Michael Mengel

Summary

Affiliation: University of Alberta
Country: Canada

Publications

  1. pmc Rationale and design of the RIACT-study: a multi-center placebo controlled double blind study to test the efficacy of RItuximab in Acute Cellular tubulointerstitial rejection with B-cell infiltrates in renal Transplant patients: study protocol for a rando
    Lena Schiffer
    Department of Medicine Nephrology, Hannover Medical School, Carl Neuberg Str, 1, Hannover, 30625, Germany
    Trials 13:199. 2012
  2. doi request reprint Banff initiative for quality assurance in transplantation (BIFQUIT): reproducibility of C4d immunohistochemistry in kidney allografts
    M Mengel
    Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Canada
    Am J Transplant 13:1235-45. 2013
  3. doi request reprint Precision diagnostics in transplantation: from bench to bedside
    M Mengel
    Transplant Diagnostics Community of Practice of the American Society of Transplantation, USA
    Am J Transplant 13:562-8. 2013
  4. doi request reprint Phenotypes of antibody-mediated rejection in organ transplants
    Michael Mengel
    Department of Laboratory Medicine and Pathology, Alberta Transplant Applied Genomics Centre, University of Alberta, Edmonton, AB, Canada
    Transpl Int 25:611-22. 2012
  5. pmc Banff 2011 Meeting report: new concepts in antibody-mediated rejection
    M Mengel
    Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB, Canada
    Am J Transplant 12:563-70. 2012
  6. doi request reprint The kidney transplant: new horizons
    Michael Mengel
    Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Alberta, Canada
    Curr Opin Nephrol Hypertens 19:260-5. 2010
  7. ncbi request reprint SWOT analysis of Banff: strengths, weaknesses, opportunities and threats of the international Banff consensus process and classification system for renal allograft pathology
    M Mengel
    Department of Medicine, Division of Nephrology and Immunology, Alberta Transplant Applied Genomics Centre, University of Alberta, Edmonton, Canada
    Am J Transplant 7:2221-6. 2007
  8. doi request reprint Scoring total inflammation is superior to the current Banff inflammation score in predicting outcome and the degree of molecular disturbance in renal allografts
    M Mengel
    Department of Laboratory Medicine and Pathology, Alberta Transplant Applied Genomics Centre, Canada
    Am J Transplant 9:1859-67. 2009
  9. doi request reprint The molecular phenotype of 6-week protocol biopsies from human renal allografts: reflections of prior injury but not future course
    M Mengel
    Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Canada
    Am J Transplant 11:708-18. 2011
  10. pmc Molecular phenotypes of acute kidney injury in kidney transplants
    Konrad S Famulski
    Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Canada
    J Am Soc Nephrol 23:948-58. 2012

Detail Information

Publications50

  1. pmc Rationale and design of the RIACT-study: a multi-center placebo controlled double blind study to test the efficacy of RItuximab in Acute Cellular tubulointerstitial rejection with B-cell infiltrates in renal Transplant patients: study protocol for a rando
    Lena Schiffer
    Department of Medicine Nephrology, Hannover Medical School, Carl Neuberg Str, 1, Hannover, 30625, Germany
    Trials 13:199. 2012
    ..Despite the promise of these observations, solid evidence is required before incorporating this treatment option into a general treatment recommendation...
  2. doi request reprint Banff initiative for quality assurance in transplantation (BIFQUIT): reproducibility of C4d immunohistochemistry in kidney allografts
    M Mengel
    Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Canada
    Am J Transplant 13:1235-45. 2013
    ..Refinement of the current Banff C4d scoring schema and harmonization of tissue processing and staining protocols is necessary to achieve acceptable reproducibility...
  3. doi request reprint Precision diagnostics in transplantation: from bench to bedside
    M Mengel
    Transplant Diagnostics Community of Practice of the American Society of Transplantation, USA
    Am J Transplant 13:562-8. 2013
    ....
  4. doi request reprint Phenotypes of antibody-mediated rejection in organ transplants
    Michael Mengel
    Department of Laboratory Medicine and Pathology, Alberta Transplant Applied Genomics Centre, University of Alberta, Edmonton, AB, Canada
    Transpl Int 25:611-22. 2012
    ..This review summarizes the current diagnostic consensus for ABMR, describes unmet needs and challenges in diagnostics, and proposes new approaches for consideration...
  5. pmc Banff 2011 Meeting report: new concepts in antibody-mediated rejection
    M Mengel
    Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB, Canada
    Am J Transplant 12:563-70. 2012
    ..Results are expected to be presented at the 12th Banff meeting to be held in 2013 in Brazil. No change to the Banff classification occurred in 2011...
  6. doi request reprint The kidney transplant: new horizons
    Michael Mengel
    Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Alberta, Canada
    Curr Opin Nephrol Hypertens 19:260-5. 2010
    ..The purpose of this review is to summarize new diagnostic insights into the identification of specific causes of late allograft failure...
  7. ncbi request reprint SWOT analysis of Banff: strengths, weaknesses, opportunities and threats of the international Banff consensus process and classification system for renal allograft pathology
    M Mengel
    Department of Medicine, Division of Nephrology and Immunology, Alberta Transplant Applied Genomics Centre, University of Alberta, Edmonton, Canada
    Am J Transplant 7:2221-6. 2007
    ..The threat is the degree to which the renal transplant community will participate in and support this process...
  8. doi request reprint Scoring total inflammation is superior to the current Banff inflammation score in predicting outcome and the degree of molecular disturbance in renal allografts
    M Mengel
    Department of Laboratory Medicine and Pathology, Alberta Transplant Applied Genomics Centre, Canada
    Am J Transplant 9:1859-67. 2009
    ..Thus, the total i-score is superior to the current Banff i-score and most diagnostic Banff categories in predicting outcome and assessing the molecular phenotype of renal allografts...
  9. doi request reprint The molecular phenotype of 6-week protocol biopsies from human renal allografts: reflections of prior injury but not future course
    M Mengel
    Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Canada
    Am J Transplant 11:708-18. 2011
    ..Thus while detecting T cell-mediated inflammation, the molecular phenotype of early protocol biopsies mostly reflects the injury-repair response to implantation stresses, and has little relationship to future events and outcomes...
  10. pmc Molecular phenotypes of acute kidney injury in kidney transplants
    Konrad S Famulski
    Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Canada
    J Am Soc Nephrol 23:948-58. 2012
    ....
  11. pmc A molecular classifier for predicting future graft loss in late kidney transplant biopsies
    Gunilla Einecke
    Alberta Transplant Applied Genomics Centre, University of Alberta, Edmonton, Alberta, Canada
    J Clin Invest 120:1862-72. 2010
    ..In an independent validation set, the molecular risk score was the only predictor of graft loss. Thus, the molecular risk score reflects active injury and is superior to either scarring or function in predicting graft failure...
  12. doi request reprint Superiority of virtual microscopy versus light microscopy in transplantation pathology
    Yasemin Ozluk
    Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB, Canada
    Clin Transplant 26:336-44. 2012
    ..g., accessibility via internet, no fading. We recommend virtual microscopy for transplant diagnostics, including utilization for clinical trials...
  13. pmc Molecular correlates of renal function in kidney transplant biopsies
    Sakarn Bunnag
    Department of Medicine, Division of Nephrology and Immunology, University of Alberta, Edmonton, Alberta, Canada
    J Am Soc Nephrol 20:1149-60. 2009
    ..Thus, in biopsies performed for clinical reasons, functional disturbances are reflected in transcriptome changes representing tissue injury and dedifferentiation but not the inflammatory burden...
  14. doi request reprint Cluster analysis of lesions in nonselected kidney transplant biopsies: microcirculation changes, tubulointerstitial inflammation and scarring
    B Sis
    Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB, Canada
    Am J Transplant 10:421-30. 2010
    ..Interpretation of lesions should reflect these associations...
  15. doi request reprint NK cell transcripts and NK cells in kidney biopsies from patients with donor-specific antibodies: evidence for NK cell involvement in antibody-mediated rejection
    L G Hidalgo
    Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Canada
    Am J Transplant 10:1812-22. 2010
    ..Thus, the strategy of using DSASTs in the biopsy to identify mechanism-related transcripts in biopsies from patients with clinical phenotypes indicates the selective involvement of NK cells in ABMR...
  16. doi request reprint Failure of neonatal B-cell tolerance induction by ABO-incompatible kidney grafts in piglets
    Mylvaganam Jeyakanthan
    1 Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada 2 Department of Surgery, University of Alberta, Edmonton, Alberta, Canada 3 Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Alberta, Canada 4 Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Alberta, Canada 5 Address correspondence to Lori J West, M D, D Phil, F R C P C, 6 002 Li Ka Shing Health Research Centre East, University of Alberta, Edmonton, Alberta, Canada T6G 2E1
    Transplantation 96:519-28. 2013
    ..Starting with this clinical observation, we sought to model neonatal ABOi organ transplantation to allow mechanistic studies of tolerance...
  17. doi request reprint The molecular phenotype of heart transplant biopsies: relationship to histopathological and clinical variables
    M Mengel
    Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Canada
    Am J Transplant 10:2105-15. 2010
    ....
  18. ncbi request reprint Microarray analysis of rejection in human kidney transplants using pathogenesis-based transcript sets
    T F Mueller
    Department of Medicine, Division of Nephrology and Immunology, University of Alberta, Edmonton, AB, Canada
    Am J Transplant 7:2712-22. 2007
    ..PBTs represent a quantitative measure of the inflammatory disturbances in organ transplants, and a new window on the mechanisms of these changes...
  19. doi request reprint Antibody-mediated microcirculation injury is the major cause of late kidney transplant failure
    G Einecke
    Alberta Transplant Applied Genomics Centre, Department of Medicine, Division of Nephrology and Transplant Immunology, University of Alberta, Edmonton, AB, Canada
    Am J Transplant 9:2520-31. 2009
    ..The major cause of late kidney transplant failure is antibody-mediated microcirculation injury, but detection of this phenotype requires new diagnostic criteria...
  20. ncbi request reprint An integrated view of molecular changes, histopathology and outcomes in kidney transplants
    P F Halloran
    Department of Medicine, Division of Nephrology and Immunology, University of Alberta, Edmonton, Canada
    Am J Transplant 10:2223-30. 2010
    ..The active injury-repair response is the strongest correlate of organ function and future progression to failure, but should always prompt a search for the initiating injury or disease...
  21. doi request reprint De novo donor-specific antibody at the time of kidney transplant biopsy associates with microvascular pathology and late graft failure
    L G Hidalgo
    Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB, Canada
    Am J Transplant 9:2532-41. 2009
    ..We propose careful assessment of de novo DSA, particularly against class II, be performed in all late kidney transplant biopsies...
  22. doi request reprint Banff '09 meeting report: antibody mediated graft deterioration and implementation of Banff working groups
    B Sis
    Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Alberta, Canada
    Am J Transplant 10:464-71. 2010
    ....
  23. ncbi request reprint The molecular phenotype of kidney transplants
    P F Halloran
    Department of Medicine, Division of Nephrology and Immunology, University of Alberta, Edmonton, Canada
    Am J Transplant 10:2215-22. 2010
    ..Thus the molecular phenotype is best described in terms of three elements: specific diseases, including rejection; the injury-repair response and the cumulative burden of injury...
  24. doi request reprint Banff 07 classification of renal allograft pathology: updates and future directions
    K Solez
    Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Canada
    Am J Transplant 8:753-60. 2008
    ....
  25. ncbi request reprint The transcriptome of the implant biopsy identifies donor kidneys at increased risk of delayed graft function
    T F Mueller
    Division of Nephrology and Transplantation Immunology, Department of Medicine, University of Alberta, Edmonton, AB, Canada
    Am J Transplant 8:78-85. 2008
    ..03) but not with clinical or histopathologic scores. The transcriptome reflects kidney quality and susceptibility to DGF better than available clinical and histopathological scoring systems...
  26. ncbi request reprint Banff '05 Meeting Report: differential diagnosis of chronic allograft injury and elimination of chronic allograft nephropathy ('CAN')
    K Solez
    University of Alberta, Edmonton, Alberta, Canada
    Am J Transplant 7:518-26. 2007
    ..Participation of B cells in allograft rejection and genomics markers of rejection were also major subjects addressed by the conference...
  27. doi request reprint Expression of B cell and immunoglobulin transcripts is a feature of inflammation in late allografts
    G Einecke
    Division of Nephrology and Transplantation Immunology, Department of Medicine, University of Alberta, Edmonton, Canada
    Am J Transplant 8:1434-43. 2008
    ..Expression of BATs and IGTs correlated with renal function, but this relationship was due to differences in early versus late biopsies: BATs and IGTs were not related to function or future function after correcting for time...
  28. doi request reprint Molecular correlates of scarring in kidney transplants: the emergence of mast cell transcripts
    M Mengel
    Department of Medicine, Division of Nephrology and Immunology, Alberta Transplant Applied Genomics Centre, Edmonton, Canada
    Am J Transplant 9:169-78. 2009
    ..Scarring is associated with a distinct pattern of inflammatory molecules, including B cell/immunoglobulin but particularly mast cell-associated transcripts, which correlated with poor outcomes...
  29. doi request reprint Comparing microarray versus RT-PCR assessment of renal allograft biopsies: similar performance despite different dynamic ranges
    K Allanach
    Department of Medicine, Division of Nephrology and Immunology, Alberta Transplant Applied Genomics Centre, University of Alberta, Edmonton, Canada
    Am J Transplant 8:1006-15. 2008
    ..The dynamic range of both platforms was sufficient to detect the relevant changes in rejection...
  30. doi request reprint The early course of kidney allograft rejection: defining the time when rejection begins
    G Einecke
    Department of Medicine, Division of Nephrology and Transplantation Immunology, University of Alberta, Edmonton, Alberta, Canada
    Am J Transplant 9:483-93. 2009
    ..Thus, in renal allografts, allorecognition by T cells occurs in perivascular sites by day 1, but alloimmune parenchymal damage begins at day 3, coinciding with the emergence of the interstitial T-cell-MMDC infiltrate...
  31. doi request reprint FOXP3 expression in human kidney transplant biopsies is associated with rejection and time post transplant but not with favorable outcomes
    S Bunnag
    Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    Am J Transplant 8:1423-33. 2008
    ..Thus FOXP3 mRNA expression is a time-dependent feature of inflammatory infiltrates in renal tissue. We hypothesize that time-dependent entry of FOXP3-positive cells represents a mechanism for stabilizing inflammatory sites...
  32. doi request reprint The transcriptome of human cytotoxic T cells: measuring the burden of CTL-associated transcripts in human kidney transplants
    L G Hidalgo
    Division of Nephrology and Immunology, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    Am J Transplant 8:637-46. 2008
    ..Thus QCAT sets robustly measure the burden of CTL and effector memory T cells in biopsies as %CTL RNA, in a manner not achieved by measurement of individual transcripts...
  33. doi request reprint Donor Fas is not necessary for T-cell-mediated rejection of mouse kidney allografts
    D Kayser
    Department of Medicine, Division of Nephrology, Alberta Transplant Applied Genomics Centre, Edmonton, Canada
    Am J Transplant 8:2049-55. 2008
    ..We propose that in TCMR, interstitial effector T cells mediate parenchymal injury by inflammatory mechanisms that require neither the perforin-granzyme nor the Fas-Fas ligand cytotoxic mechanisms...
  34. doi request reprint Acute kidney injury: arterial spin labeling to monitor renal perfusion impairment in mice-comparison with histopathologic results and renal function
    Katja Hueper
    From the Department of Radiology K H, M G, D H, F W, Department of Nephrology S R, X L, H H, F G, and Institute for Animal Science M Meier, Hannover Medical School, Carl Neuberg Str 1, 30625 Hannover, Germany and Alberta Transplant Applied Genomics Centre, University of Alberta, Edmonton, Alberta, Canada M Mengel
    Radiology 270:117-24. 2014
    ....
  35. doi request reprint Defining the canonical form of T-cell-mediated rejection in human kidney transplants
    K S Famulski
    Alberta Transplant Applied Genomics Centre, Division of Nephrology and Transplant Immunology, Department of Medicine, University of Alberta, Edmonton, AB, Canada
    Am J Transplant 10:810-20. 2010
    ..This combination of pathologic, clinical and molecular features constitutes the typical or canonical T-cell-mediated rejection...
  36. ncbi request reprint Transcriptome analysis reveals heterogeneity in the injury response of kidney transplants
    K S Famulski
    Division of Nephrology and Transplantation Immunology, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    Am J Transplant 7:2483-95. 2007
    ..The alloresponse strikingly and selectively increased the late IRITs but not the IRITs that peak early, indicating that rejection triggers parenchymal responses similar to those in ATN...
  37. ncbi request reprint Nodular B-cell aggregates associated with treatment refractory renal transplant rejection resolved by rituximab
    A Lehnhardt
    Department of Pediatric Nephrology, Hepatology and Metabolic Diseases, Hannover Medical School, D 30623 Hannover, Germany
    Am J Transplant 6:847-51. 2006
    ..Single dose rituximab may effectively reverse even long-lasting refractory rejection...
  38. ncbi request reprint Side effects of sirolimus
    S Merkel
    Department of Nephrology, Medical School of Hannover, Hannover, Germany
    Transplant Proc 38:714-5. 2006
    ..Thus, we think that caution is required, particularly in connection with preexisting glomerular disease...
  39. ncbi request reprint Protocol biopsy program after renal transplantation: structure and first results
    A Schwarz
    Nephrology Department, Hanover Medical School, Hanover, Germany
    Transplant Proc 34:2238-9. 2002
  40. ncbi request reprint Protocol biopsies in renal transplantation: insights into patient management and pathogenesis
    M Mengel
    Institute for Pathology, Hannover Medical School, Hannover, Germany
    Am J Transplant 7:512-7. 2007
    ..Wider application is expected in multicenter clinical trials to predict and validate outcomes. The principal barrier to wider use of protocol biopsies is knowledge of the benefits of intervention...
  41. ncbi request reprint Infiltrates in protocol biopsies from renal allografts
    M Mengel
    Institut fuer Pathologie, Medizinische Hochschule Hannover, Germany
    Am J Transplant 7:356-65. 2007
    ..As detected by sequential biopsies, persistence of any inflammation including those infiltrates currently not considered by the Banff classification should be regarded as a morphological correlate of ongoing allograft damage...
  42. ncbi request reprint Lymphatic neoangiogenesis in human renal allografts: results from sequential protocol biopsies
    S Stuht
    Department of Nephrology, Medizinische Hochschule Hannover, Hannover, Germany
    Am J Transplant 7:377-84. 2007
    ..In conclusion, lymphangiogenesis not only shows a clear association with cellular infiltrates but might also have an impact on the pathogenicity of these cellular infiltrates...
  43. ncbi request reprint Expression of pro- and antifibrotic genes in protocol biopsies from renal allografts with interstitial fibrosis and tubular atrophy
    M Mengel
    Institute for Pathology, Medizinische Hochschule Hannover, Germany
    Clin Nephrol 69:408-16. 2008
    ..Better understanding of early onset of interstitial fibrosis and tubular atrophy (IF/TA), as the morphological surrogate of renal allograft deterioration might improve outcome after renal transplantation...
  44. doi request reprint Peritubular capillaritis in renal allografts: prevalence, scoring system, reproducibility and clinicopathological correlates
    I W Gibson
    Department of Pathology, MS4 Health Sciences Centre, Winnipeg, Manitoba, Canada
    Am J Transplant 8:819-25. 2008
    ..0001). Capillaritis is more frequent and pronounced in ABMR, but can be observed in TCMR cases. Thus, scoring of peritubular capillaritis is feasible and can provide prognostic and diagnostic information in renal allograft biopsies...
  45. pmc CXCR4/CXCL12 expression and signalling in kidney cancer
    A J Schrader
    Department of Cell Biology and Immunology, German Research Centre for Biotechnology GBF, Mascheroder Weg 1, D 38124 Braunschweig, Germany
    Br J Cancer 86:1250-6. 2002
    ..The genetic changes reported here should provide new insights into the developmental paths leading to tumour progression and may also aid the design of new approaches to therapeutic intervention...
  46. ncbi request reprint Compartment-specific quantitative gene expression analysis after laser microdissection from archival renal allograft biopsies
    E Serinsoz
    Institut fur Pathologie, Medizinischen Hochschule, Hannover, Germany
    Clin Nephrol 63:193-201. 2005
    ....
  47. ncbi request reprint [Embryonal rhabdomyosarcoma of the orbita]
    M Durisin
    HNO Klinik der Medizinischen Hochschule Hannover
    Laryngorhinootologie 85:124-7. 2006
    ..This case demonstrates that in a child with a unilateral, progressive orbital tumor, the differential diagnosis of a soft tissue sarcoma has to be ruled out...
  48. ncbi request reprint A blue kidney--chronic renal failure as a consequence of siderosis in paroxysmal nocturnal hemoglobinuria?
    P Kümpers
    Department of Nephrology, Medical School Hannover, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Clin Nephrol 66:210-3. 2006
    ..Chronic renal failure in PNH is a diagnosis of exclusion, even if radiologic evidence of heavy siderosis draws off the physician's attention...
  49. ncbi request reprint Heterogeneous p27(Kip1) expression within primary renal cell cancers, their invasive margins and peritumoral renal parenchyma correlation with pathological and prognostic features
    A S Merseburger
    Department of Urology, Eberhard Karls University Tubingen, Germany
    Urol Int 79:164-9. 2007
    ..Therefore, in the present investigation the expression within different tissue areas obtained from renal cell carcinomas was determined...
  50. ncbi request reprint [Primary leiomyosarcoma of the pulmonary artery--a case report]
    M Mengel
    , Medizinische Hochschule Hannover
    Pneumologie 54:20-3. 2000
    ..There was no evidence of recurrence or metastasis of the primary leiomyosarcoma of the pulmonary artery in a 14-month follow-up period after operation...