E J Mills

Summary

Affiliation: University of Ottawa
Country: Canada

Publications

  1. ncbi request reprint Years of life lost to incarceration: inequities between Aboriginal and non-Aboriginal Canadians
    Akwasi Owusu-Bempah
    Faculty of Health Sciences, University of Ottawa, 25 University Private, Ottawa, Ontario K1N 6 N5, Canada
    BMC Public Health 14:585. 2014
  2. pmc Direct-acting antiviral therapies for hepatitis C genotype 1 infection: a multiple treatment comparison meta-analysis
    C Cooper
    Division of Infectious Diseases, Department of Medicine, The Ottawa Hospital, University of Ottawa, 501 Smyth Road, Ottawa, ON, Canada K1H 8L6
    QJM 106:153-63. 2013
  3. pmc Anti-tumor necrosis factor (TNF) drugs for the treatment of psoriatic arthritis: an indirect comparison meta-analysis
    Kristian Thorlund
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
    Biologics 6:417-27. 2012
  4. pmc Budget impact analysis of boceprevir and telaprevir for the treatment of hepatitis C genotype 1 infection
    Kristian Thorlund
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton
    Clinicoecon Outcomes Res 4:349-59. 2012
  5. pmc Engaging Men in Prevention and Care for HIV/AIDS in Africa
    Edward J Mills
    Faculty of Health Sciences, University of Ottawa, Ottawa, Canada
    PLoS Med 9:e1001167. 2012
  6. pmc Differences in clinical outcomes among hepatitis C genotype 1-infected patients treated with peginterferon alpha-2a or peginterferon alpha-2b plus ribavirin: a meta-analysis
    Eric Druyts
    Faculty of Health Sciences, University of Ottawa, Ottawa, ON, Canada
    Clin Exp Gastroenterol 5:11-21. 2012
  7. pmc Boceprevir and telaprevir for the treatment of chronic hepatitis C genotype 1 infection: an indirect comparison meta-analysis
    Curtis L Cooper
    Division of Infectious Diseases, Faculty of Medicine, University of Ottawa, Ottawa
    Ther Clin Risk Manag 8:105-30. 2012
  8. pmc Stability of additive treatment effects in multiple treatment comparison meta-analysis: a simulation study
    Kristian Thorlund
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton
    Clin Epidemiol 4:75-85. 2012
  9. pmc Predictive value of CD4 cell count nadir on long-term mortality in HIV-positive patients in Uganda
    Sarah Bray
    Interdisciplinary School of Health Sciences, Faculty of Health Sciences, University of Ottawa, Ottawa, Canada
    HIV AIDS (Auckl) 4:135-40. 2012
  10. pmc Preventing Antiretroviral Treatment Interruptions among HIV/AIDS Patients in Africa
    Edward J Mills
    Faculty of Health Sciences, University of Ottawa, Ottawa, Canada Stanford Prevention Research Center, Department of Medicine, Stanford University School of Humanities and Sciences, Stanford, California, United States of America
    PLoS Med 10:e1001370. 2013

Collaborators

Detail Information

Publications38

  1. ncbi request reprint Years of life lost to incarceration: inequities between Aboriginal and non-Aboriginal Canadians
    Akwasi Owusu-Bempah
    Faculty of Health Sciences, University of Ottawa, 25 University Private, Ottawa, Ontario K1N 6 N5, Canada
    BMC Public Health 14:585. 2014
    ..Aboriginal representation in Canadian correctional institutions has increased rapidly over the past decade. We calculated "years of life lost to incarceration" for Aboriginal and non-Aboriginal Canadians...
  2. pmc Direct-acting antiviral therapies for hepatitis C genotype 1 infection: a multiple treatment comparison meta-analysis
    C Cooper
    Division of Infectious Diseases, Department of Medicine, The Ottawa Hospital, University of Ottawa, 501 Smyth Road, Ottawa, ON, Canada K1H 8L6
    QJM 106:153-63. 2013
    ..New direct-acting antiviral agents for hepatitis C genotype 1 infection, boceprevir and telaprevir, offer enhanced sustained virologic response (SVR) among both treatment-naïve and treatment-experienced patients...
  3. pmc Anti-tumor necrosis factor (TNF) drugs for the treatment of psoriatic arthritis: an indirect comparison meta-analysis
    Kristian Thorlund
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
    Biologics 6:417-27. 2012
    ....
  4. pmc Budget impact analysis of boceprevir and telaprevir for the treatment of hepatitis C genotype 1 infection
    Kristian Thorlund
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton
    Clinicoecon Outcomes Res 4:349-59. 2012
    ..Boceprevir and telaprevir have recently showed dramatically better treatment outcomes than conventional PEGylated interferon plus ribavirin for the treatment of hepatitis C virus genotype 1, but the average cost per patient is unknown...
  5. pmc Engaging Men in Prevention and Care for HIV/AIDS in Africa
    Edward J Mills
    Faculty of Health Sciences, University of Ottawa, Ottawa, Canada
    PLoS Med 9:e1001167. 2012
    ..Ed Mills and colleagues argue that a more balanced approach to gender is needed so that both men and women are involved in HIV treatment and prevention...
  6. pmc Differences in clinical outcomes among hepatitis C genotype 1-infected patients treated with peginterferon alpha-2a or peginterferon alpha-2b plus ribavirin: a meta-analysis
    Eric Druyts
    Faculty of Health Sciences, University of Ottawa, Ottawa, ON, Canada
    Clin Exp Gastroenterol 5:11-21. 2012
    ....
  7. pmc Boceprevir and telaprevir for the treatment of chronic hepatitis C genotype 1 infection: an indirect comparison meta-analysis
    Curtis L Cooper
    Division of Infectious Diseases, Faculty of Medicine, University of Ottawa, Ottawa
    Ther Clin Risk Manag 8:105-30. 2012
    ..The aim of this study was to examine the relative efficacy and safety of boceprevir and telaprevir, when used in combination with pegylated interferon alpha and ribavirin, using an indirect comparison meta-analysis...
  8. pmc Stability of additive treatment effects in multiple treatment comparison meta-analysis: a simulation study
    Kristian Thorlund
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton
    Clin Epidemiol 4:75-85. 2012
    ....
  9. pmc Predictive value of CD4 cell count nadir on long-term mortality in HIV-positive patients in Uganda
    Sarah Bray
    Interdisciplinary School of Health Sciences, Faculty of Health Sciences, University of Ottawa, Ottawa, Canada
    HIV AIDS (Auckl) 4:135-40. 2012
    ..The lowest level that their CD4 cell count reaches, the nadir, may have long-term consequences in terms of mortality. We examined this health state in a large cohort of HIV+ patients in Uganda...
  10. pmc Preventing Antiretroviral Treatment Interruptions among HIV/AIDS Patients in Africa
    Edward J Mills
    Faculty of Health Sciences, University of Ottawa, Ottawa, Canada Stanford Prevention Research Center, Department of Medicine, Stanford University School of Humanities and Sciences, Stanford, California, United States of America
    PLoS Med 10:e1001370. 2013
    ..Edward Mills and Christine Nabiryo discuss a new qualitative study in PLOS Medicine that offers insight into disengagement from HIV treatment care in sub-Saharan Africa...
  11. pmc Multiple treatment comparison meta-analyses: a step forward into complexity
    Edward J Mills
    Faculty of Health Sciences, University of Ottawa, Ottawa, ON, Canada
    Clin Epidemiol 3:193-202. 2011
    ..We conclude that MTC meta-analysis is a useful tool in the context of comparative effectiveness and requires further study, as its utility and transparency will likely predict its uptake by the research and clinical community...
  12. pmc Pharmacotherapies for chronic obstructive pulmonary disease: a multiple treatment comparison meta-analysis
    Edward J Mills
    Faculty of Health Sciences, University of Ottawa, Ottawa, Ontario, Canada
    Clin Epidemiol 3:107-29. 2011
    ..Since current guidelines cannot make strong recommendations yet, our aim was to determine the relative efficacy of existing treatments and combinations to reduce the risk for COPD exacerbations...
  13. pmc Density of healthcare providers and patient outcomes: evidence from a nationally representative multi-site HIV treatment program in Uganda
    Celestin Bakanda
    The AIDS Support Organization, Headquarters, Kampala, Uganda
    PLoS ONE 6:e16279. 2011
    ..We examined the association between density of healthcare providers and patient outcomes using a large nationally representative cohort of patients receiving combination antiretroviral therapy (cART) in Uganda...
  14. pmc Tuberculosis mortality in HIV-infected individuals: a cross-national systematic assessment
    Christopher Au-Yeung
    BC Centre for Excellence in HIV AIDS, Vancouver, Canada
    Clin Epidemiol 3:21-9. 2011
    ..Tuberculosis (TB) is a leading cause of death in human immunodeficiency virus (HIV)-positive individuals. We sought to compare mortality rates in TB/HIV co-infected individuals globally and by country/territory...
  15. pmc Increased mortality among HIV-positive men on antiretroviral therapy: survival differences between sexes explained by late initiation in Uganda
    Steve Kanters
    Faculty of Health Science, Simon Fraser University, Burnaby, BC, Canada Faculty of Health Sciences, University of Ottawa, Ottawa, ON, Canada
    HIV AIDS (Auckl) 5:111-9. 2013
    ..We also specifically examined the role of antenatal services in favoring women's access to HIV care...
  16. doi request reprint A users' guide to understanding therapeutic substitutions
    Edward J Mills
    Faculty of Health Sciences, University of Ottawa, 43 Templeton Street, Ottawa, Canada K1N6X1 Centre for Clinical Epidemiology and Evaluation C2E2, University of British Columbia, 828 West 10th Ave, Research Pavilion, Vancouver, Canada, V5Z 1M9 Electronic address
    J Clin Epidemiol 67:305-13. 2014
    ..This article uses a problem-based format to address the biological mechanism, validity, and results of a scenario in which therapeutic substitutions may be considered...
  17. pmc The effects of excluding treatments from network meta-analyses: survey
    Edward J Mills
    Faculty of Health Sciences, University of Ottawa, Ottawa, Canada
    BMJ 347:f5195. 2013
    ..To examine whether the exclusion of individual treatment comparators, including placebo/no treatment, affects the results of network meta-analysis...
  18. pmc Comparative effectiveness of monotherapies and combination therapies for patients with hypertension: protocol for a systematic review with network meta-analyses
    Brian Hutton
    Ottawa Hospital Research Institute, 501 Smyth Road, Ottawa, ON, Canada, Box 201 K1H 8L6
    Syst Rev 2:44. 2013
    ..The objective of this review is to explore the relative benefits and safety of different pharmacotherapies for management of non-diabetic patients with hypertension, whether of a mild or moderate to severe nature...
  19. pmc Sample size and power considerations in network meta-analysis
    Kristian Thorlund
    Department of Clinical Epidemiology and Biostatistics, Faculty of Health Sciences, McMaster University, 1280 Main Street West, Hamilton, Ontario, Canada L8S 4 K1
    Syst Rev 1:41. 2012
    ..This issue, however, has so far only received little attention in network meta-analysis. To date, no approaches have been proposed for evaluating the adequacy of the sample size, and thus power, in a treatment network...
  20. doi request reprint Long-term health care interruptions among HIV-positive patients in Uganda
    Edward J Mills
    University of Ottawa, Ottawa, Ontario, Canada
    J Acquir Immune Defic Syndr 63:e23-7. 2013
    ..We examined risk factors for health care interruptions and loss to follow-up within a cohort receiving ART in Uganda...
  21. doi request reprint Comparisons of high-dose and combination nicotine replacement therapy, varenicline, and bupropion for smoking cessation: a systematic review and multiple treatment meta-analysis
    Edward J Mills
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
    Ann Med 44:588-97. 2012
    ..This review compared the effect of high-dose nicotine replacement therapy (NRT) and combinations of NRT for increasing smoking abstinence rates compared to standard-dose NRT patch, varenicline, and bupropion on smoking abstinence...
  22. doi request reprint Calculating additive treatment effects from multiple randomized trials provides useful estimates of combination therapies
    Edward J Mills
    Faculty of Health Sciences, University of Ottawa, 43 Templeton Street, Ottawa, Ontario, Canada
    J Clin Epidemiol 65:1282-8. 2012
    ..We discuss here the prerequisites and methods of applying additivity assumptions in synthesizing the evidence from randomized trials and multiple treatment meta-analyses...
  23. ncbi request reprint How to use an article reporting a multiple treatment comparison meta-analysis
    Edward J Mills
    Faculty of Health Sciences, University of Ottawa, Room 031, Thompson Hall, 35 University Private, Ottawa, ON, K1N 7K4, Canada
    JAMA 308:1246-53. 2012
    ..This article uses the existing Users' Guides format to address study validity, interpretation of results, and application to a patient scenario...
  24. doi request reprint The prognostic value of baseline CD4(+) cell count beyond 6 months of antiretroviral therapy in HIV-positive patients in a resource-limited setting
    Edward J Mills
    Faculty of Health Sciences, University of Ottawa, Ottawa, Canada
    AIDS 26:1425-9. 2012
    ..We examined whether initial CD4 cell count maintains a strong prognostic value among patients with at least 6 months follow-up after the initiation of ART...
  25. doi request reprint Low-dose aspirin and cancer mortality: a meta-analysis of randomized trials
    Edward J Mills
    Faculty of Health Sciences, University of Ottawa, Ontario, Canada
    Am J Med 125:560-7. 2012
    ..We aimed to determine whether cancer mortality also is reduced by low-dose aspirin in the shorter term...
  26. pmc The financial cost of doctors emigrating from sub-Saharan Africa: human capital analysis
    Edward J Mills
    Faculty of Health Sciences, University of Ottawa, Canada
    BMJ 343:d7031. 2011
    ..To estimate the lost investment of domestically educated doctors migrating from sub-Saharan African countries to Australia, Canada, the United Kingdom, and the United States...
  27. pmc Water and sanitation infrastructure for health: The impact of foreign aid
    Marianne J Botting
    Interdisciplinary School of Health Sciences, Faculty of Health Sciences, University of Ottawa, Ottawa, Canada
    Global Health 6:12. 2010
    ..The actual impact of this assistance on increasing population access to improved water and sanitation and reducing child mortality has not been examined...
  28. doi request reprint Efficacy and safety of statin treatment for cardiovascular disease: a network meta-analysis of 170,255 patients from 76 randomized trials
    E J Mills
    Faculty of Health Sciences, University of Ottawa, Ottawa, Canada
    QJM 104:109-24. 2011
    ..Statins represent the largest selling class of cardiovascular drug in the world. Previous randomized trials (RCTs) have demonstrated important clinical benefits with statin therapy...
  29. pmc Estimating the power of indirect comparisons: a simulation study
    Edward J Mills
    Faculty of Health Sciences, University of Ottawa, Ottawa, Canada
    PLoS ONE 6:e16237. 2011
    ..While indirect methods have grown in popularity and acceptance, little is known about the fragility of confidence interval estimations and hypothesis testing relying on this method...
  30. doi request reprint Smoking cessation reduces postoperative complications: a systematic review and meta-analysis
    Edward Mills
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
    Am J Med 124:144-154.e8. 2011
    ..We aimed to review randomized trials and observational evidence to establish the effect of preoperative smoking cessation on postoperative complications and to determine if there is an optimal cessation period before surgery...
  31. doi request reprint Mortality by baseline CD4 cell count among HIV patients initiating antiretroviral therapy: evidence from a large cohort in Uganda
    Edward J Mills
    Faculty of Health Sciences, University of Ottawa, Canada
    AIDS 25:851-5. 2011
    ..Funders have been reticent to recommend earlier initiation of treatment. We aimed to examine the effect of baseline CD4 cell count on mortality using data from HIV patients receiving combination antiretroviral therapy (cART) in Uganda...
  32. doi request reprint Intensive statin therapy compared with moderate dosing for prevention of cardiovascular events: a meta-analysis of >40 000 patients
    Edward J Mills
    Faculty of Health Sciences, University of Ottawa, Ottawa, Ontario, Canada V5Z 4B4 K1n6X1
    Eur Heart J 32:1409-15. 2011
    ..There is widespread interest in whether intensive dosing of statins yields larger treatment effects. We aimed to determine if intensive dosing is clinically important using a meta-analysis of randomized clinical trials (RCTs)...
  33. pmc Health system determinants of infant, child and maternal mortality: A cross-sectional study of UN member countries
    Katherine A Muldoon
    British Columbia Centre for Excellence in HIV AIDS, St, Paul s Hospital, 1081 Burrard Street, Vancouver, British Columbia, Canada
    Global Health 7:42. 2011
    ..abstract:..
  34. pmc Male gender predicts mortality in a large cohort of patients receiving antiretroviral therapy in Uganda
    Edward J Mills
    Faculty of Health Sciences, University of Ottawa, Ottawa, Canada
    J Int AIDS Soc 14:52. 2011
    ....
  35. doi request reprint Adverse events associated with individual statin treatments for cardiovascular disease: an indirect comparison meta-analysis
    M Alberton
    Faculty of Health Sciences, University of Ottawa, Ottawa, Ontario, Canada
    QJM 105:145-57. 2012
    ..Statins are the most widely prescribed drug available. Due to this reason, it is important to understand the risks involved with the drug class and individual statins...
  36. doi request reprint Antiretroviral effects on HIV-1 RNA, CD4 cell count and progression to AIDS or death: a meta-regression analysis
    E J Mills
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
    HIV Med 9:849-57. 2008
    ..We aimed to determine the strength of the association between the magnitude of the effect of changes in CD4 cell count and HIV-1 RNA and progression to AIDS or death in the highly active antiretroviral therapy (HAART) era...
  37. doi request reprint Antiretroviral therapy for initial human immunodeficiency virus/AIDS treatment: critical appraisal of the evidence from over 100 randomized trials and 400 systematic reviews and meta-analyses
    S Kanters
    School of Population and Public Health, University of British Columbia, Vancouver, BC, Canada
    Clin Microbiol Infect 20:114-22. 2014
    ..We conclude with recommendations for future clinical trials and meta-analyses. ..