Donald C McKenzie

Summary

Affiliation: University of British Columbia
Country: Canada

Publications

  1. doi request reprint Respiratory physiology: adaptations to high-level exercise
    Donald C McKenzie
    The University of British Columbia, Division of Sports Medicine, Vancouver
    Br J Sports Med 46:381-4. 2012
  2. doi request reprint Diaphragm fatigue after submaximal exercise with chest wall restriction
    Simone E Tomczak
    School of Human Kinetics, University of British Columbia, Vancouver, British Columbia, Canada
    Med Sci Sports Exerc 43:416-24. 2011
  3. doi request reprint Preserved muscle metaboreflex in chronic obstructive pulmonary disease
    Megan F B Sherman
    School of Kinesiology, University of British Columbia, Vancouver, BC V6T 1Z3, Canada
    Appl Physiol Nutr Metab 36:821-30. 2011
  4. doi request reprint Sex differences in exercise-induced diaphragmatic fatigue in endurance-trained athletes
    Jordan A Guenette
    School of Human Kinetics, University of British Columbia, Vancouver, British Columbia, Canada
    J Appl Physiol (1985) 109:35-46. 2010
  5. doi request reprint Post-exercise hypotension and cardiovascular responses to moderate orthostatic stress in endurance-trained males
    Jessica M Scott
    Cardiovascular Physiology and Rehabilitation Laboratory, University of British Columbia, Vancouver, BC, Canada
    Appl Physiol Nutr Metab 33:246-53. 2008
  6. ncbi request reprint Dose response of inhaled salbutamol on exercise performance and urine concentrations
    Benjamin C Sporer
    School of Human Kinetics, University of British Columbia, Vancouver, Canada
    Med Sci Sports Exerc 40:149-57. 2008
  7. ncbi request reprint Entrainment of breathing in cyclists and non-cyclists during arm and leg exercise
    Ben C Sporer
    School of Human Kinetics, University of British Columbia, Vancouver, BC, Canada
    Respir Physiol Neurobiol 155:64-70. 2007
  8. ncbi request reprint Human lung density is not altered following normoxic and hypoxic moderate-intensity exercise: implications for transient edema
    Alastair N H Hodges
    Allan McGavin Sports Medicine Centre, University of British Columbia, Vancouver, British Columbia, Canada
    J Appl Physiol (1985) 103:111-8. 2007
  9. doi request reprint Effects of intermittent hypoxia on the cerebrovascular responses to submaximal exercise in humans
    Jordan S Querido
    The School of Human Kinetics, The University of British Columbia, Vancouver, BC, Canada
    Eur J Appl Physiol 105:403-9. 2009
  10. ncbi request reprint Two patterns of daily hypoxic exposure and their effects on measures of chemosensitivity in humans
    Michael S Koehle
    Allan McGavin Sport Medicine Centre, Vancouver, BC, Canada
    J Appl Physiol (1985) 103:1973-8. 2007

Collaborators

Detail Information

Publications34

  1. doi request reprint Respiratory physiology: adaptations to high-level exercise
    Donald C McKenzie
    The University of British Columbia, Division of Sports Medicine, Vancouver
    Br J Sports Med 46:381-4. 2012
    ..All of these maladaptations may influence performance...
  2. doi request reprint Diaphragm fatigue after submaximal exercise with chest wall restriction
    Simone E Tomczak
    School of Human Kinetics, University of British Columbia, Vancouver, British Columbia, Canada
    Med Sci Sports Exerc 43:416-24. 2011
    ..We asked whether submaximal exercise with chest wall restriction (CWR), as a model of restrictive pulmonary disease, would result in fatigue of the diaphragm in healthy humans...
  3. doi request reprint Preserved muscle metaboreflex in chronic obstructive pulmonary disease
    Megan F B Sherman
    School of Kinesiology, University of British Columbia, Vancouver, BC V6T 1Z3, Canada
    Appl Physiol Nutr Metab 36:821-30. 2011
    ..We observed a preserved muscle metaboreflex in mild-to-severe COPD, suggesting the metaboreflex is not a contributing factor to the development of exercise intolerance in this population...
  4. doi request reprint Sex differences in exercise-induced diaphragmatic fatigue in endurance-trained athletes
    Jordan A Guenette
    School of Human Kinetics, University of British Columbia, Vancouver, British Columbia, Canada
    J Appl Physiol (1985) 109:35-46. 2010
    ..The findings from this study point to a female diaphragm that is more resistant to fatigue relative to their male counterparts...
  5. doi request reprint Post-exercise hypotension and cardiovascular responses to moderate orthostatic stress in endurance-trained males
    Jessica M Scott
    Cardiovascular Physiology and Rehabilitation Laboratory, University of British Columbia, Vancouver, BC, Canada
    Appl Physiol Nutr Metab 33:246-53. 2008
    ....
  6. ncbi request reprint Dose response of inhaled salbutamol on exercise performance and urine concentrations
    Benjamin C Sporer
    School of Human Kinetics, University of British Columbia, Vancouver, Canada
    Med Sci Sports Exerc 40:149-57. 2008
    ..This study determined the dose-response effects of inhaled salbutamol (SAL) on time-trial performance and urine concentrations of SAL (cSAL)...
  7. ncbi request reprint Entrainment of breathing in cyclists and non-cyclists during arm and leg exercise
    Ben C Sporer
    School of Human Kinetics, University of British Columbia, Vancouver, BC, Canada
    Respir Physiol Neurobiol 155:64-70. 2007
    ..These results suggest that during cycling exercise at intensities of 75% VO2max or less, regular training may result in higher %ENT and that ENT is not transferable to an unfamiliar mode of exercise using different muscle groups...
  8. ncbi request reprint Human lung density is not altered following normoxic and hypoxic moderate-intensity exercise: implications for transient edema
    Alastair N H Hodges
    Allan McGavin Sports Medicine Centre, University of British Columbia, Vancouver, British Columbia, Canada
    J Appl Physiol (1985) 103:111-8. 2007
    ..Transient interstitial pulmonary edema did not occur following sustained steady-state cycling exercise in N or H, indicating that transient edema does not result from pulmonary capillary leakage during sustained submaximal exercise...
  9. doi request reprint Effects of intermittent hypoxia on the cerebrovascular responses to submaximal exercise in humans
    Jordan S Querido
    The School of Human Kinetics, The University of British Columbia, Vancouver, BC, Canada
    Eur J Appl Physiol 105:403-9. 2009
    ..05); however, the magnitude of the response was unchanged following IH. Our findings indicate that ten daily hypoxia exposures does not alter the CBF response to submaximal exercise...
  10. ncbi request reprint Two patterns of daily hypoxic exposure and their effects on measures of chemosensitivity in humans
    Michael S Koehle
    Allan McGavin Sport Medicine Centre, Vancouver, BC, Canada
    J Appl Physiol (1985) 103:1973-8. 2007
    ..These results also suggest that the two methods of measuring CO(2) response are not completely concordant and that the changes in CO(2) control do not correlate with the increase in the HVR...
  11. doi request reprint Inhaled salbutamol and doping control: effects of dose on urine concentrations
    Benjamin C Sporer
    School of Human Kinetics, University of British Columbia, Vancouver, Canada
    Clin J Sport Med 18:282-5. 2008
    ....
  12. doi request reprint The asthmatic athlete: inhaled Beta-2 agonists, sport performance, and doping
    Donald C McKenzie
    Division of Sports Medicine, School of Human Kinetics, The University of British Columbia, 3055 Wesbrook Mall, Vancouver, BC, Canada
    Clin J Sport Med 21:46-50. 2011
    ..As a result of these changes, asthmatic athletes are being managed differently based on a World Anti-Doping Agency directive that has no foundation in pharmacological science or in clinical practice...
  13. ncbi request reprint Human ventilatory responsiveness to hypoxia is unrelated to maximal aerobic capacity
    A William Sheel
    School of Human Kinetics, The University of British Columbia, 210 6081 Univ Blvd, Vancouver, BC, Canada V6T 1Z1
    J Appl Physiol (1985) 100:1204-9. 2006
    ..We interpret these observations to mean that other factors are more important in determining hypoxic ventilatory control than physical conditioning per se...
  14. pmc Inspiratory muscle training attenuates the human respiratory muscle metaboreflex
    Jonathan D Witt
    School of Human Kinetics, University of British Columbia, Vancouver, BC, Canada
    J Physiol 584:1019-28. 2007
    ..We attribute our findings to a reduced activity of chemosensitive afferents within the inspiratory muscles and may provide a mechanism for some of the whole-body exercise endurance improvements associated with IMT...
  15. doi request reprint Is there enhanced lymphatic function in upper body trained females?
    Lianne B Dolan
    School of Human Kinetics, University of British Columbia, Vancouver, British Columbia, Canada
    Lymphat Res Biol 6:29-38. 2008
    ....
  16. doi request reprint Hemoglobin and aerobic fitness changes with supervised exercise training in breast cancer patients receiving chemotherapy
    Lianne B Dolan
    School of Human Kinetics, University of British Columbia, Vancouver, British Columbia, Canada
    Cancer Epidemiol Biomarkers Prev 19:2826-32. 2010
    ..The purpose of this study was to examine the changes in hemoglobin (Hb) levels in the Supervised Trial of Aerobic versus Resistance Training (START) and to determine its association with changes in VO(2peak)...
  17. ncbi request reprint Effects of upper extremity exercise training on peak aerobic and anaerobic fitness in patients after transplantation
    Darren E R Warburton
    School of Human Kinetics, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada
    Am J Cardiol 93:939-43. 2004
    ..It also appears that patients with cardiac and noncardiac transplants have an increased reliance on anaerobic energy systems during exercise conditions compared with healthy control subjects...
  18. ncbi request reprint Effects of pseudoephedrine on maximal cycling power and submaximal cycling efficiency
    Alastair N H Hodges
    Allan McGavin Sports Medicine Centre and School of Human Kinetics, University of British Columbia, Vancouver, British Columbia, Canada
    Med Sci Sports Exerc 35:1316-9. 2003
    ..To study the effects of a therapeutic dose of pseudoephedrine on anaerobic cycling power and aerobic cycling efficiency...
  19. ncbi request reprint Effects of enhanced human chemosensitivity on ventilatory responses to exercise
    Glen E Foster
    School of Human Kinetics, The University of British Columbia, Vancouver, BC, Canada
    Exp Physiol 91:221-8. 2006
    ..30) and day 12 (r = 0.47; P > 0.05). Our findings point to a lack of functional significance of increasing HVR via intermittent hypoxia on ventilatory responses to exercise at sea level...
  20. pmc Long-term intermittent hypoxia increases sympathetic activity and chemosensitivity during acute hypoxia in humans
    Sarah Jane C Lusina
    Health and Integrative Physiology Laboratory, School of Human Kinetics, The University of British Columbia, 6108 Thunderbird Blvd, Vancouver, B C, Canada
    J Physiol 575:961-70. 2006
    ..82) during the post-IH trial. Following IH the rise in MSNA burst frequency was strongly related to the change in HVR (r = 0.79, P < 0.05) suggesting that these sympathetic and ventilatory responses may have common central control...
  21. ncbi request reprint Effectiveness of high-intensity interval training for the rehabilitation of patients with coronary artery disease
    Darren E R Warburton
    School of Human Kinetics and Faculty of Medicine, Unit II Osborne Center, University of British Columbia, Vancouver, British Columbia, Canada
    Am J Cardiol 95:1080-4. 2005
    ..This research supports the implementation of interval training for highly functional patients with coronary artery disease...
  22. pmc Effects of two protocols of intermittent hypoxia on human ventilatory, cardiovascular and cerebral responses to hypoxia
    Glen E Foster
    School of Human Kinetics, University of British Columbia, Vancouver, BC, Canada
    J Physiol 567:689-99. 2005
    ..Our findings indicate that the vascular processes required to control blood flow and oxygen supply to cerebral tissue in a healthy human are hindered following exposure to 12 days of isocapnic intermittent hypoxia...
  23. ncbi request reprint Pulmonary oedema following exercise in humans
    Alastair N H Hodges
    School of Human Kinetics and Allan McGavin Sports Medicine Centre, University of British Columbia, Vancouver, Canada
    Sports Med 36:501-12. 2006
    ..As such, this is a phenomenon of significance to pulmonary and exercise physiologists. This possibility warrants further study in the area with more precise measurement tools than has previously been undertaken...
  24. doi request reprint Effects of exercise dose and type during breast cancer chemotherapy: multicenter randomized trial
    Kerry S Courneya
    Affiliations of authors Faculty of Physical Education and Recreation KSC, DC, CCF, LT, Department of Oncology JRM, School of Public Health YY, University of Alberta, Edmonton, Canada School of Kinesiology DCM, DJ, LBD, Department of Oncology KG, University of British Columbia, Vancouver, Canada Division of Medical Oncology, Cross Cancer Institute JRM, Edmonton, Canada Division of Medical Oncology, British Columbia Cancer Agency KG, Vancouver, Canada Department of Population Health Research, Alberta Health Services CMF, Calgary, Canada University of Ottawa Heart Institute RRD, Ottawa, Canada Ottawa Hospital Cancer Center CP, EW, RJS, Ottawa, Canada Ottawa Hospital Research Institute, Ottawa, Canada EW, RJS
    J Natl Cancer Inst 105:1821-32. 2013
    ..Exercise improves physical functioning and symptom management during breast cancer chemotherapy, but the effects of different doses and types of exercise are unknown...
  25. ncbi request reprint Incidence of exercise-induced arterial hypoxemia in prepubescent females
    Paul B Laursen
    Allan McGavin Sports Medicine Clinic, School of Human Kinetics, University of British Columbia, Vancouver, British Columbia, Canada
    Pediatr Pulmonol 34:37-41. 2002
    ..Therefore, in comparison to previous reports of EIAH in adult women with similar V'(O(2)peak), EIAH does not appear to occur in the prepubescent female population...
  26. ncbi request reprint The effects of 10 weeks of reforestation work on body composition
    Alastair N H Hodges
    Allan McGavin Sports Medicine Centre, School of Human Kinetics, University of British Columbia, Vancouver, British Columbia, Canada
    Wilderness Environ Med 16:3-8. 2005
    ..To document changes in body composition and body mass in male and female tree planters...
  27. ncbi request reprint Physiological responses to indoor rock-climbing and their relationship to maximal cycle ergometry
    A William Sheel
    School of Human Kinetics, The University of British Columbia, Vancouver, BC, Canada
    Med Sci Sports Exerc 35:1225-31. 2003
    ..It was hypothesized that as climbing difficulty increased, oxygen consumption ([V02] and heart rate would increase, and that climbing would require utilization of a significant fraction of maximal cycling values...
  28. ncbi request reprint Salbutamol and the competitive athlete
    Donald C McKenzie
    Division of Sport Medicine, University of British Columbia, Vancouver, British Columbia, Canada
    Clin J Sport Med 14:316. 2004
  29. ncbi request reprint Prevalence of exercise-induced arterial hypoxemia in healthy women
    Jennifer C Richards
    School of Human Kinetics, The University of British Columbia, Vancouver, Canada
    Med Sci Sports Exerc 36:1514-21. 2004
    ..It was hypothesized that EIAH would occur with a greater prevalence and at relatively lower predicted VO2max than that previously reported in males...
  30. ncbi request reprint Pulmonary oedema of immersion
    Michael S Koehle
    Allan McGavin Sports Medicine Centre, University of British Columbia, Vancouver, British Columbia, Canada
    Sports Med 35:183-90. 2005
    ..Cases usually resolve within 24 hours. In some cases, diuretics have been used, but there are no data as to their efficacy. Nifedipine has been used to prevent recurrence, but there is only anecdotal evidence to support its use...
  31. doi request reprint Enhancing the effectiveness of clearance for physical activity participation: background and overall process
    Veronica K Jamnik
    Cardiovascular Physiology and Rehabilitation Laboratory, The University of British Columbia, 6108 Thunderbird Boulevard, Vancouver, BC, Canada
    Appl Physiol Nutr Metab 36:S3-13. 2011
    ....
  32. ncbi request reprint Field evaluation of energy expenditure in women using Tritrac accelerometers
    Kristin L Campbell
    School of Human Kinetics, University of British Columbia, Vancouver, BC, Canada
    Med Sci Sports Exerc 34:1667-74. 2002
    ..To investigate the use of Tritrac accelerometers to measure energy expenditure (EE) of various activities for women in the field setting, as compared with portable indirect calorimetry...
  33. ncbi request reprint The asthmatic athlete, inhaled beta agonists, and performance
    Donald C McKenzie
    Division of Sports Medicine, The University of British Columbia, Vancouver, British Columbia, Canada
    Clin J Sport Med 12:225-8. 2002
    ..This review will examine the use of IBAs in the asthmatic athlete, the variability that exists between countries and sport, and outline a plan to justify the use of these medications...
  34. doi request reprint Fitness, fatigue, disease activity, and quality of life in pediatric lupus
    Kristin M Houghton
    British Columbia Children s Hospital, Vancouver, British Columbia, Canada
    Arthritis Rheum 59:537-45. 2008
    ....