Gerlinde A Metz

Summary

Affiliation: University of Lethbridge
Country: Canada

Publications

  1. pmc Maternal circulating leukocytes display early chemotactic responsiveness during late gestation
    Nardhy Gomez-Lopez
    Department of Obstetrics and Gynecology, Pediatrics and Physiology, University of Alberta, Edmonton T6G 2S2, Canada
    BMC Pregnancy Childbirth 13:S8. 2013
  2. pmc Stress-induced glucocorticoid receptor activation determines functional recovery following ischemic stroke
    Fabiola Cr Zucchi
    Canadian Centre for Behavioural Neuroscience, Department of Neuroscience, University of Lethbridge, 4401 University Drive, Lethbridge, Alberta, T1K 3M4, Canada
    Exp Transl Stroke Med 2:18. 2010
  3. ncbi request reprint Drug-induced rotation intensity in unilateral dopamine-depleted rats is not correlated with end point or qualitative measures of forelimb or hindlimb motor performance
    G A Metz
    Canadian Centre for Behavioural Neuroscience, University of Lethbridge, 4401 University Drive, AB, Canada T1K 3M4
    Neuroscience 111:325-36. 2002
  4. ncbi request reprint Cortical and subcortical lesions impair skilled walking in the ladder rung walking test: a new task to evaluate fore- and hindlimb stepping, placing, and co-ordination
    Gerlinde A Metz
    Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, Alberta, Canada T1K 3M4
    J Neurosci Methods 115:169-79. 2002
  5. ncbi request reprint Modulation of motor function by stress: a novel concept of the effects of stress and corticosterone on behavior
    Gerlinde A Metz
    Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, AB, Canada T1K 3M4
    Eur J Neurosci 22:1190-200. 2005
  6. ncbi request reprint Acute alcohol administration improves skilled reaching success in intact but not 6-OHDA dopamine depleted rats: a subsystems analysis of the motoric and anxiolytic effects of alcohol
    Gerlinde A Metz
    Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, Alta, Canada T1K 3M4
    Behav Brain Res 142:167-74. 2003
  7. ncbi request reprint The unilateral 6-OHDA rat model of Parkinson's disease revisited: an electromyographic and behavioural analysis
    Gerlinde A Metz
    Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge AB, T1K 3M4, Canada
    Eur J Neurosci 22:735-44. 2005
  8. ncbi request reprint Preserved ipsilateral-to-lesion motor map organization in the unilateral 6-OHDA-treated rat model of Parkinson's disease
    Gerlinde A Metz
    Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, AB, Canada, T1K 3M4, Canada
    Brain Res 1026:126-35. 2004
  9. ncbi request reprint Behavioral characterization in a comprehensive mouse test battery reveals motor and sensory impairments in growth-associated protein-43 null mutant mice
    G A Metz
    Canadian Center for Behavioural Neuroscience, University of Lethbridge, 4401 University Drive, Lethbridge, Alberta, T1K 3M4 Canada
    Neuroscience 129:563-74. 2004
  10. ncbi request reprint Motor improvements after focal cortical ischemia in adult rats are mediated by compensatory mechanisms
    Gerlinde A Metz
    Canadian Centre for Behavioural Neuroscience, University of Lethbridge, 4401 University Drive, Lethbridge, Alta, Canada T1K 3M4
    Behav Brain Res 162:71-82. 2005

Research Grants

Collaborators

Detail Information

Publications60

  1. pmc Maternal circulating leukocytes display early chemotactic responsiveness during late gestation
    Nardhy Gomez-Lopez
    Department of Obstetrics and Gynecology, Pediatrics and Physiology, University of Alberta, Edmonton T6G 2S2, Canada
    BMC Pregnancy Childbirth 13:S8. 2013
    ....
  2. pmc Stress-induced glucocorticoid receptor activation determines functional recovery following ischemic stroke
    Fabiola Cr Zucchi
    Canadian Centre for Behavioural Neuroscience, Department of Neuroscience, University of Lethbridge, 4401 University Drive, Lethbridge, Alberta, T1K 3M4, Canada
    Exp Transl Stroke Med 2:18. 2010
    ..This study investigated if recovery after stroke is related to glucocorticoid receptor (GR) activation in a rat model of stroke...
  3. ncbi request reprint Drug-induced rotation intensity in unilateral dopamine-depleted rats is not correlated with end point or qualitative measures of forelimb or hindlimb motor performance
    G A Metz
    Canadian Centre for Behavioural Neuroscience, University of Lethbridge, 4401 University Drive, AB, Canada T1K 3M4
    Neuroscience 111:325-36. 2002
    ....
  4. ncbi request reprint Cortical and subcortical lesions impair skilled walking in the ladder rung walking test: a new task to evaluate fore- and hindlimb stepping, placing, and co-ordination
    Gerlinde A Metz
    Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, Alberta, Canada T1K 3M4
    J Neurosci Methods 115:169-79. 2002
    ..The test is useful for assessing loss and recovery of function due to brain or spinal cord injury, the effectiveness of treatment therapies, as well as compensatory processes through which animals adapt to nervous system injury...
  5. ncbi request reprint Modulation of motor function by stress: a novel concept of the effects of stress and corticosterone on behavior
    Gerlinde A Metz
    Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, AB, Canada T1K 3M4
    Eur J Neurosci 22:1190-200. 2005
    ..These findings are discussed with respect to the role of stress in motor system function and movement disorders...
  6. ncbi request reprint Acute alcohol administration improves skilled reaching success in intact but not 6-OHDA dopamine depleted rats: a subsystems analysis of the motoric and anxiolytic effects of alcohol
    Gerlinde A Metz
    Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, Alta, Canada T1K 3M4
    Behav Brain Res 142:167-74. 2003
    ..The results are also discussed with respect to the relationship of subsystems of movement and anxiety...
  7. ncbi request reprint The unilateral 6-OHDA rat model of Parkinson's disease revisited: an electromyographic and behavioural analysis
    Gerlinde A Metz
    Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge AB, T1K 3M4, Canada
    Eur J Neurosci 22:735-44. 2005
    ..The data suggest that the unilateral rat model of PD resembles key features of human parkinsonian gait, and that asymmetric descending input may underlie the observed changes in gait patterns...
  8. ncbi request reprint Preserved ipsilateral-to-lesion motor map organization in the unilateral 6-OHDA-treated rat model of Parkinson's disease
    Gerlinde A Metz
    Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, AB, Canada, T1K 3M4, Canada
    Brain Res 1026:126-35. 2004
    ....
  9. ncbi request reprint Behavioral characterization in a comprehensive mouse test battery reveals motor and sensory impairments in growth-associated protein-43 null mutant mice
    G A Metz
    Canadian Center for Behavioural Neuroscience, University of Lethbridge, 4401 University Drive, Lethbridge, Alberta, T1K 3M4 Canada
    Neuroscience 129:563-74. 2004
    ..The results also show that the comprehensive test battery used in the present study represents a sensitive approach to assess the functional integrity of ascending and descending pathways in genetically manipulated mice...
  10. ncbi request reprint Motor improvements after focal cortical ischemia in adult rats are mediated by compensatory mechanisms
    Gerlinde A Metz
    Canadian Centre for Behavioural Neuroscience, University of Lethbridge, 4401 University Drive, Lethbridge, Alta, Canada T1K 3M4
    Behav Brain Res 162:71-82. 2005
    ..The finding that reaching success was not related to lesion size supports the idea that the degree of adaptive behavior after cortical ischemia depends on plastic properties of the remaining intact tissue...
  11. ncbi request reprint Chronic levodopa therapy does not improve skilled reach accuracy or reach range on a pasta matrix reaching task in 6-OHDA dopamine-depleted (hemi-Parkinson analogue) rats
    G A Metz
    Department of Psychology and Neuroscience, University of Lethbridge, 4401 University Drive, Lethbridge, AB, Canada, T1K 3M4
    Eur J Neurosci 14:27-37. 2001
    ..The results are discussed in relationship to the idea that the restoration of some skilled movements may require normal synaptic function...
  12. ncbi request reprint Efficient testing of motor function in spinal cord injured rats
    G A Metz
    Brain Research Institute, University and ETH Zurich, 8057, Zurich, Switzerland
    Brain Res 883:165-77. 2000
    ..This approach should help to standardize modular testing procedures across different laboratories working on spinal cord injury...
  13. ncbi request reprint Stress as a modulator of motor system function and pathology
    Gerlinde A Metz
    Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, Canada
    Rev Neurosci 18:209-22. 2007
    ..That stress represents a significant modulator of motor system function in both the healthy and the damaged brain should be recognized when developing future therapies for neurodegenerative diseases...
  14. ncbi request reprint Skilled reaching an action pattern: stability in rat (Rattus norvegicus) grasping movements as a function of changing food pellet size
    G A Metz
    Department of Psychology and Neuroscience, University of Lethbridge, 4401 University Drive, Lethbridge, Alta T1K 3M4, Canada
    Behav Brain Res 116:111-22. 2000
    ....
  15. ncbi request reprint The effects of acute and chronic stress on motor and sensory performance in male Lewis rats
    G A Metz
    Department of Psychology and Neuroscience, University of Lethbridge, Lethbridge, Canada
    Physiol Behav 72:29-35. 2001
    ..These data point towards a critical influence of acute or chronic stress on motor control and sensory performance of rats, suggesting that stress might be a critical intervening variable of the outcome of behavioral tests...
  16. ncbi request reprint Sexually dimorphic postural adjustments during vertical behaviour are altered in a unilateral 6-OHDA rat model of Parkinson's disease
    Evelyn F Field
    Department of Neuroscience, Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, Alta, Canada T1K 3M4
    Behav Brain Res 174:39-48. 2006
    ....
  17. ncbi request reprint Sequential bilateral striatal lesions have additive effects on single skilled limb use in rats
    Jamshid Faraji
    Canadian Centre for Behavioural Neuroscience, University of Lethbridge, 4401 University Drive, Lethbridge, Alta, Canada T1K 3M4
    Behav Brain Res 177:195-204. 2007
    ..This supports the notion of bilateral control of skilled forelimb use by the mesostriatal dopaminergic system...
  18. doi request reprint Predictable stress versus unpredictable stress: a comparison in a rodent model of stroke
    Fabiola C R Zucchi
    Canadian Centre for Behavioural Neuroscience, University of Lethbridge, 4401 University Drive, Lethbridge, AB, Canada T1K 3M4
    Behav Brain Res 205:67-75. 2009
    ....
  19. doi request reprint Dose-dependent loss of motor function after unilateral medial forebrain bundle rotenone lesion in rats: a cautionary note
    Alexander Klein
    Canadian Centre for Behavioural Neuroscience, Department of Neuroscience, University of Lethbridge, Lethbridge, Alberta T1K 3M4, Canada
    Behav Brain Res 222:33-42. 2011
    ..Furthermore, caution is advised concerning non-specific toxicity of rotenone and vehicle substances in experimental animal models...
  20. ncbi request reprint Distinct forelimb and hind limb stepping impairments in unilateral dopamine-depleted rats: use of the rotorod as a method for the qualitative analysis of skilled walking
    Ian Q Whishaw
    Department of Psychology and Neuroscience, Canadian Centre for Behavioural Neuroscience, University of Lethbridge, 4401 University Dr, Alberta, Lethbridge, Canada T1K 3M4
    J Neurosci Methods 126:13-23. 2003
    ..These findings not only reveal new deficits secondary to unilateral DA-depletion, but also show that the rotorod can provide a robust tool for the qualitative analysis of movement...
  21. doi request reprint The development of skilled walking in the rat
    Alexandra M Shriner
    Canadian Centre for Behavioural Neuroscience, University of Lethbridge, 4401 University Drive, Lethbridge, AB, Canada
    Behav Brain Res 205:426-35. 2009
    ..The findings are discussed in relation to the maturation of underlying structures and their relevance to studies of brain damage...
  22. doi request reprint Synergistic effects of age and stress in a rodent model of stroke
    Dawn L Merrett
    Canadian Centre for Behavioural Neuroscience, University of Lethbridge, 4401 University Drive West, Lethbridge, Alberta, Canada T1K 3M4
    Behav Brain Res 214:55-9. 2010
    ..These findings show that age or stress alone can modulate motor performance but may have greater influence by synergistically affecting stroke recovery...
  23. doi request reprint Sex differences in skilled movement in response to restraint stress and recovery from stress
    Nafisa M Jadavji
    Canadian Centre for Behavioural Neuroscience, University of Lethbridge, 4401 University Drive, Lethbridge, AB, Canada T1K3M4
    Behav Brain Res 195:251-9. 2008
    ..These results indicate sex differences in skilled reaching in response to stress, and in the recovery period after stress...
  24. doi request reprint Stress accelerates neural degeneration and exaggerates motor symptoms in a rat model of Parkinson's disease
    Lori K Smith
    Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, AB, T1K 3M4 Canada
    Eur J Neurosci 27:2133-46. 2008
    ..It is therefore possible that stress represents a key factor in the pathogenesis of human PD by impeding functional and structural compensation and exaggerating neurodegenerative processes...
  25. doi request reprint Stress and corticosterone enhance cognitive recovery from hippocampal stroke in rats
    Jamshid Faraji
    Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, AB, Canada
    Neurosci Lett 462:248-52. 2009
    ..The findings support the view that elevated levels of corticosterone may exert neuroprotective effects in the hippocampus following stroke...
  26. ncbi request reprint Absence of impairments or recovery mediated by the uncrossed pyramidal tract in the rat versus enduring deficits produced by the crossed pyramidal tract
    Ian Q Whishaw
    Canadian Centre for Behavioural Neuroscience, The University of Lethbridge, 4401 University Drive, Lethbridge, Alberta, Canada T1K 3M4
    Behav Brain Res 134:323-36. 2002
    ....
  27. doi request reprint Chronic stress prior to hippocampal stroke enhances post-stroke spatial deficits in the ziggurat task
    Jamshid Faraji
    Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, AB, Canada
    Neurobiol Learn Mem 95:335-45. 2011
    ....
  28. doi request reprint Characterization of spatial performance in male and female Long-Evans rats by means of the Morris water task and the ziggurat task
    Jamshid Faraji
    Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, AB, T1K 3M4, Canada
    Brain Res Bull 81:164-72. 2010
    ..Our findings suggest that males and females may employ different learning strategies in the MWT and ZT and that the latter task provides a more favourable task for assessing sex differences in rats...
  29. doi request reprint Delayed recovery and exaggerated infarct size by post-lesion stress in a rat model of focal cerebral stroke
    Scott W Kirkland
    Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, AB, Canada
    Brain Res 1201:151-60. 2008
    ..Lesion volume, however, is influenced by the timing of a stressful experience relative to the lesion. These findings suggest that stress represents a critical variable determining the outcome after stroke...
  30. ncbi request reprint Impairment of pronation, supination, and body co-ordination in reach-to-grasp tasks in human Parkinson's disease (PD) reveals homology to deficits in animal models
    Ian Q Whishaw
    Canadian Centre for Behavioural Neuroscience, The University of Lethbridge, 4401 University Drive, Alberta, Canada T1K 3M4
    Behav Brain Res 133:165-76. 2002
    ..These results are discussed in terms of a homology to impairments displayed animal models of PD...
  31. ncbi request reprint Bilateral alteration in stepping pattern after unilateral motor cortex injury: a new test strategy for analysis of skilled limb movements in neurological mouse models
    Tracy D Farr
    Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, AB, Canada
    J Neurosci Methods 153:104-13. 2006
    ..The findings demonstrate that this test strategy provides comprehensive assessment of motor impairments in mice and that qualitative movement analysis is a valuable tool for elaborating subtle motor disturbances...
  32. doi request reprint Rats with hippocampal lesion show impaired learning and memory in the ziggurat task: a new task to evaluate spatial behavior
    Jamshid Faraji
    Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, AB, Canada T1K 3M4
    Behav Brain Res 189:17-31. 2008
    ..The findings demonstrate that the ZT is a sensitive and efficient dry task for measuring hippocampus-dependent spatial performance in rats requiring little training and not associated with some of the disadvantages of water tasks...
  33. ncbi request reprint Task-specific compensation and recovery following focal motor cortex lesion in stressed rats
    Scott W Kirkland
    Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, AB, Canada
    J Integr Neurosci 11:33-59. 2012
    ..The observations support the notion that hypothalamic-pituitary-adrenal axis activation may be a key determinant of recovery and motor system plasticity after ischemic stroke...
  34. doi request reprint Stress after hippocampal stroke enhances spatial performance in rats
    Jamshid Faraji
    Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, AB, Canada T1K 3M4
    Physiol Behav 102:389-99. 2011
    ..No between-group structural difference was observed related to stress. These findings confirm that corticosterone-related experiences may be key factors influencing cognitive performance after HPC focal ischemic stroke...
  35. doi request reprint Stress precipitates functional deficits following striatal silent stroke: a synergistic effect
    Jamshid Faraji
    Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, AB, Canada
    Exp Neurol 232:251-60. 2011
    ..These results emphasize the importance of prevention programmes to control post-stroke levels of stress in clinical populations...
  36. doi request reprint Both pre- and post-lesion experiential therapy is beneficial in 6-hydroxydopamine dopamine-depleted female rats
    N M Jadavji
    Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, 4401 University Drive, Lethbridge, AB, Canada T1K 3M4
    Neuroscience 158:373-86. 2009
    ..These data indicate that enriched lifestyle before the onset of motor symptoms and rehabilitation programs after diagnosis might be beneficial in patients with Parkinson's disease...
  37. ncbi request reprint The pasta matrix reaching task: a simple test for measuring skilled reaching distance, direction, and dexterity in rats
    M Ballermann
    Department of Psychology and Neuroscience and NeuroDetective Inc, University of Lethbridge, 4401 University Dr. AB, T1K 3M4, Lethbridge, Canada
    J Neurosci Methods 106:39-45. 2001
    ..The task can also be modified to investigate other features of limb use including skill adjustments, laterality, and force...
  38. ncbi request reprint Locomotor recovery in spinal cord-injured rats treated with an antibody neutralizing the myelin-associated neurite growth inhibitor Nogo-A
    D Merkler
    Department of Neuromorphology, Brain Research Institute, , , Switzerland
    J Neurosci 21:3665-73. 2001
    ..These results indicating improved functional recovery suggest that the increased plastic and regenerative capabilities of the CNS after Nogo-A neutralization result in a functionally meaningful rewiring of the motor systems...
  39. doi request reprint Blockade of mineralocorticoid and glucocorticoid receptors reverses stress-induced motor impairments
    Nafisa M Jadavji
    Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, AB, Canada
    Neuroendocrinology 94:278-90. 2011
    ..The purpose of this study was to dissociate the impact of MR versus GR activation in movement and stress-associated motor disruption...
  40. doi request reprint Walking pattern analysis after unilateral 6-OHDA lesion and transplantation of foetal dopaminergic progenitor cells in rats
    Alexander Klein
    Canadian Centre for Behavioural Neuroscience, University of Lethbridge, 4401 University Drive, Lethbridge, Alberta T1K 3M4, Canada
    Behav Brain Res 199:317-25. 2009
    ..A full restoration of locomotor gait pattern might require a more complete and organotypic reconstruction of the mesotelencephalic DAergic pathway...
  41. ncbi request reprint Dietary restriction alters fine motor function in rats
    Lori K Smith
    Canadian Centre for Behavioural Neuroscience, University of Lethbridge, 4401 University Drive, Lethbridge, AB Canada T1K 3M4
    Physiol Behav 85:581-92. 2005
    ..These findings suggest that results obtained in motor tasks using food rewards need to be interpreted with caution. The findings are discussed with respect to stress associated with DR...
  42. doi request reprint Stress and risk avoidance by exploring rats: implications for stress management in fear-related behaviours
    Farshad Nemati
    Canadian Centre for Behavioural Neuroscience, Department of Neuroscience, University of Lethbridge, Lethbridge, Alberta, Canada T1K 3M4
    Behav Processes 94:89-98. 2013
    ..The results provide insights into risk avoidance strategies in rats and suggest that environmental intervention can reverse stress-related changes in behaviour...
  43. ncbi request reprint Analyzing the barriers and supports of knowledge translation using the PEO model
    Megan J Metzler
    Department of Neuroscience, The University of Lethbridge, 4401 University Drive, Lethbridge, AB, Canada, T1K 3M4
    Can J Occup Ther 77:151-8. 2010
    ..Knowledge translation is a current and growing force in Canada's health care environment...
  44. doi request reprint Translating knowledge to practice: an occupational therapy perspective
    Megan J Metzler
    Department of Neuroscience, The University of Lethbridge, 4401 University Drive, Lethbridge, AB, Canada
    Aust Occup Ther J 57:373-9. 2010
    ..How knowledge translation fits with occupational therapy practice deserves examination...
  45. ncbi request reprint Treadmill training in incomplete spinal cord injured rats
    K Fouad
    Brain Research Institute, University and ETH Zurich, Winterthurerstrasse 190, 8057, Zurich, Switzerland
    Behav Brain Res 115:107-13. 2000
    ..It is probable that the spared ventral and ventro-lateral fibers allowed spontaneous recovery and 'self-training' to occur to such an extend that systematic treadmill training did not provide additional improvement...
  46. doi request reprint Concurrent silent strokes impair motor function by limiting behavioral compensation
    Jamshid Faraji
    Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, AB, Canada T1K 3M4
    Exp Neurol 236:241-8. 2012
    ..Moreover, these findings support the notion that cortical and subcortical motor systems cooperate when adopting beneficial compensatory movement strategies...
  47. ncbi request reprint Compensatory sprouting and impulse rerouting after unilateral pyramidal tract lesion in neonatal rats
    W J Z'Graggen
    Brain Research Institute, University of Zurich and Swiss Federal Institute of Technology Zurich, CH 8057 Zurich, Switzerland
    J Neurosci 20:6561-9. 2000
    ..Movements and EMGs reappeared after wash-out of the drug. These results suggest an important role of the red nucleus in the reconnection of the cortex to the periphery after pyramidotomy...
  48. ncbi request reprint The effects of unilateral pyramidal tract section on hindlimb motor performance in the rat
    G A Metz
    Brain Research Institute, University and Swiss Federal Institute of Technology, Zurich, Switzerland
    Behav Brain Res 96:37-46. 1998
    ..We conclude that the possibility to correlate regenerative changes following selective pyramidal tract lesions with hindlimb function is thus limited...
  49. ncbi request reprint Enriched environment improves motor function in intact and unilateral dopamine-depleted rats
    N M Jadavji
    Canadian Centre for Behavioural Neuroscience, University of Lethbridge, 4401 University Drive, Lethbridge, Alberta, Canada T1K 3M4
    Neuroscience 140:1127-38. 2006
    ..These data are discussed in relation to possible mechanisms of experience-dependent modulation of the pathology of Parkinson's disease...
  50. pmc Transgenerational programming of maternal behaviour by prenatal stress
    Isaac D Ward
    Canadian Centre for Behavioural Neuroscience, University of Lethbridge, 4401 University Drive, Lethbridge, AB, Canada T1K3M4
    BMC Pregnancy Childbirth 13:S9. 2013
    ..Thus, altered antepartum maternal behaviour may serve as an indicator of an activated stress response during gestation...
  51. doi request reprint Beyond the silence: bilateral somatosensory stimulation enhances skilled movement quality and neural density in intact behaving rats
    Jamshid Faraji
    Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, AB, Canada T1K 3M4
    Behav Brain Res 253:78-89. 2013
    ..The findings emphasize the central role of bilateral somatosensory feedback in skill acquisition through modulation of cortico-motor excitability. ..
  52. pmc Genomic and epigenomic responses to chronic stress involve miRNA-mediated programming
    Olena Babenko
    Department of Biological Sciences, University of Lethbridge, Lethbridge, Alberta, Canada
    PLoS ONE 7:e29441. 2012
    ..These findings suggest a central role of miRNA-regulated gene expression in the stress response and in associated neurological function...
  53. doi request reprint Epigenetic programming of neurodegenerative diseases by an adverse environment
    Olena Babenko
    Department of Biological Sciences, University of Lethbridge, Lethbridge, Alberta, Canada
    Brain Res 1444:96-111. 2012
    ..Moreover, research into epigenetic regulation of disease may revolutionize health care by opening new avenues of personalized, preventive and curative medicine...
  54. ncbi request reprint Play fighting between kindling-prone (FAST) and kindling-resistant (SLOW) rats
    Christine J Reinhart
    Canadian Centre for Behavioural Neuroscience, Department of Psychology and Neuroscience, University of Lethbridge, Lethbridge, AB, Canada
    J Comp Psychol 120:19-30. 2006
    ..These data suggest that some components of play may be more impervious to changes in social environment than other components...
  55. ncbi request reprint Neurite growth inhibitors restrict plasticity and functional recovery following corticospinal tract lesions
    M Thallmair
    Brain Research Institute, University of Zurich, Switzerland
    Nat Neurosci 1:124-31. 1998
    ..Neutralization of myelin-associated neurite growth inhibitors thus restores in adults the structural plasticity and functional recovery normally found only at perinatal ages...
  56. pmc Transcranial direct current stimulation in stroke rehabilitation: a review of recent advancements
    Andrea Gómez Palacio Schjetnan
    Canadian Centre for Behavioural Neuroscience, Department of Neuroscience, University of Lethbridge, 4401 University Drive, Lethbridge, AB, Canada T1K 3M4
    Stroke Res Treat 2013:170256. 2013
    ..Understanding the mechanisms by which tDCS affects the neural substrate after stroke and finding ways to optimize tDCS for each patient are key to effective rehabilitation approaches...
  57. pmc The secret language of destiny: stress imprinting and transgenerational origins of disease
    Fabiola C R Zucchi
    Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, AB, Canada
    Front Genet 3:96. 2012
    ..Exploring the role of environmental factors, such as stress, in causing variations in epigenetic profiles may lead to new avenues of personalized, preventive medicine based on epigenetic signatures and interventions...
  58. ncbi request reprint Accelerated nervous system development contributes to behavioral efficiency in the laboratory mouse: a behavioral review and theoretical proposal
    I Q Whishaw
    Canadian Center for Behavioral Neuroscience, University of Lethbridge and NeuroDetective Inc, Lethbridge, Alberta, T1K 3M4
    Dev Psychobiol 39:151-70. 2001
    ..Since the mouse's biological adaptations will be reflected in laboratory behavior, suggestions are made for behavioral approaches to the study and interpretation of mouse behavior...
  59. ncbi request reprint Differential effects on forelimb grasping behavior induced by fetal dopaminergic grafts in hemiparkinsonian rats
    Alexander Klein
    Laboratory of Molecular Neurosurgery, Department of Stereotactic Neurosurgery, University Hospital Freiburg Neurocentre, Breisacher Str 64, Freiburg, Germany
    Neurobiol Dis 27:24-35. 2007
    ..These findings provide novel insights into the complex interactions of graft-derived restoration of DA neurotransmission and skilled forelimb behavior...
  60. ncbi request reprint Detection of chronic sensorimotor impairments in the ladder rung walking task in rats with endothelin-1-induced mild focal ischemia
    Monika Riek-Burchardt
    Project Group Neuropharmacology, Leibniz Institute for Neurobiology, Brenneckestr 6, 39118 Magdeburg, Germany
    J Neurosci Methods 137:227-33. 2004
    ....

Research Grants1

  1. Effects of Stress on Pathology of Parkinson's Disease
    GERLINDE METZ; Fiscal Year: 2004
    ..These approaches will provide the opportunity to understand factors involved in the pathology of PD and to develop novel therapeutic strategies for neurodegenerative motor disorders. ..