Research Topics
Species | Kelly A MecklingSummaryAffiliation: University of Guelph Country: Canada Publications
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Publications
Effects of a hypocaloric, low-carbohydrate diet on weight loss, blood lipids, blood pressure, glucose tolerance, and body composition in free-living overweight womenKelly A Meckling
Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, ON NIG 2W1, Canada
Can J Physiol Pharmacol 80:1095-105. 2002....
Fatty acid status and behavioural symptoms of attention deficit hyperactivity disorder in adolescents: a case-control studyAshley L Colter
Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON, N1G 2W1, Canada
Nutr J 7:8. 2008..A secondary purpose was to determine if there were relationships between circulating concentrations of essential fatty acids and specific ADHD behaviours as measured by the Conners' Parent Rating Scale (CPRS-L)...- A randomized trial of a hypocaloric high-protein diet, with and without exercise, on weight loss, fitness, and markers of the Metabolic Syndrome in overweight and obese womenKelly A Meckling
Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON N1G 2W1, Canada
Appl Physiol Nutr Metab 32:743-52. 2007.... 
In vitro antioxidant synergism and antagonism between food extracts can lead to similar activities in H2O2-induced cell death, caspase-3 and MMP-2 activities in H9c2 cellsSunan Wang
Guelph Food Research Center, Agriculture and Agri Food Canada, Guelph, Ontario, Canada
J Sci Food Agric 92:2983-93. 2012..This in vitro study evaluated the relationship between the in vitro antioxidant capacity of mixtures and their bioactivity when cardiomyocytes (H9c2) were challenged with H(2)O(2)...- Effect of the protein:carbohydrate ratio in hypoenergetic diets on metabolic syndrome risk factors in exercising overweight and obese womenDawn D Campbell
Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada
Br J Nutr 108:1658-71. 2012..A diet with a 1:2 protein:carbohydrate ratio promoted better improvements than either the LP or HP diets, and may be superior in reducing long-term chronic disease risk in this population... - Comparison of a low-fat diet to a low-carbohydrate diet on weight loss, body composition, and risk factors for diabetes and cardiovascular disease in free-living, overweight men and womenKelly A Meckling
Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, N1G 2W1 Ontario, Canada
J Clin Endocrinol Metab 89:2717-23. 2004..These data suggest that energy restriction achieved by a very LC diet is equally effective as a LF diet strategy for weight loss and decreasing body fat in overweight and obese adults... - Nuclear translocation of the 1,25D3-MARRS (membrane associated rapid response to steroids) receptor protein and NFkappaB in differentiating NB4 leukemia cellsWenqing Wu
Department of Human Health, University of Guelph, Guelph, Ontario, Canada
Exp Cell Res 316:1101-8. 2010..This suggests a role for 1,25D(3)-MARRS in the nucleus as a regulator of gene expression. Here it may also regulate the activity of NFkappaB and other factors with which it may be interacting... - Guanosine acts intracellularly to initiate apoptosis in NB4 cells: A role for nucleoside transportSheryl A Flanagan
Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada
Leuk Lymphoma 48:1816-27. 2007..Expression of the unique guanosine-specific nucleoside transporter csg in NB4 cells may provide an opportunity to harness guanosine-mediated cell death in the treatment of APL and related malignancies while sparing normal cells... - Involvement of 1,25D3-MARRS (membrane associated, rapid response steroid-binding), a novel vitamin D receptor, in growth inhibition of breast cancer cellsCynthia L Richard
Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada N1G2W1
Exp Cell Res 316:695-703. 2010..Further research should examine the potential for pharmacological or natural agents that modify 1,25D3-MARRS expression or activity as anticancer agents... - Nucleoside transporter expression and activity is regulated during granulocytic differentiation of NB4 cells in response to all-trans-retinoic acidSheryl A Flanagan
Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada N1G 2W1
Leuk Res 31:955-68. 2007.... - Dietary docosahexaenoic acid levels influence the outcome of arabinosylcytosine chemotherapy in L1210 leukemic miceMing C Cha
Department of Human Biology and Nutrition Sciences, University of Guelph, Guelph, ON, Canada N1G 2W1
Nutr Cancer 44:176-81. 2002..These data suggest that a modest level of dietary DHA or linoleic acid supplementation may improve the antineoplastic efficacy of AraC. However, overconsumption of DHA reverses the beneficial effect of DHA intake on drug sensitivity... - Vitamin status and cognitive function in a long-term care populationLina Paulionis
Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada
BMC Geriatr 5:16. 2005.... - Low dose docosahexaenoic acid protects normal colonic epithelial cells from araC toxicityMing C Cha
Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, Ontario, N1G 2W1, Canada
BMC Pharmacol 5:7. 2005..Here we investigate whether the omega-3 fatty acid docosahexaenoic acid (DHA) could selectively target araC toxicity toward colonic tumor cells while protecting the normal cells in vitro... - Synergistic, additive, and antagonistic effects of food mixtures on total antioxidant capacitiesSunan Wang
Guelph Food Research Center, Agriculture and Agri Food Canada, Guelph, Ontario, Canada
J Agric Food Chem 59:960-8. 2011..Compositional changes did not seem to have occurred in the mixture. Results in this study suggest the importance of strategically selecting foods or diets to maximum synergisms as well as to minimum antagonisms in antioxidant activity... - Fatty acids and exercise affect glucose transport but not tumour growth in F-344 ratsJennifer M Foley
Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, ON
Can J Appl Physiol 29:604-22. 2004..High DHA diets may also increase oxidative damage in muscle through enhanced TBARM production... - 1alpha,25-dihydroxyvitamin D3 and bryostatin-1 synergize to induce monocytic differentiation of NB4 acute promyelocytic leukemia cells by modulating cell cycle progressionChristina S Clark
Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada N1G 2W1
Exp Cell Res 294:301-11. 2004..Levels of the cyclin-dependent kinase inhibitors p21 and p27 as well as Cyclin D1 were undetectable in NB4 cell lysates, suggesting that they do not participate in the differentiation response or cell cycle control in this model... - The novel nucleoside transport system exhibited by NB4 cells, csg, transports deoxyguanosine analogues, including ara-GSheryl A Flanagan
Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, Ont, Canada N1G 2W1
Biochem Pharmacol 66:733-7. 2003..Competition assays revealed that this analogue potentiated the inward flux of guanosine and was capable of killing NB4 cells with potency similar to the conventional leukemia drug, ara-C...