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Species | John J McGuireSummaryAffiliation: University of Calgary Country: Canada Publications
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Multiple mechanisms of vascular smooth muscle relaxation by the activation of proteinase-activated receptor 2 in mouse mesenteric arteriolesJohn J McGuire
Smooth Muscle Research Group, Faculty of Medicine, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta, Canada T2N 4N1
Br J Pharmacol 135:155-69. 2002..The data are also consistent with a role for endothelium-dependent hyperpolarization of vascular smooth muscle that involves the activation of an apamin/charybdotoxin-sensitive K(+) channel(s) and, in part, may be mediated by K(+)...- Proteinase-activated receptor-2 (PAR2): vascular effects of a PAR2-derived activating peptide via a receptor different than PAR2John J McGuire
Smooth Muscle Research Group, Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada
J Pharmacol Exp Ther 303:985-92. 2002..Indeed, the data from PAR2 (-/-) mice indicate that tc-LI, in addition to activating PAR2, is an agonist of vascular smooth muscle contraction via a receptor different than PAR2... - Hyperpolarization of murine small caliber mesenteric arteries by activation of endothelial proteinase-activated receptor 2John J McGuire
Smooth Muscle Research Group, Canadiian Institutes of Health Research Group on the Regulation of Vascular Contractility, Department of Pharmacology, Faculty of Medicine, University of Calgary, Calgary, Alberta T2N 4N1, Canada
Can J Physiol Pharmacol 82:1103-12. 2004..Indeed, this hyperpolarization may be a primary mechanism for PAR-2-induced hypotension in vivo... - Persistence of PAR-2 vasodilation despite endothelial dysfunction in BPH/2 hypertensive miceJohn J McGuire
Division of Biomedical Sciences, Faculty of Medicine, Memorial University, St John s, Newfoundland, Canada
Pflugers Arch 454:535-43. 2007..In BPH/2 mice, vascular smooth muscle relaxation by PAR-2 is well preserved despite the presence of hypertension and impaired vasodilation responses to acetylcholine and bradykinin... - Blood pressures, heart rate and locomotor activity during salt loading and angiotensin II infusion in protease-activated receptor 2 (PAR2) knockout miceJohn J McGuire
Cardiovascular Research Group, Division of Biomedical Sciences, Faculty of Medicine, Memorial University, St John s, Newfoundland, Canada
BMC Physiol 8:20. 2008..In addition we tested for an influence of PAR-2 on salt-sensitivity (8% versus 0.5% NaCl diet, 2.5 weeks) and angiotensin II-induced hypertension (1 microg Ile5-angiotensin II/kg/min versus 0.25 microl/h saline, 2 weeks)... - A photosensitive vascular smooth muscle store of nitric oxide in mouse aorta: no dependence on expression of endothelial nitric oxide synthaseKaren L Andrews
Smooth Muscle Research Group, 3330 Hospital Dve, NW, University of Calgary, Calgary, Alberta, Canada, T2N 4N1
Br J Pharmacol 138:932-40. 2003..In addition, the eNOS isoform is not essential for the formation of the photorelaxation store and a non-NOS source of NO may be involved in the maintenance of this store... - Restricted ability of human mast cell tryptase to activate proteinase-activated receptor-2 in rat aortaSteven J Compton
Department of Pharmacology and Therapeutics, University of Calgary, Calgary, AB T2N 4N1, Canada
Can J Physiol Pharmacol 80:987-92. 2002..We conclude that tryptase-induced relaxation of rat aorta, most likely via PAR2, is tightly regulated by heparin and cell-surface sialic acid... - Proteinase-activated Receptor 2 (PAR2): a challenging new target for treatment of vascular diseasesJohn J McGuire
Cardiovascular Research Group, Division of Basic Medical Sciences, Faculty of Medicine, Memorial University of Newfoundland, St John s, Newfoundland A1B 3V6, Canada
Curr Pharm Des 10:2769-78. 2004..With further research and drug development, PAR2 agonists and antagonists may become a basis for a new class of therapeutic agents for treatment of vascular diseases... - The endothelium in health and disease--a target for therapeutic interventionChris R Triggle
Smooth Muscle Research Group, Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Calgary, Alberta, Canada T2N 4N1
J Smooth Muscle Res 39:249-67. 2003.... - 2-furoyl-LIGRLO-amide: a potent and selective proteinase-activated receptor 2 agonistJohn J McGuire
Cardiovascular Research Group, Division of Basic Medical Sciences, Faculty of Medicine, Memorial University of Newfoundland, St John s, Newfoundland, Canada A1B 3V6
J Pharmacol Exp Ther 309:1124-31. 2004..In conclusion, 2-furoyl-LI-GRLO-NH(2) represents the most potent and selective activator of PAR(2) in biological systems described to date... - Effects of poststroke losartan versus captopril treatment on myogenic and endothelial function in the cerebrovasculature of SHRspJohn S Smeda
Division of Basic Medical Sciences, Memorial University, Health Science Center, St John s, Newfoundland, Canada
Stroke 38:1590-6. 2007....