Research Topics
Genomes and Genes | Suresh MishraSummaryAffiliation: University of Manitoba Country: Canada Publications
| Collaborators
|
Detail Information
Publications
Transglutaminase 2 kinase activity facilitates protein kinase A-induced phosphorylation of retinoblastoma proteinSuresh Mishra
Department of Physiology, University of Manitoba, Winnipeg R3E 0W3, Canada, and the Biochemistry Laboratory, Instituto Dermapatico dell Immaculata Institute for Hospitalization, Care and Scientific Research, Tor Vergata, Italy
J Biol Chem 282:18108-15. 2007..These data indicate that Rb is a substrate for TG2 kinase activity and suggest that phosphorylation of Rb, which results from activation of PKA in fibroblasts, is indirect and requires TG2 kinase activity...- Tissue transglutaminase has intrinsic kinase activity: identification of transglutaminase 2 as an insulin-like growth factor-binding protein-3 kinaseSuresh Mishra
Department of Physiology, University of Manitoba, Winnipeg R3E 0W3, Canada
J Biol Chem 279:23863-8. 2004..Furthermore, we provide evidence that TG2 is a major component of the IGFBP-3 kinase activity present on breast cancer cell membranes... - Phosphorylation of histones by tissue transglutaminaseSuresh Mishra
Department of Physiology, University of Manitoba, Winnipeg, Manitoba R3E 0W3, Canada
J Biol Chem 281:5532-8. 2006..These studies suggest a novel role for TG2 in the regulation of chromatin structure and function... - The Prohibitins: emerging roles in diverse functionsSuresh Mishra
Department of Physiology, University of Manitoba, Winnipeg, Canada
J Cell Mol Med 10:353-63. 2006..This review presents some of the recent developments in prohibitin research and focuses on the similarities in the structure and function of these interesting proteins... - The p53 oncoprotein is a substrate for tissue transglutaminase kinase activitySuresh Mishra
Department of Physiology, University of Manitoba, Winnipeg, Canada R3E 0W3
Biochem Biophys Res Commun 339:726-30. 2006..Although TG2 cross-linking activity has been clearly implicated in apoptosis, our observations reported here suggest TG2 modification of p53 could be an additional mechanism whereby TG2 could facilitate apoptosis... 
O-GlcNAc modification: why so intimately associated with phosphorylation?Suresh Mishra
Department of Internal Medicine University of Manitoba, Winnipeg, Canada
Cell Commun Signal 9:1. 2011..Furthermore, implication of our hypothesis extends to tyrosine kinase signaling...
The role of prohibitin in cell signalingSuresh Mishra
Department of Internal Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
FEBS J 277:3937-46. 2010..A recent discovery of opposing effects of PHB on longevity under different metabolic states and its potential connection with insulin/insulin-like growth factor-I signaling is also discussed...- Prohibitin binds to C3 and enhances complement activationSuresh Mishra
Departments of Physiology and Internal Medicine, University of Manitoba, Winnipeg R3E 0W3, Canada
Mol Immunol 44:1897-902. 2007..The ability of PHB1 to bind to, and activate C3 suggests that PHB1 may have a previously unrecognized role in innate immunity... - Phosphorylation of transglutaminase 2 by PKA at Ser216 creates 14-3-3 binding sitesSuresh Mishra
Department of Physiology and Internal Medicine, University of Manitoba, Winnipeg, Man, Canada R3E 0W3
Biochem Biophys Res Commun 347:1166-70. 2006..In summary, we provide convincing evidence that phosphorylation of TG2 by PKA creates binding site(s) for 14-3-3 both in vitro and in vivo... - Insulin-like growth factor (IGF) binding protein-3 attenuates prostate tumor growth by IGF-dependent and IGF-independent mechanismsJosef V Silha
Department of Physiology, University of Manitoba, Winnipeg, Canada
Endocrinology 147:2112-21. 2006..After 15 wk of age, a marked reduction in tumor growth was apparent in LPB-Tag/PGKmBP-3 mice, indicating that the IGF-independent effects of IGFBP-3 may be important in inhibiting tumor progression... - Functional characterization of naturally occurring transglutaminase 2 mutants implicated in early-onset type 2 diabetesNeil W Salter
Department of Physiology, University of Manitoba, Winnipeg, Manitoba, Canada
J Mol Endocrinol 48:203-16. 2012.... - Overexpression of gly56/gly80/gly81-mutant insulin-like growth factor-binding protein-3 in transgenic miceJosef V Silha
Department of Physiology, University of Manitoba, Winnipeg, Canada R3E 0W3
Endocrinology 146:1523-31. 2005..The higher levels of IGF-I and murine IGFBP-3 in the 5012 Tg strain suggest that the growth inhibitory effect of mutant IGFBP-3 may be compensated for by other mechanisms... - Human IGF binding protein-3 overexpression impairs glucose regulation in mice via an inhibition of insulin secretionK Hoa Nguyen
Department of Internal Medicine, University of Manitoba, Winnipeg, Canada
Endocrinology 152:2184-96. 2011..Thus, overexpression of hIGFBP-3 in mice delays in vivo insulin clearance and reduces glucose-stimulated insulin secretion in pancreatic islets by both IGF-dependent and IGF-independent mechanisms... - Altered O-GlcNAc modification and phosphorylation of mitochondrial proteins in myoblast cells exposed to high glucoseYuanYuan Gu
Department of Internal Medicine, University of Manitoba, Winnipeg, Canada
Arch Biochem Biophys 505:98-104. 2011..High glucose induced changes in O-GlcNAcylation and phosphorylation of mitochondrial proteins may be associated with mitochondrial dysfunction and insulin resistance... - Interaction between O-GlcNAc modification and tyrosine phosphorylation of prohibitin: implication for a novel binary switchSudharsana R Ande
Department of Internal Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
PLoS ONE 4:e4586. 2009.... - Insulin induced phosphorylation of prohibitin at tyrosine 114 recruits Shp1Sudharsana R Ande
Department of Internal Medicine, University of Manitoba, Winnipeg, Canada
Biochim Biophys Acta 1793:1372-8. 2009..In summary, we have identified Tyr 114 in PHB as an important site of phosphorylation and phosphorylation at this residue creates a binding site for Shp1 both in vivo and in vitro... - Prohibitin: a potential target for new therapeuticsSuresh Mishra
Department of Physiology, University of Manitoba, Winnipeg, Manitoba R3E 3P4, Canada
Trends Mol Med 11:192-7. 2005.... - Prohibitin interacts with phosphatidylinositol 3,4,5-triphosphate (PIP3) and modulates insulin signalingSudharsana R Ande
Department of Internal Medicine, University of Manitoba, Winnipeg, Canada
Biochem Biophys Res Commun 390:1023-8. 2009..We speculate that phosphorylation of PHB may serve as a general mechanism in the regulation of PI3 kinase signaling including growth factors and immune receptor signaling... - Insulin-like growth factor binding protein-3 interacts with autocrine motility factor/phosphoglucose isomerase (AMF/PGI) and inhibits the AMF/PGI functionSuresh Mishra
Department of Physiology, University of Manitoba, Winnipeg, Manitoba, Canada
Cancer Res 64:2516-22. 2004..The ability of IGFBP-3 to bind and inhibit the actions of AMF/PGI may have some role in the antiproliferative proapoptotic effects of IGFBP-3... - Overexpression of phospho mutant forms of transglutaminase 2 downregulates epidermal growth factor receptorYi Wang
Department of Internal Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
Biochem Biophys Res Commun 417:251-5. 2012..Phospho mutant forms of TG2 reported in this study may be utilized as a part of a novel strategy to downregulate EGFR in cancers with enhanced EGFR signaling... - Nuclear coded mitochondrial protein prohibitin is an iron regulated iron binding proteinSudharsana R Ande
Department of Internal Medicine, University of Manitoba, Winnipeg, MB, Canada
Mitochondrion 11:40-7. 2011..These data together suggest that prohibitin functions as an intracellular iron binding protein and plays a role in intracellular iron homeostasis... - Perturbations in bone formation and resorption in insulin-like growth factor binding protein-3 transgenic miceJosef V Silha
Department of Physiology, University of Manitoba, Winnipeg, Canada
J Bone Miner Res 18:1834-41. 2003.... - Prohibitin attenuates insulin-stimulated glucose and fatty acid oxidation in adipose tissue by inhibition of pyruvate carboxylaseMahmood Vessal
Physiology Department, University of Manitoba, Winnipeg, Canada
FEBS J 273:568-76. 2006..On the basis of these data, we propose that PHB-1 is recycled between the extracellular space and the mitochondria by a mechanism involving lipid rafts and EHD2 and can modulate mitochondrial fuel metabolism by inhibition of PC... - Nuciferine stimulates insulin secretion from beta cells-an in vitro comparison with glibenclamideK Hoa Nguyen
Department of Physiology, University of Manitoba, Winnipeg, MB, Canada R3E3P4
J Ethnopharmacol 142:488-95. 2012..Several Asian plants are known for their anti-diabetic properties and produce alkaloids and flavonoids that may stimulate insulin secretion... - Prohibitin is expressed in pancreatic beta-cells and protects against oxidative and proapoptotic effects of ethanolJong Han Lee
Department of Physiology, Diabetes Research Group, University of Manitoba, Winnipeg, Canada
FEBS J 277:488-500. 2010..Thus, PHB is expressed in beta-cells, increases with oxidative stress and protects the cells against deleterious effects of ethanol... - Palmitoylation of prohibitin at cysteine 69 facilitates its membrane translocation and interaction with Eps 15 homology domain protein 2 (EHD2)Sudharsana Rao Ande
Department of Internal Medicine, University of Manitoba, 843 John Buhler Research Centre, 715 McDermot Ave, Winnipeg, MB R3E 3P4, Canada
Biochem Cell Biol 88:553-8. 2010..Thus, the palmitoylation and membrane translocation of PHB and its interaction with EHD2 may play a role in cell signaling... - Phosphorylation of transglutaminase 2 (TG2) at serine-216 has a role in TG2 mediated activation of nuclear factor-kappa B and in the downregulation of PTENYi Wang
Department of Internal Medicine, University of Manitoba, 843 JBRC 715 McDermot Avenue, Winnipeg, MB R3E 3P4, Canada
BMC Cancer 12:277. 2012..However, the role of TG2 phosphorylation in the modulation of NF-κB, Akt and PTEN is not explored... - Changes in adipokine expression during food deprivation in the mouse and the relationship to fasting-induced insulin resistanceYaoting Gui
Department of Physiology, University of Manitoba, Winnipeg, Canada
Can J Physiol Pharmacol 81:979-85. 2003..These data indicate that changes in the expression of leptin are more closely correlated with the insulin resistance of fasting than with changes in other adipokines or RXR-alpha and PPAR-gamma expression... - Phosphorylation of insulin-like growth factor (IGF) binding protein-3 by breast cancer cell membranes enhances IGF-I bindingSuresh Mishra
Departments of Internal Medicine and Physiology, University of Manitoba, Winnipeg, Canada, R3E 0W3
Endocrinology 144:4042-50. 2003..However, once phosphorylated the ability of IGFBP-3 to bind IGF-I is enhanced, resulting in increased association of the IGF-I with the cell membrane... - The effects of insulin-like growth factor binding protein-3 (IGFBP-3) on T47D breast cancer cells enriched for IGFBP-3 binding sitesSuresh Mishra
Departments of Internal Medicine and Physiology, University of Manitoba, Winnipeg R3E 0W3 Canada
Mol Cell Biochem 267:83-9. 2004....