choices made during design, conduct, or analysis...
  28. pmc How effective is tetracaine 4% gel, before a venipuncture, in reducing procedural pain in infants: a randomized double-blind placebo controlled trial
    Brigitte Lemyre
    Department of Pediatrics, University of Ottawa, Ottawa, Canada
    BMC Pediatr 7:7. 2007
    ..Evidence of its efficacy and safety in neonates is limited. The objective of this study was to assess the efficacy and safety of topical tetracaine on the pain response of neonates during a venipuncture...
  29. pmc Can electronic search engines optimize screening of search results in systematic reviews: an empirical study
    Margaret Sampson
    Chalmers Research Group, Children s Hospital of Eastern Ontario Research Institute, Ottawa, Canada
    BMC Med Res Methodol 6:7. 2006
    ..Our objective is to test the ability of an Ultraseek search engine to rank MEDLINE records of the included studies of Cochrane reviews within the top half of all the records retrieved by the Boolean MEDLINE search used by the reviewers...
  30. pmc STrengthening the REporting of Genetic Association Studies (STREGA): an extension of the STROBE statement
    Julian Little
    Canada Research Chair in Human Genome Epidemiology, University of Ottawa, Ottawa, Ontario, Canada
    PLoS Med 6:e22. 2009
    ..The STREGA recommendations do not prescribe or dictate how a genetic association study should be designed but seek to enhance the transparency of its reporting, regardless of choices made during design, conduct, or analysis...
  31. doi request reprint Strengthening the reporting of genetic association studies (STREGA): an extension of the STROBE Statement
    Julian Little
    Canada Research Chair in Human Genome Epidemiology, Ottawa, Canada
    Hum Genet 125:131-51. 2009
    ..The STREGA recommendations do not prescribe or dictate how a genetic association study should be designed but seek to enhance the transparency of its reporting, regardless of choices made during design, conduct, or analysis...
  32. ncbi request reprint STrengthening the REporting of Genetic Association studies (STREGA): an extension of the STROBE Statement
    Julian Little
    University of Ottawa, Ottawa, Ontario, Canada
    Ann Intern Med 150:206-15. 2009
    ..The STREGA recommendations do not prescribe or dictate how a genetic association study should be designed but seek to enhance the transparency of its reporting, regardless of choices made during design, conduct, or analysis...
  33. pmc Does journal endorsement of reporting guidelines influence the completeness of reporting of health research? A systematic review protocol
    Larissa Shamseer
    Centre for Practice Changing Research, Ottawa Hospital Research Institute, The Ottawa Hospital General Campus, 501 Smyth Road, Box 201B, Ottawa, ON, K1H 8L6, Canada
    Syst Rev 1:24. 2012
    ..The objective of this study was to assess whether endorsement of reporting guidelines by journals influences the completeness of reporting of health studies...
  34. ncbi request reprint Systematic reviews involving complementary and alternative medicine interventions had higher quality of reporting than conventional medicine reviews
    Margaret L Lawson
    Department of Pediatrics, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada
    J Clin Epidemiol 58:777-84. 2005
    ....
  35. pmc Education in health research methodology: use of a wiki for knowledge translation
    Michele P Hamm
    Alberta Research Centre for Health Evidence, Department of Pediatrics, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada
    PLoS ONE 8:e64922. 2013
    ..The focus was on preliminary usability testing of the wiki...
  36. ncbi request reprint For randomized controlled trials, the quality of reports of complementary and alternative medicine was as good as reports of conventional medicine
    Terry P Klassen
    Department of Pediatrics, Faculty of Medicine, University of Alberta, Edmonton, Alberta, Canada
    J Clin Epidemiol 58:763-8. 2005
    ....
  37. ncbi request reprint The prevalence of celiac disease in average-risk and at-risk Western European populations: a systematic review
    Catherine Dube
    Gastrointestinal Clinical Research Unit, University of Ottawa, Ottawa, Ontario, Canada
    Gastroenterology 128:S57-67. 2005
    ..The prevalence is higher still in high-risk groups. Clinicians in a variety of specialties should have a high index of suspicion for the diagnosis of CD and in particular need to pay close attention to the identified high-risk groups...
  38. doi request reprint CONSORT 2010 explanation and elaboration: updated guidelines for reporting parallel group randomised trials
    David Moher
    Ottawa Methods Centre, Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa Hospital, Ottawa, Ontario K1H 8L6, Canada
    Int J Surg 10:28-55. 2012
    ..The CONSORT 2010 Statement, this revised explanatory and elaboration document, and the associated website (www.consort-statement.org) should be helpful resources to improve reporting of randomised trials...
  39. doi request reprint Describing reporting guidelines for health research: a systematic review
    David Moher
    Ottawa Methods Centre, Clinical Epidemiology Program, Ottawa Hospital Research Institute, The Ottawa Hospital, Ottawa, Ontario, Canada
    J Clin Epidemiol 64:718-42. 2011
    ..To describe the process of development, content, and methods of implementation of reporting guidelines for health research...
  40. doi request reprint An international survey indicated that unpublished systematic reviews exist
    Andrea C Tricco
    Chalmers Research Group, Children s Hospital of Eastern Ontario Research Institute, Ottawa, Ontario, Canada
    J Clin Epidemiol 62:617-623.e5. 2009
    ..To determine the frequency of unpublished systematic reviews (SRs) and explore factors contributing to their occurrence...
  41. ncbi request reprint Language of publication restrictions in systematic reviews gave different results depending on whether the intervention was conventional or complementary
    Ba Pham
    Biomedical Data Sciences, GlaxoSmithKline, Toronto, Ontario, Canada
    J Clin Epidemiol 58:769-76. 2005
    ....
  42. doi request reprint Oral phosphodiesterase-5 inhibitors and hormonal treatments for erectile dysfunction: a systematic review and meta-analysis
    Alexander Tsertsvadze
    Ottawa Health Research Institute, University of Ottawa, Ottawa, Ontario, Canada
    Ann Intern Med 151:650-61. 2009
    ..Erectile dysfunction (ED) is a common male sexual disorder. The relative benefits and harms of pharmacologic therapies for ED, as well as the value of hormonal testing in men with ED, are uncertain...
  43. doi request reprint CONSORT 2010 Explanation and Elaboration: Updated guidelines for reporting parallel group randomised trials
    David Moher
    Ottawa Methods Centre, Ottawa Hospital Research Institute, Ottawa Hospital, Ottawa, Ontario, Canada
    J Clin Epidemiol 63:e1-37. 2010
    ..The CONSORT 2010 Statement, this revised explanatory and elaboration document, and the associated website (www.consort-statement.org) should be helpful resources to improve reporting of randomised trials...
  44. ncbi request reprint Relation of completeness of reporting of health research to journals' endorsement of reporting guidelines: systematic review
    Adrienne Stevens
    Centre for Practice Changing Research, Ottawa Hospital Research Institute, Ottawa, ON, Canada, K1H 8L6
    BMJ 348:g3804. 2014
    ..To assess whether the completeness of reporting of health research is related to journals' endorsement of reporting guidelines...
  45. ncbi request reprint Does the CONSORT checklist improve the quality of reports of randomised controlled trials? A systematic review
    Amy C Plint
    Department of Pediatrics, University of Ottawa, Ottawa, Ontario, Canada
    Med J Aust 185:263-7. 2006
    ..To determine whether the adoption of the CONSORT checklist is associated with improvement in the quality of reporting of randomised controlled trials (RCTs)...
  46. doi request reprint Consolidated standards of reporting trials (CONSORT) and the completeness of reporting of randomised controlled trials (RCTs) published in medical journals
    Lucy Turner
    Ottawa Hospital Research Institute, Ottawa, Canada
    Cochrane Database Syst Rev 11:MR000030. 2012
    ..In 2006, a systematic review of eight studies evaluating the "effectiveness of CONSORT in improving reporting quality in journals" was published...
  47. doi request reprint Developing integrative primary healthcare delivery: adding a chiropractor to the team
    Michael J Garner
    Carlington Community and Health Services, Ottawa, Ontario, Canada
    Explore (NY) 4:18-24. 2008
    ..Physicians and other healthcare practitioners are now being placed in multidisciplinary teams, yet little research on integration exists...
  48. ncbi request reprint Non-Cochrane vs. Cochrane reviews were twice as likely to have positive conclusion statements: cross-sectional study
    Andrea C Tricco
    Chalmers Research Group, Children s Hospital of Eastern Ontario Research Institute, 401 Smyth Road, Ottawa, Ontario, Canada
    J Clin Epidemiol 62:380-386.e1. 2009
    ..To determine which factors predict favorable results and positive conclusions in systematic reviews (SRs) and to assess the level of agreement between SR results and conclusions...
  49. ncbi request reprint The diagnostic accuracy of serologic tests for celiac disease: a systematic review
    Alaa Rostom
    Gastrointestinal Clinical Research Unit, University of Ottawa, Ottawa, Canada
    Gastroenterology 128:S38-46. 2005
    ..If true, the nearly perfect negative predictive value of these tests would drop. The positive predictive value of these tests is likely lower than reported when the tests are applied in low-prevalence populations...
  50. ncbi request reprint Should meta-analysts search Embase in addition to Medline?
    Margaret Sampson
    Chalmers Research Group, Children s Hospital of Eastern Ontario Research Institute, 401 Smyth Road, Ottawa, ON K1H 8L1, Canada
    J Clin Epidemiol 56:943-55. 2003
    ..88-0.99). Searching Medline but not Embase risks biasing a meta-analysis by finding studies that show larger estimates, but their prevalence seems low enough that the risk may be slight, provided the rest of the search is comprehensive...
  51. pmc Effectiveness of brief interventions as part of the Screening, Brief Intervention and Referral to Treatment (SBIRT) model for reducing the nonmedical use of psychoactive substances: a systematic review
    Matthew M Young
    Canadian Centre on Substance Abuse CCSA, 75 Albert Street, Ottawa, Ontario K1P 5E7, Canada
    Syst Rev 3:50. 2014
    ....
  52. pmc Systematic review of the effectiveness of training programs in writing for scholarly publication, journal editing, and manuscript peer review (protocol)
    James Galipeau
    Ottawa Hospital Research Institute, 501 Smyth Rd, Ottawa, K1H 8L6, Canada
    Syst Rev 2:41. 2013
    ..However, little research has taken stock of journalology training opportunities or evaluations of their effectiveness...
  53. pmc An evaluation of epidemiological and reporting characteristics of complementary and alternative medicine (CAM) systematic reviews (SRs)
    Lucy Turner
    Ottawa Hospital Research Institute, Clinical Epidemiology Program, Ottawa, Ontario, Canada
    PLoS ONE 8:e53536. 2013
    ..Here, methodological and reporting characteristics of a sample of CAM-related SRs and a sample of control SRs are evaluated and compared...
  54. pmc Funding source, trial outcome and reporting quality: are they related? Results of a pilot study
    Tammy J Clifford
    Chalmers Research Group, Ottawa, Canada
    BMC Health Serv Res 2:18. 2002
    ..There has been increasing concern regarding the potential effects of the commercialization of research...
  55. pmc Randomized controlled trials in pediatric complementary and alternative medicine: where can they be found?
    Margaret Sampson
    Chalmers Research Group, Children s Hospital of Eastern Ontario Research Institute, Canada
    BMC Pediatr 3:1. 2003
    ..The objective of this study is to identify sources of reported randomized controlled trials (RCTs) in the field of pediatric complementary and alternative medicine (CAM)...
  56. pmc Effect of point of care information on inpatient management of bronchiolitis
    W James King
    Department of Pediatrics, University of Ottawa, Ottawa, Ontario, Canada
    BMC Pediatr 7:4. 2007
    ..We studied the effects of access to point-of-care medical evidence in a computerised physician order entry system (CPOE) on management and clinical outcome of children with bronchiolitis...
  57. doi request reprint Few systematic reviews exist documenting the extent of bias: a systematic review
    Andrea C Tricco
    Chalmers Research Group, Children s Hospital of Eastern Ontario Research Institute, 401 Smyth Road, Ottawa, Ontario K1N 6N5, Canada
    J Clin Epidemiol 61:422-34. 2008
    ..To summarize the evidence concerning bias and confounding in conducting systematic reviews (SRs)...
  58. doi request reprint Surveillance search techniques identified the need to update systematic reviews
    Margaret Sampson
    Chalmers Research Group, Children s Hospital of Eastern Ontario Research Institute, 401 Smyth Road, Ottawa, Ontario K1H 8L1, Canada
    J Clin Epidemiol 61:755-62. 2008
    ..This article reports on literature surveillance methods to identify new evidence eligible for updating systematic reviews...
  59. ncbi request reprint The influence of display and statistical factors on the interpretation of metaanalysis results by physicians
    Parminder S Raina
    Department of Clinical Epidemiology and Biostatistics, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada
    Med Care 43:1242-9. 2005
    ..The objective of this study was to determine the extent to which various factors affect the interpretation of metaanalytic results by physicians...
  60. doi request reprint Systematic reviews can be produced and published faster
    Margaret Sampson
    Chalmers Research Group, Children s Hospital of Eastern Ontario Research Institute, Ottawa, Canada
    J Clin Epidemiol 61:531-6. 2008
    ....
  61. pmc A randomized, double-blind, placebo-controlled noninferiority trial of amoxicillin for clinically diagnosed acute otitis media in children 6 months to 5 years of age
    Nicole Le Saux
    Department of Pediatrics, Children s Hospital of Eastern Ontario, Ottawa, Ont
    CMAJ 172:335-41. 2005
    ..In this double-blind noninferiority trial, we compared clinical improvement rates at 14 days for children (6 months to 5 years of age) with acute otitis media who were randomly assigned to receive amoxicillin or placebo...
  62. pmc Does use of the CONSORT Statement impact the completeness of reporting of randomised controlled trials published in medical journals? A Cochrane review
    Lucy Turner
    Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Canada
    Syst Rev 1:60. 2012
    ..A systematic review recently published in the Cochrane Library assesses whether journal endorsement of CONSORT impacts the completeness of reporting of RCTs; those findings are summarised here...
  63. pmc Searching for controlled trials of complementary and alternative medicine: a comparison of 15 databases
    Elise Cogo
    Children s Hospital of Eastern Ontario Research Institute, Ottawa, Canada
    Evid Based Complement Alternat Med 2011:858246. 2011
    ..Low overlap between databases indicates comprehensive CAM literature searches will require multiple databases...
  64. ncbi request reprint The CONSORT Statement: revised recommendations for improving the quality of reports of parallel-group randomized trials 2001
    David Moher
    University of Ottawa, Thomas C Chalmers Centre for Systematic Reviews, Ontario
    Explore (NY) 1:40-5. 2005
    ..In sum, the CONSORT statement is intended to improve the reporting or an RCT, enabling readers to understand a trial's conduct and to assess the validity of its results...
  65. ncbi request reprint The CONSORT statement: revised recommendations for improving the quality of reports of parallel-group randomised trials
    David Moher
    Thomas C Chalmers Centre for Systematic Reviews, University of Ottawa, Ottawa, Ontario, Canada
    Clin Oral Investig 7:2-7. 2003
    ..In sum, the CONSORT statement is intended to improve the reporting of an RCT, enabling readers to understand a trial's conduct and to assess the validity of its results...
  66. pmc Improving the reporting of pragmatic trials: an extension of the CONSORT statement
    Merrick Zwarenstein
    Health Services Sciences, Sunnybrook Hospital, Toronto, Ontario, Canada
    BMJ 337:a2390. 2008
    ..In the meantime we recommend that those who support, conduct, and report pragmatic trials should use this extension of the CONSORT statement to facilitate the use of trial results in decisions about health care...
  67. pmc Comparative effectiveness of monotherapies and combination therapies for patients with hypertension: protocol for a systematic review with network meta-analyses
    Brian Hutton
    Ottawa Hospital Research Institute, 501 Smyth Road, Ottawa, ON, Canada, Box 201 K1H 8L6
    Syst Rev 2:44. 2013
    ..The objective of this review is to explore the relative benefits and safety of different pharmacotherapies for management of non-diabetic patients with hypertension, whether of a mild or moderate to severe nature...
  68. pmc Do health care institutions value research? A mixed methods study of barriers and facilitators to methodological rigor in pediatric randomized trials
    Michele P Hamm
    Alberta Research Centre for Health Evidence, Department of Pediatrics, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada
    BMC Med Res Methodol 12:158. 2012
    ..Pediatric randomized controlled trials (RCTs) are susceptible to a high risk of bias. We examined the barriers and facilitators that pediatric trialists face in the design and conduct of unbiased trials...
  69. pmc Evaluation of the efficacy and safety of olanzapine as an adjunctive treatment for anorexia nervosa in adolescent females: a randomized, double-blind, placebo-controlled trial
    Wendy Spettigue
    Mental Health Department, Children s Hospital of Eastern Ontario Research Institute, 401 Smyth Rd, Ottawa, ON, K1H 8L1, Canada
    BMC Pediatr 8:4. 2008
    ..This randomized, double-blind placebo-controlled trial seeks to examine the effectiveness and safety of olanzapine in female youth with AN...
  70. pmc Guidance for developers of health research reporting guidelines
    David Moher
    Ottawa Methods Centre, Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada
    PLoS Med 7:e1000217. 2010
    b>David Moher and colleagues from the EQUATOR network offer guidance and recommended steps for developing health research reporting guidelines.
  71. doi request reprint The art and science of knowledge synthesis
    Andrea C Tricco
    Ottawa Hospital Research Institute, The Ottawa Hospital, Ottawa, Ontario, Canada
    J Clin Epidemiol 64:11-20. 2011
    ..To review methods for completing knowledge synthesis...
  72. pmc Updating systematic reviews: an international survey
    Chantelle Garritty
    The Ottawa Methods Centre, Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Canada
    PLoS ONE 5:e9914. 2010
    ..However, little guidance is available about when and how to update SRs. Moreover, the updating policies and practices of organizations that commission or produce SRs are unclear...
  73. doi request reprint Systematic review: comparative effectiveness and harms of combination therapy and monotherapy for dyslipidemia
    Mukul Sharma
    University of Ottawa, Clinical Epidemiology Program, Ottawa Hospital Research Institute, Institute, Ottawa, Ontario, Canada
    Ann Intern Med 151:622-30. 2009
    ..Statin therapy effectively prevents vascular disease, but treatment targets are often not achieved...
  74. ncbi request reprint Blinded versus unblinded assessments of risk of bias in studies included in a systematic review
    Kate Morissette
    Health Canada, Ottawa, Ontario, Canada
    Cochrane Database Syst Rev 9:MR000025. 2011
    ..e. the assessor is unaware of the study author's name, institution, sponsorship, journal, etc.) versus unblinded assessments of risk of bias yield systematically different assessments in a systematic review...
  75. pmc Selective serotonin reuptake inhibitors for unipolar depression: a systematic review of classic long-term randomized controlled trials
    Dorian Deshauer
    Department of Psychiatry, University of Ottawa, Ottawa, Ont
    CMAJ 178:1293-301. 2008
    ..We conducted a systematic review to examine the efficacy and acceptability of long-term therapy with selective serotonin reuptake inhibitors relative to placebo in the treatment of unipolar depression...
  76. doi request reprint A review of five cardiology journals found that observer variability of measured variables was infrequently reported
    Robert M Gow
    Children s Hospital of Eastern Ontario Research Institute, 410 Smyth Road, Ottawa, Ontario, Canada K1H 8L1
    J Clin Epidemiol 61:394-401. 2008
    ..To investigate the reporting of the analysis of interobserver and intra-observer variability within clinical research studies from five high-impact cardiology journals published in 2005...
  77. pmc Measurement properties of questionnaires assessing complementary and alternative medicine use in pediatrics: a systematic review
    Karine Toupin April
    Department of Epidemiology and Community Medicine, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada
    PLoS ONE 7:e39611. 2012
    ..However, no studies have attempted to appraise measurement properties of these questionnaires. The aim of this systematic review was to critically appraise and summarize measurement properties of questionnaires of CAM use in pediatrics...
  78. pmc A review of interventions triggered by hepatitis A infected food-handlers in Canada
    Andrea C Tricco
    Epidemiology and Biostatistics, GlaxoSmithKline Canada, Mississauga, Ontario, Canada
    BMC Health Serv Res 6:157. 2006
    ..We undertook a systematic review of such incidents to evaluate the extent of viral transmission through food contamination and the scope of post-exposure prophylaxis (PEP) interventions...
  79. doi request reprint Oral sildenafil citrate (viagra) for erectile dysfunction: a systematic review and meta-analysis of harms
    Alexander Tsertsvadze
    Clinical Epidemiology Program, Ottawa Health Research Institute, Box 208, 501 Smyth Rd, Ottawa K1H 8L6, Ontario, Canada
    Urology 74:831-836.e8. 2009
    ..To summarize and compare evidence on harms in sildenafil- and placebo-treated men with erectile dysfunction (ED) in a systematic review and meta-analysis...
  80. pmc Reporting guidelines for survey research: an analysis of published guidance and reporting practices
    Carol Bennett
    Ottawa Hospital Research Institute, Clinical Epidemiology Program, Ottawa, Canada
    PLoS Med 8:e1001069. 2010
    ..Reporting guidelines have been developed to inform reporting for a variety of study designs. The objective of this study was to identify whether there is a need to develop a reporting guideline for survey research...
  81. ncbi request reprint How quickly do systematic reviews go out of date? A survival analysis
    Kaveh G Shojania
    Ottawa Health Research Institute, University of Ottawa, Chalmers Research Group, and Children s Hospital of Eastern Ontario Research Institute, Ottawa, Ontario, Canada
    Ann Intern Med 147:224-33. 2007
    ..Systematic reviews are often advocated as the best source of evidence to guide clinical decisions and health care policy, yet we know little about the extent to which they require updating...
  82. ncbi request reprint Critical appraisal of clinical studies in Chinese herbal medicine
    Simon Dagenais
    Chalmers Research Group, Children s Hospital of Eastern Ontario Research Institute, Ottawa, Canada
    Zhong Xi Yi Jie He Xue Bao 4:455-66. 2006
    ....
  83. pmc Strengthening the reporting of genetic association studies (STREGA): an extension of the STROBE statement
    Julian Little
    Canada Research Chair in Human Genome Epidemiology, Toronto, ON, Canada
    Eur J Epidemiol 24:37-55. 2009
    ..The STREGA recommendations do not prescribe or dictate how a genetic association study should be designed but seek to enhance the transparency of its reporting, regardless of choices made during design, conduct, or analysis...
  84. doi request reprint Intravesical oxybutynin for children with poorly compliant neurogenic bladder: a systematic review
    Luis Antonio Guerra
    Division of Pediatric Urology, Children s Hospital of Eastern Ontario, University of Ottawa, Ottawa, Ontario, Canada
    J Urol 180:1091-7. 2008
    ..They may become nonresponders to the drug or present with severe side effects. We evaluated the effectiveness and tolerability of intravesical oxybutynin in children with poorly compliant neurogenic bladder...
  85. pmc How efficacious and safe is short-acting methylphenidate for the treatment of attention-deficit disorder in children and adolescents? A meta-analysis
    H M Schachter
    Thomas C Chalmers Centre for Systematic Reviews, Children s Hospital of Eastern Ontario Research Institute, Ottawa
    CMAJ 165:1475-88. 2001
    ..However, no meta-analyses that carefully examined these questions have been done. We reviewed the behavioural evidence from all the randomized controlled trials that compared methylphenidate and placebo, and completed a meta-analysis...
  86. ncbi request reprint Is there a "best" way to detect and minimize publication bias? An empirical evaluation
    B Pham
    Children s Hospital of Eastern Ontario Research Institute
    Eval Health Prof 24:109-25. 2001
    ..Our results also suggest that the appropriate use of these methods improves the reliability and accuracy of meta-analysis...
  87. pmc STrengthening the REporting of Genetic Association studies (STREGA)--an extension of the STROBE statement
    Julian Little
    Canada Research Chair in Human Genome Epidemiology, Ottawa, ON, Canada
    Eur J Clin Invest 39:247-66. 2009
    ..The STREGA recommendations do not prescribe or dictate how a genetic association study should be designed, but seek to enhance the transparency of its reporting, regardless of choices made during design, conduct or analysis...
  88. ncbi request reprint Recommendations for reporting randomized controlled trials of herbal interventions: Explanation and elaboration
    Joel J Gagnier
    Department of Health Policy, Management and Evaluation, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
    J Clin Epidemiol 59:1134-49. 2006
    ..These recommendations for the reporting of herbal medicinal products presented here are open to revision as more evidence accumulates and critical comments are collected...
  89. ncbi request reprint David Moher, MSc The CONSORT Guidelines: improving the quality of research. Consolidated Standards of Reporting Trials. Interview by Bonnie Horrigan
    David Moher
    Children s Hospital Eastern Ontario Research Institute, Ottawa, Ontario, Canada
    Altern Ther Health Med 8:103-8. 2002
  90. ncbi request reprint When to disbelieve the believable
    David Riley
    Children s Hospital of Eastern Ontario Research Institute, Ottowa, Canada
    Altern Ther Health Med 8:36-7. 2002
  91. doi request reprint Parents are reluctant to use technological means of communication in pediatric day care
    Kimmo Murto
    Department of Anesthesiology Children s Hospital of Eastern Ontario, 401 Smyth Rd, Ottawa, Ontario K1H 8L1, Canada
    Can J Anaesth 55:214-22. 2008
    ..We hypothesized that advanced information and communication technology (ICT) would be acceptable to parents in a pediatric surgical, and diagnostic imaging day care setting...
  92. ncbi request reprint The CONSORT statement: revised recommendations for improving the quality of reports of parallel-group randomised trials
    D Moher
    University of Ottawa, Thomas C Chalmers Centre for Systematic Reviews, Ottawa, Ontario, Canada
    Lancet 357:1191-4. 2001
    ..In sum, the CONSORT statement is intended to improve the reporting of an RCT, enabling readers to understand a trial's conduct and to assess the validity of its results...
  93. pmc Poor reporting of scientific leadership information in clinical trial registers
    Melanie Sekeres
    Kunin Lunenfeld Applied Research Unit, Baycrest, Toronto, Ontario, Canada
    PLoS ONE 3:e1610. 2008
    ..Identifying those scientifically responsible for trial conduct increases accountability. The objective is to examine the proportion of registered clinical trials providing valid scientific leadership information...
  94. ncbi request reprint The CONSORT statement: revised recommendations for improving the quality of reports of parallel-group randomized trials
    D Moher
    University of Ottawa, Thomas C. Chalmers Centre for Systematic Reviews, Ottawa, Ontario, Canada
    JAMA 285:1987-91. 2001
    ..In sum, the CONSORT statement is intended to improve the reporting of an RCT, enabling readers to understand a trial's conduct and to assess the validity of its results...
  95. ncbi request reprint Randomized controlled trials in cancer: improving the quality of their reports will also facilitate better conduct
    D Moher
    Children s Hospital of Eastern Ontario Research Institute, University of Ottawa, Ontario
    Ann Oncol 9:483-7. 1998
    ..This work has also focused increased attention on how clinical trials are planned and executed. Some common problems are reviewed and suggestions for improving their conduct are also discussed...
  96. ncbi request reprint The CONSORT statement: revised recommendations for improving the quality of reports of parallel-group randomized trials
    D Moher
    Thomas C. Chalmers Center for Systematic Reviews, Children's Hospital of Eastern Ontario Research Institute, Room R2226, 401 Smyth Road, Ottawa, Ontario K1H 8L1, Canada
    Ann Intern Med 134:657-62. 2001
    ..In sum, the CONSORT statement is intended to improve the reporting of an RCT, enabling readers to understand a trial's conduct and to assess the validity of its results...
  97. ncbi request reprint The inclusion of reports of randomised trials published in languages other than English in systematic reviews
    D Moher
    Department of Pediatrics, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada
    Health Technol Assess 7:1-90. 2003
    ....
  98. ncbi request reprint Does quality of reports of randomised trials affect estimates of intervention efficacy reported in meta-analyses?
    D Moher
    Children s Hospital of Eastern Ontario Research Institute, and Department of Epidemiology and Community Medicine, University of Ottawa, Canada
    Lancet 352:609-13. 1998
    ..We investigated whether different methods of quality assessment provide different estimates of intervention efficacy evaluated in randomised controlled trials (RCTs)...
  99. ncbi request reprint Use of the CONSORT statement and quality of reports of randomized trials: a comparative before-and-after evaluation
    D Moher
    Thomas C. Chalmers Centre for Systematic Reviews, Children's Hospital of Eastern Ontario Research Institute, 401 Smyth Rd, Ottawa, Ontario, K1H 8L1 Canada
    JAMA 285:1992-5. 2001
    ..7; mean change, 0.4; 95% CI, 0.1-0.8). CONCLUSION: Use of the CONSORT statement is associated with improvements in the quality of reports of RCTs...
  100. pmc Advanced vertebral fracture among newly diagnosed children with acute lymphoblastic leukemia: results of the Canadian Steroid-Associated Osteoporosis in the Pediatric Population (STOPP) research program
    Jacqueline Halton
    University of Ottawa, Ontario, Canada
    J Bone Miner Res 24:1326-34. 2009
    ..5-14.5). These results show that vertebral compression is an under-recognized complication of newly diagnosed ALL. Whether the fractures will resolve through bone growth during or after leukemia chemotherapy remains to be determined...
  101. ncbi request reprint A randomized trial of aspirin on the risk of embolic events in patients with infective endocarditis
    Kwan Leung Chan
    Department of Medicine, University of Ottawa and University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, Ontario, Canada K1Y 4W7
    J Am Coll Cardiol 42:775-80. 2003
    ..This study examined the effect of aspirin on the risk of embolic events in infective endocarditis (IE)...