Research Topics
Genomes and GenesSpecies | Mohammed H MoghadasianSummaryAffiliation: University of Manitoba Country: Canada Publications
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Publications
Dietary phytosterols reduce cyclosporine-induced hypercholesterolemia in apolipoprotein E-knockout miceMohammed H Moghadasian
Department of Human Nutritional Sciences, University of Manitoba and the National Centre for Agri food Research in Medicine, St Boniface Hospital Research Centre, Winnipeg, Manitoba, Canada
Transplantation 81:207-13. 2006..Reducing this side effect of cyclosporine by dietary agents may be safe, cost-effective, and attractive to both patients and health professionals...- Cerebrotendinous xanthomatosis: clinical course, genotypes and metabolic backgroundsMohammed H Moghadasian
Department of Human Nutritional Sciences and National Centre for Agri food Research in Medicine, University of Manitoba, Winnipeg, Man
Clin Invest Med 27:42-50. 2004..The mechanism of cholestanol accumulation in affected tissues and its pathogenesis are undefined and therefore warrant further investigation... - Species-related variations in lipoprotein metabolism: the impact of FER(HDL) on susceptibility to atherogenesisThomas J Green
Department of Human Nutritional Sciences and National Centre for Agri food Research in Medicine, University of Manitoba, Winnipeg, Canada
Life Sci 74:2441-9. 2004..These findings are in agreement with data reported in humans. More research is needed to identify the better animal models which closely resemble human lipoprotein metabolism... 
Advances in dietary enrichment with n-3 fatty acidsMohammed H Moghadasian
Department of Human Nutritional Sciences, University of Manitoba and Canadian Center for Agri food Research in Health and Medicine, St Boniface Hospital Research Centre, Winnipeg, Canada
Crit Rev Food Sci Nutr 48:402-10. 2008..The advantages and disadvantages of the above-mentioned methods have been discussed. The evidence for health-promoting effects of such enriched food products has been included...- 'Designer oils' low in n-6:n-3 fatty acid ratio beneficially modifies cardiovascular risks in miceNatalie D Riediger
Department of Human Nutritional Sciences, University of Manitoba, Winnipeg, R3T 2N2, Canada
Eur J Nutr 48:307-14. 2009..Significant liver pathology was observed in the control group only. Lowering dietary ratio of n-6:n-3 fatty acids may significantly reduce cardiovascular and metabolic risks in mice regardless of the source of n-3 fatty acids... - Pro-atherogenic effects of probucol in apo E-KO mice may be mediated through alterations in immune system: Parallel alterations in gene expression in the aorta and liverZuyuan Xu
Department of Human Nutritional Sciences, University of Manitoba, and Canadian Center for Agri food Research in Health and Medicine, St Boniface Hospital Research Center, 351 Tache Avenue, Winnipeg, MB, Canada R2H 2A6
Atherosclerosis 206:427-33. 2009..To establish underlying molecular mechanisms of pro-atherogenic effects of probucol in apo E-KO mice... - Effects of long-term consumption of a high-fructose diet on conventional cardiovascular risk factors in Sprague-Dawley ratsMohammad M Abdullah
Departments of Human Nutritional Sciences, The University of Manitoba and St Boniface General Hospital Research Centre, Winnipeg, MB, Canada
Mol Cell Biochem 327:247-56. 2009..HF-feeding resulted in significant reductions in plasma levels of certain inflammatory biomarkers. HF intake over time may negatively impact cardiovascular health and liver function in rats... - A high-lipid diet potentiates left ventricular dysfunction in nitric oxide synthase 3-deficient mice after chronic pressure overloadRoien Ahmadie
Institute of Cardiovascular Sciences, St Boniface General Hospital, University of Manitoba, Winnipeg, Manitoba, Canada
J Nutr 140:1438-44. 2010..A HLD potentiates LV dysfunction in NOS3(-/-) mice in a chronic pressure overload state... - Paradoxical effects of fenofibrate and nicotinic acid in apo E-deficient miceVanessa Declercq
Department of Human Nutritional Sciences, St. Boniface Hospital Research Centre and University of Manitoba, Winnipeg, Manitoba, Canada
J Cardiovasc Pharmacol 46:18-24. 2005..Identification of mechanisms underlying paradoxical effects of fenofibrate on lipoprotein metabolisms in apo E-KO mice merits further investigation... - A comparison of the effects of fish oil and flaxseed oil on cardiac allograft chronic rejection in ratsRgia A Othman
Department of Human Nutritional Sciences, University of Manitoba and Saint Boniface General Hospital Research Centre, Winnipeg, Canada
Am J Physiol Heart Circ Physiol 294:H1452-8. 2008.... - Lack of evidence for antiatherogenic effects of wheat bran or corn bran in apolipoprotein E-knockout miceZhaohui Zhao
Department of Human Nutritional Sciences, University of Manitoba, and Canadian Center for Agri food Research in Health and Medicine, St Boniface Hospital Research Center, Winnipeg, Canada
J Agric Food Chem 57:6455-60. 2009..The results suggest that phenolic antioxidants from the two types of bran may not be sufficient to reduce atherosclerosis in this animal model... - Long-term phytosterol treatment alters gene expression in the liver of apo E-deficient miceZuyuan Xu
Department of Human Nutritional Sciences, University of Manitoba, Canadian Center for Agri food Research in Health and Medicine, St Boniface Hospital Research Center, Winnipeg, Canada R2H 2A6
J Nutr Biochem 19:545-54. 2008..Further multivariate correlation or association analysis is needed to establish the relations between changes in the expression of these genes and prevention of atherosclerosis by phytosterols... - Dietary flaxseed inhibits atherosclerosis in the LDL receptor-deficient mouse in part through antiproliferative and anti-inflammatory actionsChantal M C Dupasquier
Canadian Center for Agri food Research in Health and Medicine, St Boniface Hospital Research Center, Winnipeg, Canada
Am J Physiol Heart Circ Physiol 293:H2394-402. 2007..Our results demonstrate that dietary flaxseed can inhibit atherosclerosis in the LDLrKO mouse through a reduction of circulating cholesterol levels and, at a cellular level, via antiproliferative and anti-inflammatory actions... - Low n-6:n-3 fatty acid ratio, with fish- or flaxseed oil, in a high fat diet improves plasma lipids and beneficially alters tissue fatty acid composition in miceNatalie D Riediger
Dept of Human Nutritional Sciences, University of Manitoba, Winnipeg, MB, Canada
Eur J Nutr 47:153-60. 2008..Health benefits from low n-6:n-3 fatty acid (FA) ratio on cardiovascular risk have been shown. However, the impact of the source of n-3 FAs has not been fully investigated... - The role of Tissue Doppler imaging in the noninvasive detection of chronic rejection after heterotopic cardiac transplantation in ratsDavinder S Jassal
Cardiology Division, Department of Cardiac Sciences, St Boniface General Hospital, Manitoba, Canada
Echocardiography 26:37-43. 2009..Recent advances in murine echocardiography, in particular Tissue Doppler imaging (TDI), may allow for objective in vivo monitoring of chronic rejection in this transplant model... - Combination of dietary phytosterols plus niacin or fenofibrate: effects on lipid profile and atherosclerosis in apo E-KO miceBehzad Yeganeh
Department of Human Nutritional Sciences, University of Manitoba, Winnipeg, Manitoba, Canada R2H 2A6
J Nutr Biochem 16:222-8. 2005..Further studies in other animal models are needed to establish synergetic effects between these lipid-modifying dietary and pharmacological agents... - Dietary phytosterols reduce probucol-induced atherogenesis in apo E-KO miceMohammed H Moghadasian
Departments of Human Nutritional Sciences and Pathology, The University of Manitoba, Winnipeg, Man, Canada R2H 2A6
Atherosclerosis 188:28-34. 2006..Further studies warrant the investigation of the underlying mechanisms of the observed beneficial interactions between dietary phytosterols and probucol... - A systemic review of the roles of n-3 fatty acids in health and diseaseNatalie D Riediger
Department of Human Nutritional Sciences, University of Manitoba and Canadian Centre for Agri Food Research in Medicine, St Boniface Hospital Research Centre, Winnipeg, MB, Canada
J Am Diet Assoc 109:668-79. 2009.... - Carcinogenesis alters fatty acid profile in breast tissueNazila Azordegan
Departments of Human Nutritional Sciences, Canadian Centre for Agri Food Research in Health and Medicine, University of Manitoba, 351 Tache Avenue, Winnipeg, MB, R2H 2A6, Canada
Mol Cell Biochem 374:223-32. 2013..Should this theory be confirmed by larger studies, deviation of phospholipid composition from normal values can be used as markers of susceptibility of tissue to cancer development... - The effects of simultaneous administration of dietary conjugated linoleic acid and telmisartan on cardiovascular risks in ratsMohammad M Abdullah
Department of Human Nutritional Sciences, The University of Manitoba and St Boniface General Hospital Research Centre, Winnipeg, MB, Canada
Lipids 42:855-64. 2007..This combination of nutraceuticals and pharmaceuticals may be a safe and cost-effective strategy in a number of high-risk subjects. Future studies will further document clinical benefits of such combination therapy... - Antiatherogenic effects of dietary plant sterols are associated with inhibition of proinflammatory cytokine production in Apo E-KO miceBaher Nashed
Department of Human Nutritional Sciences and Pathology, and National Centre for Agri food Research in Medicine, St Boniface Hospital Research Centre, The University of Manitoba, Winnipeg, Canada
J Nutr 135:2438-44. 2005..Thus, the desirable suppression of proinflammatory cytokine production that was associated with inhibition of atherogenesis did not impair the capacity to mount responses to foreign antigens... - Beyond cholesterol-lowering effects of plant sterols: clinical and experimental evidence of anti-inflammatory propertiesRgia A Othman
Department of Human Nutritional Sciences, University of Manitoba and Canadian Centre for Agri food Research in Health and Medicine, St Boniface Hospital Research Centre, Winnipeg, Canada
Nutr Rev 69:371-82. 2011..Additional well-designed placebo-controlled studies are needed to better understand how and to what extent dietary plant sterols may modify the immune system and the production of inflammatory markers... - Cholesterol-lowering effects of oat β-glucanRgia A Othman
Department of Human Nutritional Sciences and Canadian Centre for Agri food Research in Health and Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
Nutr Rev 69:299-309. 2011..Significant scientific agreement continues to support a relationship between oat β-glucan and blood cholesterol levels, with newer data being consistent with earlier conclusions made by the FDA and JHCI... - A rare case of coexistence of carcinoid tumor of appendix vermicularis and ileal endometriosisNazila Azordegan
Pathology Research Laboratory, and Canadian Centre for Agri Food Research in Health and Medicine, St Boniface Hospital Research Centre, 351 Tache Avenue, Winnipeg, Manitoba, Canada
Arch Gynecol Obstet 279:183-7. 2009..Carcinoid tumor is the most common tumor of appendix with overall good prognosis. Endometriosis is the implantation of endometrial glands and stroma outside the uterus... - The role of marine n-3 fatty acids in improving cardiovascular health: a reviewTiffany Nicholson
St Boniface Research Centre, 351 Tache Ave, Winnipeg, Manitoba, Canada R2H 2A6
Food Funct 4:357-65. 2013..Due to the originality of the Index, additional evidence is required to assess this as a tool for predicting CVD. Future research is needed to determine the individual effects of EPA and DHA for cardio-protection... - Patterns of fruit and vegetable consumption and the influence of sex, age and socio-demographic factors among Canadian elderlyNatalie D Riediger
Department of Human Nutritional Sciences, University of Manitoba, and St Boniface Hospital Research Centre, Winnipeg, Manitoba, Canada
J Am Coll Nutr 27:306-13. 2008..The aim of the present study was to: 1) describe the patterns of fruit and vegetable (f&v) intake in Canadian elderly and 2) identify socio-demographic factors that were associated with the low consumption... - Involvement of NADPH oxidase in up-regulation of plasminogen activator inhibitor-1 and heat shock factor-1 in mouse embryo fibroblasts induced by oxidized LDL and in apolipoprotein E-deficient miceRuozhi Zhao
Department of Internal Medicine, University of Manitoba, Winnipeg, MB, Canada
Free Radic Res 45:1013-23. 2011..The results suggest that NOX is required for oLDL-induced HSF1 or PAI-1 expression in MEF, which was supported by the up-regulation of NOX, LOX-1, HSF1 and PAI-1 in apoE-KO mice... - Flaxseed oil and fish-oil capsule consumption alters human red blood cell n-3 fatty acid composition: a multiple-dosing trial comparing 2 sources of n-3 fatty acidGwendolyn Barcelo-Coblijn
Department of Pharmacology, University of North Dakota, Grand Forks, ND, USA
Am J Clin Nutr 88:801-9. 2008.... - Fish oil significantly alters fatty acid profiles in various lipid fractions but not atherogenesis in apo E-KO miceZuyuan Xu
Dept of Human Nutritional Sciences University of Manitoba, Winnipeg MB, Canada
Eur J Nutr 46:103-10. 2007..Consumption of fish oil and n-3 fatty acids is associated with beneficial modifications in plasma lipid levels. The impact of these modifications on development of atherosclerotic lesions merits further investigation... - Comparison of cholesterol-lowering efficacy and anti-atherogenic properties of hydrogenated versus non-hydrogenated (Phytrol) tall oil-derived phytosterols in apo E-deficient miceP Haydn Pritchard
Healthy Heart Program, Department of Pathology and Laboratory Medicine, St. Paul's Hospital and University of British Columbia, Vancouver, Canada
Cardiovasc Drugs Ther 17:443-9. 2003..In conclusion, this study did not show statistically significant differences between hydrogenated and non-hydrogenated plant sterols with regard to their cholesterol-lowering and anti-atherosclerotic properties in apo E-KO mice... - Statins and menopauseMohammed H Moghadasian
Department of Pathology The University of British Columbia, Vancouver, British Columbia, Canada
Drugs 62:2421-31. 2002.... - Disodium ascorbyl phytostanyl phosphate reduces plasma cholesterol concentrations and atherosclerotic lesion formation in apolipoprotein E-deficient miceTatjana Lukic
Forbes Medi-Tech Inc, Vancouver, Canada
Metabolism 52:425-31. 2003..A trend in decreasing plasma triglyceride levels was also observed. Taken together these data suggest that FM-VP4 has both lipid-lowering and antiatherosclerotic properties following 12-week administration to ApoE-deficient mice... - Cerebrotendinous xanthomatosis: a rare disease with diverse manifestationsMohammed H Moghadasian
Healthy Heart Program, St Paul s Hospital, Suite 180, 1081 Burrard St, Vancouver, British Columbia, Canada V6Z 1Y6
Arch Neurol 59:527-9. 2002..Chenodeoxycholic acid is the most effective therapy. The causative role and detrimental effects (at a low plasma level) of cholestanol merit further investigation... - A safety look at currently available statinsMohammed H Moghadasian
Division of Toxicological Studies, PhenoPharma Research, Inc, St Paul s Hospital and University of British Columbia, 180 1081 Burrard Street, Vancouver, BC, Canada V6Z 1Y6
Expert Opin Drug Saf 1:269-74. 2002..Future clinical studies and surveillance information will warrant long-term safety of each member of this class of lipid-lowering agents... - Ultrastructural evidence of early endothelial damage in coronary arteries of rat cardiac allograftsJohn C K Lai
University of British Columbia McDonald Research Laboratories, iCAPTUR4E Centre, Department of Pathology and Laboratory Medicine, St. Paul's Hospital, Providence Health Care, Vancouver, British Columbia, Canada
J Heart Lung Transplant 22:993-1004. 2003..CONCLUSIONS: Our findings indicate that, especially when immunosuppression is insufficient, early endothelial damage may promote vascular permeability and thereby initiate TVD... - Experimental atherosclerosis: a historical overviewMohammed H Moghadasian
Healthy Heart Program, St Paul s Hospital, Vancouver, BC, Canada
Life Sci 70:855-65. 2002....