Research Topics
| Anthony Randal McIntoshSummaryAffiliation: University of Toronto Country: Canada Publications
| Collaborators
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Detail Information
Publications
Functional connectivity of the medial temporal lobe relates to learning and awarenessAnthony Randal McIntosh
Rotman Research Institute of Baycrest Centre, University of Toronto, Toronto, Ontario M6A 2E1, Canada
J Neurosci 23:6520-8. 2003..Thus, the contribution of the MTL to learning and awareness is shaped by the pattern of interregional interactions, the neural context...- Towards a network theory of cognitionA R McIntosh
Rotman Research Institute, Baycrest Centre, Department of Psychology, University of Toronto, Ontario, Canada
Neural Netw 13:861-70. 2000..Instead, the neural context in which an area is active may define the cognitive function. Neural context emphasizes that the particular spatiotemporal pattern of neural interactions may hold the key to bridge between brain and mind... - Recruitment of unique neural systems to support visual memory in normal agingA R McIntosh
Rotman Research Institute of Baycrest Centre, Toronto, Ontario, Canada
Curr Biol 9:1275-8. 1999..These unique areas were strongly interactive and their activity was related to performance only in old participants. Therefore, these areas may have acted to compensate for reduced interactions between the other brain areas... - Interactions of prefrontal cortex in relation to awareness in sensory learningA R McIntosh
Rotman Research Institute of Baycrest Centre, 3560 Bathurst Street, Toronto, Ontario M6A 2E1, Canada
Science 284:1531-3. 1999..Several of the interacting areas correlated with aware subjects' behavior. These results suggest cerebral processes underlying awareness are mediated through interactions of large-scale neurocognitive systems... - Partial least squares analysis of neuroimaging data: applications and advancesAnthony Randal McIntosh
Rotman Research Institute of Baycrest Centre, University of Toronto, Toronto, Ontario, Canada M6A 2E1
Neuroimage 23:S250-63. 2004..We further discuss its role as an important tool in a pluralistic analytic approach to neuroimaging... - Convergence of neural systems processing stimulus associations and coordinating motor responsesA R McIntosh
Rotman Research Institute of Baycrest Centre, Toronto, Ontario, Canada
Cereb Cortex 8:648-59. 1998.... - Contexts and catalysts: a resolution of the localization and integration of function in the brainAnthony Randal McIntosh
Rotman Research Institute of Baycrest Centre, University of Toronto, 3560 Bathurst Street, Ontario M6A 2E1, Canada
Neuroinformatics 2:175-82. 2004..An imaging study on the changing interregional interactions involving the hippocampus in learning and awareness serves as an example of neural context. In this case, the hippocampus may serve to catalyze the transition to awareness... - Spatiotemporal analysis of event-related fMRI data using partial least squaresA R McIntosh
Rotman Research Institute of Baycrest Centre, University of Toronto, 3560 Bathurst Street, Toronto, Ontario, Canada M6A 2E1
Neuroimage 23:764-75. 2004..These features enable ST-PLS to act as an important complement to other multivariate and univariate approaches used in neuroimaging research... 
The co-occurrence of multisensory facilitation and cross-modal conflict in the human brainAndreea Oliviana Diaconescu
Rotman Research Institute, Baycrest Centre, Toronto, Canada
J Neurophysiol 106:2896-909. 2011..However, as participants are required to evaluate cross-modal stimuli based on their semantic category or their degree of congruence, multisensory processes extend in cingulate, temporal, and prefrontal cortices...- Modality-independent processes in cued motor preparation revealed by cortical potentialsAndreea Oliviana Diaconescu
Rotman Research Institute of Baycrest Centre, University of Toronto, Toronto, Ontario, Canada
Neuroimage 42:1255-65. 2008..The effects carried by both patterns showed temporal overlap in the interval between the first and second stimulus presentation, but with differences in their relation to response rule processing and behavioural facilitation... - Neural system interactions underlying human transitive inferenceSandra N Moses
Department of Diagnostic Imaging, Hospital for Sick Children, Toronto, Ontario, Canada
Hippocampus 20:894-901. 2010..Contrary to prior assumptions, the hippocampus and caudate interact cooperatively to facilitate successful TI. We suggest that the dynamics of the relationship between the hippocampus and caudate depends critically upon task demands... - Modality-dependent "what" and "where" preparatory processes in auditory and visual systemsAndreea Oliviana Diaconescu
Rotman Research Institute, Baycrest Centre, Toronto, Ontario, Canada
J Cogn Neurosci 23:1609-23. 2011.... - Transperceptual encoding and retrieval processes in memory: a PET study of visual and haptic objectsM Lepage
Rotman Research Institute of Baycrest Centre, University of Toronto, 3560 Bathurst Street, Toronto, Ontario, M6A 2E1, Canada
Neuroimage 14:572-84. 2001..These results provide initial evidence that some processes involved in memory encoding and retrieval operate beyond perceptual processes and in that sense are transperceptual... 
Increased brain signal variability accompanies lower behavioral variability in developmentAnthony Randal McIntosh
Rotman Research Institute of Baycrest Centre, University of Toronto, Toronto, Ontario, Canada
PLoS Comput Biol 4:e1000106. 2008..Our results suggest that the moment-to-moment variability in brain activity may be a critical index of the cognitive capacity of the brain...- The interplay of cue modality and response latency in brain areas supporting crossmodal motor preparation: an event-related fMRI studyZainab Fatima
Rotman Research Institute, Baycrest Centre, 3560 Bathurst St, Toronto, ON M6A 2E1, Canada
Exp Brain Res 214:9-17. 2011..Our results show that both modality-dependent and modality-independent brain areas with different brain-behaviour relationships are implicated in crossmodal motor preparation... - Limbic-frontal circuitry in major depression: a path modeling metanalysisD A Seminowicz
Rotman Research Institute, Baycrest Centre for Geriatric Care, 3560 Bathurst Street, Toronto, Ontario, Canada M6A 2E1
Neuroimage 22:409-18. 2004.... - Networks of domain-specific and general regions involved in episodic memory for spatial location and object identityS Kohler
Rotman Research Institute of Baycrest Centre for Geriatric Care, University of Toronto, Ontario, Canada
Neuropsychologia 36:129-42. 1998.... - Neural correlates of semantic associative encoding in episodic memoryM Lepage
Rotman Research Institute of Baycrest Centre for Geriatric Care, 3560 Bathurst Street, University of Toronto, Toronto, ON, Canada
Brain Res Cogn Brain Res 9:271-80. 2000..These regions have been consistently reported in previous functional neuroimaging studies of associative encoding and may constitute key structures in association formation... - Encoding the future: successful processing of intentions engages predictive brain networksJ Poppenk
Department of Psychology, University of Toronto, 100 St George Street, Toronto, Ontario, Canada
Neuroimage 49:905-13. 2010..It also provides the first evidence that PM encoding, like PM retrieval, is supported by both a common episodic memory network and an executive network specifically recruited by future-oriented processing... - Distinct functional networks associated with improvement of affective symptoms and cognitive function during citalopram treatment in geriatric depressionAndreea Oliviana Diaconescu
Rotman Research Institute, Baycrest Centre, Toronto, Ontario, Canada
Hum Brain Mapp 32:1677-91. 2011..Thus, alterations in specific brain networks associated with improvement of affective symptoms and cognitive function are observed during citalopram treatment in geriatric depression... - Learning related activation of somatosensory cortex by an auditory stimulus recorded with magnetoencephalographySandra N Moses
Department of Diagnostic Imaging, Hospital for Sick Children, Toronto, Canada
Neuroimage 53:275-82. 2010..This differentiation was largest between 150 and 350ms following US omission. We show that cross-modal CRs in the primary sensorimotor system are predominantly characterized by modulation of ongoing cortical oscillations... - General and specific brain regions involved in encoding and retrieval of events: what, where, and whenL Nyberg
Rotman Research Institute of Baycrest Centre, University of Toronto, North York, ON, Canada
Proc Natl Acad Sci U S A 93:11280-5. 1996..These results point to the existence of general encoding and retrieval networks of episodic memory whose operations are augmented by unique brain areas recruited for processing specific aspects of remembered events... - The effects of aging on visual memory: evidence for functional reorganization of cortical networksP J Bennett
Department of Psychology, University of Toronto, Suite 4020, 100 St. George St, Toronto, Ont. M5S 3G3, Canada
Acta Psychol (Amst) 107:249-73. 2001..However, the neural systems correlated with good performance differed for the two age groups. The results support the hypothesis that the functional networks that underlie visual memory undergo reorganization during aging... - Neural correlates of the episodic encoding of pictures and wordsC L Grady
Rotman Research Institute of Baycrest Centre and Department of Psychology, University of Toronto, 3560 Bathurst Street, Toronto, Ontario, Canada, M6A 2E1
Proc Natl Acad Sci U S A 95:2703-8. 1998.... - Groupwise independent component decomposition of EEG data and partial least square analysisNatasa Kovacevic
Rotman Research Institute Baycrest Centre 3560 Bathurst Street, Toronto, Ontario, Canada M6A 2E1
Neuroimage 35:1103-12. 2007..Comparative PLS analysis on the independent components versus original electrode data shows that task effects are not only preserved under compression, but also enhanced statistically... - Dopamine-induced changes in neural network patterns supporting aversive conditioningAndreea Oliviana Diaconescu
Rotman Research Institute, Baycrest Centre for Geriatric Care, Toronto, Ontario, Canada
Brain Res 1313:143-61. 2010..These data provide insight into the distinct effects of DA agents on the functional connectivity between striatal, limbic, and prefrontal areas... - Corticolimbic interactions associated with performance on a short-term memory task are modified by ageV Della-Maggiore
Rotman Research Institute of Baycrest Centre, Toronto, Ontario M6A 2E1, Canada
J Neurosci 20:8410-6. 2000..Recruitment of a distinct corticolimbic network for visual memory in the elderly suggests that age-related neurobiological deterioration not only results in focal changes but also in the modification of large-scale network operations... - Episodic encoding and recognition of pictures and words: role of the human medial temporal lobesS Kohler
Rotman Research Institute of Baycrest Centre for Geriatric Care, University of Toronto, Toronto, Canada
Acta Psychol (Amst) 105:159-79. 2000..Together, our results provide evidence that the involvement of some but not all MTL regions in episodic encoding and recognition is format specific... - Frontotemporal interactions in face encoding and recognitionM N Rajah
Rotman Research Institute of Baycrest Centre, University of Toronto, 3560 Bathurst Street, Toronto, ON, Canada
Brain Res Cogn Brain Res 8:259-69. 1999..This pattern of interaction was specific to the recognition task and might represent the process whereby the input faces are compared to the internal representation laid down during encoding, thus enabling recognition... - Individual differences in the functional neuroanatomy of verbal discrimination learning revealed by positron emission tomographyR Habib
Rotman Research Institute, Baycrest Centre for Geriatric Care, 3560 Bathurst Street, North York, Ont, Canada M6A 2E1
Acta Psychol (Amst) 105:141-57. 2000..These results suggest that individual differences in memory performance are related to differences in neural activity within specific brain circuits... - Spatiotemporal analysis of experimental differences in event-related potential data with partial least squaresN J Lobaugh
Rotman Research Institute, Baycrest Centre for Geriatric Care and University of Toronto, Canada
Psychophysiology 38:517-30. 2001..PLS provides a mechanism to describe experimental differences in ERP waveforms, simultaneously across the head... - Functional reorganisation of memory after traumatic brain injury: a study with H(2)(15)0 positron emission tomographyB Levine
Rotman Research Institute, Baycrest Centre for Geriatric Care, Toronto, Canada
J Neurol Neurosurg Psychiatry 73:173-81. 2002..To study the effects of moderate to severe traumatic brain injury (TBI) on the functional neuroanatomy supporting memory retrieval... - An examination of the effects of stimulus type, encoding task, and functional connectivity on the role of right prefrontal cortex in recognition memoryC L Grady
Rotman Research Institute, University of Toronto, Toronto, Ontario M6A 2E1, Canada
Neuroimage 14:556-71. 2001.... - Episodic memory and the self in a case of isolated retrograde amnesiaB Levine
Rotman Research Institute, Baycrest Centre for Geriatric Care, North York, Ontario, Canada
Brain 121:1951-73. 1998..Reorganized brain systems mediate certain preserved cognitive operations in M.L., but without the normal complement of information concerning the self with respect to both past and future events... - The effects of divided attention on encoding- and retrieval-related brain activity: A PET study of younger and older adultsN D Anderson
University of Toronto and Rotman Research Institute, Baycrest Centre for Geriatric Care, Toronto, Ontario, Canada
J Cogn Neurosci 12:775-92. 2000.... - Quantifying head motion associated with motor tasks used in fMRIE Seto
Imaging/Bioengineering Research, Sunnybrook and Women's College Health Sciences Centre, Toronto, Ontario, M4N 3M5, Canada
Neuroimage 14:284-97. 2001..These results lead to several recommendations on the design of fMRI motor experiments and suggest that improved motion correction strategies are required to examine such patient populations comprehensively... - Mapping cognition to the brain through neural interactionsA R McIntosh
University of Toronto, Canada
Memory 7:523-48. 1999.... - Understanding neural interactions in learning and memory using functional neuroimagingA R McIntosh
Rotman Research Institute of Baycrest Centre, Toronto, Ontario, Canada
Ann N Y Acad Sci 855:556-71. 1998.... - Tracing the route to path analysis in neuroimagingAnthony Randal McIntosh
Rotman Research Institute at Baycrest Center, Department of Psychology, University of Toronto, 3560 Bathurst Street, Toronto, Ontario, Canada M6A 2E1
Neuroimage 62:887-90. 2012..A method is useful when it provides insights that were previously inaccessible, and reflecting this, the paper concludes with a synopsis of the theoretical developments that arose for the routine use of methods like path analysis... - Semantic information alters neural activation during transverse patterning performanceSandra N Moses
Department of Diagnostic Imaging, Hospital for Sick Children, Toronto, Ontario, Canada
Neuroimage 46:863-73. 2009..These activation patterns may represent a shift towards reliance upon existing semantic knowledge. This shift likely permits successful TP performance with meaningful stimuli and relations following hippocampal damage... - Why is the meaning of a sentence better remembered than its form? An fMRI study on the role of novelty-encoding processesJ Poppenk
Department of Psychology, University of Western Ontario, London, Ontario, Canada
Hippocampus 18:909-18. 2008..Our findings suggest that the verbatim effect can be linked to hippocampally-based novelty-assessment processes that operate based on semantic relationships... - Multi-modality imaging data analysis with partial least squaresW Chau
Rotman Research Institute, Baycrest Centre for Geriatric Care, University of Toronto, Ont, Canada
Brain Cogn 54:140-2. 2004 - On the marriage of cognition and neuroscienceA R McIntosh
Rotman Research Institute of Baycrest Centre, University of Toronto, Toronto, Ontario M6A 2E1, Canada
Neuroimage 14:1231-7. 2001..The imprecision of explanations for cognitive neuroscience data was also seen as a significant problem, suggesting that more principled attempts at explicit model specifications and prediction will be necessary for the field to develop... - PET activation studies comparing two speech tasks widely used in surgical mappingDiana Vanlancker-Sidtis
Department of Neurology, University of Southern California, Los Angeles, CA, USA
Brain Lang 85:245-61. 2003..Further studies are suggested to better understand differences between neurological substrates for non-propositional and automatic speech...