Suresh Mishra

Summary

Affiliation: University of Manitoba
Country: Canada

Publications

  1. ncbi Transglutaminase 2 kinase activity facilitates protein kinase A-induced phosphorylation of retinoblastoma protein
    Suresh Mishra
    Department of Physiology, University of Manitoba, Winnipeg R3E 0W3, Canada, and the Biochemistry Laboratory, Instituto Dermapatico dell Immaculata Institute for Hospitalization, Care and Scientific Research, Tor Vergata, Italy
    J Biol Chem 282:18108-15. 2007
  2. ncbi Tissue transglutaminase has intrinsic kinase activity: identification of transglutaminase 2 as an insulin-like growth factor-binding protein-3 kinase
    Suresh Mishra
    Department of Physiology, University of Manitoba, Winnipeg R3E 0W3, Canada
    J Biol Chem 279:23863-8. 2004
  3. ncbi Phosphorylation of histones by tissue transglutaminase
    Suresh Mishra
    Department of Physiology, University of Manitoba, Winnipeg, Manitoba R3E 0W3, Canada
    J Biol Chem 281:5532-8. 2006
  4. ncbi The p53 oncoprotein is a substrate for tissue transglutaminase kinase activity
    Suresh Mishra
    Department of Physiology, University of Manitoba, Winnipeg, Canada R3E 0W3
    Biochem Biophys Res Commun 339:726-30. 2006
  5. ncbi Prohibitin attenuates insulin-stimulated glucose and fatty acid oxidation in adipose tissue by inhibition of pyruvate carboxylase
    Mahmood Vessal
    Physiology Department, University of Manitoba, Winnipeg, Canada
    FEBS J 273:568-76. 2006
  6. ncbi Prohibitin binds to C3 and enhances complement activation
    Suresh Mishra
    Departments of Physiology and Internal Medicine, University of Manitoba, Winnipeg R3E 0W3, Canada
    Mol Immunol 44:1897-902. 2007
  7. ncbi Phosphorylation of transglutaminase 2 by PKA at Ser216 creates 14-3-3 binding sites
    Suresh Mishra
    Department of Physiology and Internal Medicine, University of Manitoba, Winnipeg, Man, Canada R3E 0W3
    Biochem Biophys Res Commun 347:1166-70. 2006
  8. doi The role of prohibitin in cell signaling
    Suresh Mishra
    Department of Internal Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
    FEBS J 277:3937-46. 2010
  9. pmc O-GlcNAc modification: why so intimately associated with phosphorylation?
    Suresh Mishra
    Department of Internal Medicine University of Manitoba, Winnipeg, Canada
    Cell Commun Signal 9:1. 2011
  10. ncbi Insulin-like growth factor (IGF) binding protein-3 attenuates prostate tumor growth by IGF-dependent and IGF-independent mechanisms
    Josef V Silha
    Department of Physiology, University of Manitoba, Winnipeg, Canada
    Endocrinology 147:2112-21. 2006

Collaborators

Detail Information

Publications32

  1. ncbi Transglutaminase 2 kinase activity facilitates protein kinase A-induced phosphorylation of retinoblastoma protein
    Suresh Mishra
    Department of Physiology, University of Manitoba, Winnipeg R3E 0W3, Canada, and the Biochemistry Laboratory, Instituto Dermapatico dell Immaculata Institute for Hospitalization, Care and Scientific Research, Tor Vergata, Italy
    J Biol Chem 282:18108-15. 2007
    ..These data indicate that Rb is a substrate for TG2 kinase activity and suggest that phosphorylation of Rb, which results from activation of PKA in fibroblasts, is indirect and requires TG2 kinase activity...
  2. ncbi Tissue transglutaminase has intrinsic kinase activity: identification of transglutaminase 2 as an insulin-like growth factor-binding protein-3 kinase
    Suresh Mishra
    Department of Physiology, University of Manitoba, Winnipeg R3E 0W3, Canada
    J Biol Chem 279:23863-8. 2004
    ..Furthermore, we provide evidence that TG2 is a major component of the IGFBP-3 kinase activity present on breast cancer cell membranes...
  3. ncbi Phosphorylation of histones by tissue transglutaminase
    Suresh Mishra
    Department of Physiology, University of Manitoba, Winnipeg, Manitoba R3E 0W3, Canada
    J Biol Chem 281:5532-8. 2006
    ..These studies suggest a novel role for TG2 in the regulation of chromatin structure and function...
  4. ncbi The p53 oncoprotein is a substrate for tissue transglutaminase kinase activity
    Suresh Mishra
    Department of Physiology, University of Manitoba, Winnipeg, Canada R3E 0W3
    Biochem Biophys Res Commun 339:726-30. 2006
    ..Although TG2 cross-linking activity has been clearly implicated in apoptosis, our observations reported here suggest TG2 modification of p53 could be an additional mechanism whereby TG2 could facilitate apoptosis...
  5. ncbi Prohibitin attenuates insulin-stimulated glucose and fatty acid oxidation in adipose tissue by inhibition of pyruvate carboxylase
    Mahmood Vessal
    Physiology Department, University of Manitoba, Winnipeg, Canada
    FEBS J 273:568-76. 2006
    ..On the basis of these data, we propose that PHB-1 is recycled between the extracellular space and the mitochondria by a mechanism involving lipid rafts and EHD2 and can modulate mitochondrial fuel metabolism by inhibition of PC...
  6. ncbi Prohibitin binds to C3 and enhances complement activation
    Suresh Mishra
    Departments of Physiology and Internal Medicine, University of Manitoba, Winnipeg R3E 0W3, Canada
    Mol Immunol 44:1897-902. 2007
    ..The ability of PHB1 to bind to, and activate C3 suggests that PHB1 may have a previously unrecognized role in innate immunity...
  7. ncbi Phosphorylation of transglutaminase 2 by PKA at Ser216 creates 14-3-3 binding sites
    Suresh Mishra
    Department of Physiology and Internal Medicine, University of Manitoba, Winnipeg, Man, Canada R3E 0W3
    Biochem Biophys Res Commun 347:1166-70. 2006
    ..In summary, we provide convincing evidence that phosphorylation of TG2 by PKA creates binding site(s) for 14-3-3 both in vitro and in vivo...
  8. doi The role of prohibitin in cell signaling
    Suresh Mishra
    Department of Internal Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
    FEBS J 277:3937-46. 2010
    ..A recent discovery of opposing effects of PHB on longevity under different metabolic states and its potential connection with insulin/insulin-like growth factor-I signaling is also discussed...
  9. pmc O-GlcNAc modification: why so intimately associated with phosphorylation?
    Suresh Mishra
    Department of Internal Medicine University of Manitoba, Winnipeg, Canada
    Cell Commun Signal 9:1. 2011
    ..Furthermore, implication of our hypothesis extends to tyrosine kinase signaling...
  10. ncbi Insulin-like growth factor (IGF) binding protein-3 attenuates prostate tumor growth by IGF-dependent and IGF-independent mechanisms
    Josef V Silha
    Department of Physiology, University of Manitoba, Winnipeg, Canada
    Endocrinology 147:2112-21. 2006
    ..After 15 wk of age, a marked reduction in tumor growth was apparent in LPB-Tag/PGKmBP-3 mice, indicating that the IGF-independent effects of IGFBP-3 may be important in inhibiting tumor progression...
  11. doi Functional characterization of naturally occurring transglutaminase 2 mutants implicated in early-onset type 2 diabetes
    Neil W Salter
    Department of Physiology, University of Manitoba, Winnipeg, Manitoba, Canada
    J Mol Endocrinol 48:203-16. 2012
    ....
  12. ncbi Overexpression of gly56/gly80/gly81-mutant insulin-like growth factor-binding protein-3 in transgenic mice
    Josef V Silha
    Department of Physiology, University of Manitoba, Winnipeg, Canada R3E 0W3
    Endocrinology 146:1523-31. 2005
    ..The higher levels of IGF-I and murine IGFBP-3 in the 5012 Tg strain suggest that the growth inhibitory effect of mutant IGFBP-3 may be compensated for by other mechanisms...
  13. pmc Phosphorylation of transglutaminase 2 (TG2) at serine-216 has a role in TG2 mediated activation of nuclear factor-kappa B and in the downregulation of PTEN
    Yi Wang
    Department of Internal Medicine, University of Manitoba, 843 JBRC 715 McDermot Avenue, Winnipeg, MB R3E 3P4, Canada
    BMC Cancer 12:277. 2012
    ..However, the role of TG2 phosphorylation in the modulation of NF-κB, Akt and PTEN is not explored...
  14. doi Human IGF binding protein-3 overexpression impairs glucose regulation in mice via an inhibition of insulin secretion
    K Hoa Nguyen
    Department of Internal Medicine, University of Manitoba, Winnipeg, Canada
    Endocrinology 152:2184-96. 2011
    ..Thus, overexpression of hIGFBP-3 in mice delays in vivo insulin clearance and reduces glucose-stimulated insulin secretion in pancreatic islets by both IGF-dependent and IGF-independent mechanisms...
  15. doi Insulin induced phosphorylation of prohibitin at tyrosine 114 recruits Shp1
    Sudharsana R Ande
    Department of Internal Medicine, University of Manitoba, Winnipeg, Canada
    Biochim Biophys Acta 1793:1372-8. 2009
    ..In summary, we have identified Tyr 114 in PHB as an important site of phosphorylation and phosphorylation at this residue creates a binding site for Shp1 both in vivo and in vitro...
  16. pmc Interaction between O-GlcNAc modification and tyrosine phosphorylation of prohibitin: implication for a novel binary switch
    Sudharsana R Ande
    Department of Internal Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
    PLoS ONE 4:e4586. 2009
    ....
  17. doi Altered O-GlcNAc modification and phosphorylation of mitochondrial proteins in myoblast cells exposed to high glucose
    YuanYuan Gu
    Department of Internal Medicine, University of Manitoba, Winnipeg, Canada
    Arch Biochem Biophys 505:98-104. 2011
    ..High glucose induced changes in O-GlcNAcylation and phosphorylation of mitochondrial proteins may be associated with mitochondrial dysfunction and insulin resistance...
  18. ncbi Prohibitin: a potential target for new therapeutics
    Suresh Mishra
    Department of Physiology, University of Manitoba, Winnipeg, Manitoba R3E 3P4, Canada
    Trends Mol Med 11:192-7. 2005
    ....
  19. ncbi Insulin-like growth factor binding protein-3 interacts with autocrine motility factor/phosphoglucose isomerase (AMF/PGI) and inhibits the AMF/PGI function
    Suresh Mishra
    Department of Physiology, University of Manitoba, Winnipeg, Manitoba, Canada
    Cancer Res 64:2516-22. 2004
    ..The ability of IGFBP-3 to bind and inhibit the actions of AMF/PGI may have some role in the antiproliferative proapoptotic effects of IGFBP-3...
  20. ncbi The Prohibitins: emerging roles in diverse functions
    Suresh Mishra
    Department of Physiology, University of Manitoba, Winnipeg, Canada
    J Cell Mol Med 10:353-63. 2006
    ..This review presents some of the recent developments in prohibitin research and focuses on the similarities in the structure and function of these interesting proteins...
  21. doi Prohibitin interacts with phosphatidylinositol 3,4,5-triphosphate (PIP3) and modulates insulin signaling
    Sudharsana R Ande
    Department of Internal Medicine, University of Manitoba, Winnipeg, Canada
    Biochem Biophys Res Commun 390:1023-8. 2009
    ..We speculate that phosphorylation of PHB may serve as a general mechanism in the regulation of PI3 kinase signaling including growth factors and immune receptor signaling...
  22. doi Overexpression of phospho mutant forms of transglutaminase 2 downregulates epidermal growth factor receptor
    Yi Wang
    Department of Internal Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
    Biochem Biophys Res Commun 417:251-5. 2012
    ..Phospho mutant forms of TG2 reported in this study may be utilized as a part of a novel strategy to downregulate EGFR in cancers with enhanced EGFR signaling...
  23. doi Nuclear coded mitochondrial protein prohibitin is an iron regulated iron binding protein
    Sudharsana R Ande
    Department of Internal Medicine, University of Manitoba, Winnipeg, MB, Canada
    Mitochondrion 11:40-7. 2011
    ..These data together suggest that prohibitin functions as an intracellular iron binding protein and plays a role in intracellular iron homeostasis...
  24. ncbi Perturbations in bone formation and resorption in insulin-like growth factor binding protein-3 transgenic mice
    Josef V Silha
    Department of Physiology, University of Manitoba, Winnipeg, Canada
    J Bone Miner Res 18:1834-41. 2003
    ....
  25. doi Nuciferine stimulates insulin secretion from beta cells-an in vitro comparison with glibenclamide
    K Hoa Nguyen
    Department of Physiology, University of Manitoba, Winnipeg, MB, Canada R3E3P4
    J Ethnopharmacol 142:488-95. 2012
    ..Several Asian plants are known for their anti-diabetic properties and produce alkaloids and flavonoids that may stimulate insulin secretion...
  26. ncbi Palmitoylation of prohibitin at cysteine 69 facilitates its membrane translocation and interaction with Eps 15 homology domain protein 2 (EHD2)
    Sudharsana Rao Ande
    Department of Internal Medicine, University of Manitoba, 843 John Buhler Research Centre, 715 McDermot Ave, Winnipeg, MB R3E 3P4, Canada
    Biochem Cell Biol 88:553-8. 2010
    ..Thus, the palmitoylation and membrane translocation of PHB and its interaction with EHD2 may play a role in cell signaling...
  27. ncbi Prohibitin is expressed in pancreatic beta-cells and protects against oxidative and proapoptotic effects of ethanol
    Jong Han Lee
    Department of Physiology, Diabetes Research Group, University of Manitoba, Winnipeg, Canada
    FEBS J 277:488-500. 2010
    ..Thus, PHB is expressed in beta-cells, increases with oxidative stress and protects the cells against deleterious effects of ethanol...
  28. ncbi Changes in adipokine expression during food deprivation in the mouse and the relationship to fasting-induced insulin resistance
    Yaoting Gui
    Department of Physiology, University of Manitoba, Winnipeg, Canada
    Can J Physiol Pharmacol 81:979-85. 2003
    ..These data indicate that changes in the expression of leptin are more closely correlated with the insulin resistance of fasting than with changes in other adipokines or RXR-alpha and PPAR-gamma expression...
  29. ncbi Phosphorylation of insulin-like growth factor (IGF) binding protein-3 by breast cancer cell membranes enhances IGF-I binding
    Suresh Mishra
    Departments of Internal Medicine and Physiology, University of Manitoba, Winnipeg, Canada, R3E 0W3
    Endocrinology 144:4042-50. 2003
    ..However, once phosphorylated the ability of IGFBP-3 to bind IGF-I is enhanced, resulting in increased association of the IGF-I with the cell membrane...
  30. ncbi The effects of insulin-like growth factor binding protein-3 (IGFBP-3) on T47D breast cancer cells enriched for IGFBP-3 binding sites
    Suresh Mishra
    Departments of Internal Medicine and Physiology, University of Manitoba, Winnipeg R3E 0W3 Canada
    Mol Cell Biochem 267:83-9. 2004
    ....