R McPherson

Summary

Affiliation: University of Ottawa Heart Institute
Country: Canada

Publications

  1. ncbi Genetic and phenotypic architecture of metabolic syndrome-associated components in dyslipidemic and normolipidemic subjects: the GEMS Study
    Heide Stirnadel
    World Wide Epidemiology, GlaxoSmithKline, Harlow, UK
    Atherosclerosis 197:868-76. 2008
  2. ncbi Decreased mitochondrial proton leak and reduced expression of uncoupling protein 3 in skeletal muscle of obese diet-resistant women
    Mary Ellen Harper
    Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Faculty of Medicine, Ottawa, Ontarion, Canada
    Diabetes 51:2459-66. 2002
  3. ncbi Molecular regulation of SREBP function: the Insig-SCAP connection and isoform-specific modulation of lipid synthesis
    Ruth McPherson
    Lipoprotein and Atherosclerosis Group, University of Ottawa Heart Institute, ON, Canada
    Biochem Cell Biol 82:201-11. 2004
  4. ncbi Identifying genes for coronary artery disease: An idea whose time has come
    Robert Roberts
    University of Ottawa Heart Institute, Ontario
    Can J Cardiol 23:7A-15A. 2007
  5. ncbi From genome-wide association studies to functional genomics: new insights into cardiovascular disease
    Ruth McPherson
    Division of Cardiology, University of Ottawa Heart Institute, 40 Ruskin St H4203, Ottawa, Canada
    Can J Cardiol 29:23-9. 2013
  6. ncbi Inflammation and coronary artery disease: insights from genetic studies
    Ruth McPherson
    University of Ottawa Heart Institute, Ottawa, Ontario, Canada
    Can J Cardiol 28:662-6. 2012
  7. ncbi Gene expression profiling in whole blood identifies distinct biological pathways associated with obesity
    Sujoy Ghosh
    Biomedical Biotechnology Research Institute, North Carolina Central University, Durham, USA
    BMC Med Genomics 3:56. 2010
  8. ncbi The INSIG2 rs7566605 genetic variant does not play a major role in obesity in a sample of 24,722 individuals from four cohorts
    Jan Bressler
    Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX 77030, USA
    BMC Med Genet 10:56. 2009
  9. ncbi A common allele on chromosome 9 associated with coronary heart disease
    Ruth McPherson
    Division of Cardiology, University of Ottawa Heart Institute, Ottawa K1Y4W7, Canada
    Science 316:1488-91. 2007
  10. ncbi Canadian Cardiovascular Society position statement--recommendations for the diagnosis and treatment of dyslipidemia and prevention of cardiovascular disease
    Ruth McPherson
    University of Ottawa Heart Institute, Ottawa, Canada
    Can J Cardiol 22:913-27. 2006

Detail Information

Publications65

  1. ncbi Genetic and phenotypic architecture of metabolic syndrome-associated components in dyslipidemic and normolipidemic subjects: the GEMS Study
    Heide Stirnadel
    World Wide Epidemiology, GlaxoSmithKline, Harlow, UK
    Atherosclerosis 197:868-76. 2008
    ....
  2. ncbi Decreased mitochondrial proton leak and reduced expression of uncoupling protein 3 in skeletal muscle of obese diet-resistant women
    Mary Ellen Harper
    Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Faculty of Medicine, Ottawa, Ontarion, Canada
    Diabetes 51:2459-66. 2002
    ..Thus, proton leak and the expression of UCP3 correlate with weight loss success and may be candidates for pharmacological regulation of fat oxidation in obese diet-resistant subjects...
  3. ncbi Molecular regulation of SREBP function: the Insig-SCAP connection and isoform-specific modulation of lipid synthesis
    Ruth McPherson
    Lipoprotein and Atherosclerosis Group, University of Ottawa Heart Institute, ON, Canada
    Biochem Cell Biol 82:201-11. 2004
    ....
  4. ncbi Identifying genes for coronary artery disease: An idea whose time has come
    Robert Roberts
    University of Ottawa Heart Institute, Ontario
    Can J Cardiol 23:7A-15A. 2007
    ..To detect a minor allele frequency of 5% or greater with an odds ratio for risk of 1.3 or greater and 90% power, an estimated 14,000 (9000 affected and 5000 control) subjects are required...
  5. ncbi From genome-wide association studies to functional genomics: new insights into cardiovascular disease
    Ruth McPherson
    Division of Cardiology, University of Ottawa Heart Institute, 40 Ruskin St H4203, Ottawa, Canada
    Can J Cardiol 29:23-9. 2013
    ....
  6. ncbi Inflammation and coronary artery disease: insights from genetic studies
    Ruth McPherson
    University of Ottawa Heart Institute, Ottawa, Ontario, Canada
    Can J Cardiol 28:662-6. 2012
    ..Candidate gene studies also support a causative role of inflammation pathways in atherosclerosis. Of note, a common loss of function coding variant in the IL-6 receptor gene (IL6R) is associated with a reduction in CAD risk...
  7. ncbi Gene expression profiling in whole blood identifies distinct biological pathways associated with obesity
    Sujoy Ghosh
    Biomedical Biotechnology Research Institute, North Carolina Central University, Durham, USA
    BMC Med Genomics 3:56. 2010
    ..Obesity is reaching epidemic proportions and represents a significant risk factor for cardiovascular disease, diabetes, and cancer...
  8. ncbi The INSIG2 rs7566605 genetic variant does not play a major role in obesity in a sample of 24,722 individuals from four cohorts
    Jan Bressler
    Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX 77030, USA
    BMC Med Genet 10:56. 2009
    ..The combined study sample is comprised of 24,722 white, African-American, and Mexican-American participants...
  9. ncbi A common allele on chromosome 9 associated with coronary heart disease
    Ruth McPherson
    Division of Cardiology, University of Ottawa Heart Institute, Ottawa K1Y4W7, Canada
    Science 316:1488-91. 2007
    ..Homozygotes for the risk allele make up 20 to 25% of Caucasians and have a approximately 30 to 40% increased risk of CHD...
  10. ncbi Canadian Cardiovascular Society position statement--recommendations for the diagnosis and treatment of dyslipidemia and prevention of cardiovascular disease
    Ruth McPherson
    University of Ottawa Heart Institute, Ottawa, Canada
    Can J Cardiol 22:913-27. 2006
    ..0) and recommendations regarding additional investigations of potential use in the further evaluation of coronary artery disease risk in subjects in the moderate-risk category...
  11. ncbi Genetic contributors to obesity
    Ruth McPherson
    University of Ottawa Heart Institute, Ontario
    Can J Cardiol 23:23A-27A. 2007
    ..Rare variants in the coding sequences of major candidate genes account for an obese phenotype in 5% to 10% of individuals...
  12. ncbi Cerivastatin versus branded pravastatin in the treatment of primary hypercholesterolemia in primary care practice in Canada: a one-year, open-label, randomized, comparative study of efficacy, safety, and cost-effectiveness
    R McPherson
    University of Ottawa Heart Institute, Ontario, Canada
    Clin Ther 23:1492-507. 2001
    ..Potential cost differences between statins are driven primarily by drug costs, differential lowering effects on low-density lipoprotein cholesterol (LDL-C) levels, and adverse drug interactions and reactions...
  13. ncbi Is hormone replacement therapy cardioprotective? Decision-making after the heart and estrogen/progestin replacement study
    R McPherson
    Ottawa Heart Institute, Ottawa, Canada
    Can J Cardiol 16:14A-9A. 2000
    ..Until the results of other randomized controlled studies are complete, advice regarding HRT should be based on anticipated benefits on CAD risk factors versus the overall risk of both venous and arterial thrombosis...
  14. ncbi Efficacy of atorvastatin in achieving National Cholesterol Education Program low-density lipoprotein targets in women with severe dyslipidemia and cardiovascular disease or risk factors for cardiovascular disease: The Women's Atorvastatin Trial on Cholest
    R McPherson
    University of Ottawa Heart Institute, Ottawa, Ontario, Canada
    Am Heart J 141:949-56. 2001
    ..The ability to achieve established treatment goals for low-density lipoprotein cholesterol (LDL-C) in women with clearly defined risk factors has not been examined in detail...
  15. ncbi Controversies in primary prevention among hyperlipidemic patients
    R McPherson
    University of Ottawa Heart Institute, Ottawa, Canada
    Can J Cardiol 15:16B-19B. 1999
    ..To assist in both primary and secondary prevention strategies, an outline of guidelines developed by a Health Canada working group for the management of hyperlipidemia have recently been published...
  16. ncbi Coronary artery disease and women: applying the guidelines for risk factor management
    R McPherson
    Ottawa Heart Institute, Ottawa, Canada
    Can J Cardiol 16:5A-10A. 2000
    ..Physician risk factor assessment and adherence to current guideline recommendations are essential in preventing the development or progression of CAD in women...
  17. ncbi Randomized trial of a portable, self-administered decision aid for postmenopausal women considering long-term preventive hormone therapy
    A M O'Connor
    University of Ottawa School of Nursing, Ottawa Civic Hospital Loeb Research Institute, Ontario, Canada
    Med Decis Making 18:295-303. 1998
    ..Levels of general knowledge about the main benefits and risks were comparable for the two interventions. It is concluded that tailored decision aids prepare women for decision making better than do general pamphlets...
  18. ncbi Naturally occurring R225W mutation of the gene encoding AMP-activated protein kinase (AMPK)gamma(3) results in increased oxidative capacity and glucose uptake in human primary myotubes
    S A Crawford
    Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada
    Diabetologia 53:1986-97. 2010
    ....
  19. ncbi Increased susceptibility to oxidative damage in post-diabetic human myotubes
    S R Costford
    Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, 451 Smyth Road, Ottawa, ON K1H 8M5, Canada
    Diabetologia 52:2405-15. 2009
    ..We hypothesised that chronic exposure to high glucose and insulin would re-elicit impaired metabolism in primary myotubes from patients with a history of type 2 diabetes...
  20. ncbi Cholesteryl ester transfer protein directly mediates selective uptake of high density lipoprotein cholesteryl esters by the liver
    Andre Gauthier
    Division of Cardiology, University of Ottawa Heart Institute, Ottawa, Canada
    Arterioscler Thromb Vasc Biol 25:2177-84. 2005
    ....
  21. ncbi Comparative effects of simvastatin and cholestyramine on plasma lipoproteins and CETP in humans
    R McPherson
    University of Ottawa Heart Institute, Ottawa, Ontario, Canada
    Can J Clin Pharmacol 6:85-90. 1999
    ..This study demonstrates that, compared with cholestyramine, simvastatin results in more favourable improvements in the plasma lipoprotein profile and also lowers plasma levels of CETP...
  22. ncbi Plasma kinetics of cholesteryl ester transfer protein in the rabbit. Effects of dietary cholesterol
    R McPherson
    Lipoprotein and Atherosclerosis Group, University of Ottawa Heart Institute, Canada
    Arterioscler Thromb Vasc Biol 17:203-10. 1997
    ..The effect of dietary cholesterol on plasma CETP mass can be explained largely by the effects on CETP synthesis, consistent with the observed effects of cholesterol on tissue mRNA levels...
  23. ncbi Severe hypoalphalipoproteinemia in mice expressing human hepatic lipase deficient in binding to heparan sulfate proteoglycan
    Robert J Brown
    Lipoprotein and Atherosclerosis Research Group, University of Ottawa Heart Institute, Ottawa, Ontario K1Y 4W7, Canada
    J Biol Chem 279:42403-9. 2004
    ..These results suggest that expression of HSPG binding-deficient hHL has a profound HDL-lowering effect...
  24. ncbi The transcription factor GATA-2 does not associate with angiographic coronary artery disease in the Ottawa Heart Genomics and Cleveland Clinic GeneBank Studies
    Sonny Dandona
    The John and Jennifer Ruddy Canadian Cardiovascular Genetics Centre, University of Ottawa Heart Institute, Ottawa, Canada
    Hum Genet 127:101-5. 2010
    ..Neither of the genotyped SNPs associates with CAD in the OHGS1 or CC/OHGS2 populations. Our data suggest that GATA2 does not contribute to the development of angiographic CAD among sporadic cases...
  25. ncbi Role of cholesteryl ester transfer protein in selective uptake of high density lipoprotein cholesteryl esters by adipocytes
    Gerard Vassiliou
    Lipoprotein and Atherosclerosis Group, University of Ottawa Heart Institute, Ottawa, Ontario K1Y 4E9, Canada
    J Lipid Res 45:1683-93. 2004
    ..In contrast, CETP-specific PL uptake did not attain saturation at 5 microg/ml HDL and was approximately 6-fold greater than the uptake of CE. We propose two possible mechanisms to account for the role of CETP in selective uptake...
  26. ncbi A novel efflux-recapture process underlies the mechanism of high-density lipoprotein cholesteryl ester-selective uptake mediated by the low-density lipoprotein receptor-related protein
    Gerard Vassiliou
    Lipoprotein and Atherosclerosis Group, Lab H453, University of Ottawa Heart Institute, Ottawa ON K1Y 4W7, Canada
    Arterioscler Thromb Vasc Biol 24:1669-75. 2004
    ..To determine the mechanism of low-density lipoprotein (LDL) receptor-related protein (LRP)-mediated selective uptake of high-density lipoprotein (HDL)-derived cholesteryl esters (CE)...
  27. ncbi Role of Lp A-I and Lp A-I/A-II in cholesteryl ester transfer protein-mediated neutral lipid transfer. Studies in normal subjects and in hypertriglyceridemic patients before and after fenofibrate therapy
    R McPherson
    University of Ottawa Heart Institute, Canada
    Arterioscler Thromb Vasc Biol 16:1340-6. 1996
    ..Lp A-I/A-II is an efficient donor for CE transfer to TG-rich lipoproteins, and its low affinity for CETP may in fact facilitate neutral lipid transfer either by a shuttle mechanism or by formation of a ternary complex...
  28. ncbi Secretory vesicular transport from the Golgi is altered during ATP-binding cassette protein A1 (ABCA1)-mediated cholesterol efflux
    Xiaohui Zha
    Lipoprotein and Atherosclerosis Group, University of Ottawa Heart Institute, Ontario K1Y 4W7, Canada
    J Biol Chem 278:10002-5. 2003
    ..ABCA1 may influence cholesterol efflux in part by enhancing vesicular trafficking from the Golgi to the plasma membrane...
  29. ncbi Adipocyte low density lipoprotein receptor-related protein gene expression and function is regulated by peroxisome proliferator-activated receptor gamma
    Andre Gauthier
    Lipoprotein and Atherosclerosis Group, University of Ottawa Heart Institute, Ottawa K1Y 4W7, Canada
    J Biol Chem 278:11945-53. 2003
    ..These data demonstrate that fatty acids and rosiglitazone directly stimulate transcription of the LRP gene through activation of PPARgamma and increase functional LRP expression...
  30. ncbi Functional analysis of the chromosome 9p21.3 coronary artery disease risk locus
    Olga Jarinova
    University of Ottawa Heart Institute, Ottawa, Canada
    Arterioscler Thromb Vasc Biol 29:1671-7. 2009
    ..We have investigated the functional significance of conserved sequences within the 9p21.3 risk locus for coronary artery disease (CAD) and determined the relationship of 9p21.3 to expression of ANRIL and to whole genome gene expression...
  31. ncbi The low density lipoprotein receptor-related protein contributes to selective uptake of high density lipoprotein cholesteryl esters by SW872 liposarcoma cells and primary human adipocytes
    G Vassiliou
    Lipoprotein and Atherosclerosis Group, University of Ottawa Heart Institute, Ottawa, Ontario K1Y 4E9, Canada
    J Biol Chem 276:48823-30. 2001
    ..We discuss the possible mechanisms by which the endocytic receptor, LRP, can mediate selective uptake...
  32. ncbi UCP3 and its putative function: consistencies and controversies
    M E Harper
    Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, 451 Smyth Road, Ottawa, ON, Canada K1H 8M5
    Biochem Soc Trans 29:768-73. 2001
    ..Overall, findings support a role for Ucp3 in fatty acid metabolism that may have implications for obesity and/or Type II diabetes...
  33. ncbi Endocytosis is enhanced in Tangier fibroblasts: possible role of ATP-binding cassette protein A1 in endosomal vesicular transport
    X Zha
    Lipoprotein and Atherosclerosis Group, University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, Ontario K1Y 4W7, Canada
    J Biol Chem 276:39476-83. 2001
    ..We speculate that this is related to the PS translocase function of ABCA1. A loss of functional ABCA1, as in the case of Tangier cells, enhances membrane inward bending and facilitates endocytosis...
  34. ncbi Relationship of adipose tissue cholesteryl ester transfer protein (CETP) mRNA to plasma concentrations of CETP in man
    T Radeau
    Lipoprotein and Atherosclerosis Group, University of Ottawa Heart Institute, Canada
    Atherosclerosis 139:369-76. 1998
    ..The decrease in plasma concentrations of CETP with age may be explained in part by changes in adipose tissue CETP gene expression...
  35. ncbi A decision aid for women considering hormone therapy after menopause: decision support framework and evaluation
    A M O'Connor
    University of Ottawa, School of Nursing, Ontario, Canada
    Patient Educ Couns 33:267-79. 1998
    ..Most participants found the decision aid comprehensible, acceptable in length and pace, and balanced. Decision aids are useful in preparing women for decision making about this complex, personal issue...
  36. ncbi Distinct skeletal muscle fiber characteristics and gene expression in diet-sensitive versus diet-resistant obesity
    Martin F Gerrits
    Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, 451 Smyth Rd, Ottawa, ON, Canada
    J Lipid Res 51:2394-404. 2010
    ..lean women. Altogether, our findings demonstrate differences in muscle gene expression and fiber composition related to clinical weight loss success...
  37. ncbi Predominance of a proinflammatory phenotype in monocyte-derived macrophages from subjects with low plasma HDL-cholesterol
    Lea Sarov-Blat
    University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, Ontario, K1Y 4W7, Canada
    Arterioscler Thromb Vasc Biol 27:1115-22. 2007
    ..Reduced plasma concentrations of high-density lipoprotein-cholesterol (HDL-C) are a significant risk factor for cardiovascular disease. Mechanisms that regulate HDL-C concentrations represent an important area of investigation...
  38. ncbi Genetic etiology of isolated low HDL syndrome: incidence and heterogeneity of efflux defects
    Robert S Kiss
    University of Ottawa Heart Institute, 40 Ruskin St, Ottawa, Ontario, K1Y 4W7, Canada
    Arterioscler Thromb Vasc Biol 27:1139-45. 2007
    ..We have used a multitiered approach to identify genetic and cellular contributors to high-density lipoprotein (HDL) deficiency in 124 human subjects...
  39. ncbi Gene dosage of the common variant 9p21 predicts severity of coronary artery disease
    Sonny Dandona
    John and Jennifer Ruddy Canadian Cardiovascular Genetics Centre, University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, Ontario, Canada
    J Am Coll Cardiol 56:479-86. 2010
    ..The purpose of this study was to test the hypothesis that 9p21 gene dosage determines the severity of coronary artery disease (CAD)...
  40. ncbi Hepatic SR-BI-mediated cholesteryl ester selective uptake occurs with unaltered efficiency in the absence of cellular energy
    Chris J Harder
    Lipoprotein and Atherosclerosis Group, University of Ottawa Heart Institute, Ottawa, Ontario, Canada K1Y 4W7
    J Lipid Res 47:492-503. 2006
    ....
  41. ncbi Disruption at the PTCHD1 Locus on Xp22.11 in Autism spectrum disorder and intellectual disability
    Abdul Noor
    Neurogenetics Section, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Sci Transl Med 2:49ra68. 2010
    ..Thus, our systematic screen of PTCHD1 and its 5' flanking regions suggests that this locus is involved in ~1% of individuals with ASD and intellectual disability...
  42. ncbi Peroxisome proliferator-activated receptor gamma 2 and acyl-CoA synthetase 5 polymorphisms influence diet response
    Kristi B Adamo
    Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ontario, Canada
    Obesity (Silver Spring) 15:1068-75. 2007
    ..Skeletal muscle ACSL5 mRNA expression was significantly lower in carriers of the wildtype compared with the variant rs2419621 allele (p = 0.03). Our results suggest a link between PPARgamma2 and ACSL5 genotype and diet responsiveness...
  43. ncbi SR-BI undergoes cholesterol-stimulated transcytosis to the bile canaliculus in polarized WIF-B cells
    Christopher J Harder
    Lipoprotein and Atherosclerosis Group, University of Ottawa Heart Institute, Ottawa, Ontario K1Y 4W7, Canada
    J Biol Chem 282:1445-55. 2007
    ..Taken together, these data demonstrate that hepatic SR-BI transcytosis is regulated by cholesterol and suggest that SR-BI has a stationary function on the bile canaliculus...
  44. ncbi Scavenger receptor class B type I localizes to a late endosomal compartment
    Malika Ahras
    Division of Cardiology, University of Ottawa Heart Institute, Ottawa, Canada K1Y 4W7
    J Lipid Res 49:1569-76. 2008
    ..In addition to its role as a plasma membrane receptor, SR-BI may function in cholesterol trafficking from late endosomes/lysosomes...
  45. ncbi Cholesteryl ester transfer protein (CETP) expression protects against diet induced atherosclerosis in SR-BI deficient mice
    Christopher Harder
    Lipoprotein and Atherosclerosis Research Group, University of Ottawa Heart Institute, Ottawa, Canada
    Arterioscler Thromb Vasc Biol 27:858-64. 2007
    ..To determine whether expression of the human CETP transgene protects against diet-induced atherosclerosis in SR-BI deficient mice...
  46. ncbi Early effects of statin therapy on endothelial function and microvascular reactivity in patients with coronary artery disease
    Michael C Ling
    Division of Cardiology, Department of Medicine, Cardiac PET Centre, University of Ottawa Heart Institute, Ottawa, Ontario, Canada
    Am Heart J 149:1137. 2005
    ..CONCLUSIONS: Short-term LDL reduction with simvastatin therapy improves peripheral endothelial function in patients with stable CAD, although an early effect on coronary vascular reactivity could not be demonstrated...
  47. ncbi Peering through the darkened glass: success and disappointment in the management of cardiovascular risk
    Ruth McPherson
    University of Ottawa Heart Institute, Ottawa, Canada
    Curr Opin Lipidol 17:615-8. 2006
  48. ncbi Cathepsin D, a lysosomal protease, regulates ABCA1-mediated lipid efflux
    Bassam Haidar
    Lipoprotein and Atherosclerosis Research Group, University of Ottawa Heart Institute, Ottawa, Ontario, K1Y 4W7, Canada
    J Biol Chem 281:39971-81. 2006
    ..These studies demonstrate a novel and potentially important role for CTSD in intracellular cholesterol trafficking and ABCA1-mediated efflux. Therefore, decreased CTSD expression may contribute to low plasma HDL-C levels...
  49. ncbi Multiple rare alleles contribute to low plasma levels of HDL cholesterol
    Jonathan C Cohen
    Donald W Reynolds Cardiovascular Clinical Research Center and McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA
    Science 305:869-72. 2004
    ..Thus, rare alleles with major phenotypic effects contribute significantly to low plasma HDL-C levels in the general population...
  50. ncbi Lack of MEF2A mutations in coronary artery disease
    Li Weng
    US Department of Energy, Joint Genome Institute, Walnut Creek, California, USA
    J Clin Invest 115:1016-20. 2005
    ..These studies support that MEF2A mutations are not a common cause of CAD in white people and argue strongly against a role for the MEF2A 21-bp deletion in autosomal dominant CAD...
  51. ncbi Recommendations for the management of dyslipidemia and the prevention of cardiovascular disease: summary of the 2003 update
    Jacques Genest
    Royal Victoria Hospital, McGill University, , Que
    CMAJ 169:921-4. 2003
  52. ncbi A PYY Q62P variant linked to human obesity
    Nadav Ahituv
    Genomics Division, One Cyclotron Road, MS 84 171, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Hum Mol Genet 15:387-91. 2006
    ..Taken together, these results are the first to support that rare sequence variants within PYY can influence human susceptibility to obesity...
  53. ncbi LDL-cholesterol concentrations: a genome-wide association study
    Manjinder S Sandhu
    Department of Public Health and Primary Care, Strangeways Research Laboratory, University of Cambridge, Cambridge, UK
    Lancet 371:483-91. 2008
    ..We therefore did a genome-wide association study of LDL-cholesterol concentrations...
  54. ncbi The metabolic syndrome and type 2 diabetes: role of the adipocyte
    Ruth McPherson
    Curr Opin Lipidol 14:549-53. 2003
  55. ncbi Statin therapy in acute coronary syndrome
    Vincent E Friedewald
    University of Texas Health Sciences Center at Houston, Houston, Texas, USA
    Am J Cardiol 99:213-21. 2007
  56. ncbi Relation between atherogenic dyslipidemia and the Adult Treatment Program-III definition of metabolic syndrome (Genetic Epidemiology of Metabolic Syndrome Project)
    Diego F Wyszynski
    Department of Medicine (Genetics Program, Boston University School of Medicine, Boston, MA, USA
    Am J Cardiol 95:194-8. 2005
    ..In subjects aged <35 years, atherogenic dyslipidemia frequently occurs in the absence of other metabolic syndrome risk factors...
  57. ncbi The analysis by Manuel and colleagues creates controversy with headlines, not data
    Jacques Genest
    Division of Cardiology, Royal Victoria Hospital, McGill University, , Que
    CMAJ 172:1033-4; discussion 1037. 2005
  58. ncbi Statins for primary prevention of coronary artery disease
    Ruth McPherson
    Lancet 369:1078; author reply 1079. 2007
  59. ncbi Statin therapy and the management of acute coronary syndromes
    Anatoly Langer
    Canadian Heart Research Centre and St Michael s Hospital, University of Toronto, Toronto, Canada
    Can J Cardiol 19:921-7. 2003
    ....
  60. ncbi Multiple QTLs influencing triglyceride and HDL and total cholesterol levels identified in families with atherogenic dyslipidemia
    Yi Yu
    Department of Medicine (Genetics Program, Boston University School of Medicine, Boston, MA, USA
    J Lipid Res 46:2202-13. 2005
    ..These data also indicate that a large proportion of the variance of TG levels in the Turkish population is explained by the interaction of multiple genetic loci...
  61. ncbi Lack of support for the association between GAD2 polymorphisms and severe human obesity
    Michael M Swarbrick
    Diabetes Center, University of California, San Francisco, California, USA
    PLoS Biol 3:e315. 2005
    ....
  62. ncbi Medical sequencing at the extremes of human body mass
    Nadav Ahituv
    Genomics Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Am J Hum Genet 80:779-91. 2007
    ..Together, these data suggest that multiple rare alleles contribute to obesity in the population and provide a medical sequencing-based approach to detect them...
  63. ncbi Statin therapy in Canadian patients with hypercholesterolemia: the Canadian Lipid Study -- Observational (CALIPSO)
    C Bourgault
    McGill University, Montreal, Canada
    Can J Cardiol 21:1187-93. 2005
    ..Although statins are widely used to reduce low density lipoprotein cholesterol (LDL-C), there is little information about patient profiles, treatment patterns and goal achievement among statin-treated patients in Canada...
  64. ncbi Clinical and public health assessment of benefits and risks of statins in primary prevention of coronary events: resolved and unresolved issues
    Yola Moride
    Faculty of Pharmacy, Universite de Montreal, Montreal, Quebec
    Can J Cardiol 24:293-300. 2008
    ..However, the benefit-risk ratio would likely be optimized through interventions designed to increase persistence and adherence in a real-life setting...
  65. ncbi Antibody phenotyping test for the human apolipoprotein E2 isoform
    Robert L Raffai
    The Gladstone Institute of Cardiovascular Disease, Cardiovascular Research Institute, University of California, San Francisco, CA 94141 9100, USA
    Clin Chem 49:1524-6. 2003