Research Topics
Genomes and GenesSpecies | GREGORY EVAN MILLERSummaryAffiliation: University of British Columbia Country: Canada Publications
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Publications
Low early-life social class leaves a biological residue manifested by decreased glucocorticoid and increased proinflammatory signalingGregory E Miller
Department of Psychology, Child and Family Research Institute, University of British Columbia, Vancouver, BC, Canada
Proc Natl Acad Sci U S A 106:14716-21. 2009..Although these response patterns could serve adaptive functions during acute threats to well-being, over the long term they might exact an allostatic toll on the body that ultimately contributes to the chronic diseases of aging...- Clustering of depression and inflammation in adolescents previously exposed to childhood adversityGregory E Miller
Department of Psychology, University of British Columbia, Vancouver, Canada
Biol Psychiatry 72:34-40. 2012..However, research on depression and inflammation has yielded conflicting findings, fostering speculation that these conditions associate only in certain subgroups, such as patients exposed to childhood adversity... - Serum contents of endocannabinoids are correlated with blood pressure in depressed womenW S Vanessa Ho
Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
Lipids Health Dis 11:32. 2012.... 
Depressive symptoms and the regulation of proinflammatory cytokine expression in patients with coronary heart diseaseGregory E Miller
Department of Psychology, University of British Columbia, 2136 West Mall, Vancouver BC, Canada V6T 1Z4
J Psychosom Res 59:231-6. 2005..This study examined whether depressive symptoms are associated with the dysregulation of inflammatory cytokine production in response to an in vitro infectious challenge...- Clinical depression and regulation of the inflammatory response during acute stressGregory E Miller
Department of Psychology, University of British Columbia, Vancouver, British Columbia, Canada
Psychosom Med 67:679-87. 2005..This study examined whether clinical depression is associated with a differential inflammatory response to an acute bout of psychological stress... 
Health psychology: developing biologically plausible models linking the social world and physical healthGregory Miller
Department of Psychology, University of British Columbia, Vancouver, V6T 1Z4, British Columbia, Canada
Annu Rev Psychol 60:501-24. 2009....- Harsh family climate in early life presages the emergence of a proinflammatory phenotype in adolescenceGregory E Miller
University of British Columbia, 2136 W Mall Ave, Vancouver, British Columbia, Canada V6T 1Z4
Psychol Sci 21:848-56. 2010..If sustained, these tendencies may place children from harsh families on a developmental trajectory toward the chronic diseases of aging... - Unfavorable socioeconomic conditions in early life presage expression of proinflammatory phenotype in adolescenceGregory Miller
Department of Psychology, University of British Columbia, Vancouver, BC, Canada
Psychosom Med 69:402-9. 2007..Unfavorable socioeconomic status (SES) circumstances early in life are associated with heightened vulnerability to respiratory and cardiovascular diseases in adulthood. However, little is known about mechanisms underlying this phenomenon... - Chronic interpersonal stress predicts activation of pro- and anti-inflammatory signaling pathways 6 months laterGregory E Miller
Department of Psychology, University of British Columbia, Vancouver, British Columbia, Canada
Psychosom Med 71:57-62. 2009..To understand the mechanisms underlying chronic interpersonal difficulties and their detrimental influence on mental and physical health... - Life stress and diminished expression of genes encoding glucocorticoid receptor and beta2-adrenergic receptor in children with asthmaGregory E Miller
Department of Psychology, University of British Columbia, 2136 West Mall, Vancouver, BC, Canada V6T 1Z4
Proc Natl Acad Sci U S A 103:5496-501. 2006..To the extent that it diminishes sensitivity to the antiinflammatory properties of glucocorticoids or the bronchodilatory properties of beta-agonists, this process could explain the increased asthma morbidity associated with stress... - If it goes up, must it come down? Chronic stress and the hypothalamic-pituitary-adrenocortical axis in humansGregory E Miller
Department of Psychology, University of British Columbia UBC, Vancouver, BC, Canada
Psychol Bull 133:25-45. 2007..Finally, HPA activity is shaped by a person's response to the situation; it increases with subjective distress but is lower in persons with posttraumatic stress disorder... - A functional genomic fingerprint of chronic stress in humans: blunted glucocorticoid and increased NF-kappaB signalingGregory E Miller
Department of Psychology, University of British Columbia, Vancouver, Canada
Biol Psychiatry 64:266-72. 2008..Chronic stressors are known to increase vulnerability to medical illness, but the mechanisms underlying this phenomenon are poorly understood... - Relation of depressive symptoms to C-reactive protein and pathogen burden (cytomegalovirus, herpes simplex virus, Epstein-Barr virus) in patients with earlier acute coronary syndromesGregory E Miller
Department of Psychology, University of British Columbia, Vancouver, British Columbia, Canada
Am J Cardiol 95:317-21. 2005..In doing so, they highlight a mechanism through which depressive symptoms might foster morbidity and mortality among patients who have cardiac disease... - Psychological stress in childhood and susceptibility to the chronic diseases of aging: moving toward a model of behavioral and biological mechanismsGregory E Miller
Department of Psychology, University of British Columbia
Psychol Bull 137:959-97. 2011..Acting in concert with other exposures and genetic liabilities, the resulting inflammation drives forward pathogenic mechanisms that ultimately foster chronic disease... - Pathways linking depression, adiposity, and inflammatory markers in healthy young adultsGregory E Miller
Department of Psychology, Washington University, Campus Box 1125, One Brookings Drive, St Louis, MO 63130, USA
Brain Behav Immun 17:276-85. 2003..99; NNFI =.99; RMSEA =.05). It did not support a sickness behavior model in which the inflammatory molecules arising from expanded adipose tissue promote depressive symptoms... - Cynical hostility, depressive symptoms, and the expression of inflammatory risk markers for coronary heart diseaseGregory E Miller
Department of Psychology, Washington University, Saint Louis, Missouri, USA
J Behav Med 26:501-15. 2003..These findings highlight the importance of considering both the independent and interactive relationships among psychosocial characteristics involved in disease... - Psychological stress and antibody response to influenza vaccination: when is the critical period for stress, and how does it get inside the body?Gregory E Miller
Department of Psychology, University of British Columbia, Vancouver, Canada
Psychosom Med 66:215-23. 2004.... - You've gotta know when to fold 'em: goal disengagement and systemic inflammation in adolescenceGregory E Miller
University of British Columbia, Vancouver, British Columbia, Canada
Psychol Sci 18:773-7. 2007..Because excessive inflammation contributes to a variety of adverse medical outcomes, these findings suggest that in some contexts, persistence may actually undermine well-being and good health... - Pathways to resilience: maternal nurturance as a buffer against the effects of childhood poverty on metabolic syndrome at midlifeGregory E Miller
Department of Psychology, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada
Psychol Sci 22:1591-9. 2011..However, results were consistent with a buffering scenario, in which high levels of maternal nurturance offset the metabolic consequences of childhood disadvantage... - Parental support and cytokine activity in childhood asthma: the role of glucocorticoid sensitivityGregory E Miller
Department of Psychology, University of British Columbia, Vancouver, British Columbia, Canada
J Allergy Clin Immunol 123:824-30. 2009..This problem is especially difficult because stress elicits secretion of cortisol, a hormone that dampens airway inflammation and ameliorates asthma symptoms... - Differentiating the impact of episodic and chronic stressors on hypothalamic-pituitary-adrenocortical axis regulation in young womenTeresa J Marin
Department of Psychology, University of British Columbia, Vancouver, BC, Canada
Health Psychol 26:447-55. 2007..To explore the potential downstream consequences of altered HPA dynamics, the authors also assessed indicators of metabolic control and systemic inflammation... - Clinical depression and inflammatory risk markers for coronary heart diseaseGregory E Miller
Department of Psychology, Washington University, St Louis, Missouri 63130, USA
Am J Cardiol 90:1279-83. 2002..Increased body mass appears to be partially, although not completely, responsible for this relation... - Acute deviations from long-term trait depressive symptoms predict systemic inflammatory activityNicolas Rohleder
Department of Psychology, University of British Columbia, 2136 West Mall, Vancouver, BC, Canada
Brain Behav Immun 22:709-16. 2008..While higher levels of inflammatory mediators have been found in dysphoric individuals, it is not known whether long-term or short-term mood changes are responsible for this phenomenon... - Chronic psychological stress and the regulation of pro-inflammatory cytokines: a glucocorticoid-resistance modelGregory E Miller
Department of Psychology, Washington University, St Louis, Missouri 63130, USA
Health Psychol 21:531-41. 2002..Findings suggest a novel pathway by which chronic stress might alter the course of inflammatory disease... - Biologic cost of caring for a cancer patient: dysregulation of pro- and anti-inflammatory signaling pathwaysNicolas Rohleder
Brandeis University, Department of Psychology, Waltham, MA 02454, USA
J Clin Oncol 27:2909-15. 2009..This study observed familial caregivers of patients with brain cancer for a year after diagnosis and tracked changes in neurohormonal and inflammatory processes... - Regret intensity, diurnal cortisol secretion, and physical health in older individuals: evidence for directional effects and protective factorsCarsten Wrosch
Department of Psychology, Centre for Research in Human Development, Concordia University, Montreal, PQ, Canada
Psychol Aging 22:319-30. 2007..In addition, the intervention evidenced a beneficial effect on the association between initial regret intensity and increased sleep problems over time... - Parent psychological states predict changes in inflammatory markers in children with asthma and healthy childrenJutta M Wolf
University of British Columbia, Department of Psychology, 2136 West Mall, Vancouver, BC, Canada
Brain Behav Immun 22:433-41. 2008..These changes in inflammatory makers may represent one biological mechanism underlying the association between parental distress and child asthma morbidity... - Heart rate variability and markers of inflammation and coagulation in depressed patients with coronary heart diseaseRobert M Carney
Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA
J Psychosom Res 62:463-7. 2007..Cardiac autonomic nervous system (ANS) dysregulation, proinflammatory processes, and procoagulant processes have been suggested as possible explanations... - Adaptive self-regulation of unattainable goals: goal disengagement, goal reengagement, and subjective well-beingCarsten Wrosch
Department of Psychology, Concordia University, Montreal, QC, Canada
Pers Soc Psychol Bull 29:1494-508. 2003..In addition, the results showed that goal disengagement and goal reengagement can have interactive effects on subjective well-being. The importance of the findings for effective self-regulation and successful development are discussed... - What do trajectories of childhood socioeconomic status tell us about markers of cardiovascular health in adolescence?Teresa J Marin
Department of Psychology, University of British Columbia, 2136 West Mall, Vancouver, BC, Canada V6T 1Z4
Psychosom Med 70:152-9. 2008.... - Double-exposure to acute stress and chronic family stress is associated with immune changes in children with asthmaTeresa J Marin
Department of Psychology, University of British Columbia, 2136 West Mall Avenue, Vancouver, Canada
Psychosom Med 71:378-84. 2009..To understand how psychological stress heightens risk for asthma flare-ups, we examined the relationship between acute stress, chronic family stress, and the production of asthma-related cytokines... - Clinical potentials for measuring stress in youth with asthmaHannah M C Schreier
Department of Psychology, University of British Columbia, 2136 West Mall, Vancouver, BC V6T 1Z4, Canada
Immunol Allergy Clin North Am 31:41-54. 2011..In addition, this kind of information seems to be more robustly linked to pediatric asthma outcomes of interest... - The psychobiology of trait shame in young women: extending the social self preservation theoryNicolas Rohleder
Department of Psychology, University of British Columbia, Vancouver, British Columbia, Canada
Health Psychol 27:523-32. 2008..While this is supported in acute stress studies, there is no data on chronic experiences of shame... - Mere visual perception of other people's disease symptoms facilitates a more aggressive immune responseMark Schaller
Department of Psychology, University of British Columbia, 2136 West Mall, Vancouver, British Columbia V6T 1Z4, Canada
Psychol Sci 21:649-52. 2010..These results provide the first empirical evidence that visual perception of other people's symptoms may cause the immune system to respond more aggressively to infection. Adaptive origins and functional implications are discussed... - Depression and oxidative damage to lipidsSarah Yager
Department of Psychology, University of British Columbia, Vancouver, British Columbia, Canada
Psychoneuroendocrinology 35:1356-62. 2010..In conclusion, oxidative damage to lipid molecules may represent a common pathophysiological mechanism by which depressed individuals become more vulnerable to atherosclerosis and its clinical sequelae... - Socioeconomic status associated with exhaled nitric oxide responses to acute stress in children with asthmaEdith Chen
University of British Columbia, Department of Psychology, Canada
Brain Behav Immun 24:444-50. 2010..This study suggests that lower SES children with asthma may be more vulnerable to heightened airway inflammation in response to stress... - Neighbourhood socioeconomics status predicts non-cardiovascular mortality in cardiac patients with access to universal health careClaire L Heslop
Department of Pathology and Laboratory Medicine, Atherosclerosis Specialty Laboratory, James Hogg iCAPTURE Centre, Providence Heart Lung Institute, University of British Columbia St Paul s Hospital, Vancouver, Canada
PLoS ONE 4:e4120. 2009.... - How low socioeconomic status affects 2-year hormonal trajectories in childrenEdith Chen
University of British Columbia, Vancouver, British Columbia, Canada V6T1Z4
Psychol Sci 21:31-7. 2010.... - Uncoupling of social zeitgebers and diurnal cortisol secretion in clinical depressionCinnamon Stetler
Department of Psychology, University of British Columbia, 2136 West Mall, Vancouver, BC, Canada V6T 1Z4
Psychoneuroendocrinology 29:1250-9. 2004..This lack of social entrainment may underlie some of the circadian disturbances in depression... - Blunted cortisol response to awakening in mild to moderate depression: regulatory influences of sleep patterns and social contactsCinnamon Stetler
Department of Psychology, University of British Columbia, Vancouver, BC, Canada
J Abnorm Psychol 114:697-705. 2005..These psychosocial factors may contribute to a normal CAR, but their regulatory influence may become disrupted during mild to moderate clinical depression... - Written disclosure of experiences with racial discrimination and antibody response to an influenza vaccineCinnamon Stetler
University of British Columbia, Vancouver, Canada
Int J Behav Med 13:60-8. 2006..The attributional ambiguity sometimes associated with racism may inhibit the benefits of disclosure interventions for these types of stressors... - Socioeconomic status and inflammatory processes in childhood asthma: the role of psychological stressEdith Chen
Department of Psychology, University of British Columbia, Vancouver, Canada
J Allergy Clin Immunol 117:1014-20. 2006..Although social environment variables such as socioeconomic status (SES) have been linked to childhood asthma, little is known about the psychobiological mechanisms underlying this relationship... - Stress and inflammation in exacerbations of asthmaEdith Chen
University of British Columbia, Department of Psychology, 2136 West Mall, Vancouver, BC, Canada V6T 1Z4
Brain Behav Immun 21:993-9. 2007..Empirical evidence for this model is reviewed, and conclusions and future research directions are discussed... - The role of the social environment in children and adolescents with asthmaEdith Chen
Department of Psychology, University of British Columbia, Vancouver, BC, Canada
Am J Respir Crit Care Med 176:644-9. 2007..Biopsychosocial models of asthma have been proposed in the literature, but few empirical tests of social factors at various levels of influence have been conducted... - Symptoms of depression and impaired endothelial function in healthy adolescent womenLianne M Tomfohr
Department of Psychology, University of British Columbia, Vancouver, BC, Canada
J Behav Med 31:137-43. 2008..Most patients in our sample had subclinical depressive symptoms, suggesting that even mild affective difficulties are capable of negatively influencing endothelial function in otherwise healthy youngsters... - Diurnal cortisol secretion and 2-year changes in older adults' physical symptoms: the moderating roles of negative affect and sleepCarsten Wrosch
Department of Psychology, Centre for Research in Human Development, Concordia University, Montreal, QC H4B 1R6, Canada
Health Psychol 27:685-93. 2008..The authors expected that physical health effects would emerge particularly when cortisol disturbances co-occur in the context of high levels of trait negative affect or poor sleep... - Loneliness, social network size, and immune response to influenza vaccination in college freshmenSarah D Pressman
Department of Psychology, Carnegie Mellon University, Pittsburgh, PA 15213, USA
Health Psychol 24:297-306. 2005..None of these variables were associated with social network size, and hence none were potential mediators of the relation between network size and immunization response... - Depressive symptoms can be useful: self-regulatory and emotional benefits of dysphoric mood in adolescenceCarsten Wrosch
Department of Psychology, Centre for Research in Human Development, Concordia University, Montreal, QC, Canada
J Pers Soc Psychol 96:1181-90. 2009..The findings suggest that depressive symptomatology may serve adaptive functions by facilitating the development of goal disengagement capacities in adolescence... - Psychological stress and diseaseSheldon Cohen
Department of Psychology, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, USA
JAMA 298:1685-7. 2007 - Depression as a risk factor for cardiac mortality and morbidity: a review of potential mechanismsRobert M Carney
Department of Psychiatry, Suite 420, Behavioral Medicine Center, Washington University School of Medicine, 4625 Lindell Boulevard, St Louis, MO 63108, USA
J Psychosom Res 53:897-902. 2002..inflammatory processes. Despite recent advances in our understanding of these potential mechanisms, further research is needed to determine how depression increases risk for cardiac morbidity and mortality... - Physical health problems, depressive mood, and cortisol secretion in old age: buffer effects of health engagement control strategiesCarsten Wrosch
Department of Psychology, Centre for Research in Human Development, Concordia University, and Douglas Hospital Research Center, Montreal, Quebec, Canada
Health Psychol 26:341-9. 2007..It was expected that adaptive levels of HECS would buffer the adverse effects of physical health problems on depressive mood and diurnal cortisol secretion... - Applying mixed regression models to the analysis of repeated-measures data in psychosomatic medicineEkin Blackwell
University of British Columbia, Department of Psychology, 2136 West Mall, Vancouver, BC V6T 1Z4, Canada
Psychosom Med 68:870-8. 2006..The goal of this article is to introduce readers to mixed regression models, which provide a more flexible and accurate framework for managing repeated-measures data... - Circulating endocannabinoids and N-acyl ethanolamines are differentially regulated in major depression and following exposure to social stressMatthew N Hill
Department of Psychology, University of British Columbia, Vancouver, B C, Canada
Psychoneuroendocrinology 34:1257-62. 2009..The magnitude of these responses did not differ between depressed and control subjects. These are the first data to demonstrate that the peripheral endocannabinoid/NAE system is responsive to exposure to stress... - Increased serum levels of 8-hydroxy-2'-deoxyguanosine in clinical depressionMichael J Forlenza
Faculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, Canada
Psychosom Med 68:1-7. 2006..We sought to understand the pathophysiological effects of depression by examining group differences in serum levels of 8-hydroxy-2'-deoxyguanosine (8-OHdG), a biomarker of oxidative damage... - Depression and obstructive sleep apnea in patients with coronary heart diseaseRobert M Carney
Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri, USA
Psychosom Med 68:443-8. 2006..Obstructive sleep apnea/hypopnea syndrome (OSAHS) is frequently comorbid with depression and is also a risk factor for cardiac events. Undetected OSAHS could help explain the increased risk associated with depression... - Psychological stress and the human immune system: a meta-analytic study of 30 years of inquirySuzanne C Segerstrom
Department of Psychology, University of Kentucky, Lexington, KY 40506, USA
Psychol Bull 130:601-30. 2004..loss). Subjective reports of stress generally did not associate with immune change. In some cases, physical vulnerability as a function of age or disease also increased vulnerability to immune change during stressors... - Where there is depression, there is inflammation... sometimes!Alexander H Glassman
Biol Psychiatry 62:280-1. 2007 - Is it beneficial to involve a family member? A meta-analysis of psychosocial interventions for chronic illnessLynn M Martire
University of Pittsburgh, Department of Psychiatry and University Center for Social and Urban Research, Pittsburgh, PA 15260, USA
Health Psychol 23:599-611. 2004..Although statistically significant aggregate effects were found, they were generally small in magnitude. These findings provide guidance in developing future interventions in this area... - Giving up on unattainable goals: benefits for health?Carsten Wrosch
Concordia University, Department of Psychology and Centre for Research in Human Development, Montreal, Quebec, Canada
Pers Soc Psychol Bull 33:251-65. 2007..The results also indicate that subjective well-being can mediate the associations between goal disengagement tendencies and physical health... - Social integration of daily activities and cortisol secretion: a laboratory based manipulationCinnamon A Stetler
Furman University, Greenville, SC, USA
J Behav Med 31:249-57. 2008..However, cortisol slope differences were significant when participants had contact with someone whom they usually saw every day. Social relationships that provide daily contact may have the strongest influence on biological rhythms... - The Great Debate, revisitedKenneth E Freedland
Psychosom Med 68:179-84. 2006 - Gregory E. Miller: award for distinguished scientific early career contributions to psychologyGregory E Miller
Am Psychol 59:710-2. 2004
Research Grants
- Biological Embedding of Early-Life SESGREGORY EVAN MILLER; Fiscal Year: 2010..It examines the idea that poverty in early childhood changes the way the immune system functions, and does so in a fashion that persists across the lifespan and renders a person vulnerable to diseases in adulthood. ..
- Biological Embedding of Early-Life SESGREGORY EVAN MILLER; Fiscal Year: 2011..It examines the idea that poverty in early childhood changes the way the immune system functions, and does so in a fashion that persists across the lifespan and renders a person vulnerable to diseases in adulthood. ..