J McLaurin

Summary

Affiliation: University of Toronto
Country: Canada

Publications

  1. pmc Mechanisms of amyloid-Beta Peptide uptake by neurons: the role of lipid rafts and lipid raft-associated proteins
    Aaron Y Lai
    Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, 6 Queen s Park Crescent West, Toronto, ON, Canada M5S 3H2
    Int J Alzheimers Dis 2011:548380. 2010
  2. pmc Sodium/myo-Inositol transporters: substrate transport requirements and regional brain expression in the TgCRND8 mouse model of amyloid pathology
    Daniela Fenili
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
    PLoS ONE 6:e24032. 2011
  3. ncbi request reprint In vivo uptake of β-amyloid by non-plaque associated microglia
    Cheryl A Hawkes
    Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada
    Curr Alzheimer Res 9:890-901. 2012
  4. doi request reprint Amyloid-β-dependent compromise of microvascular structure and function in a model of Alzheimer's disease
    Adrienne Dorr
    Sunnybrook Research Institute, 2075 Bayview Avenue, Toronto, Ontario, Canada
    Brain 135:3039-50. 2012
  5. pmc Requirement of aggregation propensity of Alzheimer amyloid peptides for neuronal cell surface binding
    David A Bateman
    Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada
    BMC Neurosci 8:29. 2007
  6. pmc Dimerization of the transmembrane domain of amyloid precursor proteins and familial Alzheimer's disease mutants
    Paul M Gorman
    Ontario Cancer Institute and Department of Medical Biophysics, University of Toronto, Toronto, Ontario, M5G 2M9, Canada
    BMC Neurosci 9:17. 2008
  7. ncbi request reprint Cyclohexanehexol inhibitors of Abeta aggregation prevent and reverse Alzheimer phenotype in a mouse model
    JoAnne McLaurin
    Centre for Research in Neurodegenerative Diseases, 6 Queen s Park Crescent West, Toronto, Ontario M5S 3H2 Canada
    Nat Med 12:801-8. 2006
  8. ncbi request reprint Cholesterol, a modulator of membrane-associated Abeta-fibrillogenesis
    J McLaurin
    Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada M5S 3G9
    Ann N Y Acad Sci 977:376-83. 2002
  9. ncbi request reprint Cholesterol, a modulator of membrane-associated Abeta-fibrillogenesis
    J McLaurin
    Centre for Research in Neurodegenerative Diseases and Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
    Pharmacopsychiatry 36:S130-5. 2003
  10. ncbi request reprint Interactions of Alzheimer amyloid-beta peptides with glycosaminoglycans effects on fibril nucleation and growth
    J McLaurin
    Centre for Research in Neurodegenerative Diseases, University of Toronto, Ontario, Canada
    Eur J Biochem 266:1101-10. 1999

Collaborators

Detail Information

Publications43

  1. pmc Mechanisms of amyloid-Beta Peptide uptake by neurons: the role of lipid rafts and lipid raft-associated proteins
    Aaron Y Lai
    Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, 6 Queen s Park Crescent West, Toronto, ON, Canada M5S 3H2
    Int J Alzheimers Dis 2011:548380. 2010
    ..Uptake mechanisms independent of lipid rafts have also been implicated. The aim of this paper is to summarize these findings and discuss their significance in the pathogenesis of AD...
  2. pmc Sodium/myo-Inositol transporters: substrate transport requirements and regional brain expression in the TgCRND8 mouse model of amyloid pathology
    Daniela Fenili
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
    PLoS ONE 6:e24032. 2011
    ..Given the fact that scyllo-inositol is currently in clinical trials for the treatment of AD, the stable expression of inositol transporters regardless of disease pathology is an important finding...
  3. ncbi request reprint In vivo uptake of β-amyloid by non-plaque associated microglia
    Cheryl A Hawkes
    Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada
    Curr Alzheimer Res 9:890-901. 2012
    ..These results reveal a novel, beneficial role for non-plaque associated microglia in the regulation of cerebral Aβ levels in a mouse model of AD...
  4. doi request reprint Amyloid-β-dependent compromise of microvascular structure and function in a model of Alzheimer's disease
    Adrienne Dorr
    Sunnybrook Research Institute, 2075 Bayview Avenue, Toronto, Ontario, Canada
    Brain 135:3039-50. 2012
    ....
  5. pmc Requirement of aggregation propensity of Alzheimer amyloid peptides for neuronal cell surface binding
    David A Bateman
    Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada
    BMC Neurosci 8:29. 2007
    ..Here we investigate the relationship between peptide aggregation and cell surface binding of three forms of Abeta (Abeta40, Abeta42, and an Abeta mutant)...
  6. pmc Dimerization of the transmembrane domain of amyloid precursor proteins and familial Alzheimer's disease mutants
    Paul M Gorman
    Ontario Cancer Institute and Department of Medical Biophysics, University of Toronto, Toronto, Ontario, M5G 2M9, Canada
    BMC Neurosci 9:17. 2008
    ..The transmembrane domain (TM) of APP contains the known dimerization motif GXXXA. We have investigated the dimerization of both wild type and FAD mutant APP transmembrane domains...
  7. ncbi request reprint Cyclohexanehexol inhibitors of Abeta aggregation prevent and reverse Alzheimer phenotype in a mouse model
    JoAnne McLaurin
    Centre for Research in Neurodegenerative Diseases, 6 Queen s Park Crescent West, Toronto, Ontario M5S 3H2 Canada
    Nat Med 12:801-8. 2006
    ....
  8. ncbi request reprint Cholesterol, a modulator of membrane-associated Abeta-fibrillogenesis
    J McLaurin
    Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada M5S 3G9
    Ann N Y Acad Sci 977:376-83. 2002
    ..Our results suggest that the enhanced amyloidogenic properties of Abeta42 are not correlated with fibril formation, but with aggregation on bilayer surfaces...
  9. ncbi request reprint Cholesterol, a modulator of membrane-associated Abeta-fibrillogenesis
    J McLaurin
    Centre for Research in Neurodegenerative Diseases and Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
    Pharmacopsychiatry 36:S130-5. 2003
    ..Our results suggest that the enhanced amyloidogenic properties of Abeta42 are not correlated with fibril formation but aggregation on bilayer surfaces...
  10. ncbi request reprint Interactions of Alzheimer amyloid-beta peptides with glycosaminoglycans effects on fibril nucleation and growth
    J McLaurin
    Centre for Research in Neurodegenerative Diseases, University of Toronto, Ontario, Canada
    Eur J Biochem 266:1101-10. 1999
    ....
  11. ncbi request reprint Effect of amino-acid substitutions on Alzheimer's amyloid-beta peptide-glycosaminoglycan interactions
    J McLaurin
    Centre for Research in Neurodegenerative Diseases, Department of Laboratory Medicine, University of Toronto, Toronto, Ontario, Canada
    Eur J Biochem 267:6353-61. 2000
    ....
  12. ncbi request reprint Inositol stereoisomers stabilize an oligomeric aggregate of Alzheimer amyloid beta peptide and inhibit abeta -induced toxicity
    J McLaurin
    Centre for Research in Neurodegenerative Diseases, Department of Laboratory Medicine, University of Toronto, Toronto, Ontario, M5S 3H2, Canada
    J Biol Chem 275:18495-502. 2000
    ..Inositol stereoisomers are naturally occurring molecules that readily cross the blood-brain barrier and may represent a viable treatment for AD through the complexation of Abeta and attenuation of Abeta neurotoxic effects...
  13. ncbi request reprint A sulfated proteoglycan aggregation factor mediates amyloid-beta peptide fibril formation and neurotoxicity
    J McLaurin
    Centre for Research in Neurodegenerative Diseases, University of Toronto, Ontario, Canada
    Amyloid 6:233-43. 1999
    ..We also propose that the MAF model system may be useful in delineating these interactions and represent a means to develop and examine potential inhibitors of the proteoglycan effects...
  14. ncbi request reprint Therapeutically effective antibodies against amyloid-beta peptide target amyloid-beta residues 4-10 and inhibit cytotoxicity and fibrillogenesis
    J McLaurin
    Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada
    Nat Med 8:1263-9. 2002
    ..These findings provide the basis for improved immunization antigens as well as attempts to design small-molecule mimics as alternative therapies...
  15. ncbi request reprint Cholesterol, a modulator of membrane-associated Abeta-fibrillogenesis and neurotoxicity
    C M Yip
    Institute for Biomaterials and Biomedical Engineering and Centre for Studies in Molecular Imaging, University of Toronto, Ontario, Canada
    J Mol Biol 311:723-34. 2001
    ..These results collectively suggest that Abeta-cell surface interactions are mediated by cellular cholesterol levels, the distribution of cholesterol throughout the cell, and membrane fluidity...
  16. ncbi request reprint Assembly of Alzheimer's amyloid-beta fibrils and approaches for therapeutic intervention
    D S Yang
    Centre for Research in Neurodegenerative Diseases, University of Toronto, Ontario, Canada
    Amyloid 8:10-9. 2001
    ..In addition, the use of small compounds that interfere with the proteoglycan-amyloid pathway may be effective therapeutic agents that can be assessed through the use of these transgenic models...
  17. ncbi request reprint Examining the zinc binding site of the amyloid-beta peptide
    D S Yang
    Centre for Research in Neurodegenerative Diseases, Department of Laboratory Medicine and Pathobiology, University of Toronto, Ontario, Canada
    Eur J Biochem 267:6692-8. 2000
    ..Our results indicate that substitution of either His13 or His14 but not His6 eliminates the zinc-mediated effects. These observations indicate a specific zinc binding site within Abeta that involves these central histidine residues...
  18. pmc Amyloid-beta peptide assembly: a critical step in fibrillogenesis and membrane disruption
    C M Yip
    Institute for Biomaterials and Biomedical Engineering and Centre for Studies in Molecular Imaging, University of Toronto, Toronto, Ontario M5S 3G9 Canada
    Biophys J 80:1359-71. 2001
    ..These observations suggest that the fibrillogenic properties of Abeta peptide are in part a consequence of membrane composition, peptide sequence, and mode of assembly within the membrane...
  19. ncbi request reprint A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease
    C Janus
    Centre for Research in Neurodegenerative Diseases, Department of Medicine, University of Toronto, Ontario, Canada
    Nature 408:979-82. 2000
    ..This implies that either a approximately 50% reduction in dense-cored A beta plaques is sufficient to affect cognition, or that vaccination may modulate the activity/abundance of a small subpopulation of especially toxic A beta species...
  20. ncbi request reprint alpha-Synuclein membrane interactions and lipid specificity
    E Jo
    Centre for Research in Neurodegenerative Diseases, University of Toronto, Ontario, Canada
    J Biol Chem 275:34328-34. 2000
    ..These results suggest that alpha-Syn membrane interactions are physiologically important and the lipid composition of the cellular membranes may affect these interactions in vivo...
  21. pmc Aβ(1-42) assembly in the presence of scyllo-inositol derivatives: identification of an oxime linkage as important for the development of assembly inhibitors
    J E Shaw
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
    ACS Chem Neurosci 3:167-77. 2012
    ..The data to suggest that compounds must maintain a planar conformation to exhibit activity similar to scyllo-inositol and that the oxime derivative represents the lead backbone for future development...
  22. ncbi request reprint alpha-Synuclein-synaptosomal membrane interactions: implications for fibrillogenesis
    Euijung Jo
    Centre for Research in Neurodegenerative Diseases, University of Toronto, Ontario, Canada
    Eur J Biochem 271:3180-9. 2004
    ..These results suggest that alterations in alpha-synuclein-lipid interactions may contribute to physiological changes detected in early onset PD...
  23. ncbi request reprint Properties of scyllo-inositol as a therapeutic treatment of AD-like pathology
    Daniela Fenili
    Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, M5S 3H2, Canada
    J Mol Med (Berl) 85:603-11. 2007
    ..These combined results demonstrate that scyllo-inositol accumulates within the CNS up to tenfold endogenous levels and does not interfere with phosphatidylinositol lipid production...
  24. ncbi request reprint Abeta42-peptide assembly on lipid bilayers
    Christopher M Yip
    Department of Chemical Engineering and Applied Chemistry, Institute for Biomaterials and Biomedical Engineering and Centre for Studies in Molecular Imaging, University of Toronto, Toronto, Ontario, Canada M5S 3G9
    J Mol Biol 318:97-107. 2002
    ..Our results demonstrate that the composition of the lipid bilayer governs the outcome of Abeta interactions...
  25. ncbi request reprint TgCRND8 amyloid precursor protein transgenic mice exhibit an altered gamma-secretase processing and an aggressive, additive amyloid pathology subject to immunotherapeutic modulation
    Gregory D Van Vickle
    The Longtine Center for Molecular Biology and Genetics, Sun Health Research Institute, Sun City, Arizona 85351, USA
    Biochemistry 46:10317-27. 2007
    ..However, given the phylogenetic distance and the differences in APP processing and Abeta chemistry between Tg mice and AD, caution should be applied in projecting mouse therapeutic interventions onto human subjects...
  26. ncbi request reprint Immunotherapy as treatment for Alzheimer's disease
    Cheryl A Hawkes
    Center for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada
    Expert Rev Neurother 7:1535-48. 2007
    ....
  27. ncbi request reprint Phenotypic and functional changes in glial cells as a function of age
    Wai H Yu
    Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada
    Neurobiol Aging 23:105-15. 2002
    ..In particular, IL-1beta was increased 2 fold between adult and aged glial cells. The elevated cytokine expression may contribute to enhanced susceptibility to neurodegenerative diseases...
  28. doi request reprint Modulation of amyloid-beta aggregation and toxicity by inosose stereoisomers
    Mark Nitz
    Department of Chemistry, University of Toronto, 6 Queen s Park Crescent West, Toronto, Ontario, Canada
    FEBS J 275:1663-74. 2008
    ..These molecules help in the further elucidation of the structure-activity relationships of inositol-Abeta interactions and identify both allo-inositol and epi-2-inosose as in vitro inhibitors of Abeta aggregation...
  29. ncbi request reprint Ciglitazone increases basal cytokine expression in the central nervous system of adult rats
    David S Gelinas
    Centre for Research in Neurodegenerative Diseases, Tanz Neuroscience Building, 6 Queen s Park Crescent West, Toronto, Ontario, Canada M5S3H2
    Brain Res 1034:139-46. 2005
    ....
  30. ncbi request reprint Vaccine development for Alzheimer's disease
    Kevin A DaSilva
    Centre for Research in Neurodegenerative Diseases, University of Toronto, 6 Queen s Park Crescent West, Toronto, Ontario, Canada, M5S 3H2
    Curr Pharm Des 12:4283-93. 2006
    ..If so, Abeta vaccination could supplant current symptomatic treatment and represent one of the first therapeutic options for AD based on the amyloid cascade hypothesis...
  31. ncbi request reprint Cholesterol and apoe: a target for Alzheimer's disease therapeutics
    Daniela Fenili
    Centre for Research in Neurodegenerative Diseases and Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada
    Curr Drug Targets CNS Neurol Disord 4:553-67. 2005
    ..Elevated cholesterol levels and presence of the apolipoprotein E eta4 allele increase AD risk. How these two factors may contribute to AD pathogenesis and some therapeutic strategies for alleviating AD risk will be discussed...
  32. ncbi request reprint Contribution of simple saccharides to the stabilization of amyloid structure
    Justin Fung
    Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ont, M5S 3H2, Canada
    Biochem Biophys Res Commun 328:1067-72. 2005
    ..Our studies suggest that utilization of a combinatorial strategy to alter H-bonding capacity across a simple carbohydrate molecule may represent a novel drug design strategy...
  33. ncbi request reprint Current concepts and future prospects for Alzheimer disease vaccines
    Frank L Heppner
    Institute of Neuropathology, University Hospital Zurich, Zurich, Switzerland
    Alzheimer Dis Assoc Disord 18:38-43. 2004
    ..Such knowledge might facilitate the design of specific vaccination regimens, allowing exclusive targeting of A beta plaques without inducing detrimental side effects...
  34. ncbi request reprint Refining an Alzheimer's vaccine to avoid an inflammatory response
    Mary E Brown
    Centre for Research in Neurodegenerative Diseases, University of Toronto, Tanz Neuroscience Building, 6 Queen s Park Crescent West, Toronto, Ontario, M5S 3H2, Canada
    Expert Opin Biol Ther 5:809-16. 2005
    ..In harnessing and steering the immune system, an effective response can be generated against Abeta, one that might have attenuated immune responses with robust disease-altering activity...
  35. pmc Immunotherapy for Alzheimer's disease
    David S Gelinas
    Centre for Research in Neurodegenerative Diseases, University of Toronto, 6 Queen s Park Crescent West, Toronto, ON M5S 3H2, Canada
    Proc Natl Acad Sci U S A 101:14657-62. 2004
    ..In harnessing and steering the immune system, an effective response can be generated against A beta. If this proves successful, A beta vaccination could provide the first definitive treatment for AD...
  36. ncbi request reprint Biophysical characterization of longer forms of amyloid beta peptides: possible contribution to flocculent plaque formation
    Mark H L Lambermon
    Centre for Research in Neurodegenerative Diseases and Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
    J Neurochem 95:1667-76. 2005
    ..All peptides accelerated the random to beta-structural transitions and fibril formation of Abeta40 and 42...
  37. ncbi request reprint Identification and structural characterisation of carboxy-terminal polypeptides and antibody epitopes of Alzheimer's amyloid precursor protein using high-resolution mass spectrometry
    Xiaodan Tian
    Department of Chemistry, Analytical Chemistry, University of Konstanz, 78457 Konstanz, Germany
    Eur J Mass Spectrom (Chichester, Eng) 11:547-56. 2005
    ..These results demonstrate high-resolution FT-ICR-MS as a powerful method for characterising biochemical pathways and molecular recognition structures of APP...
  38. ncbi request reprint PPAR-alpha expression inversely correlates with inflammatory cytokines IL-1beta and TNF-alpha in aging rats
    David S Gelinas
    Centre for Research in Neurodegenerative Diseases and Department of Laboratory Medicine and Pathobiology, University of Toronto, Tanz Neuroscience Building, 6 Queen s Park Crescent West, Toronto, Ontario, M5S3H2, Canada
    Neurochem Res 30:1369-75. 2005
    ..These findings underline a differential role for DHEAS in PPAR-alpha expression that is age-dependent, and also, that beneficial effects of DHEAS on cognitive function are unlikely mediated by a decrease in cytokine expression...
  39. ncbi request reprint Immunization with amyloid-beta using GM-CSF and IL-4 reduces amyloid burden and alters plaque morphology
    Kevin DaSilva
    Centre for Research in Neurodegenerative Diseases, University of Toronto, Ontario, Canada
    Neurobiol Dis 23:433-44. 2006
    ..Thus, GM-CSF and IL-4 are effective adjuvants for Abeta immunotherapy...
  40. ncbi request reprint Design of peptide-based inhibitors of human islet amyloid polypeptide fibrillogenesis
    Louise A Scrocchi
    Centre for Research in Neurodegenerative Diseases, University of Toronto, Tanz Neuroscience Building, 6 Queen s Park Crescent West, Toronto, Ontario, Canada M5S 3H2
    J Mol Biol 318:697-706. 2002
    ..This study has identified internal IAPP peptide fragments which can regulate fibrillogenesis and may be of therapeutic use for the treatment of type-2 diabetes...
  41. ncbi request reprint Interaction of human and mouse Abeta peptides
    Justin Fung
    Centre for Research in Neurodegenerative Diseases, Ontario Cancer Institute, Toronto, Ontario, Canada
    J Neurochem 91:1398-403. 2004
    ..Furthermore, these results suggest that the presence of endogenous murine Abeta in human APP transgenic mice does not account for the increased solubility of plaques...
  42. pmc Genomic DNA functions as a universal external standard in quantitative real-time PCR
    James J Yun
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada M5S 1A8
    Nucleic Acids Res 34:e85. 2006
    ..A simple method that can assist achieving absolute quantification of gene expression would broadly enhance the uses of real-time qPCR and in particular, augment the evaluation of global gene expression studies...
  43. doi request reprint Synthesis of scyllo-inositol derivatives and their effects on amyloid beta peptide aggregation
    Yedi Sun
    Department of Chemistry, University of Toronto, 80 St George Street, Toronto, Ont, Canada M5S 3H6
    Bioorg Med Chem 16:7177-84. 2008
    ..The other derivatives showed some alterations in the morphology of the Abeta42 fibers produced. These findings indicate the importance of all of the hydroxyl groups of scyllo-inositol for complete inhibition of Abeta aggregation...