E J Mills

Summary

Affiliation: University of Ottawa
Country: Canada

Publications

  1. doi request reprint A users' guide to understanding therapeutic substitutions
    Edward J Mills
    Faculty of Health Sciences, University of Ottawa, 43 Templeton Street, Ottawa, Canada K1N6X1 Centre for Clinical Epidemiology and Evaluation C2E2, University of British Columbia, 828 West 10th Ave, Research Pavilion, Vancouver, Canada, V5Z 1M9 Electronic address
    J Clin Epidemiol 67:305-13. 2014
  2. pmc The effects of excluding treatments from network meta-analyses: survey
    Edward J Mills
    Faculty of Health Sciences, University of Ottawa, Ottawa, Canada
    BMJ 347:f5195. 2013
  3. pmc Comparative effectiveness of monotherapies and combination therapies for patients with hypertension: protocol for a systematic review with network meta-analyses
    Brian Hutton
    Ottawa Hospital Research Institute, 501 Smyth Road, Ottawa, ON, Canada, Box 201 K1H 8L6
    Syst Rev 2:44. 2013
  4. pmc Sample size and power considerations in network meta-analysis
    Kristian Thorlund
    Department of Clinical Epidemiology and Biostatistics, Faculty of Health Sciences, McMaster University, 1280 Main Street West, Hamilton, Ontario, Canada L8S 4 K1
    Syst Rev 1:41. 2012
  5. doi request reprint Long-term health care interruptions among HIV-positive patients in Uganda
    Edward J Mills
    University of Ottawa, Ottawa, Ontario, Canada
    J Acquir Immune Defic Syndr 63:e23-7. 2013
  6. doi request reprint Comparisons of high-dose and combination nicotine replacement therapy, varenicline, and bupropion for smoking cessation: a systematic review and multiple treatment meta-analysis
    Edward J Mills
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
    Ann Med 44:588-97. 2012
  7. doi request reprint Calculating additive treatment effects from multiple randomized trials provides useful estimates of combination therapies
    Edward J Mills
    Faculty of Health Sciences, University of Ottawa, 43 Templeton Street, Ottawa, Ontario, Canada
    J Clin Epidemiol 65:1282-8. 2012
  8. ncbi request reprint How to use an article reporting a multiple treatment comparison meta-analysis
    Edward J Mills
    Faculty of Health Sciences, University of Ottawa, Room 031, Thompson Hall, 35 University Private, Ottawa, ON, K1N 7K4, Canada
    JAMA 308:1246-53. 2012
  9. doi request reprint The prognostic value of baseline CD4(+) cell count beyond 6 months of antiretroviral therapy in HIV-positive patients in a resource-limited setting
    Edward J Mills
    Faculty of Health Sciences, University of Ottawa, Ottawa, Canada
    AIDS 26:1425-9. 2012
  10. doi request reprint Low-dose aspirin and cancer mortality: a meta-analysis of randomized trials
    Edward J Mills
    Faculty of Health Sciences, University of Ottawa, Ontario, Canada
    Am J Med 125:560-7. 2012

Detail Information

Publications23

  1. doi request reprint A users' guide to understanding therapeutic substitutions
    Edward J Mills
    Faculty of Health Sciences, University of Ottawa, 43 Templeton Street, Ottawa, Canada K1N6X1 Centre for Clinical Epidemiology and Evaluation C2E2, University of British Columbia, 828 West 10th Ave, Research Pavilion, Vancouver, Canada, V5Z 1M9 Electronic address
    J Clin Epidemiol 67:305-13. 2014
    ..This article uses a problem-based format to address the biological mechanism, validity, and results of a scenario in which therapeutic substitutions may be considered...
  2. pmc The effects of excluding treatments from network meta-analyses: survey
    Edward J Mills
    Faculty of Health Sciences, University of Ottawa, Ottawa, Canada
    BMJ 347:f5195. 2013
    ..To examine whether the exclusion of individual treatment comparators, including placebo/no treatment, affects the results of network meta-analysis...
  3. pmc Comparative effectiveness of monotherapies and combination therapies for patients with hypertension: protocol for a systematic review with network meta-analyses
    Brian Hutton
    Ottawa Hospital Research Institute, 501 Smyth Road, Ottawa, ON, Canada, Box 201 K1H 8L6
    Syst Rev 2:44. 2013
    ..The objective of this review is to explore the relative benefits and safety of different pharmacotherapies for management of non-diabetic patients with hypertension, whether of a mild or moderate to severe nature...
  4. pmc Sample size and power considerations in network meta-analysis
    Kristian Thorlund
    Department of Clinical Epidemiology and Biostatistics, Faculty of Health Sciences, McMaster University, 1280 Main Street West, Hamilton, Ontario, Canada L8S 4 K1
    Syst Rev 1:41. 2012
    ..This issue, however, has so far only received little attention in network meta-analysis. To date, no approaches have been proposed for evaluating the adequacy of the sample size, and thus power, in a treatment network...
  5. doi request reprint Long-term health care interruptions among HIV-positive patients in Uganda
    Edward J Mills
    University of Ottawa, Ottawa, Ontario, Canada
    J Acquir Immune Defic Syndr 63:e23-7. 2013
    ..We examined risk factors for health care interruptions and loss to follow-up within a cohort receiving ART in Uganda...
  6. doi request reprint Comparisons of high-dose and combination nicotine replacement therapy, varenicline, and bupropion for smoking cessation: a systematic review and multiple treatment meta-analysis
    Edward J Mills
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
    Ann Med 44:588-97. 2012
    ..This review compared the effect of high-dose nicotine replacement therapy (NRT) and combinations of NRT for increasing smoking abstinence rates compared to standard-dose NRT patch, varenicline, and bupropion on smoking abstinence...
  7. doi request reprint Calculating additive treatment effects from multiple randomized trials provides useful estimates of combination therapies
    Edward J Mills
    Faculty of Health Sciences, University of Ottawa, 43 Templeton Street, Ottawa, Ontario, Canada
    J Clin Epidemiol 65:1282-8. 2012
    ..We discuss here the prerequisites and methods of applying additivity assumptions in synthesizing the evidence from randomized trials and multiple treatment meta-analyses...
  8. ncbi request reprint How to use an article reporting a multiple treatment comparison meta-analysis
    Edward J Mills
    Faculty of Health Sciences, University of Ottawa, Room 031, Thompson Hall, 35 University Private, Ottawa, ON, K1N 7K4, Canada
    JAMA 308:1246-53. 2012
    ..This article uses the existing Users' Guides format to address study validity, interpretation of results, and application to a patient scenario...
  9. doi request reprint The prognostic value of baseline CD4(+) cell count beyond 6 months of antiretroviral therapy in HIV-positive patients in a resource-limited setting
    Edward J Mills
    Faculty of Health Sciences, University of Ottawa, Ottawa, Canada
    AIDS 26:1425-9. 2012
    ..We examined whether initial CD4 cell count maintains a strong prognostic value among patients with at least 6 months follow-up after the initiation of ART...
  10. doi request reprint Low-dose aspirin and cancer mortality: a meta-analysis of randomized trials
    Edward J Mills
    Faculty of Health Sciences, University of Ottawa, Ontario, Canada
    Am J Med 125:560-7. 2012
    ..We aimed to determine whether cancer mortality also is reduced by low-dose aspirin in the shorter term...
  11. pmc The financial cost of doctors emigrating from sub-Saharan Africa: human capital analysis
    Edward J Mills
    Faculty of Health Sciences, University of Ottawa, Canada
    BMJ 343:d7031. 2011
    ..To estimate the lost investment of domestically educated doctors migrating from sub-Saharan African countries to Australia, Canada, the United Kingdom, and the United States...
  12. pmc Water and sanitation infrastructure for health: The impact of foreign aid
    Marianne J Botting
    Interdisciplinary School of Health Sciences, Faculty of Health Sciences, University of Ottawa, Ottawa, Canada
    Global Health 6:12. 2010
    ..The actual impact of this assistance on increasing population access to improved water and sanitation and reducing child mortality has not been examined...
  13. doi request reprint Efficacy and safety of statin treatment for cardiovascular disease: a network meta-analysis of 170,255 patients from 76 randomized trials
    E J Mills
    Faculty of Health Sciences, University of Ottawa, Ottawa, Canada
    QJM 104:109-24. 2011
    ..Statins represent the largest selling class of cardiovascular drug in the world. Previous randomized trials (RCTs) have demonstrated important clinical benefits with statin therapy...
  14. pmc Estimating the power of indirect comparisons: a simulation study
    Edward J Mills
    Faculty of Health Sciences, University of Ottawa, Ottawa, Canada
    PLoS ONE 6:e16237. 2011
    ..While indirect methods have grown in popularity and acceptance, little is known about the fragility of confidence interval estimations and hypothesis testing relying on this method...
  15. doi request reprint Smoking cessation reduces postoperative complications: a systematic review and meta-analysis
    Edward Mills
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
    Am J Med 124:144-154.e8. 2011
    ..We aimed to review randomized trials and observational evidence to establish the effect of preoperative smoking cessation on postoperative complications and to determine if there is an optimal cessation period before surgery...
  16. doi request reprint Mortality by baseline CD4 cell count among HIV patients initiating antiretroviral therapy: evidence from a large cohort in Uganda
    Edward J Mills
    Faculty of Health Sciences, University of Ottawa, Canada
    AIDS 25:851-5. 2011
    ..Funders have been reticent to recommend earlier initiation of treatment. We aimed to examine the effect of baseline CD4 cell count on mortality using data from HIV patients receiving combination antiretroviral therapy (cART) in Uganda...
  17. doi request reprint Intensive statin therapy compared with moderate dosing for prevention of cardiovascular events: a meta-analysis of >40 000 patients
    Edward J Mills
    Faculty of Health Sciences, University of Ottawa, Ottawa, Ontario, Canada V5Z 4B4 K1n6X1
    Eur Heart J 32:1409-15. 2011
    ..There is widespread interest in whether intensive dosing of statins yields larger treatment effects. We aimed to determine if intensive dosing is clinically important using a meta-analysis of randomized clinical trials (RCTs)...
  18. pmc Health system determinants of infant, child and maternal mortality: A cross-sectional study of UN member countries
    Katherine A Muldoon
    British Columbia Centre for Excellence in HIV AIDS, St, Paul s Hospital, 1081 Burrard Street, Vancouver, British Columbia, Canada
    Global Health 7:42. 2011
    ..abstract:..
  19. pmc Male gender predicts mortality in a large cohort of patients receiving antiretroviral therapy in Uganda
    Edward J Mills
    Faculty of Health Sciences, University of Ottawa, Ottawa, Canada
    J Int AIDS Soc 14:52. 2011
    ....
  20. doi request reprint Adverse events associated with individual statin treatments for cardiovascular disease: an indirect comparison meta-analysis
    M Alberton
    Faculty of Health Sciences, University of Ottawa, Ottawa, Ontario, Canada
    QJM 105:145-57. 2012
    ..Statins are the most widely prescribed drug available. Due to this reason, it is important to understand the risks involved with the drug class and individual statins...
  21. doi request reprint Antiretroviral effects on HIV-1 RNA, CD4 cell count and progression to AIDS or death: a meta-regression analysis
    E J Mills
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
    HIV Med 9:849-57. 2008
    ..We aimed to determine the strength of the association between the magnitude of the effect of changes in CD4 cell count and HIV-1 RNA and progression to AIDS or death in the highly active antiretroviral therapy (HAART) era...
  22. pmc Direct-acting antiviral therapies for hepatitis C genotype 1 infection: a multiple treatment comparison meta-analysis
    C Cooper
    Division of Infectious Diseases, Department of Medicine, The Ottawa Hospital, University of Ottawa, 501 Smyth Road, Ottawa, ON, Canada K1H 8L6
    QJM 106:153-63. 2013
    ..New direct-acting antiviral agents for hepatitis C genotype 1 infection, boceprevir and telaprevir, offer enhanced sustained virologic response (SVR) among both treatment-naïve and treatment-experienced patients...
  23. doi request reprint Antiretroviral therapy for initial human immunodeficiency virus/AIDS treatment: critical appraisal of the evidence from over 100 randomized trials and 400 systematic reviews and meta-analyses
    S Kanters
    School of Population and Public Health, University of British Columbia, Vancouver, BC, Canada
    Clin Microbiol Infect 20:114-22. 2014
    ..We conclude with recommendations for future clinical trials and meta-analyses. ..