Mohammed H Moghadasian

Summary

Affiliation: University of Manitoba
Country: Canada

Publications

  1. pmc Menhaden oil, but not safflower or soybean oil, aids in restoring the polyunsaturated fatty acid profile in the novel delta-6-desaturase null mouse
    Jessica Monteiro
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON, Canada
    Lipids Health Dis 11:60. 2012
  2. doi request reprint Advances in dietary enrichment with n-3 fatty acids
    Mohammed H Moghadasian
    Department of Human Nutritional Sciences, University of Manitoba and Canadian Center for Agri food Research in Health and Medicine, St Boniface Hospital Research Centre, Winnipeg, Canada
    Crit Rev Food Sci Nutr 48:402-10. 2008
  3. ncbi request reprint Dietary phytosterols reduce cyclosporine-induced hypercholesterolemia in apolipoprotein E-knockout mice
    Mohammed H Moghadasian
    Department of Human Nutritional Sciences, University of Manitoba and the National Centre for Agri food Research in Medicine, St Boniface Hospital Research Centre, Winnipeg, Manitoba, Canada
    Transplantation 81:207-13. 2006
  4. ncbi request reprint Cerebrotendinous xanthomatosis: clinical course, genotypes and metabolic backgrounds
    Mohammed H Moghadasian
    Department of Human Nutritional Sciences and National Centre for Agri food Research in Medicine, University of Manitoba, Winnipeg, Man
    Clin Invest Med 27:42-50. 2004
  5. ncbi request reprint Species-related variations in lipoprotein metabolism: the impact of FER(HDL) on susceptibility to atherogenesis
    Thomas J Green
    Department of Human Nutritional Sciences and National Centre for Agri food Research in Medicine, University of Manitoba, Winnipeg, Canada
    Life Sci 74:2441-9. 2004
  6. ncbi request reprint 'Designer oils' low in n-6:n-3 fatty acid ratio beneficially modifies cardiovascular risks in mice
    Natalie D Riediger
    Department of Human Nutritional Sciences, University of Manitoba, Winnipeg, R3T 2N2, Canada
    Eur J Nutr 48:307-14. 2009
  7. doi request reprint Pro-atherogenic effects of probucol in apo E-KO mice may be mediated through alterations in immune system: Parallel alterations in gene expression in the aorta and liver
    Zuyuan Xu
    Department of Human Nutritional Sciences, University of Manitoba, and Canadian Center for Agri food Research in Health and Medicine, St Boniface Hospital Research Center, 351 Tache Avenue, Winnipeg, MB, Canada R2H 2A6
    Atherosclerosis 206:427-33. 2009
  8. doi request reprint Effects of long-term consumption of a high-fructose diet on conventional cardiovascular risk factors in Sprague-Dawley rats
    Mohammad M Abdullah
    Departments of Human Nutritional Sciences, The University of Manitoba and St Boniface General Hospital Research Centre, Winnipeg, MB, Canada
    Mol Cell Biochem 327:247-56. 2009
  9. ncbi request reprint A high-lipid diet potentiates left ventricular dysfunction in nitric oxide synthase 3-deficient mice after chronic pressure overload
    Roien Ahmadie
    Institute of Cardiovascular Sciences, St Boniface General Hospital, University of Manitoba, Winnipeg, Manitoba, Canada
    J Nutr 140:1438-44. 2010
  10. ncbi request reprint Paradoxical effects of fenofibrate and nicotinic acid in apo E-deficient mice
    Vanessa Declercq
    Department of Human Nutritional Sciences, St Boniface Hospital Research Centre and University of Manitoba, Winnipeg, Manitoba, Canada
    J Cardiovasc Pharmacol 46:18-24. 2005

Collaborators

Detail Information

Publications40

  1. pmc Menhaden oil, but not safflower or soybean oil, aids in restoring the polyunsaturated fatty acid profile in the novel delta-6-desaturase null mouse
    Jessica Monteiro
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON, Canada
    Lipids Health Dis 11:60. 2012
    ..However, a potential confounder in this model is the production of novel Δ-5 desaturase (D5D) derived fatty acids when D6KO mice are fed diets containing LA and ALA, but void of arachidonic acid...
  2. doi request reprint Advances in dietary enrichment with n-3 fatty acids
    Mohammed H Moghadasian
    Department of Human Nutritional Sciences, University of Manitoba and Canadian Center for Agri food Research in Health and Medicine, St Boniface Hospital Research Centre, Winnipeg, Canada
    Crit Rev Food Sci Nutr 48:402-10. 2008
    ..The advantages and disadvantages of the above-mentioned methods have been discussed. The evidence for health-promoting effects of such enriched food products has been included...
  3. ncbi request reprint Dietary phytosterols reduce cyclosporine-induced hypercholesterolemia in apolipoprotein E-knockout mice
    Mohammed H Moghadasian
    Department of Human Nutritional Sciences, University of Manitoba and the National Centre for Agri food Research in Medicine, St Boniface Hospital Research Centre, Winnipeg, Manitoba, Canada
    Transplantation 81:207-13. 2006
    ..Reducing this side effect of cyclosporine by dietary agents may be safe, cost-effective, and attractive to both patients and health professionals...
  4. ncbi request reprint Cerebrotendinous xanthomatosis: clinical course, genotypes and metabolic backgrounds
    Mohammed H Moghadasian
    Department of Human Nutritional Sciences and National Centre for Agri food Research in Medicine, University of Manitoba, Winnipeg, Man
    Clin Invest Med 27:42-50. 2004
    ..The mechanism of cholestanol accumulation in affected tissues and its pathogenesis are undefined and therefore warrant further investigation...
  5. ncbi request reprint Species-related variations in lipoprotein metabolism: the impact of FER(HDL) on susceptibility to atherogenesis
    Thomas J Green
    Department of Human Nutritional Sciences and National Centre for Agri food Research in Medicine, University of Manitoba, Winnipeg, Canada
    Life Sci 74:2441-9. 2004
    ..These findings are in agreement with data reported in humans. More research is needed to identify the better animal models which closely resemble human lipoprotein metabolism...
  6. ncbi request reprint 'Designer oils' low in n-6:n-3 fatty acid ratio beneficially modifies cardiovascular risks in mice
    Natalie D Riediger
    Department of Human Nutritional Sciences, University of Manitoba, Winnipeg, R3T 2N2, Canada
    Eur J Nutr 48:307-14. 2009
    ..Significant liver pathology was observed in the control group only. Lowering dietary ratio of n-6:n-3 fatty acids may significantly reduce cardiovascular and metabolic risks in mice regardless of the source of n-3 fatty acids...
  7. doi request reprint Pro-atherogenic effects of probucol in apo E-KO mice may be mediated through alterations in immune system: Parallel alterations in gene expression in the aorta and liver
    Zuyuan Xu
    Department of Human Nutritional Sciences, University of Manitoba, and Canadian Center for Agri food Research in Health and Medicine, St Boniface Hospital Research Center, 351 Tache Avenue, Winnipeg, MB, Canada R2H 2A6
    Atherosclerosis 206:427-33. 2009
    ..To establish underlying molecular mechanisms of pro-atherogenic effects of probucol in apo E-KO mice...
  8. doi request reprint Effects of long-term consumption of a high-fructose diet on conventional cardiovascular risk factors in Sprague-Dawley rats
    Mohammad M Abdullah
    Departments of Human Nutritional Sciences, The University of Manitoba and St Boniface General Hospital Research Centre, Winnipeg, MB, Canada
    Mol Cell Biochem 327:247-56. 2009
    ..HF-feeding resulted in significant reductions in plasma levels of certain inflammatory biomarkers. HF intake over time may negatively impact cardiovascular health and liver function in rats...
  9. ncbi request reprint A high-lipid diet potentiates left ventricular dysfunction in nitric oxide synthase 3-deficient mice after chronic pressure overload
    Roien Ahmadie
    Institute of Cardiovascular Sciences, St Boniface General Hospital, University of Manitoba, Winnipeg, Manitoba, Canada
    J Nutr 140:1438-44. 2010
    ..A HLD potentiates LV dysfunction in NOS3(-/-) mice in a chronic pressure overload state...
  10. ncbi request reprint Paradoxical effects of fenofibrate and nicotinic acid in apo E-deficient mice
    Vanessa Declercq
    Department of Human Nutritional Sciences, St Boniface Hospital Research Centre and University of Manitoba, Winnipeg, Manitoba, Canada
    J Cardiovasc Pharmacol 46:18-24. 2005
    ..Identification of mechanisms underlying paradoxical effects of fenofibrate on lipoprotein metabolisms in apo E-KO mice merits further investigation...
  11. doi request reprint Lack of evidence for antiatherogenic effects of wheat bran or corn bran in apolipoprotein E-knockout mice
    Zhaohui Zhao
    Department of Human Nutritional Sciences, University of Manitoba, and Canadian Center for Agri food Research in Health and Medicine, St Boniface Hospital Research Center, Winnipeg, Canada
    J Agric Food Chem 57:6455-60. 2009
    ..The results suggest that phenolic antioxidants from the two types of bran may not be sufficient to reduce atherosclerosis in this animal model...
  12. doi request reprint A comparison of the effects of fish oil and flaxseed oil on cardiac allograft chronic rejection in rats
    Rgia A Othman
    Department of Human Nutritional Sciences, University of Manitoba and Saint Boniface General Hospital Research Centre, Winnipeg, Canada
    Am J Physiol Heart Circ Physiol 294:H1452-8. 2008
    ....
  13. ncbi request reprint The effects of fish oil consumption on cardiovascular remodeling in ApoE deficient mice
    Kelby Cleverley
    a Institute of Cardiovascular Sciences, St Boniface Research Centre, University of Manitoba, Winnipeg, Manitoba, Canada
    Can J Physiol Pharmacol 91:960-5. 2013
    ..This suggests that high-fat diet supplemented with fish oil may lead to adverse cardiovascular effects in ApoE deficient mice. ..
  14. ncbi request reprint Wild rice (Zizania palustris L.) prevents atherogenesis in LDL receptor knockout mice
    Gangadaran Surendiran
    Department of Human Nutritional Sciences, University of Manitoba, Winnipeg, MB, Canada Canadian Center for Agri Food Research in Health and Medicine, St Boniface Hospital Research Center, Winnipeg, MB, Canada
    Atherosclerosis 230:284-92. 2013
    ..The purpose of the present study was to investigate the potential cardiovascular benefits of wild rice in male and female LDL-receptor-deficient (LDLr-KO) mice...
  15. ncbi request reprint Dietary flaxseed inhibits atherosclerosis in the LDL receptor-deficient mouse in part through antiproliferative and anti-inflammatory actions
    Chantal M C Dupasquier
    Canadian Center for Agri food Research in Health and Medicine, St Boniface Hospital Research Center, Winnipeg, Canada
    Am J Physiol Heart Circ Physiol 293:H2394-402. 2007
    ..Our results demonstrate that dietary flaxseed can inhibit atherosclerosis in the LDLrKO mouse through a reduction of circulating cholesterol levels and, at a cellular level, via antiproliferative and anti-inflammatory actions...
  16. doi request reprint The role of Tissue Doppler imaging in the noninvasive detection of chronic rejection after heterotopic cardiac transplantation in rats
    Davinder S Jassal
    Cardiology Division, Department of Cardiac Sciences, St Boniface General Hospital, Manitoba, Canada
    Echocardiography 26:37-43. 2009
    ..Recent advances in murine echocardiography, in particular Tissue Doppler imaging (TDI), may allow for objective in vivo monitoring of chronic rejection in this transplant model...
  17. ncbi request reprint Combination of dietary phytosterols plus niacin or fenofibrate: effects on lipid profile and atherosclerosis in apo E-KO mice
    Behzad Yeganeh
    Department of Human Nutritional Sciences, University of Manitoba, Winnipeg, Manitoba, Canada R2H 2A6
    J Nutr Biochem 16:222-8. 2005
    ..Further studies in other animal models are needed to establish synergetic effects between these lipid-modifying dietary and pharmacological agents...
  18. doi request reprint Low n-6:n-3 fatty acid ratio, with fish- or flaxseed oil, in a high fat diet improves plasma lipids and beneficially alters tissue fatty acid composition in mice
    Natalie D Riediger
    Dept of Human Nutritional Sciences, University of Manitoba, Winnipeg, MB, Canada
    Eur J Nutr 47:153-60. 2008
    ..Health benefits from low n-6:n-3 fatty acid (FA) ratio on cardiovascular risk have been shown. However, the impact of the source of n-3 FAs has not been fully investigated...
  19. ncbi request reprint Long-term phytosterol treatment alters gene expression in the liver of apo E-deficient mice
    Zuyuan Xu
    Department of Human Nutritional Sciences, University of Manitoba, Canadian Center for Agri food Research in Health and Medicine, St Boniface Hospital Research Center, Winnipeg, Canada R2H 2A6
    J Nutr Biochem 19:545-54. 2008
    ..Further multivariate correlation or association analysis is needed to establish the relations between changes in the expression of these genes and prevention of atherosclerosis by phytosterols...
  20. ncbi request reprint The role of marine n-3 fatty acids in improving cardiovascular health: a review
    Tiffany Nicholson
    St Boniface Research Centre, 351 Tache Ave, Winnipeg, Manitoba, Canada R2H 2A6
    Food Funct 4:357-65. 2013
    ..Due to the originality of the Index, additional evidence is required to assess this as a tool for predicting CVD. Future research is needed to determine the individual effects of EPA and DHA for cardio-protection...
  21. ncbi request reprint Dietary phytosterols reduce probucol-induced atherogenesis in apo E-KO mice
    Mohammed H Moghadasian
    Departments of Human Nutritional Sciences and Pathology, The University of Manitoba, Winnipeg, Man, Canada R2H 2A6
    Atherosclerosis 188:28-34. 2006
    ..Further studies warrant the investigation of the underlying mechanisms of the observed beneficial interactions between dietary phytosterols and probucol...
  22. doi request reprint A systemic review of the roles of n-3 fatty acids in health and disease
    Natalie D Riediger
    Department of Human Nutritional Sciences, University of Manitoba and Canadian Centre for Agri Food Research in Medicine, St Boniface Hospital Research Centre, Winnipeg, MB, Canada
    J Am Diet Assoc 109:668-79. 2009
    ....
  23. doi request reprint Carcinogenesis alters fatty acid profile in breast tissue
    Nazila Azordegan
    Departments of Human Nutritional Sciences, Canadian Centre for Agri Food Research in Health and Medicine, University of Manitoba, 351 Tache Avenue, Winnipeg, MB, R2H 2A6, Canada
    Mol Cell Biochem 374:223-32. 2013
    ..Should this theory be confirmed by larger studies, deviation of phospholipid composition from normal values can be used as markers of susceptibility of tissue to cancer development...
  24. ncbi request reprint The effects of simultaneous administration of dietary conjugated linoleic acid and telmisartan on cardiovascular risks in rats
    Mohammad M Abdullah
    Department of Human Nutritional Sciences, The University of Manitoba and St Boniface General Hospital Research Centre, Winnipeg, MB, Canada
    Lipids 42:855-64. 2007
    ..This combination of nutraceuticals and pharmaceuticals may be a safe and cost-effective strategy in a number of high-risk subjects. Future studies will further document clinical benefits of such combination therapy...
  25. ncbi request reprint Antiatherogenic effects of dietary plant sterols are associated with inhibition of proinflammatory cytokine production in Apo E-KO mice
    Baher Nashed
    Department of Human Nutritional Sciences and Pathology, and National Centre for Agri food Research in Medicine, St Boniface Hospital Research Centre, The University of Manitoba, Winnipeg, Canada
    J Nutr 135:2438-44. 2005
    ..Thus, the desirable suppression of proinflammatory cytokine production that was associated with inhibition of atherogenesis did not impair the capacity to mount responses to foreign antigens...
  26. doi request reprint Beyond cholesterol-lowering effects of plant sterols: clinical and experimental evidence of anti-inflammatory properties
    Rgia A Othman
    Department of Human Nutritional Sciences, University of Manitoba and Canadian Centre for Agri food Research in Health and Medicine, St Boniface Hospital Research Centre, Winnipeg, Canada
    Nutr Rev 69:371-82. 2011
    ..Additional well-designed placebo-controlled studies are needed to better understand how and to what extent dietary plant sterols may modify the immune system and the production of inflammatory markers...
  27. doi request reprint Cholesterol-lowering effects of oat β-glucan
    Rgia A Othman
    Department of Human Nutritional Sciences and Canadian Centre for Agri food Research in Health and Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
    Nutr Rev 69:299-309. 2011
    ..Significant scientific agreement continues to support a relationship between oat β-glucan and blood cholesterol levels, with newer data being consistent with earlier conclusions made by the FDA and JHCI...
  28. doi request reprint A rare case of coexistence of carcinoid tumor of appendix vermicularis and ileal endometriosis
    Nazila Azordegan
    Pathology Research Laboratory, and Canadian Centre for Agri Food Research in Health and Medicine, St Boniface Hospital Research Centre, 351 Tache Avenue, Winnipeg, Manitoba, Canada
    Arch Gynecol Obstet 279:183-7. 2009
    ..Carcinoid tumor is the most common tumor of appendix with overall good prognosis. Endometriosis is the implantation of endometrial glands and stroma outside the uterus...
  29. ncbi request reprint Nutritional constituents and health benefits of wild rice (Zizania spp.)
    Gangadaran Surendiran
    Department of Human Nutritional Sciences and Canadian Centre for Agri food Research in Health and Medicine, University of Manitoba, Winnipeg, MB, Canada
    Nutr Rev 72:227-36. 2014
    ..While evidence for the cardiovascular benefits of wild rice consumption is accumulating, additional studies are warranted to determine the clinical benefits of regular consumption of wild rice. ..
  30. ncbi request reprint Patterns of fruit and vegetable consumption and the influence of sex, age and socio-demographic factors among Canadian elderly
    Natalie D Riediger
    Department of Human Nutritional Sciences, University of Manitoba, and St Boniface Hospital Research Centre, Winnipeg, Manitoba, Canada
    J Am Coll Nutr 27:306-13. 2008
    ..The aim of the present study was to: 1) describe the patterns of fruit and vegetable (f&v) intake in Canadian elderly and 2) identify socio-demographic factors that were associated with the low consumption...
  31. ncbi request reprint Involvement of NADPH oxidase in up-regulation of plasminogen activator inhibitor-1 and heat shock factor-1 in mouse embryo fibroblasts induced by oxidized LDL and in apolipoprotein E-deficient mice
    Ruozhi Zhao
    Department of Internal Medicine, University of Manitoba, Winnipeg, MB, Canada
    Free Radic Res 45:1013-23. 2011
    ..The results suggest that NOX is required for oLDL-induced HSF1 or PAI-1 expression in MEF, which was supported by the up-regulation of NOX, LOX-1, HSF1 and PAI-1 in apoE-KO mice...
  32. ncbi request reprint Flaxseed oil and fish-oil capsule consumption alters human red blood cell n-3 fatty acid composition: a multiple-dosing trial comparing 2 sources of n-3 fatty acid
    Gwendolyn Barcelo-Coblijn
    Department of Pharmacology, University of North Dakota, Grand Forks, ND, USA
    Am J Clin Nutr 88:801-9. 2008
    ....
  33. ncbi request reprint Fish oil significantly alters fatty acid profiles in various lipid fractions but not atherogenesis in apo E-KO mice
    Zuyuan Xu
    Dept of Human Nutritional Sciences University of Manitoba, Winnipeg MB, Canada
    Eur J Nutr 46:103-10. 2007
    ..Consumption of fish oil and n-3 fatty acids is associated with beneficial modifications in plasma lipid levels. The impact of these modifications on development of atherosclerotic lesions merits further investigation...
  34. ncbi request reprint Comparison of cholesterol-lowering efficacy and anti-atherogenic properties of hydrogenated versus non-hydrogenated (Phytrol) tall oil-derived phytosterols in apo E-deficient mice
    P Haydn Pritchard
    Healthy Heart Program, Department of Pathology and Laboratory Medicine, St Paul s Hospital and University of British Columbia, Vancouver, Canada
    Cardiovasc Drugs Ther 17:443-9. 2003
    ..In conclusion, this study did not show statistically significant differences between hydrogenated and non-hydrogenated plant sterols with regard to their cholesterol-lowering and anti-atherosclerotic properties in apo E-KO mice...
  35. ncbi request reprint Statins and menopause
    Mohammed H Moghadasian
    Department of Pathology The University of British Columbia, Vancouver, British Columbia, Canada
    Drugs 62:2421-31. 2002
    ....
  36. ncbi request reprint Disodium ascorbyl phytostanyl phosphate reduces plasma cholesterol concentrations and atherosclerotic lesion formation in apolipoprotein E-deficient mice
    Tatjana Lukic
    Forbes Medi Tech Inc, Vancouver, Canada
    Metabolism 52:425-31. 2003
    ..A trend in decreasing plasma triglyceride levels was also observed. Taken together these data suggest that FM-VP4 has both lipid-lowering and antiatherosclerotic properties following 12-week administration to ApoE-deficient mice...
  37. ncbi request reprint Cerebrotendinous xanthomatosis: a rare disease with diverse manifestations
    Mohammed H Moghadasian
    Healthy Heart Program, St Paul s Hospital, Suite 180, 1081 Burrard St, Vancouver, British Columbia, Canada V6Z 1Y6
    Arch Neurol 59:527-9. 2002
    ..Chenodeoxycholic acid is the most effective therapy. The causative role and detrimental effects (at a low plasma level) of cholestanol merit further investigation...
  38. ncbi request reprint A safety look at currently available statins
    Mohammed H Moghadasian
    Division of Toxicological Studies, PhenoPharma Research, Inc, St Paul s Hospital and University of British Columbia, 180 1081 Burrard Street, Vancouver, BC, Canada V6Z 1Y6
    Expert Opin Drug Saf 1:269-74. 2002
    ..Future clinical studies and surveillance information will warrant long-term safety of each member of this class of lipid-lowering agents...
  39. ncbi request reprint Ultrastructural evidence of early endothelial damage in coronary arteries of rat cardiac allografts
    John C K Lai
    University of British Columbia McDonald Research Laboratories, iCAPTUR4E Centre, Department of Pathology and Laboratory Medicine, St Paul s Hospital, Providence Health Care, Vancouver, British Columbia, Canada
    J Heart Lung Transplant 22:993-1004. 2003
    ..In this study, we examined endothelial integrity in coronary arteries and the proximal aorta after cardiac transplantation in rats...
  40. ncbi request reprint Experimental atherosclerosis: a historical overview
    Mohammed H Moghadasian
    Healthy Heart Program, St Paul s Hospital, Vancouver, BC, Canada
    Life Sci 70:855-65. 2002
    ....