Archibald McNicol

Summary

Affiliation: University of Manitoba
Country: Canada

Publications

  1. ncbi request reprint Platelets and anti-platelet therapy
    Archibald McNicol
    Department of Oral Biology, University of Manitoba, Winnipeg, Canada
    J Pharmacol Sci 93:381-96. 2003
  2. ncbi request reprint Translocation and phosphorylation of cytosolic phospholipase A2 in activated platelets
    A McNicol
    Department of Oral Biology, University of Manitoba, Winnipeg, Canada
    Thromb Res 92:19-26. 1998
  3. doi request reprint Streptococcus sanguinis-induced cytokine release from platelets
    A McNicol
    Department of Oral Biology, University of Manitoba, Winnipeg, MB, Canada
    J Thromb Haemost 9:2038-49. 2011
  4. doi request reprint Mechanisms of oral bacteria-induced platelet activation
    Archibald McNicol
    Department of Oral Biology, University of Manitoba, Winnipeg, Canada
    Can J Physiol Pharmacol 88:510-24. 2010
  5. ncbi request reprint A role for immunoglobulin G in donor-specific Streptococcus sanguis-induced platelet aggregation
    Archibald McNicol
    Department of Oral Biology, 780 Bannatyne Avenue, Winnipeg, Manitoba R3E 0W2, Canada
    Thromb Haemost 95:288-93. 2006
  6. ncbi request reprint Effects of the mitogen-activated protein (MAP) kinase kinase inhibitor 2-(2'-amino-3'-methoxyphenyl)-oxanaphthalen-4-one (PD98059) on human platelet activation
    A McNicol
    Department of Oral Biology and Pharmacology, University of Manitoba, Winnipeg, Canada
    Biochem Pharmacol 55:1759-67. 1998
  7. ncbi request reprint Incorporation of map kinases into the platelet cytoskeleton
    A McNicol
    Department of Oral Biology, University of Manitoba, R3E 0W2, Winnipeg, Manitoba, Canada
    Thromb Res 103:25-34. 2001
  8. ncbi request reprint Inhibition of the MEK/ERK pathway has no effect on agonist-induced aggregation of human platelets
    Archibald McNicol
    Department of Oral Biology, University of Manitoba, 780 Bannatyne Avenue, Winnipeg, Man, Canada R3E 0W2
    Biochem Pharmacol 65:1243-50. 2003
  9. ncbi request reprint Streptococcus sanguis-induced platelet activation involves two waves of tyrosine phosphorylation mediated by FcgammaRIIA and alphaIIbbeta3
    Caroline Pampolina
    Department of Oral Biology, Winnipeg, Manitoba, Canada
    Thromb Haemost 93:932-9. 2005
  10. ncbi request reprint Evidence for a role for phospholipase C, but not phospholipase A2, in platelet activation in response to low concentrations of collagen
    L K Lockhart
    Department of Oral Biology, University of Manitoba, Winnipeg, Canada
    Thromb Haemost 85:882-9. 2001

Collaborators

  • Sara J Israels
  • Zhikang Peng
  • Diane E Roberts
  • Ratna Bose
  • J G White
  • D F Bainton
  • K J Clemetson
  • Elke C G Jackson
  • Ahmed Y Abdulrehman
  • Catherine Robertson
  • Dongfeng Sun
  • Caroline Pampolina
  • Brent Nickolaychuk
  • C L Hall
  • L K Lockhart
  • J M Gerrard
  • Stephanie A Booth
  • Daniel R Beniac
  • Timothy F Booth
  • Anthony A James
  • Michael B Coulthart
  • Catalena Birek
  • James Gilchrist
  • E A Turley
  • J Bo A
  • L A Collis
  • B R Nickolaychuk
  • C Pampolina
  • L Lange
  • A Shalev
  • M Nishibori
  • N Jain
  • A H Greenberg
  • B Cham
  • C J Witkop
  • E M McMillan
  • G Michaud
  • W L Nichols
  • S Singhroy
  • M Ray
  • M L Schroeder
  • A J Bishop
  • L L Beattie
  • D Walz
  • E D Israels

Detail Information

Publications31

  1. ncbi request reprint Platelets and anti-platelet therapy
    Archibald McNicol
    Department of Oral Biology, University of Manitoba, Winnipeg, Canada
    J Pharmacol Sci 93:381-96. 2003
    ..Recent advances in understanding of platelet physiology have suggested several novel, if yet untested, targets for anti-platelet therapy. These include the thrombin receptor, the serotonin handling system, and the leptin receptor...
  2. ncbi request reprint Translocation and phosphorylation of cytosolic phospholipase A2 in activated platelets
    A McNicol
    Department of Oral Biology, University of Manitoba, Winnipeg, Canada
    Thromb Res 92:19-26. 1998
    ..Activation of both pathways, as occurs in response to thrombin, is required for arachidonic acid liberation...
  3. doi request reprint Streptococcus sanguinis-induced cytokine release from platelets
    A McNicol
    Department of Oral Biology, University of Manitoba, Winnipeg, MB, Canada
    J Thromb Haemost 9:2038-49. 2011
    ..The oral micro-organism S. sanguinis stimulates platelet aggregation in vitro in a strain-dependent manner, although there are no reports of associated cytokine production...
  4. doi request reprint Mechanisms of oral bacteria-induced platelet activation
    Archibald McNicol
    Department of Oral Biology, University of Manitoba, Winnipeg, Canada
    Can J Physiol Pharmacol 88:510-24. 2010
    ..The current review describes the heterogeneous mechanisms of platelet activation employed by individual bacterial species. The pathological and clinical implications of platelet activation by orally derived bacteria are discussed...
  5. ncbi request reprint A role for immunoglobulin G in donor-specific Streptococcus sanguis-induced platelet aggregation
    Archibald McNicol
    Department of Oral Biology, 780 Bannatyne Avenue, Winnipeg, Manitoba R3E 0W2, Canada
    Thromb Haemost 95:288-93. 2006
    ..sanguis determines platelet responsiveness, neither the levels of IgG nor FcgammaRIIA polymorphisms can fully account for donor variability...
  6. ncbi request reprint Effects of the mitogen-activated protein (MAP) kinase kinase inhibitor 2-(2'-amino-3'-methoxyphenyl)-oxanaphthalen-4-one (PD98059) on human platelet activation
    A McNicol
    Department of Oral Biology and Pharmacology, University of Manitoba, Winnipeg, Canada
    Biochem Pharmacol 55:1759-67. 1998
    ..Furthermore, the inhibitory effects of PD98059 on collagen- and arachidonic acid-induced responses suggest that PD98059 may inhibit the conversion of arachidonic acid to thromboxane, in addition to its reported effects on MEK1...
  7. ncbi request reprint Incorporation of map kinases into the platelet cytoskeleton
    A McNicol
    Department of Oral Biology, University of Manitoba, R3E 0W2, Winnipeg, Manitoba, Canada
    Thromb Res 103:25-34. 2001
    ..These data suggest either that MAP kinases play a role in cytoskeletal rearrangement or that the cytoskeleton act as a frame to align MAP kinases with substrates in a highly integrated signal transduction pathway...
  8. ncbi request reprint Inhibition of the MEK/ERK pathway has no effect on agonist-induced aggregation of human platelets
    Archibald McNicol
    Department of Oral Biology, University of Manitoba, 780 Bannatyne Avenue, Winnipeg, Man, Canada R3E 0W2
    Biochem Pharmacol 65:1243-50. 2003
    ..In addition, the effects of higher concentrations of U0126 are likely due to an action on protein kinase C, likely unrelated to ERK inhibition, suggesting that the inhibitor concentration is crucial to the interpretation of such studies...
  9. ncbi request reprint Streptococcus sanguis-induced platelet activation involves two waves of tyrosine phosphorylation mediated by FcgammaRIIA and alphaIIbbeta3
    Caroline Pampolina
    Department of Oral Biology, Winnipeg, Manitoba, Canada
    Thromb Haemost 93:932-9. 2005
    ..Subsequent engagement of alpha(IIb)beta(3) leads to SHP-1 dephosphorylation permiting a second wave of signaling leading to TxA(2) release and consequent platelet aggregation...
  10. ncbi request reprint Evidence for a role for phospholipase C, but not phospholipase A2, in platelet activation in response to low concentrations of collagen
    L K Lockhart
    Department of Oral Biology, University of Manitoba, Winnipeg, Canada
    Thromb Haemost 85:882-9. 2001
    ..In contrast, the data are consistent with phospholipase Cgamma2 playing a role in an intricately controlled pathway, or multiple pathways, mediating the release of arachidonic acid in collagen-stimulated platelets...
  11. doi request reprint Platelet activation by Streptococcus sanguinis is accompanied by MAP kinase phosphorylation
    Ahmed Y Abdulrehman
    Departments of Oral Biology, University of Manitoba, Winnipeg, Manitoba, Canada
    Platelets 24:6-14. 2013
    ..sanguinis strain 2017-78, and is consistent with a role for Erk2, but not for p38, in the cPLA(2) phosphorylation in response to S. sanguinis...
  12. doi request reprint Cyclic nucleotides inhibit MAP kinase activity in low-dose collagen-stimulated platelets
    Elke C G Jackson
    Department of Oral Biology, University of Manitoba, 780 Bannatyne Avenue, Winnipeg, Manitoba, Canada R3E 0W2
    Thromb Res 125:147-51. 2010
    ..The study also supports an inhibitory, rather than stimulatory, role for guanylate cyclase in platelet signaling...
  13. ncbi request reprint Platelet dense granule membranes contain both granulophysin and P-selectin (GMP-140)
    S J Israels
    Department of Paediatrics, University of Manitoba, Winnipeg, Canada
    Blood 80:143-52. 1992
    ..The results demonstrate that granulophysin is localized to the dense granules of platelets and is redistributed to the plasma membrane after platelet activation...
  14. ncbi request reprint Mechanism of collagen activation in human platelets
    Diane E Roberts
    Department of Pharmacology and Therapeutics, University of Manitoba, 753 McDermot Avenue, Winnipeg, Manitoba R3E 0W3, Canada
    J Biol Chem 279:19421-30. 2004
    ....
  15. ncbi request reprint CD63 associates with the alphaIIb beta3 integrin-CD9 complex on the surface of activated platelets
    S J Israels
    Department of Pediatrics and the Manitoba Institute of Cell Biology, University of Manitoba, Winnipeg, Canada
    Thromb Haemost 85:134-41. 2001
    ....
  16. pmc The protein CD63 is in platelet dense granules, is deficient in a patient with Hermansky-Pudlak syndrome, and appears identical to granulophysin
    M Nishibori
    Department of Paediatrics, University of Manitoba, Winnipeg, Canada
    J Clin Invest 91:1775-82. 1993
    ..This is the first report of a protein present in platelet dense granules, lysosomes, and melanocytes, but deficient in a patient with Hermansky-Pudlak syndrome...
  17. ncbi request reprint The empty sack syndrome: a platelet storage pool deficiency associated with empty dense granules
    A McNicol
    Manitoba Institute of Cell Biology, University of Manitoba, Winnipeg, Canada
    Br J Haematol 86:574-82. 1994
    ..This observation represents a novel form of storage pool disease which we have termed the empty sack syndrome...
  18. ncbi request reprint Phospholipase C activity in platelets from Bernard-Soulier syndrome patients
    A McNicol
    Manitoba Institute of Cell Biology, Winnipeg, Canada
    Arterioscler Thromb 13:1567-71. 1993
    ..These data indicated a postreceptor defect in phospholipase C activation in Bernard-Soulier syndrome platelets and confirmed earlier observations of potential proteolytic and nonproteolytic mechanisms of platelet activation...
  19. ncbi request reprint Defective thrombin-induced calcium changes and aggregation of Bernard-Soulier platelets are not associated with deficient moderate-affinity receptors
    A McNicol
    Department of Oral Biology, University of Manitoba, Winnipeg, Canada
    Arterioscler Thromb Vasc Biol 16:628-32. 1996
    ....
  20. ncbi request reprint Beyond hemostasis: the role of platelets in inflammation, malignancy and infection
    Archibald McNicol
    Department of Oral Biology, University of Manitoba, Winnipeg, Manitoba, Canada
    Cardiovasc Hematol Disord Drug Targets 8:99-117. 2008
    ..The primary focus of this review is the "non-haemostatic" functions of platelets in physiological and pathological states...
  21. ncbi request reprint The effects of genistein on platelet function are due to thromboxane receptor antagonism rather than inhibition of tyrosine kinase
    A McNicol
    Manitoba Institute of Cell Biology, University of Manitoba, Winnipeg, Canada
    Prostaglandins Leukot Essent Fatty Acids 48:379-84. 1993
    ..These data suggest that the inhibitory effects of genistein on platelet activation occurs as a result of antagonism of the thromboxane receptor...
  22. ncbi request reprint The lysosomal granule membrane protein, LAMP-2, is also present in platelet dense granule membranes
    S J Israels
    Department of Pediatrics, University of Manitoba, Winnipeg, Canada
    Thromb Haemost 75:623-9. 1996
    ..These data indicate that LAMP-2 is present in the membranes of platelet dense granules in addition to lysosomal granules, and has a similar distribution to CD63...
  23. ncbi request reprint Platelet storage pool deficiency: diagnosis in patients with prolonged bleeding times and normal platelet aggregation
    S J Israels
    Manitoba Institute of Cell Biology, University of Manitoba, Winnipeg, Canada
    Br J Haematol 75:118-21. 1990
    ..Evidence of storage pool deficiency should be considered in all patients with an isolated unexplained prolongation of the bleeding time. The methods used in this study are readily applicable to most clinical laboratories...
  24. ncbi request reprint Evidence for a role of mitogen-activated protein kinases in proliferating and differentiating odontogenic epithelia of inflammatory and developmental cysts
    Brent Nickolaychuk
    Department of Preventive Dental Science, Faculty of Dentistry, University of Manitoba, Winnipeg, Canada
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 93:720-9. 2002
    ....
  25. ncbi request reprint Cellular prion protein is released on exosomes from activated platelets
    Catherine Robertson
    Department of Oral Biology, University of Manitoba, 780 Bannatyne Avenue, Winnipeg, Manitoba, Canada R3E 0W2
    Blood 107:3907-11. 2006
    ..The presence of PrP(C) on platelet-derived exosomes suggests a possible mechanism for PrP(C) transport in blood and for cell-to-cell transmission...
  26. ncbi request reprint Expression of functional recombinant mosquito salivary apyrase: a potential therapeutic platelet aggregation inhibitor
    Dongfeng Sun
    Department of Pediatrics and Child Health, Faculty of Medicine, University of Manitoba, Manitoba, Canada
    Platelets 17:178-84. 2006
    ....
  27. ncbi request reprint Platelet storage pool deficiency, leukemia, and myelodysplastic syndromes
    J M Gerrard
    Manitoba Institute of Cell Biology, Winnipeg, Canada
    Leuk Lymphoma 8:277-81. 1992
    ....
  28. ncbi request reprint Inherited platelet-storage pool deficiency associated with a high incidence of acute myeloid leukaemia
    J M Gerrard
    Department of Paediatrics, University of Manitoba, Winnipeg, Canada
    Br J Haematol 79:246-55. 1991
    ..This congenital storage pool deficiency is associated with a high incidence of acute myeloid leukaemia in this family...
  29. ncbi request reprint Quantification of a novel dense granule protein (granulophysin) in platelets of patients with dense granule storage pool deficiency
    A Shalev
    Department of Pediatrics, University of Manitoba, Winnipeg, Canada
    Blood 80:1231-7. 1992
    ..Thus, granulophysin quantitation facilitates characterization of delta-SPD patients and may provide clues to the nature of defective granules in delta-SPD subtypes...
  30. ncbi request reprint Fibroblasts require protein kinase C activation to respond to hyaluronan with increased locomotion
    C L Hall
    Manitoba Institute of Cell Biology, University of Manitoba, Winnipeg, Manitoba, Canada
    Matrix Biol 20:183-92. 2001
    ..These results suggest that the ability of cells to respond to HA is regulated by a protein kinase C-dependent process that may promote uptake of HA...
  31. ncbi request reprint A role for von Willebrand factor in Streptococcus sanguis-induced platelet activation
    Archibald McNicol
    Thromb Haemost 98:1382-4. 2007