Research Topics
Species | C MessierSummaryAffiliation: University of Ottawa Country: Canada Publications
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Detail Information
Publications
Longitudinal study of the effects of a high-fat diet on glucose regulation, hippocampal function, and cerebral insulin sensitivity in C57BL/6 miceJohn G Mielke
Neurobiology Program, Institute for Biological Sciences, National Research Council of Canada, 1200 Montreal Road, Building M-54, Ottawa, Ont, Canada
Behav Brain Res 175:374-82. 2006....
Glucose regulation is associated with cognitive performance in young nondiabetic adultsClaude Messier
School of Psychology, University of Ottawa, 136 Jean Jacques Lussier, Ottawa, Ontario, K1N 6N5, Canada
Behav Brain Res 222:81-8. 2011..These findings suggest that cognitive decrements are observable in young, nondiabetic adults, prior to the onset of impaired glucose regulation and diabetes...- Glucose improvement of memory: a reviewClaude Messier
School of Psychology, University of Ottawa, 145 Jean Jacques Lussier Room 352, Ottawa, Ontario, Canada K1N 6N5
Eur J Pharmacol 490:33-57. 2004..Results of a few studies also suggest that drug treatments that improve glucose regulation also produce cognitive improvement in diabetic patients... - The relationships between atherosclerosis, heart disease, type 2 diabetes and dementiaClaude Messier
School of Psychology, University of Ottawa, Ontario, Canada K1N 6N5
Neurol Res 26:567-72. 2004.... - Impact of impaired glucose tolerance and type 2 diabetes on cognitive agingClaude Messier
School of Psychology, University of Ottawa, 145 Jean Jacques Lussier Room 352, Ottawa, Ont, Canada
Neurobiol Aging 26:26-30. 2005..After that age, diabetes appears to produce faster cognitive decline and may increase the occurrence of pathological changes associated with vascular dementia or Alzheimer's disease... 
The role of insulin, insulin growth factor, and insulin-degrading enzyme in brain aging and Alzheimer's diseaseClaude Messier
School of Psychology, University of Ottawa, Ottawa, Ontario, Canada K1N 6N5
Neural Plast 12:311-28. 2005..Such a decrease involves the insulin receptor cascade and can also increase amyloid toxicity. Insulin and IGF-I may modulate brain levels of insulin degrading enzyme, which would also lead to an accumulation of Abeta amyloid...- The effects of a high-fat, high-fructose, and combination diet on learning, weight, and glucose regulation in C57BL/6 miceClaude Messier
School of Psychology, University of Ottawa, 11 Marie Curie, Room 215, Ottawa, Ont, Canada K1N 6N5
Behav Brain Res 178:139-45. 2007..The present experiment confirm the deleterious impact of high-fat diets on glucose regulation and weight but suggest that high-fructose diets, contrary to what has been observed in hamsters, do not have the same effect... - Glucose regulation and brain agingC Messier
School of Psychology, University of Ottawa, Vanier Room 215, Ottawa, Ontario, K1N 6N5, Canada
J Nutr Health Aging 4:208-13. 2000..Finally, the dysfunction of glucoregulatory mechanisms may be an important intervening factor when studying the evolution of cognitive function through the aging process... - Effect of age and glucoregulation on cognitive performanceClaude Messier
School of Psychology, University of Ottawa, Ottawa, Ontario, Canada
J Clin Exp Neuropsychol 32:809-21. 2010..These results suggest that cognitive functions may be impaired before glucoregulatory impairment reaches levels consistent with a type 2 diabetes diagnosis... - Diabetes, Alzheimer's disease and apolipoprotein genotypeClaude Messier
School of Psychology, University of Ottawa, 145 Jean Jacques Lussier Room 352, Ottawa, Ont, Canada KIN 6N5
Exp Gerontol 38:941-6. 2003..In people with other risk factors such as ApoE4 allele, diabetes appears to lead to a more dramatic increase in Alzheimer's disease pathology... - Object recognition in mice: improvement of memory by glucoseC Messier
School of Psychology, University of Ottawa, Ontario, Canada
Neurobiol Learn Mem 67:172-5. 1997.... - Dose-dependent action of glucose on memory processes in women: effect on serial position and recall priorityC Messier
School of Psychology University of Ottawa, Vanier 215, Ottawa, Ontario, Canada
Brain Res Cogn Brain Res 7:221-33. 1998..Cholinergic drugs have been shown to alter the recall of the primacy part of word lists and this observation is consistent with the hypothesis that glucose acts on memory through an interaction with brain cholinergic systems... - The absence of effect of glucose on memory is associated with low susceptibility to the amnestic effects of scopolamine in a strain of miceC Messier
School of Psychology, University of Ottawa, Ontario, Canada
Behav Brain Res 96:47-57. 1998..The comparison of these two strains could be the basis for a useful animal model to investigate the relationship between age-related changes in memory and central cholinergic function... - Contribution of cholinergic and gabaergic functions to memory processes in BALB/cANnCrlBR miceC Messier
School of Psychology, University of Ottawa, Vanier Room 215, Ottawa, Ontario, K1N 6N5, Canada
Brain Res 818:583-92. 1999..Results are discussed relative to possible altered septo-hippocampal cholinergic neurotransmission in BALB/cANnCrlBR mice... - Effect of glucose, glucose regulation, and word imagery value on human memoryC Messier
School of Psychology, University of Ottawa, Ontario, Canada
Behav Neurosci 113:431-8. 1999..This study supports the hypothesis that poor glucoregulation is associated with poor memory performance even in young healthy participants and that the ingestion of glucose can improve their memory... - Concurrent modulation of anxiety and memoryP M Wall
School of Psychology, University of Ottawa, Vanier Room 215, Ottawa, Canada
Behav Brain Res 109:229-41. 2000..These results also support the hypothesis that immediate memory processing may modulate the induction of anxiety-related behaviours... - Infralimbic muscarinic M1 receptors modulate anxiety-like behaviour and spontaneous working memory in miceP M Wall
School of Psychology, Behavioural Neuroscience, University of Ottawa, Ottawa, Ontario, Canada K1N 6N5
Psychopharmacology (Berl) 155:58-68. 2001..Spontaneous working memory and anxiety-like behaviour can be concurrently influenced following kappa 1 opioid agonist or antagonist infusions in the infralimbic (IL) area of the ventromedial prefrontal cortex (vmPFC) in CD-1 mice... - U-69,593 microinjection in the infralimbic cortex reduces anxiety and enhances spontaneous alternation memory in miceP M Wall
School of Psychology, University of Ottawa, Vanier Room 215, Ottawa, Canada
Brain Res 856:259-80. 2000.... - The relationship between impaired glucose tolerance, type 2 diabetes, and cognitive functionNesrine Awad
School of Psychology, University of Ottawa, Ottawa, Ontario, Canada
J Clin Exp Neuropsychol 26:1044-80. 2004..In older adults (70 years and over), diabetes likely interacts with other dementing processes such as vascular disease and Alzheimer's disease to hasten cognitive decline... - Glucose regulation and cognitive functions: relation to Alzheimer's disease and diabetesC Messier
School of Psychology, University of Ottawa, Ontario, Canada
Behav Brain Res 75:1-11. 1996..Finally, if such a relationship is observed, the next logical step would be to determine whether AD patients could benefit from treatments aimed at normalizing blood glucose regulation and improving insulin sensitivity... - Glucose and glucoregulatory modulation of memory scanning, event-related potentials and EEG in elderly subjectsV Knott
Department of Psychiatry and Psychology, University of Ottawa Royal Ottawa Hospital and Institute of Mental Health Research, Ottawa, Ont, Canada
Neuropsychobiology 44:156-66. 2001..The study results suggest that peripheral glucoregulation can influence neuroelectric measures of cognition and that the acute ingestion of glucose can modulate central arousal processes... - The hippocampal formation--orbitomedial prefrontal cortex circuit in the attentional control of active memoryP M Wall
School of Psychology, Behavioral Neuroscience, University of Ottawa, Vanier Room 202 INTRA 108, Ottawa, Ontario, Canada K1N 6N5
Behav Brain Res 127:99-117. 2001.... - Ethological confirmatory factor analysis of anxiety-like behaviour in the murine elevated plus-mazeP M Wall
School of Psychology, Behavioural Neuroscience, University of Ottawa, Vanier Room 202, K1N 6N5, Ottawa, Ont, Canada
Behav Brain Res 114:199-212. 2000..Taken together, a reduction in the growing number of behavioural indices reported in elevated plus-maze pharmacological studies is suggested... - Food restriction induces long-lasting recovery of spatial memory deficits following global ischemia in delayed matching and non-matching-to-sample radial arm maze tasksM C Roberge
University of Ottawa, School of Psychology, 11, Marie Curie, Vanier Building Room 204, Ottawa, ON, Canada K1N 9A4
Neuroscience 156:11-29. 2008.... - Longitudinal evaluation of memory performance and peripheral neuropathy in the Ins2C96Y Akita miceCosette Choeiri
School of Psychology, University of Ottawa, 11 Marie Curie, Room 215, Ottawa, Ont, Canada KIN 6N5
Behav Brain Res 157:31-8. 2005..We found that, up to the age of 34 weeks old, uncontrolled hyperglycemia produced peripheral neuropathy and reduced hippocampal GLUT3 levels in the absence of any effect on spatial memory processing... - Effect of age and glucoregulation on cognitive performanceClaude Messier
School of Psychology, University of Ottawa, 145 Jean-Jacques Lussier Room 352, Ont, K1N 6N5, Ottawa, Canada
Neurobiol Aging 24:985-1003. 2003..These results suggest that cognitive functions may be impaired before glucoregulatory impairment reaches levels consistent with a type II diabetes diagnosis... - Impact of peripheral glucoregulation on memoryNesrine Awad
School of Psychology, University of Ottawa, Ontario, Canada
Behav Neurosci 116:691-702. 2002..Results suggest that poor peripheral glucoregulation has an impact on central nervous system functions... - Glucose transporter plasticity during memory processingC Choeiri
School of Psychology, University of Ottawa, 11 Marie Curie, Room 215, Ottawa, Ontario, Canada K1N 6N5
Neuroscience 130:591-600. 2005..The learning-induced localized increases in GLUT1 protein as well as mRNA levels observed in the present study confirm the previous findings that GLUT1 expression is plastic and respond to changes in cellular metabolic demands... - A comparative study of the performance of individuals with fragile X syndrome and Fmr1 knockout mice on Hebb-Williams mazesL S MacLeod
School of Psychology, University of Ottawa, Ottawa, Ontario, Canada
Genes Brain Behav 9:53-64. 2010..The implications of these data are discussed including the notion that Hebb-Williams mazes may represent a useful tool to examine the impact of pharmacological interventions on mitigating or reversing the symptoms associated with FXS... - Methodological and conceptual issues in the use of the elevated plus-maze as a psychological measurement instrument of animal anxiety-like behaviorP M Wall
School of Psychology, Behavioral Neuroscience, University of Ottawa, Vanier Room 202, Ottawa, Ontario, K1N 6N5, Canada
Neurosci Biobehav Rev 25:275-86. 2001.... - Neurobehavioral effect of chronic and bolus doses of methylmercury following prenatal exposure in C57BL/6 weanling miceJacky Liang
School of Psychology, University of Ottawa, 200 Lees, Building E, 2nd Floor, Room 260 J, Ottawa, ON, Canada K1N 6N5
Neurotoxicol Teratol 31:372-81. 2009..Alternatively, bolus MeHg could have had a larger impact if administered on different gestation days when some neural development processes are more sensitive to MeHg... - Comparing the Rey and Taylor complex figures: a test-retest study in young and older adultsMichele Gagnon
Institute of Mental Health Research, University of Ottawa, Ottawa, Ont, Canada
J Clin Exp Neuropsychol 25:878-90. 2003..The present findings reveal the importance of test order and provide equations that can be used to facilitate the comparison of scores derived from the two figures in test-retest situations... - Immunohistochemical localization and quantification of glucose transporters in the mouse brainC Choeiri
School of Psychology, University of Ottawa, Vanier Building, Room 202, Ottawa, ON, Canada K1N 6N5
Neuroscience 111:19-34. 2002..We conclude that the cellular and regional distributions of the glucose transporters in the rodent brain seem to be relevant to their corresponding functions... - Food restriction attenuates ischemia-induced spatial learning and memory deficits despite extensive CA1 ischemic injuryMarie Claude Roberge
School of Psychology, 11, Marie Curie, Vanier 204, Ottawa, ON K1N 9A9, Canada
Behav Brain Res 187:123-32. 2008..The relative sparing of spatial memory performance in food-restricted ischemic animals suggests that food restriction facilitates functional recovery... - Neuroprotection and functional recovery conferred by administration of kappa- and delta 1-opioid agonists in a rat model of global ischemiaCharlaine Charron
University of Ottawa, School of Psychology, Ottawa, ON, Canada K1N 9A9
Physiol Behav 93:502-11. 2008..Similar to U50,488H, DPDPE had no significant impact on locomotor activity. These findings support a role for kappa- and delta-opioid receptors in attenuation of ischemia-induced hippocampal damage and cognitive impairments... - Explicit and objective scoring criteria for the taylor complex figure testNesrine Awad
School of Psychology, University of Ottawa, 145 Jean-Jacques Lussier, Ottawa, Ont, Canada K1N 6N5 6N5
J Clin Exp Neuropsychol 26:405-15. 2004..The present study also reveals the limitations of the use of the Taylor and the Rey in test-retest situations but suggests that administering the Taylor first would improve the comparability of the two figures in a test-retest situation... - Addressing the differences in speed of processing of the intervening calculation task on the modified Brown-Peterson taskMaria Tsiakas
School of Psychology, University of Ottawa, Ontario, Canada
Appl Neuropsychol 11:103-6. 2004..This observation suggests that the results on this test are independent of mathematical ability and represent a useful measure of working memory... - Exploratory factor analysis of neuropsychological tests and their relationship to the Brown-Peterson taskValérie B Mertens
School of Psychology, University of Ottawa, 145 Jean Jacques Lussier, Room 352, Ottawa, Ont, Canada K1N 6N5
Arch Clin Neuropsychol 21:733-9. 2006..Results suggest that the performance after the intervening serial subtraction task evaluates dual information processing, complex attention, and working memory... - Infralimbic kappa opioid and muscarinic M1 receptor interactions in the concurrent modulation of anxiety and memoryPhilip M Wall
Department of Psychology, University of Hawaii at Manoa, 2430 Campus Road, Honolulu, HI 96822, USA
Psychopharmacology (Berl) 160:233-44. 2002..These data prompted us to evaluate the effects of simultaneous IL norBNI/pirenzepine infusions on anxiety and spontaneous working memory...