Z Merali

Summary

Affiliation: University of Ottawa
Country: Canada

Publications

  1. ncbi request reprint Role of bombesin-related peptides in the control of food intake
    Z Merali
    School of Psychology, University of Ottawa, Ottawa, Ontario, K1N 6N5
    Neuropeptides 33:376-86. 1999
  2. doi request reprint Long-term behavioral effects of neonatal blockade of gastrin-releasing peptide receptors in rats: Similarities to autism spectrum disorders
    Z Merali
    School of Psychology, University of Ottawa, Ottawa, ON K1N 6N5, Canada Department of Psychiatry, University of Ottawa, Ottawa, ON K1N 6N5, Canada Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON K1N 6N5, Canada University of Ottawa, Institute of Mental Health Research, Ottawa, ON, K1Z 7K4, Canada Electronic address
    Behav Brain Res 263:60-9. 2014
  3. doi request reprint Activation of gastrin-releasing peptide receptors at the infralimbic cortex elicits gastrin-releasing peptide release at the basolateral amygdala: implications for conditioned fear
    Z Merali
    School of Psychology, University of Ottawa, Ottawa, Ontario, Canada K1N 6N5
    Neuroscience 243:97-103. 2013
  4. ncbi request reprint Anticipatory cues differentially provoke in vivo peptidergic and monoaminergic release at the medial prefrontal cortex
    Zul Merali
    School of Psychology, University of Ottawa, Ottawa, Ontario, Canada
    Neuropsychopharmacology 29:1409-18. 2004
  5. doi request reprint Impact of repeated stressor exposure on the release of corticotropin-releasing hormone, arginine-vasopressin and bombesin-like peptides at the anterior pituitary
    Z Merali
    University of Ottawa, Department of Psychology, Ottawa, Ontario, K1N 6N5, Canada
    Behav Brain Res 198:105-12. 2009
  6. doi request reprint Effects of intracerebral ventricular administration of gastrin-releasing peptide and its receptor antagonist RC-3095 on learned fear responses in the rat
    Zul Merali
    Department of Psychology, University of Ottawa, Ottawa, ON, Canada K1N 6N5
    Behav Brain Res 216:519-24. 2011
  7. ncbi request reprint Differential impact of predator or immobilization stressors on central corticotropin-releasing hormone and bombesin-like peptides in Fast and Slow seizing rat
    Z Merali
    School of Psychology, University of Ottawa, 11 Marie Curie, Ottawa, ON, Canada K1N 6N5
    Brain Res 906:60-73. 2001
  8. doi request reprint Nesfatin-1 increases anxiety- and fear-related behaviors in the rat
    Z Merali
    Department of Psychology, University of Ottawa, Ottawa, ON, Canada
    Psychopharmacology (Berl) 201:115-23. 2008
  9. ncbi request reprint Bombesin receptors as a novel anti-anxiety therapeutic target: BB1 receptor actions on anxiety through alterations of serotonin activity
    Zul Merali
    Institute of Mental Health Research and Department of Psychiatry, School of Psychology, University of Ottawa, Ottawa, Ontario, Canada K1N 6N5
    J Neurosci 26:10387-96. 2006
  10. ncbi request reprint Corticotropin-releasing hormone, arginine vasopressin, gastrin-releasing peptide, and neuromedin B alterations in stress-relevant brain regions of suicides and control subjects
    Zul Merali
    Institute of Mental Health Research, University of Ottawa, Ontario, Canada
    Biol Psychiatry 59:594-602. 2006

Collaborators

Detail Information

Publications72

  1. ncbi request reprint Role of bombesin-related peptides in the control of food intake
    Z Merali
    School of Psychology, University of Ottawa, Ottawa, Ontario, K1N 6N5
    Neuropeptides 33:376-86. 1999
    ..Hence, pharmacological targeting of these systems may be of therapeutic value...
  2. doi request reprint Long-term behavioral effects of neonatal blockade of gastrin-releasing peptide receptors in rats: Similarities to autism spectrum disorders
    Z Merali
    School of Psychology, University of Ottawa, Ottawa, ON K1N 6N5, Canada Department of Psychiatry, University of Ottawa, Ottawa, ON K1N 6N5, Canada Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON K1N 6N5, Canada University of Ottawa, Institute of Mental Health Research, Ottawa, ON, K1Z 7K4, Canada Electronic address
    Behav Brain Res 263:60-9. 2014
    ....
  3. doi request reprint Activation of gastrin-releasing peptide receptors at the infralimbic cortex elicits gastrin-releasing peptide release at the basolateral amygdala: implications for conditioned fear
    Z Merali
    School of Psychology, University of Ottawa, Ottawa, Ontario, Canada K1N 6N5
    Neuroscience 243:97-103. 2013
    ..Together these findings provide further evidence for the involvement of GRP in fear and anxiety-related disorders...
  4. ncbi request reprint Anticipatory cues differentially provoke in vivo peptidergic and monoaminergic release at the medial prefrontal cortex
    Zul Merali
    School of Psychology, University of Ottawa, Ottawa, Ontario, Canada
    Neuropsychopharmacology 29:1409-18. 2004
    ..The activity of DA and 5-HT neurons, in contrast, is more closely aligned with the cognitive appraisal of predictor stimuli...
  5. doi request reprint Impact of repeated stressor exposure on the release of corticotropin-releasing hormone, arginine-vasopressin and bombesin-like peptides at the anterior pituitary
    Z Merali
    University of Ottawa, Department of Psychology, Ottawa, Ontario, K1N 6N5, Canada
    Behav Brain Res 198:105-12. 2009
    ....
  6. doi request reprint Effects of intracerebral ventricular administration of gastrin-releasing peptide and its receptor antagonist RC-3095 on learned fear responses in the rat
    Zul Merali
    Department of Psychology, University of Ottawa, Ottawa, ON, Canada K1N 6N5
    Behav Brain Res 216:519-24. 2011
    ..0 nmol) significantly increased the basal startle amplitude without affecting fear-potentiation, suggesting elevated fear at the onset of testing. These data provide further evidence that GRP is involved in conditioned fear responses...
  7. ncbi request reprint Differential impact of predator or immobilization stressors on central corticotropin-releasing hormone and bombesin-like peptides in Fast and Slow seizing rat
    Z Merali
    School of Psychology, University of Ottawa, 11 Marie Curie, Ottawa, ON, Canada K1N 6N5
    Brain Res 906:60-73. 2001
    ..Taken together, the results demonstrate that these two lines of rats show differential endocrinological and neurochemical response patterns to these stressors...
  8. doi request reprint Nesfatin-1 increases anxiety- and fear-related behaviors in the rat
    Z Merali
    Department of Psychology, University of Ottawa, Ottawa, ON, Canada
    Psychopharmacology (Berl) 201:115-23. 2008
    ..However, the relation between nesfatin-1 and stressor-related behaviors like anxiety and/or fear has not yet been investigated...
  9. ncbi request reprint Bombesin receptors as a novel anti-anxiety therapeutic target: BB1 receptor actions on anxiety through alterations of serotonin activity
    Zul Merali
    Institute of Mental Health Research and Department of Psychiatry, School of Psychology, University of Ottawa, Ottawa, Ontario, Canada K1N 6N5
    J Neurosci 26:10387-96. 2006
    ..The finding that this action was attenuated by BB receptor (BB1 and/or BB2) antagonists suggests that these compounds may represent a novel class of anxiolytic agents...
  10. ncbi request reprint Corticotropin-releasing hormone, arginine vasopressin, gastrin-releasing peptide, and neuromedin B alterations in stress-relevant brain regions of suicides and control subjects
    Zul Merali
    Institute of Mental Health Research, University of Ottawa, Ontario, Canada
    Biol Psychiatry 59:594-602. 2006
    ..Postmortem levels of several stress- and depression-relevant neuropeptides were assessed in brain regions of depressed suicides relative to control subjects that had died of other causes...
  11. doi request reprint Effects of corticosterone on corticotrophin-releasing hormone and gastrin-releasing peptide release in response to an aversive stimulus in two regions of the forebrain (central nucleus of the amygdala and prefrontal cortex)
    Zul Merali
    Department of Psychology, University of Ottawa, Ottawa, Canada
    Eur J Neurosci 28:165-72. 2008
    ....
  12. ncbi request reprint Does amygdaloid corticotropin-releasing hormone (CRH) mediate anxiety-like behaviors? Dissociation of anxiogenic effects and CRH release
    Z Merali
    Institute of Mental Health Research, University of Ottawa, Ottawa, Ontario, Canada K1N 6 N5
    Eur J Neurosci 20:229-39. 2004
    ..Rather than provoking anxiety, these systems might serve to draw attention to events or cues of biological significance, including those posing a threat to survival...
  13. ncbi request reprint Differential involvement of amygdaloid CRH system(s) in the salience and valence of the stimuli
    Zul Merali
    Institute of Mental Health Research, Royal Ottawa Hospital, University of Ottawa, 1145 Carling Avenue, K1Z 7K4, Ottawa, ON, Canada
    Prog Neuropsychopharmacol Biol Psychiatry 27:1201-12. 2003
    ..We suggest that the CRH responses at the CeA may be involved in a preparatory capacity and, as such, may accompany a range of emotionally significant stimuli, be they appetitive or aversive...
  14. ncbi request reprint Aversive and appetitive events evoke the release of corticotropin-releasing hormone and bombesin-like peptides at the central nucleus of the amygdala
    Z Merali
    School of Psychology, University of Ottawa, Ottawa, Ontario, Canada K1N 6N5
    J Neurosci 18:4758-66. 1998
    ..Rather than evoking feelings of fear and anxiety, these systems may serve to draw attention to events or cues of biological significance, such as those associated with food availability as well as those posing a threat to survival...
  15. ncbi request reprint Effects of interleukin-1beta and mild stress on alterations of norepinephrine, dopamine and serotonin neurotransmission: a regional microdialysis study
    Z Merali
    School of Psychology, University of Ottawa, Ont, Canada
    Brain Res 761:225-35. 1997
    ..These data also lend support to the contention that neurogenic stressors may have a much greater impact on central neurotransmission under conditions of immune activation...
  16. ncbi request reprint Pharmaco-ontogenic modulation of feeding by oxytocin, bombesin, and their antagonists
    Z Merali
    School of Psychology, University of Ottawa, Ontario, Canada
    Peptides 17:1119-26. 1996
    ..These results suggest that pharmacological effects to OX and BN are apparent from hours after birth and that these peptides may play a role in the regulation of ingestive behavior from early on in ontogeny...
  17. ncbi request reprint Stressor-induced corticotropin-releasing hormone, bombesin, ACTH and corticosterone variations in strains of mice differentially responsive to stressors
    H Anisman
    Institute of Neurosciences, Carleton University, Ottawa, Ontario
    Stress 2:209-20. 1998
    ....
  18. doi request reprint Plasticity of the GABA(A) receptor subunit cassette in response to stressors in reactive versus resilient mice
    M O Poulter
    Molecular Brain Research Group, Robarts Research Institute, Department of Physiology and Pharmacology, University of Western Ontario, London, ON, Canada
    Neuroscience 165:1039-51. 2010
    ..These findings support the view that analyses involving subunit organization, rather than just differences in absolute levels, may be expedient in assessing GABA(A) functioning in stressor-related psychological disturbances...
  19. ncbi request reprint Acoustic startle and fear-potentiated startle in rats selectively bred for fast and slow kindling rates: relation to monoamine activity
    H Anisman
    Institute of Neuroscience, Carleton University, Ottawa, Ontario K1S 5B6, Canada
    Eur J Neurosci 12:4405-16. 2000
    ..This suggested that relative to Slow rats, dopamine neurons in prefrontal cortex of Fast rats do not react normally to environmental stimuli, and this phenomenon could lead to disturbances of attention or impulsivity...
  20. ncbi request reprint Psychogenic, neurogenic, and systemic stressor effects on plasma corticosterone and behavior: mouse strain-dependent outcomes
    H Anisman
    Institute of Neuroscience, Carleton University, Ottawa, Ontario, Canada
    Behav Neurosci 115:443-54. 2001
    ..It appears that whereas stressor reactivity and adrenal glucocorticoid release may be exaggerated in BALB/cByJ mice, such effects may be dependent on the specific characteristic of the stressor situation...
  21. ncbi request reprint Central bombesin activates the hypothalamic-pituitary-adrenal axis. Effects on regional levels and release of corticotropin-releasing hormone and arginine-vasopressin
    P Kent
    School of Psychology, University of Ottawa, Ottawa, Ontario, K1N 6N5, Canada
    Neuroendocrinology 73:203-14. 2001
    ....
  22. ncbi request reprint Influence of psychogenic and neurogenic stressors on neuroendocrine and central monoamine activity in fast and slow kindling rats
    D C McIntyre
    Institute of Neuroscience, Carleton University, Ottawa, Ontario, Canada
    Brain Res 840:65-74. 1999
    ..Similarly, DA alterations also were greater in the left medial amygdala in response to stressors. Despite very different behavioral styles, however, the two lines often exhibited similar amine alterations in response to both stressors...
  23. ncbi request reprint Central monoamine and plasma corticosterone changes induced by a bacterial endotoxin: sensitization and cross-sensitization effects
    S Hayley
    Institute of Neuroscience, Carleton University, Ottawa, Ontario K1S 5B6, Canada
    Eur J Neurosci 13:1155-65. 2001
    ....
  24. ncbi request reprint Time-dependent sensitization of corticotropin-releasing hormone, arginine vasopressin and c-fos immunoreactivity within the mouse brain in response to tumor necrosis factor-alpha
    S Hayley
    Institute of Neuroscience, Life Science Research Building, Carleton University, 1125 Colonel By Drive, Ottawa, Ontario, Canada K1S 5B6
    Neuroscience 106:137-48. 2001
    ..It is suggested that such a sensitization may influence the response to immunological and traumatic insults and may thus be relevant to behavioral pathology...
  25. ncbi request reprint Endocrine and cytokine correlates of major depression and dysthymia with typical or atypical features
    H Anisman
    Institute of Neurosciences, Carleton University, Ottawa, Ontario, Canada
    Mol Psychiatry 4:182-8. 1999
    ..Given that circulating cytokines influence neuroendocrine functioning, and may affect neurovegetative features, a role for interleukins may exist with respect to the pathophysiology of certain subtypes of depression...
  26. ncbi request reprint Bombesin-induced HPA and sympathetic activation requires CRH receptors
    P Kent
    School of Psychology, University of Ottawa, 11 Marie Curie, Ottawa, Ontario, Canada
    Peptides 22:57-65. 2001
    ..These findings support the notion that BN-induced HPA axis and sympathetic activation are mediated, at least in part, via activation of CRH neurons...
  27. ncbi request reprint Role of bombesin-related peptides in the mediation or integration of the stress response
    Z Merali
    School of Psychology, University of Ottawa, Ontario, Canada
    Cell Mol Life Sci 59:272-87. 2002
    ..Several hypothetical mechanisms for such peptidergic interactions are discussed as to the implications of considering BN-LPs as 'stress peptides'...
  28. ncbi request reprint Do early-life events permanently alter behavioral and hormonal responses to stressors?
    H Anisman
    Institute of Neuroscience, Carleton University, Ottawa, Ontario, Canada
    Int J Dev Neurosci 16:149-64. 1998
    ..In contrast, in relatively hardy animals the early-life manipulations may have less obvious effects...
  29. ncbi request reprint Influence of psychosocial, psychogenic and neurogenic stressors on several aspects of immune functioning in mice
    Z W Lu
    Institute of Neuroscience, Carleton University, Ottawa, Ontario, Canada
    Stress 3:55-70. 1999
    ..It is suggested that analysis of stressor effects need to consider in greater detail the characteristics of the organism being stressed, as well as the characteristics of the stressor itself...
  30. ncbi request reprint Rodent models of depression: learned helplessness induced in mice
    H Anisman
    Carleton University, Ottawa, Ontario, Canada
    Curr Protoc Neurosci . 2001
    ..This unit describes the procedure used to assess the effects of controllable and uncontrollable shock on subsequent shock escape performance in mice using an escape-delay procedure...
  31. ncbi request reprint Individual differences in sucrose consumption in the rat: motivational and neurochemical correlates of hedonia
    K Brennan
    Institute of Neuroscience, Carleton University, School of Psychology, University of Ottawa, Ottawa, Ontario, Canada
    Psychopharmacology (Berl) 157:269-76. 2001
    ....
  32. ncbi request reprint Phytochemical and biological analysis of skullcap (Scutellaria lateriflora L.): a medicinal plant with anxiolytic properties
    R Awad
    Ottawa Carleton Institute of Biology, University of Ottawa, Ottawa, Canada
    Phytomedicine 10:640-9. 2003
    ..These compounds may play a role in anxiolytic activity since baicalin and baicalein are known to bind to the benzodiazepine site of the GABAA receptor and since GABA is the main inhibitory neurotransmitter...
  33. ncbi request reprint Evaluation of anxiolytic properties of Gotukola--(Centella asiatica) extracts and asiaticoside in rat behavioral models
    P Wijeweera
    Ottawa Carleton Institute of Biology, University of Ottawa Institute of Mental Health Research, Royal Ottawa Hospital, Canada
    Phytomedicine 13:668-76. 2006
    ..Furthermore, the asiaticoside did not affect locomotor activity, suggesting these compounds do not have sedative effects in rodents...
  34. ncbi request reprint Effects of traditionally used anxiolytic botanicals on enzymes of the gamma-aminobutyric acid (GABA) system
    R Awad
    Ottawa Carleton Institute of Biology, University of Ottawa, Ottawa, ON K1N6N5, Canada
    Can J Physiol Pharmacol 85:933-42. 2007
    ..11-0.65 mg/mL). Several of these species may therefore warrant further pharmacological investigation. The relation between enzyme activity and possible in vivo mode of action is discussed...
  35. ncbi request reprint Effects of central neuromedin B and related peptides on blood glucose
    H Plamondon
    School of Psychology, University of Ottawa, Canada
    Regul Pept 47:133-40. 1993
    ..31 nM) NB analogues elevate blood glucose with a lower efficacy than Bn (Bn > NB-32 > NB-10 > or = NAcNB-10). NB-32 appears more potent and efficacious than the other NB congeners used.(ABSTRACT TRUNCATED AT 250 WORDS)..
  36. ncbi request reprint Further evidence for the depressive effects of cytokines: anhedonia and neurochemical changes
    Hymie Anisman
    Institute of Neuroscience, Life Science Research Building, Carleton University, Ottawa, ON, Canada
    Brain Behav Immun 16:544-56. 2002
    ....
  37. ncbi request reprint Maternal factors and monoamine changes in stress-resilient and susceptible mice: cross-fostering effects
    Priya Prakash
    Institute of Neuroscience, Carleton University, Life Science Research Bldg, Ottawa, Ontario, Canada
    Brain Res 1111:122-33. 2006
    ..Although monoamine variations were largely determined by genetic factors, maternal influences contributed to stressor-elicited neurochemical changes in some regions, particularly dopamine activation within the prefrontal cortex...
  38. ncbi request reprint Role of gastrin-releasing peptide and neuromedin B in anxiety and fear-related behavior
    Tania Bedard
    University of Ottawa, Department of Psychology, Ottawa, Ontario, Canada K1N 6N5
    Behav Brain Res 179:133-40. 2007
    ..These data suggest that NMB and GRP do affect the stress response. However, whereas NMB manipulations affected both anxiety and fear responses, GRP alterations selectively affected fear-related responses...
  39. ncbi request reprint Neurochemical sensitization associated with systemic administration of tumor necrosis factor-alpha: adjuvant action in combination with bovine serum albumin
    Hymie Anisman
    Institute of Neuroscience, Carleton University, Ottawa, Ontario, Canada K1S 5B6
    J Neuroimmunol 145:91-102. 2003
    ..It is suggested that mTNF-alpha acts as an adjuvant to the anaphylactic actions elicited by BSA, but may provoke a sensitization of monoamine activity which is time-dependent and varies across brain regions...
  40. ncbi request reprint The effects of chronic mild stress on male Sprague-Dawley and Long Evans rats: I. Biochemical and physiological analyses
    C Bielajew
    School of Psychology, University of Ottawa, 11 Marie Curie, Ottowa, ON, Canada K1N 6N5
    Behav Brain Res 136:583-92. 2002
    ..Physiological indices however are less influenced by this experience, at least when the exposure is limited to 3 weeks...
  41. ncbi request reprint The pathogenesis of clinical depression: stressor- and cytokine-induced alterations of neuroplasticity
    S Hayley
    Institute of Neuroscience, Carleton University, 1125 Colonel By Drive, Ottawa, Ontario, Canada K1S 5B6
    Neuroscience 135:659-78. 2005
    ..Thus, depressive illness may be considered a disorder of neuroplasticity as well as one of neurochemical imbalances, and cytokines may act as mediators of both aspects of this illness...
  42. ncbi request reprint Differential impact of audiogenic stressors on Lewis and Fischer rats: behavioral, neurochemical, and endocrine variations
    David S Michaud
    Consumer and Clinical Radiation Protection Bureau, Health Canada, Ottawa, Ontario, Canada
    Neuropsychopharmacology 28:1068-81. 2003
    ..Behaviorally, the Fischer rats displayed an active stress response, whereas the Lewis strain adopted freezing as a defensive style. The role of CRH in the genesis of the overall strain-dependent response to stressors is discussed...
  43. ncbi request reprint Anxiety in rats selectively bred for Fast and Slow kindling rates: situation-specific outcomes
    Owen P Kelly
    Institute of Neuroscience, Carleton University, Ottawa, Ont, Canada
    Stress 6:289-95. 2003
    ..These data indicate the need to differentiate subtypes of anxiety in animal models, and raise the issue that anxiety elicited by specific environmental triggers may interact with genetically determined trait characteristics...
  44. doi request reprint Functional interactions between dopamine, serotonin and norepinephrine neurons: an in-vivo electrophysiological study in rats with monoaminergic lesions
    Bruno P Guiard
    Institute of Mental Health Research, University of Ottawa, Ottawa, Ontario, Canada
    Int J Neuropsychopharmacol 11:625-39. 2008
    ..Indeed, based on the understanding of such interactions, it may be possible to develop strategies to improve the effectiveness of antidepressant drugs by preventing counter-productive negative feedback actions...
  45. doi request reprint A study of brain and serum brain-derived neurotrophic factor protein in Wistar and Wistar-Kyoto rat strains after electroconvulsive stimulus
    C Kyeremanteng
    Institute of Mental Health Research, University of Ottawa, Ottawa, Ontario, Canada
    Pharmacopsychiatry 45:244-9. 2012
    ..However, animal studies have failed to demonstrate a clear link between BDNF protein in serum and brain tissue...
  46. ncbi request reprint Posttraumatic stress symptoms and salivary cortisol levels
    H Anisman
    Institute of Neuroscience, Carleton University, Ottawa, Ontario, Canada
    Am J Psychiatry 158:1509-11. 2001
    ..This study assessed the relationship between posttraumatic stress symptoms and salivary cortisol levels after a severe ice storm...
  47. ncbi request reprint Validation of a simple, ethologically relevant paradigm for assessing anxiety in mice
    Zul Merali
    Institute of Mental Health Research, Royal Ottawa Hospital, and Department of Cellular and Molecular Medicine, University of Ottawa, Ontario, Canada
    Biol Psychiatry 54:552-65. 2003
    ....
  48. ncbi request reprint Influence of poly I:C on sickness behaviors, plasma cytokines, corticosterone and central monoamine activity: moderation by social stressors
    Reno Gandhi
    Institute of Neuroscience, Carleton University, Ottawa, Ont, Canada K1S 5B6
    Brain Behav Immun 21:477-89. 2007
    ..Mechanisms that might be responsible for the interactive effects of social disruption and immune activation are presented, and the data were related to depressive symptoms associated with stressor and cytokine treatments...
  49. ncbi request reprint Amygdala amino acid and monoamine levels in genetically Fast and Slow kindling rat strains during massed amygdala kindling: a microdialysis study
    Rick S Shin
    Department of Psychology, Life Sciences Research Building, Carleton University, Ottawa, Ontario, K1S 5B6, Canada
    Eur J Neurosci 20:185-94. 2004
    ....
  50. ncbi request reprint The role of gastrin-releasing peptide on conditioned fear: differential cortical and amygdaloid responses in the rat
    Christine Mountney
    School of Psychology, University of Ottawa, Ottawa, ON, Canada
    Psychopharmacology (Berl) 189:287-96. 2006
    ..Bombesin (BB), an amphibian peptide, was shown to affect the expression of the stress response. However, the physiological role of the mammalian counterparts of BB in mediating anxiety and fear responses remain to be characterized...
  51. pmc Serotonin receptor subtype and p11 mRNA expression in stress-relevant brain regions of suicide and control subjects
    Hymie Anisman
    Institute of Neuroscience, Carleton University, Ottawa, ON, Canada
    J Psychiatry Neurosci 33:131-41. 2008
    ..Our objective was to investigate which 5-HT receptor subtypes might be associated with depression and suicide, whether receptor differences vary across brain regions and whether they are moderated by sex...
  52. ncbi request reprint Evaluation of the effects of chronic mild stressors on hedonic and physiological responses: sex and strain compared
    Anne T M Konkle
    School of Psychology, University of Ottawa, Ottawa, Ontario, Canada K1N 6N5
    Brain Res 992:227-38. 2003
    ..The usefulness of sucrose intake or preference as behavioral indices of CMS-induced anhedonia in males and females is modest at best...
  53. doi request reprint GABAA receptor promoter hypermethylation in suicide brain: implications for the involvement of epigenetic processes
    Michael O Poulter
    Molecular Brain Research Group, Robarts Research Institute, Department of Physiology and Pharmacology University of Western Ontario, London, Ontario, Canada
    Biol Psychiatry 64:645-52. 2008
    ..Epigenetic mechanisms may be involved in the reprogramming of gene expression in response to stressful stimuli. This investigation determined whether epigenetic phenomena might similarly be associated with suicide/depression...
  54. doi request reprint Effects of gastrin-releasing peptide agonist and antagonist administered to the basolateral nucleus of the amygdala on conditioned fear in the rat
    Christine Mountney
    School of Psychology, University of Ottawa, Ottawa, Ontario, Canada
    Psychopharmacology (Berl) 200:51-8. 2008
    ..In line with this view, central administration of gastrin-releasing peptide (GRP; a mammalian analogue of BB) or its receptor antagonist (D-Tpi6, Leu13 psi[CH2NH]-Leu14) BB(6-14) (RC-3095) modulates conditioned fear...
  55. ncbi request reprint Corticotropin releasing hormone receptor alterations elicited by acute and chronic unpredictable stressor challenges in stressor-susceptible and resilient strains of mice
    Hymie Anisman
    Institute of Neuroscience, Carleton University, Ottawa, Ontario, Canada
    Behav Brain Res 181:180-90. 2007
    ....
  56. doi request reprint Ethnopharmacology of Q'eqchi' Maya antiepileptic and anxiolytic plants: effects on the GABAergic system
    Rosalie Awad
    Biology Department, University of Ottawa, Ontario, Canada
    J Ethnopharmacol 125:257-64. 2009
    ..The Q'eqchi' Maya possess a large selection of plants to treat neurological disorders, including epilepsy and susto (fright), a culture-bound illness related to anxiety disorders...
  57. ncbi request reprint Dysregulation in the suicide brain: mRNA expression of corticotropin-releasing hormone receptors and GABA(A) receptor subunits in frontal cortical brain region
    Zul Merali
    University of Ottawa Institute of Mental Health Research, University of Ottawa, Ottawa, Ontario K1N 6N5, Canada
    J Neurosci 24:1478-85. 2004
    ....
  58. ncbi request reprint Effects of acute or chronic omega-3 and omega-6 polyunsaturated fatty acid treatment on behavioral, neuroendocrine and cytokine changes elicited by exogenous interleukin-1beta challenge
    Maia Miguelez
    Institute of Neuroscience, University of Carleton, Neuroscience Building, Rm 333, Ottawa, Ontario, Canada K1S 5B6
    J Neuroimmunol 181:19-28. 2006
    ....
  59. ncbi request reprint Cytokines as a stressor: implications for depressive illness
    Hymie Anisman
    Institute of Neuroscience, Carleton University, Ottawa, Ontario, Canada
    Int J Neuropsychopharmacol 5:357-73. 2002
    ..Given that the effects of cytokines are evident within hypothalamic, as well as extrahypothalamic sites, including various limbic regions, it is suggested that cytokines may impact on emotional changes, including depression...
  60. ncbi request reprint Ethnopharmacological investigation of plants used to treat susto, a folk illness
    Natalie Bourbonnais-Spear
    Ottawa Carleton Institute of Biology, University of Ottawa, Ottawa, Ontario, Canada K1N 6N5
    J Ethnopharmacol 109:380-7. 2007
    ..In light of the available literature, this represents the first experimental investigation of the biological activity of plants specifically in the perspective of their use in treating a culture-bound syndrome...
  61. ncbi request reprint Sensitization associated with stressors and cytokine treatments
    Hymie Anisman
    Institute of Neurosciences, Carleton University, Ont, K1S 5B6, Ottawa, Canada
    Brain Behav Immun 17:86-93. 2003
    ..Cytokines may independently prime multiple regulatory systems, and by virtue of the neurochemical changes imparted, have both immediate and proactive influences on the evolution of psychopathology...
  62. ncbi request reprint Changes in extracellular levels of amygdala amino acids in genetically fast and slow kindling rat strains
    Rick S Shin
    Institute of Neuroscience, Department of Psychology, Life Sciences Research Building, Carleton University, 1125 Colonel By Drive, Ottawa, Ontario K1S 5B6, Canada
    Brain Res 946:31-42. 2002
    ....
  63. ncbi request reprint Dissociating anorexia and anhedonia elicited by interleukin-1beta: antidepressant and gender effects on responding for "free chow" and "earned" sucrose intake
    Zul Merali
    Institute of Mental Health Research, Royal Ottawa Hospital, Ottawa, Canada
    Psychopharmacology (Berl) 165:413-8. 2003
    ..Analysis of the behavioral effects of interleukin-1beta (IL-1beta), and their modification by antidepressants, is complicated since the anorexic and anhedonic effects of the cytokine are not readily dissociated from one another...
  64. ncbi request reprint Hypoxia alters the expression of inhibitor of apoptosis proteins after brain trauma in the mouse
    Angelo Mikrogianakis
    Division of Pediatric Emergency Medicine, Department of Pediatrics, The Hospital for Sick Children, Toronto, Ontario, Canada
    J Neurotrauma 24:338-53. 2007
    ..These findings show that IAPs have a potential role in the increased vulnerability of brain cells to hypoxia following TBI, and have implications for configuring future therapies for TBI...
  65. ncbi request reprint Interferon-alpha effects are exaggerated when administered on a psychosocial stressor backdrop: cytokine, corticosterone and brain monoamine variations
    Hymie Anisman
    Institute of Neuroscience, Carleton University, Ontario, Canada K1S 5B6
    J Neuroimmunol 186:45-53. 2007
    ..It is suggested that the depressive effects of immunotherapy in humans likewise reflects the synergistic actions of the cytokine and the ongoing distress experienced by patients...
  66. ncbi request reprint Inhibition of calpains prevents neuronal and behavioral deficits in an MPTP mouse model of Parkinson's disease
    Stephen J Crocker
    Neuroscience Research Group, Ottawa Health Research Institute, Canada
    J Neurosci 23:4081-91. 2003
    ..Taken together, our findings provide a potentially novel correlation between calpain proteolytic activity in an MPTP model of PD and the etiology of neuronal loss in PD in humans...
  67. ncbi request reprint Bombesin-like peptides and associated receptors within the brain: distribution and behavioral implications
    Terry W Moody
    CCR, National Cancer Institute Office of the Director, National Institutes of Health, Department of Health and Human Services, Room 3A34, Building 31, 31 Center Drive, Bethesda, MD 20892, USA
    Peptides 25:511-20. 2004
    ..GRP and NMB modulate distinct biological processes through discrete brain regions or circuits, and globally these peptidergic systems may serve in an integrative or homeostatic function...
  68. ncbi request reprint Therapeutic and protective effect of environmental enrichment against psychogenic and neurogenic stress
    Cosette Fox
    Wright Patterson Air Force Base WPAFB, AFRL HEPA Branch, 2800 Q Street, Building 824, OH 45433 7022, United States
    Behav Brain Res 175:1-8. 2006
    ....
  69. doi request reprint Experiential and genetic contributions to depressive- and anxiety-like disorders: clinical and experimental studies
    Hymie Anisman
    Institute of Neuroscience, Carleton University, Ottawa, Ontario K1S 5B6, Canada
    Neurosci Biobehav Rev 32:1185-206. 2008
    ..It is suggested that depression is a life-long disorder, which even after effective treatment, has a high rate of re-occurrence owing to sensitized processes or epigenetic factors that promote persistent alterations of gene expression...
  70. pmc Effects of short-term administration of valproate on serotonin-1A and dopamine receptor function in healthy human subjects
    Nicholas J Delva
    Departments of Psychiatry and Physiology, Queen s University, Providence Continuing Care Centre, Mental Health Services, Kingston, ON
    J Psychiatry Neurosci 27:429-37. 2002
    ..To examine the effects of short-term valproate treatment on human brain serotonin and dopamine function by means of challenge tests with ipsapirone, a partial agonist at 5-HT1A receptors, and apomorphine, a dopamine receptor agonist...
  71. ncbi request reprint Stress and cytokine-elicited neuroendocrine and neurotransmitter sensitization: implications for depressive illness
    Shawn Hayley
    Institute of Neuroscience, Carleton University, Canada
    Stress 6:19-32. 2003
    ..It is suggested that by virtue of these neurochemical changes, cytokines may have both immediate and proactive effects on mood states...
  72. ncbi request reprint Cytokines as a precipitant of depressive illness: animal and human studies
    Hymie Anisman
    Institute of Neuroscience, Carleton University, Ottawa, Ontario K1S 5B6, Canada
    Curr Pharm Des 11:963-72. 2005
    ..Further, the effects of the cytokine treatments may act synergistically with stressors, and cytokines may provoke a sensitization effect so that the effects of later stressor experiences are exacerbated...