John J McGuire

Summary

Affiliation: University of Calgary
Country: Canada

Publications

  1. pmc Multiple mechanisms of vascular smooth muscle relaxation by the activation of proteinase-activated receptor 2 in mouse mesenteric arterioles
    John J McGuire
    Smooth Muscle Research Group, Faculty of Medicine, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta, Canada T2N 4N1
    Br J Pharmacol 135:155-69. 2002
  2. ncbi request reprint Proteinase-activated receptor-2 (PAR2): vascular effects of a PAR2-derived activating peptide via a receptor different than PAR2
    John J McGuire
    Smooth Muscle Research Group, Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada
    J Pharmacol Exp Ther 303:985-92. 2002
  3. ncbi request reprint Hyperpolarization of murine small caliber mesenteric arteries by activation of endothelial proteinase-activated receptor 2
    John J McGuire
    Smooth Muscle Research Group, Canadiian Institutes of Health Research Group on the Regulation of Vascular Contractility, Department of Pharmacology, Faculty of Medicine, University of Calgary, Calgary, Alberta T2N 4N1, Canada
    Can J Physiol Pharmacol 82:1103-12. 2004
  4. pmc Blood pressures, heart rate and locomotor activity during salt loading and angiotensin II infusion in protease-activated receptor 2 (PAR2) knockout mice
    John J McGuire
    Cardiovascular Research Group, Division of Biomedical Sciences, Faculty of Medicine, Memorial University, St John s, Newfoundland, Canada
    BMC Physiol 8:20. 2008
  5. ncbi request reprint Persistence of PAR-2 vasodilation despite endothelial dysfunction in BPH/2 hypertensive mice
    John J McGuire
    Division of Biomedical Sciences, Faculty of Medicine, Memorial University, St John s, Newfoundland, Canada
    Pflugers Arch 454:535-43. 2007
  6. pmc A photosensitive vascular smooth muscle store of nitric oxide in mouse aorta: no dependence on expression of endothelial nitric oxide synthase
    Karen L Andrews
    Smooth Muscle Research Group, 3330 Hospital Dve, NW, University of Calgary, Calgary, Alberta, Canada, T2N 4N1
    Br J Pharmacol 138:932-40. 2003
  7. ncbi request reprint Restricted ability of human mast cell tryptase to activate proteinase-activated receptor-2 in rat aorta
    Steven J Compton
    Department of Pharmacology and Therapeutics, University of Calgary, Calgary, AB T2N 4N1, Canada
    Can J Physiol Pharmacol 80:987-92. 2002
  8. pmc Attenuated vasodilator effectiveness of protease-activated receptor 2 agonist in heterozygous par2 knockout mice
    John C Hennessey
    Cardiovascular Research Group, Division of Biomedical Sciences, Faculty of Medicine, Memorial University of Newfoundland, St John s, Newfoundland and Labrador, Canada
    PLoS ONE 8:e55965. 2013
  9. ncbi request reprint The endothelium in health and disease--a target for therapeutic intervention
    Chris R Triggle
    Smooth Muscle Research Group, Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Calgary, Alberta, Canada T2N 4N1
    J Smooth Muscle Res 39:249-67. 2003
  10. ncbi request reprint Proteinase-activated Receptor 2 (PAR2): a challenging new target for treatment of vascular diseases
    John J McGuire
    Cardiovascular Research Group, Division of Basic Medical Sciences, Faculty of Medicine, Memorial University of Newfoundland, St John s, Newfoundland A1B 3V6, Canada
    Curr Pharm Des 10:2769-78. 2004

Detail Information

Publications12

  1. pmc Multiple mechanisms of vascular smooth muscle relaxation by the activation of proteinase-activated receptor 2 in mouse mesenteric arterioles
    John J McGuire
    Smooth Muscle Research Group, Faculty of Medicine, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta, Canada T2N 4N1
    Br J Pharmacol 135:155-69. 2002
    ..The data are also consistent with a role for endothelium-dependent hyperpolarization of vascular smooth muscle that involves the activation of an apamin/charybdotoxin-sensitive K(+) channel(s) and, in part, may be mediated by K(+)...
  2. ncbi request reprint Proteinase-activated receptor-2 (PAR2): vascular effects of a PAR2-derived activating peptide via a receptor different than PAR2
    John J McGuire
    Smooth Muscle Research Group, Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada
    J Pharmacol Exp Ther 303:985-92. 2002
    ..Indeed, the data from PAR2 (-/-) mice indicate that tc-LI, in addition to activating PAR2, is an agonist of vascular smooth muscle contraction via a receptor different than PAR2...
  3. ncbi request reprint Hyperpolarization of murine small caliber mesenteric arteries by activation of endothelial proteinase-activated receptor 2
    John J McGuire
    Smooth Muscle Research Group, Canadiian Institutes of Health Research Group on the Regulation of Vascular Contractility, Department of Pharmacology, Faculty of Medicine, University of Calgary, Calgary, Alberta T2N 4N1, Canada
    Can J Physiol Pharmacol 82:1103-12. 2004
    ..Indeed, this hyperpolarization may be a primary mechanism for PAR-2-induced hypotension in vivo...
  4. pmc Blood pressures, heart rate and locomotor activity during salt loading and angiotensin II infusion in protease-activated receptor 2 (PAR2) knockout mice
    John J McGuire
    Cardiovascular Research Group, Division of Biomedical Sciences, Faculty of Medicine, Memorial University, St John s, Newfoundland, Canada
    BMC Physiol 8:20. 2008
    ..In addition we tested for an influence of PAR-2 on salt-sensitivity (8% versus 0.5% NaCl diet, 2.5 weeks) and angiotensin II-induced hypertension (1 microg Ile5-angiotensin II/kg/min versus 0.25 microl/h saline, 2 weeks)...
  5. ncbi request reprint Persistence of PAR-2 vasodilation despite endothelial dysfunction in BPH/2 hypertensive mice
    John J McGuire
    Division of Biomedical Sciences, Faculty of Medicine, Memorial University, St John s, Newfoundland, Canada
    Pflugers Arch 454:535-43. 2007
    ..In BPH/2 mice, vascular smooth muscle relaxation by PAR-2 is well preserved despite the presence of hypertension and impaired vasodilation responses to acetylcholine and bradykinin...
  6. pmc A photosensitive vascular smooth muscle store of nitric oxide in mouse aorta: no dependence on expression of endothelial nitric oxide synthase
    Karen L Andrews
    Smooth Muscle Research Group, 3330 Hospital Dve, NW, University of Calgary, Calgary, Alberta, Canada, T2N 4N1
    Br J Pharmacol 138:932-40. 2003
    ..In addition, the eNOS isoform is not essential for the formation of the photorelaxation store and a non-NOS source of NO may be involved in the maintenance of this store...
  7. ncbi request reprint Restricted ability of human mast cell tryptase to activate proteinase-activated receptor-2 in rat aorta
    Steven J Compton
    Department of Pharmacology and Therapeutics, University of Calgary, Calgary, AB T2N 4N1, Canada
    Can J Physiol Pharmacol 80:987-92. 2002
    ..We conclude that tryptase-induced relaxation of rat aorta, most likely via PAR2, is tightly regulated by heparin and cell-surface sialic acid...
  8. pmc Attenuated vasodilator effectiveness of protease-activated receptor 2 agonist in heterozygous par2 knockout mice
    John C Hennessey
    Cardiovascular Research Group, Division of Biomedical Sciences, Faculty of Medicine, Memorial University of Newfoundland, St John s, Newfoundland and Labrador, Canada
    PLoS ONE 8:e55965. 2013
    ..We conclude that the lower PAR2-mediated responses in PAR2-HET aortas are consistent with evidence of a lower quantity of functional receptor expression, despite the apparently normal PAR2 mRNA content in PAR2-HET aortas...
  9. ncbi request reprint The endothelium in health and disease--a target for therapeutic intervention
    Chris R Triggle
    Smooth Muscle Research Group, Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Calgary, Alberta, Canada T2N 4N1
    J Smooth Muscle Res 39:249-67. 2003
    ....
  10. ncbi request reprint Proteinase-activated Receptor 2 (PAR2): a challenging new target for treatment of vascular diseases
    John J McGuire
    Cardiovascular Research Group, Division of Basic Medical Sciences, Faculty of Medicine, Memorial University of Newfoundland, St John s, Newfoundland A1B 3V6, Canada
    Curr Pharm Des 10:2769-78. 2004
    ..With further research and drug development, PAR2 agonists and antagonists may become a basis for a new class of therapeutic agents for treatment of vascular diseases...
  11. ncbi request reprint 2-furoyl-LIGRLO-amide: a potent and selective proteinase-activated receptor 2 agonist
    John J McGuire
    Cardiovascular Research Group, Division of Basic Medical Sciences, Faculty of Medicine, Memorial University of Newfoundland, St John s, Newfoundland, Canada A1B 3V6
    J Pharmacol Exp Ther 309:1124-31. 2004
    ..In conclusion, 2-furoyl-LI-GRLO-NH(2) represents the most potent and selective activator of PAR(2) in biological systems described to date...
  12. ncbi request reprint Effects of poststroke losartan versus captopril treatment on myogenic and endothelial function in the cerebrovasculature of SHRsp
    John S Smeda
    Division of Basic Medical Sciences, Memorial University, Health Science Center, St John s, Newfoundland, Canada
    Stroke 38:1590-6. 2007
    ....