Sangeeta Mehta

Summary

Affiliation: University of Toronto
Country: Canada

Publications

  1. ncbi Utility of routine chest radiographs in a medical-surgical intensive care unit: a quality assurance survey
    N Chahine-Malus
    Mount Sinai Hospital, Toronto, Ontario, Canada
    Crit Care 5:271-5. 2001
  2. ncbi Implementing and troubleshooting high-frequency oscillatory ventilation in adults in the intensive care unit
    S Mehta
    Department of Medicine, Mount Sinai Hospital, University of Toronto, Ontario, Canada
    Respir Care Clin N Am 7:683-95. 2001
  3. ncbi Daily sedation interruption in mechanically ventilated critically ill patients cared for with a sedation protocol: a randomized controlled trial
    Sangeeta Mehta
    Division of Critical Care, Department of Medicine and Interdepartmental Mount Sinai Hospital and University of Toronto, Toronto, Canada
    JAMA 308:1985-92. 2012
  4. ncbi A patient survey of sleep quality in the Intensive Care Unit
    A Little
    Mount Sinai Hospital, Toronto, Ontario, Canada
    Minerva Anestesiol 78:406-14. 2012
  5. ncbi Bench-to-bedside review: high-frequency oscillatory ventilation in adults with acute respiratory distress syndrome
    James Downar
    Department of Medicine, Mount Sinai Hospital and University of Toronto, 600 University Avenue #18-216, Toronto, Ontario, Canada
    Crit Care 10:240. 2006
  6. ncbi Practising evidence-based medicine: the design and implementation of a multidisciplinary team-driven extubation protocol
    P K Chan
    Department of Medicine, Queen Elisabeth Hospital, Intensive Care Unit, Kowloon, Hong Kong, China
    Crit Care 5:349-54. 2001
  7. ncbi Current sedation practices: lessons learned from international surveys
    Sangeeta Mehta
    Medical Surgical Intensive Care Unit, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario M5G 1X5, Canada
    Crit Care Clin 25:471-88, vii-viii. 2009
  8. ncbi Neuromuscular disease causing acute respiratory failure
    Sangeeta Mehta
    Interdepartmental Division of Critical Care Medicine, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario, M5G 1X5, Canada
    Respir Care 51:1016-21; discussion 1021-3. 2006
  9. ncbi Noninvasive ventilation in patients with acute cardiogenic pulmonary edema
    Sangeeta Mehta
    Mount Sinai Hospital, Toronto, Ontario, M5G 1X5, Canada
    Respir Care 54:186-95; discussion 195-7. 2009
  10. ncbi High-frequency oscillatory ventilation in adults: the Toronto experience
    Sangeeta Mehta
    Mount Sinai Hospital, 600 University Ave, No 1818, Toronto, ON, Canada, M5G 1X5
    Chest 126:518-27. 2004

Detail Information

Publications66

  1. ncbi Utility of routine chest radiographs in a medical-surgical intensive care unit: a quality assurance survey
    N Chahine-Malus
    Mount Sinai Hospital, Toronto, Ontario, Canada
    Crit Care 5:271-5. 2001
    ..To determine the utility of routine chest radiographs (CXRs) in clinical decision-making in the intensive care unit (ICU)...
  2. ncbi Implementing and troubleshooting high-frequency oscillatory ventilation in adults in the intensive care unit
    S Mehta
    Department of Medicine, Mount Sinai Hospital, University of Toronto, Ontario, Canada
    Respir Care Clin N Am 7:683-95. 2001
    ..Further evaluation of the efficacy of HFOV and potential impact on outcomes are needed in adults, particularly in the form of randomized, controlled trials...
  3. ncbi Daily sedation interruption in mechanically ventilated critically ill patients cared for with a sedation protocol: a randomized controlled trial
    Sangeeta Mehta
    Division of Critical Care, Department of Medicine and Interdepartmental Mount Sinai Hospital and University of Toronto, Toronto, Canada
    JAMA 308:1985-92. 2012
    ..We hypothesized that combining these strategies would augment the benefits...
  4. ncbi A patient survey of sleep quality in the Intensive Care Unit
    A Little
    Mount Sinai Hospital, Toronto, Ontario, Canada
    Minerva Anestesiol 78:406-14. 2012
    ..Patient-related factors, environmental factors, and health-support techniques contribute to sleep disruption. This quality improvement study examines potential factors contributing to poor sleep in the ICU...
  5. ncbi Bench-to-bedside review: high-frequency oscillatory ventilation in adults with acute respiratory distress syndrome
    James Downar
    Department of Medicine, Mount Sinai Hospital and University of Toronto, 600 University Avenue #18-216, Toronto, Ontario, Canada
    Crit Care 10:240. 2006
    ..Several studies suggest that HFOV may improve outcomes if used early in the course of ARDS, or if used in certain populations. This review will summarize the evidence supporting the use of HFOV in adults with ARDS...
  6. ncbi Practising evidence-based medicine: the design and implementation of a multidisciplinary team-driven extubation protocol
    P K Chan
    Department of Medicine, Queen Elisabeth Hospital, Intensive Care Unit, Kowloon, Hong Kong, China
    Crit Care 5:349-54. 2001
    ..CONCLUSION: An MDT approach to protocol-directed extubation can be implemented safely and effectively in a multidisciplinary ICU. Such an effort is viewed favourably by the entire team and is useful in enhancing team building...
  7. ncbi Current sedation practices: lessons learned from international surveys
    Sangeeta Mehta
    Medical Surgical Intensive Care Unit, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario M5G 1X5, Canada
    Crit Care Clin 25:471-88, vii-viii. 2009
    ....
  8. ncbi Neuromuscular disease causing acute respiratory failure
    Sangeeta Mehta
    Interdepartmental Division of Critical Care Medicine, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario, M5G 1X5, Canada
    Respir Care 51:1016-21; discussion 1021-3. 2006
    ....
  9. ncbi Noninvasive ventilation in patients with acute cardiogenic pulmonary edema
    Sangeeta Mehta
    Mount Sinai Hospital, Toronto, Ontario, M5G 1X5, Canada
    Respir Care 54:186-95; discussion 195-7. 2009
    ..We review the randomized controlled trials and summarize the evidence on NIV and CPAP in patients with ACPE...
  10. ncbi High-frequency oscillatory ventilation in adults: the Toronto experience
    Sangeeta Mehta
    Mount Sinai Hospital, 600 University Ave, No 1818, Toronto, ON, Canada, M5G 1X5
    Chest 126:518-27. 2004
    ..To review the clinical experience with high-frequency oscillatory ventilation (HFOV) in three medical-surgical ICUs in Toronto, ON, Canada, and to describe patient characteristics, HFOV strategies, and outcomes...
  11. ncbi A randomized trial of daily awakening in critically ill patients managed with a sedation protocol: a pilot trial
    Sangeeta Mehta
    Inter Departmental Division of Critical Care Medicine, Mount Sinai Hospital, University Health Network, and University of Toronto, Toronto, Ontario, Canada
    Crit Care Med 36:2092-9. 2008
    ..Our objective was to determine the safety and feasibility of a randomized trial to determine whether adults managed with both PS + DI have a shorter duration of MV than patients managed with PS alone...
  12. ncbi Morbidity and mortality of patients with invasive group A streptococcal infections admitted to the ICU
    Sangeeta Mehta
    Interdepartmental Division of Critical Care Medicine, Mount Sinai Hospital, 600 University Ave, Suite 18 216, Toronto, Ontario, Canada M5G 1X5
    Chest 130:1679-86. 2006
    ..To describe the clinical features and outcome of patients with invasive group A streptococcal (GAS) infections admitted to the ICU...
  13. ncbi Impact of endotracheal tube size on preextubation respiratory variables
    Sangeeta Mehta
    Division of Respirology and Interdepartmental Division of Critical Care Medicine, Department of Internal Medicine, Mount Sinai Hospital and University of Toronto, Toronto, Ontario, Canada
    J Crit Care 25:483-8. 2010
    ..These are all affected by extrapulmonary variables. The purpose of this study was to evaluate the effect of endotracheal tube (ETT) size on preextubation predictors of successful extubation...
  14. ncbi Why substitute decision makers provide or decline consent for ICU research studies: a questionnaire study
    Sangeeta Mehta
    Department of Medicine and Interdepartmental Division of Critical Care Medicine, Mount Sinai Hospital, 600 University Ave, 18 216, Toronto, ON M5G 1X5, Canada
    Intensive Care Med 38:47-54. 2012
    ..In this study we explored SDMs' reasons for declining or providing consent for research studies for critically ill adult family members...
  15. ncbi Functional disability 5 years after acute respiratory distress syndrome
    Margaret S Herridge
    Department of Medicine, University Health Network, University of Toronto, Toronto, ON, Canada
    N Engl J Med 364:1293-304. 2011
    ..There have been few detailed, in-person interviews and examinations to obtain follow-up data on 5-year outcomes among survivors of the acute respiratory distress syndrome (ARDS)...
  16. ncbi Canadian survey of the use of sedatives, analgesics, and neuromuscular blocking agents in critically ill patients
    Sangeeta Mehta
    Interdepartmental Division of Critical Care Medicine, Mount Sinai Hospital
    Crit Care Med 34:374-80. 2006
    ....
  17. ncbi A multicenter survey of Ontario intensive care unit nurses regarding the use of sedatives and analgesics for adults receiving mechanical ventilation
    Sangeeta Mehta
    University of Toronto, Toronto, Ontario, Canada M5G 1X5
    J Crit Care 22:191-6. 2007
    ..Nursing-directed sedation protocols have been shown to reduce the duration of mechanical ventilation and shorten the length of intensive care unit (ICU) stay among critically ill adult patients...
  18. ncbi Recall of intensive care unit stay in patients managed with a sedation protocol or a sedation protocol with daily sedative interruption: a pilot study
    Cheryl Ethier
    Department of Medicine and Interdepartmental Division of Critical Care Medicine, Mount Sinai Hospital, Toronto, Ontario, Canada M5G 1X5
    J Crit Care 26:127-32. 2011
    ..The objective of this pilot study was to evaluate recall of ICU stay in patients managed with 2 sedation strategies: a sedation protocol or a combination of sedation protocol and daily sedative/analgesic interruption...
  19. ncbi Combining high-frequency oscillatory ventilation and recruitment maneuvers in adults with early acute respiratory distress syndrome: the Treatment with Oscillation and an Open Lung Strategy (TOOLS) Trial pilot study
    Niall D Ferguson
    Department of Medicine, Division of Respirology, and the Interdepartmental Division of Critical Care Medicine, University Health Network and Mount Sinai Hospital, University of Toronto, Toronto, Canada
    Crit Care Med 33:479-86. 2005
    ..This explicit high-frequency oscillatory ventilation protocol appears well tolerated, feasible, and physiologically sound...
  20. ncbi Two-year outcomes, health care use, and costs of survivors of acute respiratory distress syndrome
    Angela M Cheung
    Department of Medicine, University Health Network, Toronto, ON, Canada
    Am J Respir Crit Care Med 174:538-44. 2006
    ..Little is known about the long-term outcomes and costs of survivors of acute respiratory distress syndrome (ARDS)...
  21. ncbi Prospective evaluation of an internet-linked handheld computer critical care knowledge access system
    Stephen E Lapinsky
    Technology Application Unit, Mount Sinai Hospital and Interdepartmental Division of Critical Care, University of Toronto, Toronto, Ontario, Canada
    Crit Care 8:R414-21. 2004
    ..We evaluated the feasibility and potential benefits of a handheld computer based knowledge access system linking a central academic intensive care unit (ICU) to multiple community-based ICUs...
  22. ncbi High-frequency oscillation in early acute respiratory distress syndrome
    Niall D Ferguson
    Interdepartmental Division of Critical Care Medicine, Department of Medicine, University of Toronto, University Health Network and Mount Sinai Hospital, Toronto, ON, Canada
    N Engl J Med 368:795-805. 2013
    ....
  23. ncbi The 4Ts scoring system for heparin-induced thrombocytopenia in medical-surgical intensive care unit patients
    Mark Andrew Crowther
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
    J Crit Care 25:287-93. 2010
    ..The 4Ts score (Thrombocytopenia, Timing of thrombocytopenia, Thrombosis, and oTher reason) might identify individual patients at risk of having this disorder...
  24. ncbi Optimizing sedation and analgesia in mechanically ventilated patients--an evidence-based approach
    Patricia Hynes-Gay
    Mount Sinai Hospital, Toronto, Ontario
    Dynamics 14:10-3. 2003
    ..This article provides a review of three recent studies evaluating these new approaches to the administration of sedation and analgesia in the adult ICU...
  25. ncbi Analgesic and sedative pharmacology in the intensive care unit
    Cindy Wong
    Mount Sinai Hospital, Toronto, Ontario
    Dynamics 15:23-6; quiz 27-8. 2004
    ..An understanding of the pharmacotherapy of sedation and analgesia in the ICU will help support appropriate usage of these agents and improve patient care...
  26. ncbi Screening of ARDS patients using standardized ventilator settings: influence on enrollment in a clinical trial
    Niall D Ferguson
    Division of Respirology, Department of Medicine, and the Interdepartmental Division of Critical Care Medicine, University Health Network and Mount Sinai Hospital, University of Toronto, Toronto, Canada
    Intensive Care Med 30:1111-6. 2004
    ....
  27. ncbi Recruitment maneuvers for acute lung injury: a systematic review
    Eddy Fan
    Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Ontario, Canada
    Am J Respir Crit Care Med 178:1156-63. 2008
    ..There are conflicting data regarding the safety and efficacy of recruitment maneuvers (RMs) in patients with acute lung injury (ALI)...
  28. ncbi Temporal change, reproducibility, and interobserver variability in pressure-volume curves in adults with acute lung injury and acute respiratory distress syndrome
    Sangeeta Mehta
    Interdepartmental Divison of Critical Care Medicine, University of Toronto, and Mount Sinai Hospital, ON, Canada
    Crit Care Med 31:2118-25. 2003
    ..Both LIP and UIP show appreciable daily variability in patients with ALI/ARDS. The multiple occlusion and syringe techniques generate similar values for LIP and UIP...
  29. ncbi High-frequency oscillation in adults: a utilization review
    Neill K J Adhikari
    Department of Critical Care Medicine and the Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, Canada
    Crit Care Med 39:2631-44. 2011
    ..Given the uncertain benefits, our objective was to describe contemporary patient selection, high-frequency oscillation utilization, and outcomes...
  30. ncbi Critical care nurses' pain assessment and management practices: a survey in Canada
    Louise Rose
    Lawrence S Bloomberg Faculty of Nursing, University of Toronto, 155 College St, Toronto, Ontario, Canada, M5T IP8
    Am J Crit Care 21:251-9. 2012
    ..Regular pain assessment can lead to decreased incidence of pain and shorter durations of mechanical ventilation and stays in the intensive care unit...
  31. ncbi In-house, overnight physician staffing: a cross-sectional survey of Canadian adult and pediatric intensive care units
    Christopher S Parshuram
    Department of Critical Care Medicine and Division of Clinical Pharmacology, Population Health Sciences, The Research Institute, The Hospital for Sick Children, Toronto, and McMaster University, Hamilton, Ontario, Canada
    Crit Care Med 34:1674-8. 2006
    ..The duration of most ICU shifts raises concern about workload-associated fatigue and medical error. The impact of current nighttime staffing requires further evaluation with respect to patient outcomes...
  32. ncbi Noninvasive ventilation for acute respiratory failure near the end of life
    Tasnim Sinuff
    Department of Critical Care Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada
    Crit Care Med 36:789-94. 2008
    ....
  33. ncbi Regional citrate anticoagulation for PrismaFlex continuous renal replacement therapy
    Lisa D Burry
    Department of Pharmacy, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada
    Ann Pharmacother 43:1419-25. 2009
    ..However, RCA has been associated with significant metabolic complications including hypocalcemia, hypernatremia, metabolic alkalosis, and citrate toxicity...
  34. ncbi Current therapeutic uses, pharmacology, and clinical considerations of neuromuscular blocking agents for critically ill adults
    Julia Warr
    University of Waterloo, Waterloo, Ontario, Canada
    Ann Pharmacother 45:1116-26. 2011
    ....
  35. ncbi Bench-to-bedside review: Recruitment and recruiting maneuvers
    Stephen E Lapinsky
    Intensive Care Unit, Mount Sinai Hospital, and Interdepartmental Division of Critical Care, University of Toronto, Toronto, Canada
    Crit Care 9:60-5. 2005
    ..In this review we discuss the pathophysiologic basis for the use of recruitment maneuvers and recent evidence, as well as the practical application of the technique...
  36. ncbi Acute oxygenation response to inhaled nitric oxide when combined with high-frequency oscillatory ventilation in adults with acute respiratory distress syndrome
    Sangeeta Mehta
    Department of Medicine, Mount Sinai Hospital, University of Toronto, Canada
    Crit Care Med 31:383-9. 2003
    ..40 +/- 17, p=.08). CONCLUSIONS: INO delivered at doses of 5 to 20 ppm during high-frequency oscillatory ventilation increases Pao2/Fio2 and may be a safe and effective rescue therapy for patients with severe oxygenation failure...
  37. ncbi Errors Associated with IV Infusions in Critical Care
    Claudia Summa-Sorgini
    BScPharm, ACPR, was, At the time this study was conducted, a pharmacy resident at Mount Sinai Hospital, Toronto, Ontario She is now a Clinical Pharmacist with the University Health Network, Toronto, Ontario
    Can J Hosp Pharm 65:19-26. 2012
    ..According to the literature, IV medications are associated with 54% of potential adverse events, and 56% of medication errors...
  38. ncbi Prophylaxis of Thromboembolism in Critical Care (PROTECT) Trial: a pilot study
    Deborah J Cook
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada L8N 3Z5
    J Crit Care 20:364-72. 2005
    ..Its additional goals were to evaluate the suitability of the exclusion criteria and to document the range of research activities that precede accrual of patients into a trial to plan multisite management...
  39. ncbi Pro/con clinical debate: is high-frequency oscillatory ventilation useful in the management of adult patients with respiratory failure?
    Jeffrey M Singh
    Department of Medicine, Mount Sinai Hospital, Toronto, Canada
    Crit Care 6:183-5. 2002
    ....
  40. ncbi High-frequency oscillatory ventilation and adjunctive therapies: inhaled nitric oxide and prone positioning
    Eddy Fan
    Interdepartmental Division of Critical Care, University of Toronto, Toronto, Canada
    Crit Care Med 33:S182-7. 2005
    ..More rigorous randomized, controlled trials are needed to help delineate the therapeutic role of combination therapy in adults with ARDS...
  41. ncbi Agreement in electrocardiogram interpretation in patients with septic shock
    Sangeeta Mehta
    Department of Medicine, Interdepartmental Division of Critical Care Medicine, Mount Sinai Hospital, USA
    Crit Care Med 39:2080-6. 2011
    ..In adults with septic shock, we assessed intra- and inter-rater agreement of electrocardiogram interpretation, and the effect of knowledge of troponin values on these interpretations...
  42. ncbi One-year outcomes in survivors of the acute respiratory distress syndrome
    Margaret S Herridge
    Department of Medicine, University Health Network, Toronto, Ont, Canada
    N Engl J Med 348:683-93. 2003
    ..As more patients survive the acute respiratory distress syndrome, an understanding of the long-term outcomes of this condition is needed...
  43. ncbi Safety and efficacy of a sustained inflation for alveolar recruitment in adults with respiratory failure
    S E Lapinsky
    Department of Medicine, Mount Sinai Hospital, Ontario, Canada
    Intensive Care Med 25:1297-301. 1999
    ..To assess the safety and efficacy of a sustained inflation, used as a lung volume recruitment maneuver in ventilated patients with hypoxemic respiratory failure...
  44. ncbi Handheld computers in critical care
    S E Lapinsky
    Intensive Care Unit, Mount Sinai Hospital, and Interdepartmental Division of Critical Care and Department of Medicine, University of Toronto, Room 1825, 600 University Ave, Toronto, ON M5G 1X5, Canada
    Crit Care 5:227-31. 2001
    ..We evaluated the role of this technology for managing patient data and accessing medical reference information, in an academic intensive-care unit (ICU)...
  45. ncbi Detection of critical illness-related corticosteroid insufficiency using 1 μg adrenocorticotropic hormone test
    Lisa Burry
    Department of Pharmacy, Mount Sinai Hospital, Toronto, Ontario, Canada
    Shock 39:144-8. 2013
    ..The highest mortality rates were observed in patients with high baseline cortisol and in those who failed to respond appropriately to ACTH. The administration of corticosteroids was not associated with a reduction in mortality...
  46. ncbi Optimizing sedative use in the intensive care unit
    Niall D Ferguson
    Department of Medicine, Division of Respirology, Critical Care Medicine Program, Mount Sinai Hospital, 600 University Avenue, Toronto, Ont, M5G 1X5, Canada
    Intensive Care Med 28:44-7. 2002
  47. ncbi Rates and determinants of informed consent: a case study of an international thromboprophylaxis trial
    Orla M Smith
    Interdepartmental Division of Critical Care, Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    J Crit Care 28:28-39. 2013
    ..Successful completion of randomized trials depends upon efficiently and ethically screening patients and obtaining informed consent. Awareness of modifiable barriers to obtaining consent may inform ongoing and future trials...
  48. ncbi Diagnostic and prognostic implications of endotoxemia in critical illness: results of the MEDIC study
    John C Marshall
    University Health Network, University of Toronto, Toronto, Ontario, Canada
    J Infect Dis 190:527-34. 2004
    ..Stepwise logistic regression analysis showed that elevated Acute Physiology and Chronic Health Evaluation II score, gram-negative infection, and emergency admission status were independent predictors of EA...
  49. ncbi Open the lung with high-frequency oscillation ventilation or conventional mechanical ventilation? It may not matter!
    Vito Fanelli
    The Keenan Research Centre of the Li Ka Shing Knowledge Institute of St Michael s Hospital, 30 Bond Street, Toronto, Ontario, Canada M5B 1W8
    Crit Care 14:1010. 2010
    ....
  50. ncbi Handheld computing in medicine
    Sandra Fischer
    Technology Application Unit, Intensive Care Unit, Mount Sinai Hospital, 600 University Avenue #1825, University of Toronto, Toronto, Ontario M5G 1X5, Canada
    J Am Med Inform Assoc 10:139-49. 2003
    ..This article aims to increase the awareness among physicians about the potential roles for handheld computers in medicine and to encourage the further evaluation of their use...
  51. ncbi Current sedation practices: lessons learned from international surveys
    Sangeeta Mehta
    Medical Surgical Intensive Care Unit, Mount Sinai Hospital, 600 University Avenue Room 18 216, Toronto, Ontario M5G 1X5, Canada Department of Medicine, Mount Sinai Hospital, University of Toronto, 600 University Avenue Room 18 216, Toronto, Ontario M5G 1X5, Canada
    Anesthesiol Clin 29:607-24. 2011
    ....
  52. ncbi Prospective trial of high-frequency oscillation in adults with acute respiratory distress syndrome
    S Mehta
    Departments of Medicine and Anesthesia, Mount Sinai Hospital, Toronto, Ontario, Canada
    Crit Care Med 29:1360-9. 2001
    ..In addition, early institution of HFOV may be advantageous...
  53. ncbi The role of high-frequency oscillatory ventilation in the treatment of acute respiratory failure in adults
    Terence Ip
    Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Ontario, Canada
    Curr Opin Crit Care 18:70-9. 2012
    ..In this review, we will summarize the trials evaluating HFOV in adults with ARDS and discuss issues relevant to the clinician regarding the use of HFOV...
  54. ncbi Radiologic pattern of disease in patients with severe acute respiratory syndrome: the Toronto experience
    Narinder S Paul
    Thoracic Division, Department of Medical Imaging, University Health Network and Mount Sinai Hospital, University of Toronto, Canada
    Radiographics 24:553-63. 2004
    ..To aid in the differential diagnosis and management of SARS, radiologists must be familiar with the typical clinical and histopathologic findings, as well as the radiologic features of the disease...
  55. ncbi Prognostic significance of the radiographic pattern of disease in patients with severe acute respiratory syndrome
    Narinder S Paul
    Department of Medical Imaging, University Health Network and Mount Sinai Hospital, Toronto, ON, Canada
    AJR Am J Roentgenol 182:493-8. 2004
    ..Patients with SARS present with recognizable patterns of disease that have prognostic significance...
  56. ncbi Randomized trial of combination versus monotherapy for the empiric treatment of suspected ventilator-associated pneumonia
    Daren K Heyland
    Kingston General Hospital and Queen s University, Kingston, ON, Canada
    Crit Care Med 36:737-44. 2008
    ..To compare a strategy of combination therapy with a strategy of monotherapy with broad-spectrum antibiotics for suspected late ventilator-associated pneumonia...
  57. ncbi Leak compensation in positive pressure ventilators: a lung model study
    S Mehta
    Mt Sinai Hospital, University of Toronto, Canada
    Eur Respir J 17:259-67. 2001
    ..Adequate inspiratory flows and durations should be used, triggering sensitivity should be adjusted to prevent autocycling, and a mechanism should be available to limit inspiratory time and avoid I:E ratio inversion...
  58. ncbi Noninvasive measurement of exhaled nitric oxide in a spontaneously breathing mouse
    S Weicker
    A.C. Burton Vascular Biology Laboratory, London Health Science Centre, London, Ontario, Canada
    Am J Respir Crit Care Med 163:1113-6. 2001
    ..This novel technique provides a stable, reproducible, and responsive measure of E(NO) in mice. This technique will be of use in determining cellular and isoform sources of E(NO), as well as the role of endogenous NO in lung disease...
  59. ncbi Safety of pressure-volume curve measurement in acute lung injury and ARDS using a syringe technique
    Warren L Lee
    InterDepartmental Critical Care Medicine Division (Drs. Lee and Stewart) and the Department of Medicine, Division of Respirology (Drs. Mehta and Lapinsky, University of Toronto
    Chest 121:1595-601. 2002
    ..CONCLUSIONS: PV curve measurement by syringe technique is well tolerated in most patients. Nonetheless, the maneuver may cause significant changes in oxygenation and/or hemodynamics, necessitating close monitoring...
  60. ncbi Continuous versus bilevel positive airway pressure in acute cardiogenic pulmonary edema? A good question!
    Sangeeta Mehta
    Crit Care Med 32:2546-8. 2004
  61. ncbi High-frequency oscillatory ventilation for adult patients with ARDS
    Kenneth P W Chan
    Department of Respiratory and Critical Care Medicine, Singapore General Hospital, Singapore
    Chest 131:1907-16. 2007
    ..Further research is needed to identify optimal patient selection, technique, the actual Vt delivered, and the role of combining HFOV with other interventions, such as recruitment maneuvers, prone positioning, and nitric oxide...
  62. ncbi ARDS--shake, rattle, and roll!
    Stephen E Lapinsky
    Crit Care Med 35:303-4. 2007
  63. ncbi High-frequency oscillatory ventilation for acute respiratory distress syndrome in adults: a randomized, controlled trial
    Stephen Derdak
    Pulmonary Critical Care Medicine, Wilford Hall Medical Center, San Antonio, Texas 78236, USA
    Am J Respir Crit Care Med 166:801-8. 2002
    ..We conclude that high-frequency oscillation is a safe and effective mode of ventilation for the treatment of acute respiratory distress syndrome in adults...
  64. ncbi Vasopressin versus norepinephrine infusion in patients with septic shock
    James A Russell
    iCAPTURE Centre, Vancouver, BC, Canada
    N Engl J Med 358:877-87. 2008
    ..We hypothesized that low-dose vasopressin as compared with norepinephrine would decrease mortality among patients with septic shock who were being treated with conventional (catecholamine) vasopressors...
  65. ncbi Mask ventilation and cardiogenic pulmonary edema: "another brick in the wall"
    Sangeeta Mehta
    Intensive Care Med 31:757-9. 2005
  66. ncbi High-frequency oscillation and prone position
    Sangeeta Mehta
    Crit Care Med 34:1578; author reply 1578-9. 2006