J D McGhee

Summary

Affiliation: University of Calgary
Country: Canada

Publications

  1. doi request reprint The Caenorhabditis elegans intestine
    James D McGhee
    Department of Biochemistry and Molecular Biology, Alberta Children s Hospital Research Institute, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada
    Wiley Interdiscip Rev Dev Biol 2:347-67. 2013
  2. pmc Characterization of the C. elegans erlin homologue
    Maja B Hoegg
    Department of Biochemistry and Molecular Biology, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta T2N 4N1, Canada
    BMC Cell Biol 13:2. 2012
  3. pmc ELT-2 is the predominant transcription factor controlling differentiation and function of the C. elegans intestine, from embryo to adult
    James D McGhee
    Department of Biochemistry and Molecular Biology, Department of Medical Genetics, Genes and Development Research Group, University of Calgary, Calgary, Alberta, Canada T2N 4N1
    Dev Biol 327:551-65. 2009
  4. ncbi request reprint The ELT-2 GATA-factor and the global regulation of transcription in the C. elegans intestine
    James D McGhee
    Department of Biochemistry and Molecular Biology, University of Calgary, 3330 Hospital Drive N W, Calgary, Alberta, Canada T2N 4N1
    Dev Biol 302:627-45. 2007
  5. ncbi request reprint Homologous tails? Or tales of homology?
    J D McGhee
    Department of Biochemistry and Molecular Biology, Genes and Development Research Group, University of Calgary, Calgary, Alberta, Canada
    Bioessays 22:781-5. 2000
  6. ncbi request reprint ELT-3: A Caenorhabditis elegans GATA factor expressed in the embryonic epidermis during morphogenesis
    J S Gilleard
    Department of Biochemistry and Molecular Biology, University of Calgary, Calgary, Alberta, T2N 4N1, Canada
    Dev Biol 208:265-80. 1999
  7. ncbi request reprint pha-4 is Ce-fkh-1, a fork head/HNF-3alpha,beta,gamma homolog that functions in organogenesis of the C. elegans pharynx
    J M Kalb
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Calgary, Health Sciences Centre, Room 2265, NW, Calgary, Alberta, Canada T2N 4N1
    Development 125:2171-80. 1998
  8. ncbi request reprint Coordination of ges-1 expression between the Caenorhabditis pharynx and intestine
    S D Marshall
    Department of Biochemistry and Molecular Biology, University of Calgary, Calgary, Alberta, Canada T2N 4N1
    Dev Biol 239:350-63. 2001
  9. pmc Direct visualization of the elt-2 gut-specific GATA factor binding to a target promoter inside the living Caenorhabditis elegans embryo
    T Fukushige
    Department of Biochemistry, University of Calgary, Calgary, Alberta, Canada T2N 4N1
    Proc Natl Acad Sci U S A 96:11883-8. 1999
  10. ncbi request reprint Transcriptional control and patterning of the pho-1 gene, an essential acid phosphatase expressed in the C. elegans intestine
    Tetsunari Fukushige
    Department of Biochemistry and Molecular Biology, Genes and Development Research Group, University of Calgary Faculty of Medicine, Room 2205 Health Sciences Centre, 3330 Hospital Drive, N W, Calgary, Alberta, Canada T2N 4N1
    Dev Biol 279:446-61. 2005

Collaborators

Detail Information

Publications24

  1. doi request reprint The Caenorhabditis elegans intestine
    James D McGhee
    Department of Biochemistry and Molecular Biology, Alberta Children s Hospital Research Institute, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada
    Wiley Interdiscip Rev Dev Biol 2:347-67. 2013
    ..The mature intestine expresses several thousand genes, apparently all controlled, at least in part, by cis-acting GATA-type motifs...
  2. pmc Characterization of the C. elegans erlin homologue
    Maja B Hoegg
    Department of Biochemistry and Molecular Biology, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta T2N 4N1, Canada
    BMC Cell Biol 13:2. 2012
    ..elegans erlin modulates IP3R-dependent processes, such as egg laying, embryonic development and defecation rates. We also explore the possibility that erlin might play a more general role in the ERAD pathway of C. elegans...
  3. pmc ELT-2 is the predominant transcription factor controlling differentiation and function of the C. elegans intestine, from embryo to adult
    James D McGhee
    Department of Biochemistry and Molecular Biology, Department of Medical Genetics, Genes and Development Research Group, University of Calgary, Calgary, Alberta, Canada T2N 4N1
    Dev Biol 327:551-65. 2009
    ....
  4. ncbi request reprint The ELT-2 GATA-factor and the global regulation of transcription in the C. elegans intestine
    James D McGhee
    Department of Biochemistry and Molecular Biology, University of Calgary, 3330 Hospital Drive N W, Calgary, Alberta, Canada T2N 4N1
    Dev Biol 302:627-45. 2007
    ..Other intestinal transcription factors would thus modulate the action of ELT-2, depending on the worm's nutritional and physiological needs...
  5. ncbi request reprint Homologous tails? Or tales of homology?
    J D McGhee
    Department of Biochemistry and Molecular Biology, Genes and Development Research Group, University of Calgary, Calgary, Alberta, Canada
    Bioessays 22:781-5. 2000
    ..We will discuss this proposal and try to decide whether the gene sequences, gene interactions and gene expression patterns allow any conclusions to be made about the rear end of the ancestral metazoan...
  6. ncbi request reprint ELT-3: A Caenorhabditis elegans GATA factor expressed in the embryonic epidermis during morphogenesis
    J S Gilleard
    Department of Biochemistry and Molecular Biology, University of Calgary, Calgary, Alberta, T2N 4N1, Canada
    Dev Biol 208:265-80. 1999
    ..Many features of the elt-3 genomic and transcript structure are conserved between the two species, suggesting that elt-3 is likely to perform an evolutionarily significant function during development...
  7. ncbi request reprint pha-4 is Ce-fkh-1, a fork head/HNF-3alpha,beta,gamma homolog that functions in organogenesis of the C. elegans pharynx
    J M Kalb
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Calgary, Health Sciences Centre, Room 2265, NW, Calgary, Alberta, Canada T2N 4N1
    Development 125:2171-80. 1998
    ..Overall, our results provide evidence for a highly conserved pathway regulating formation of the digestive tract in all (triploblastic) metazoa...
  8. ncbi request reprint Coordination of ges-1 expression between the Caenorhabditis pharynx and intestine
    S D Marshall
    Department of Biochemistry and Molecular Biology, University of Calgary, Calgary, Alberta, Canada T2N 4N1
    Dev Biol 239:350-63. 2001
    ..We suggest that this control circuitry is maintained in Caenorhabditis because pharyngeal expression of ges-1 is advantageous only under certain developmental or environmental conditions...
  9. pmc Direct visualization of the elt-2 gut-specific GATA factor binding to a target promoter inside the living Caenorhabditis elegans embryo
    T Fukushige
    Department of Biochemistry, University of Calgary, Calgary, Alberta, Canada T2N 4N1
    Proc Natl Acad Sci U S A 96:11883-8. 1999
    ..The approach should be applicable to studying other transcription factors binding target promoters, all within the living C. elegans embryo...
  10. ncbi request reprint Transcriptional control and patterning of the pho-1 gene, an essential acid phosphatase expressed in the C. elegans intestine
    Tetsunari Fukushige
    Department of Biochemistry and Molecular Biology, Genes and Development Research Group, University of Calgary Faculty of Medicine, Room 2205 Health Sciences Centre, 3330 Hospital Drive, N W, Calgary, Alberta, Canada T2N 4N1
    Dev Biol 279:446-61. 2005
    ..We suggest that pho-1 is required by the maternal intestine to assimilate some nutrient or cleavage product that is subsequently provided to the next generation of embryos...
  11. ncbi request reprint The GATA-factor elt-2 is essential for formation of the Caenorhabditis elegans intestine
    T Fukushige
    Department of Biochemistry and Molecular Biology, University of Calgary, Alberta, Canada
    Dev Biol 198:286-302. 1998
    ..We discuss whether elements of this regulatory network may be conserved in all metazoa...
  12. pmc Production of null mutants in the major intestinal esterase gene (ges-1) of the nematode Caenorhabditis elegans
    J D McGhee
    Department of Medical Biochemistry, University of Calgary, Alberta, Canada
    Genetics 125:505-14. 1990
    ..These ges-1(0) strains now allow us to investigate the developmental control of the ges-1 gene by DNA-mediated transformation, in which the ges-1 gene acts as its own reporter...
  13. ncbi request reprint Caenorhabditis elegans LET-502 is related to Rho-binding kinases and human myotonic dystrophy kinase and interacts genetically with a homolog of the regulatory subunit of smooth muscle myosin phosphatase to affect cell shape
    A Wissmann
    University of Calgary, Department of Medical Biochemistry, Alberta, Canada
    Genes Dev 11:409-22. 1997
    ..LET-502 may directly regulate the activity of the MEL-11 containing phosphatase complex and the similarity between LET-502 and DM-kinase suggests a similar function for DM-kinase...
  14. pmc The evolutionary duplication and probable demise of an endodermal GATA factor in Caenorhabditis elegans
    Tetsunari Fukushige
    Genes and Development Research Group, Department of Biochemistry and Molecular Biology, University of Calgary, Alberta T2N 4N1, Canada
    Genetics 165:575-88. 2003
    ..Although elt-4 must confer (or must have conferred) some selective advantage to C. elegans, we suggest that its ultimate evolutionary fate will be disappearance from the C. elegans genome...
  15. ncbi request reprint Development of the C. elegans digestive tract
    Jay D Kormish
    Department of Molecular Biology and Biochemistry, Department of Medical Genetics, Alberta Children s Hospital Research Institute for Child and Maternal Health, University of Calgary, Calgary, Alberta, Canada
    Curr Opin Genet Dev 20:346-54. 2010
    ..The FoxA-factor dominated development of the pharynx (and rectum) is less well understood but is beginning to reveal how transcription factor combinations produce unique cell types within organs...
  16. pmc Reevaluation of the role of the med-1 and med-2 genes in specifying the Caenorhabditis elegans endoderm
    Barbara Goszczynski
    Department of Biochemistry and Molecular Biology, Genes and Development Research Group, University of Calgary, Alberta, Canada
    Genetics 171:545-55. 2005
    ..Furthermore, we found no evidence for a maternal contribution of the med genes to endoderm specification. We conclude that the major pathway(s) for endoderm specification in C. elegans must be independent of the med-1 and med-2 genes...
  17. ncbi request reprint The C. elegans lethal gut-obstructed gob-1 gene is trehalose-6-phosphate phosphatase
    Jay D Kormish
    Department of Biochemistry and Molecular Biology, Genes and Development Research Group, University of Calgary Faculty of Medicine, Health Sciences Centre, Calgary, Alberta, Canada T2N 4N1
    Dev Biol 287:35-47. 2005
    ..GOB-1 is the first trehalose-6-phosphate phosphatase to be identified in nematodes and, because of its associated lethality and distinctive sequence properties, provides a new and attractive target for anti-parasitic drugs...
  18. pmc Neither maternal nor zygotic med-1/med-2 genes play a major role in specifying the Caenorhabditis elegans endoderm
    Vasile V Captan
    Department of Biochemistry and Molecular Biology, Genes and Development Research Group, University of Calgary, Calgary, Alberta T2N 4N1, Canada
    Genetics 175:969-74. 2007
    ..We thus suggest that the experimental evidence for a maternal med-1/2 effect should be reexamined and may instead reflect cosuppression caused by multiple transgenic unc-32 sequences, not med sequences...
  19. ncbi request reprint The C. elegans neuronally expressed homeobox gene ceh-10 is closely related to genes expressed in the vertebrate eye
    P C Svendsen
    Department of Medical Biochemistry, University of Calgary, Alberta, Canada
    Development 121:1253-62. 1995
    ..Our results emphasize the highly conserved nature of sensory regulatory mechanisms and suggest one way in which photosensitive organelles might have originated in evolution...
  20. ncbi request reprint Interference between the PHA-4 and PEB-1 transcription factors in formation of the Caenorhabditis elegans pharynx
    John M Kalb
    Department of Biochemistry and Molecular Biology, Genes and Development Research Group, Faculty of Medicine, Health Sciences Centre, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta, Canada T2N 4N1
    J Mol Biol 320:697-704. 2002
    ..elegans pharynx...
  21. doi request reprint Recent advances in understanding the molecular mechanisms regulating C. elegans transcription
    Jeb Gaudet
    Department of Biochemistry and Molecular Biology, Alberta Children s Hospital Research Institute for Child and Maternal Health, University of Calgary, Calgary, Alberta, Canada
    Dev Dyn 239:1388-404. 2010
    ..elegans "chromatin"; and (v) some characteristics of histone variants and histone modifications and their possible roles in controlling C. elegans transcription...
  22. ncbi request reprint The C. elegans pvf-1 gene encodes a PDGF/VEGF-like factor able to bind mammalian VEGF receptors and to induce angiogenesis
    Marina Tarsitano
    Institute of Genetics and Biophysics A Buzzati Traverso, CNR, Naples, Italy
    FASEB J 20:227-33. 2006
    ..elegans can provide a simple experimental system in which to investigate how these factors function...
  23. ncbi request reprint The apical disposition of the Caenorhabditis elegans intestinal terminal web is maintained by LET-413
    Olaf Bossinger
    Institut fur Genetik, Heinrich Heine Universitat Dusseldorf, D 40225 Duesseldorf, Germany
    Dev Biol 268:448-56. 2004
    ..Finally, the distance at which the terminal web intermediate filament layer lies beneath the gut cell surface (both apical and basolateral) must be determined independently of apical junction position...
  24. ncbi request reprint The GATA family (vertebrates and invertebrates)
    Roger K Patient
    Institute of Genetics, University of Nottingham, Queen s Medical Centre, UK
    Curr Opin Genet Dev 12:416-22. 2002
    ..In the liver, GATA4 is elevated by BMP and FGF signalling, and is able to bind to chromatin targets. Invertebrate GATA factors play a central role in specifying the mesendoderm...