Robert J McDonald

Summary

Affiliation: University of Lethbridge
Country: Canada

Publications

  1. doi request reprint Multiple effects of circadian dysfunction induced by photoperiod shifts: alterations in context memory and food metabolism in the same subjects
    Robert J McDonald
    Canadian Centre for Behavioural Neuroscience, Department of Neuroscience, University of Lethbridge, Lethbridge, AB, Canada
    Physiol Behav 118:14-24. 2013
  2. ncbi request reprint NMDA-receptor blockade by CPP impairs post-training consolidation of a rapidly acquired spatial representation in rat hippocampus
    Robert J McDonald
    Canadian Centre for Behavioural Neuroscience, Department of Psychology and Neuroscience, University of Lethbridge, Lethbridge, AB, Canada
    Eur J Neurosci 22:1201-13. 2005
  3. ncbi request reprint A double dissociation of dorsal and ventral hippocampal function on a learning and memory task mediated by the dorso-lateral striatum
    Robert J McDonald
    Canadian Centre for Behavioural Neuroscience, Department of Neuroscience, University of Lethbridge, Lethbridge, AB, Canada
    Eur J Neurosci 24:1789-801. 2006
  4. doi request reprint Neurotoxic lesions of the medial prefrontal cortex or medial striatum impair multiple-location place learning in the water task: evidence for neural structures with complementary roles in behavioural flexibility
    Robert J McDonald
    Canadian Centre for Behavioural Neuroscience, Department of Neuroscience, University of Lethbridge, 4401 University Drive, Lethbridge, AB, Canada
    Exp Brain Res 187:419-27. 2008
  5. doi request reprint Neurotoxic damage to the dorsomedial striatum exaggerates the behavioral influence of a context-specific inhibitory association mediated by the ventral hippocampus
    Robert J McDonald
    Canadian Centre for Behavioural Neuroscience, Department of Neuroscience, University of Lethbridge, Alberta, Canada
    Behav Neurosci 122:27-35. 2008
  6. ncbi request reprint A complex associative structure formed in the mammalian brain during acquisition of a simple visual discrimination task: dorsolateral striatum, amygdala, and hippocampus
    Robert J McDonald
    Canadian Centre for Behavioural Neuroscience, Department of Neuroscience, University of Lethbridge, 4401 University Drive, Lethbridge, Alberta, Canada
    Hippocampus 17:759-74. 2007
  7. ncbi request reprint The role of medial prefrontal cortex in context-specific inhibition during reversal learning of a visual discrimination
    R J McDonald
    Canadian Centre for Behavioural Neuroscience, Department of Psychology and Neuroscience, University of Lethbridge, Lethbridge, AB, Canada T1K 3M4
    Exp Brain Res 177:509-19. 2007
  8. ncbi request reprint A dissociation of dorso-lateral striatum and amygdala function on the same stimulus-response habit task
    R J McDonald
    Department of Psychology, University of Toronto, Toronto, Ontario, Canada M5S 3G3
    Neuroscience 124:507-13. 2004
  9. ncbi request reprint Empirical tests of the functional significance of amygdala-based modulation of hippocampal representations: evidence for multiple memory consolidation pathways
    Robert J McDonald
    Canadian Centre for Behavioral Neuroscience, Department of Neuroscience, University of Lethbridge, Lethbridge, Alberta, Canada
    Eur J Neurosci 25:1568-80. 2007
  10. ncbi request reprint Multiple memory systems: the power of interactions
    Robert J McDonald
    Department of Psychology and Neuroscience, Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, AB T1K 3M4, Canada
    Neurobiol Learn Mem 82:333-46. 2004

Collaborators

Detail Information

Publications66

  1. doi request reprint Multiple effects of circadian dysfunction induced by photoperiod shifts: alterations in context memory and food metabolism in the same subjects
    Robert J McDonald
    Canadian Centre for Behavioural Neuroscience, Department of Neuroscience, University of Lethbridge, Lethbridge, AB, Canada
    Physiol Behav 118:14-24. 2013
    ..These results show that chronic photoperiod shifting, which likely resulted in circadian dysfunction, impairs multiple functions of the brain and/or body in the same individual. ..
  2. ncbi request reprint NMDA-receptor blockade by CPP impairs post-training consolidation of a rapidly acquired spatial representation in rat hippocampus
    Robert J McDonald
    Canadian Centre for Behavioural Neuroscience, Department of Psychology and Neuroscience, University of Lethbridge, Lethbridge, AB, Canada
    Eur J Neurosci 22:1201-13. 2005
    ..Our results therefore reinforce the notion that hippocampal NMDA-receptors participate in post-training memory consolidation but are not essential for the processes necessary to learn or retain navigational information in the short term...
  3. ncbi request reprint A double dissociation of dorsal and ventral hippocampal function on a learning and memory task mediated by the dorso-lateral striatum
    Robert J McDonald
    Canadian Centre for Behavioural Neuroscience, Department of Neuroscience, University of Lethbridge, Lethbridge, AB, Canada
    Eur J Neurosci 24:1789-801. 2006
    ..The formation of an incidental inhibitory association was dependent on ventral but not dorsal hippocampal circuitry, and the opposite dependence was found for the spatial component of a tactile/spatial discrimination...
  4. doi request reprint Neurotoxic lesions of the medial prefrontal cortex or medial striatum impair multiple-location place learning in the water task: evidence for neural structures with complementary roles in behavioural flexibility
    Robert J McDonald
    Canadian Centre for Behavioural Neuroscience, Department of Neuroscience, University of Lethbridge, 4401 University Drive, Lethbridge, AB, Canada
    Exp Brain Res 187:419-27. 2008
    ..The results were interpreted as suggestive of a complementary role of these neural structures in behavioural flexibility...
  5. doi request reprint Neurotoxic damage to the dorsomedial striatum exaggerates the behavioral influence of a context-specific inhibitory association mediated by the ventral hippocampus
    Robert J McDonald
    Canadian Centre for Behavioural Neuroscience, Department of Neuroscience, University of Lethbridge, Alberta, Canada
    Behav Neurosci 122:27-35. 2008
    ..A discussion of potential pathways and mechanisms for these different effects is presented...
  6. ncbi request reprint A complex associative structure formed in the mammalian brain during acquisition of a simple visual discrimination task: dorsolateral striatum, amygdala, and hippocampus
    Robert J McDonald
    Canadian Centre for Behavioural Neuroscience, Department of Neuroscience, University of Lethbridge, 4401 University Drive, Lethbridge, Alberta, Canada
    Hippocampus 17:759-74. 2007
    ..Although this representation is not required for acquisition of the task in the anterograde direction, removal of this representation has a disruptive effect on expression of the task...
  7. ncbi request reprint The role of medial prefrontal cortex in context-specific inhibition during reversal learning of a visual discrimination
    R J McDonald
    Canadian Centre for Behavioural Neuroscience, Department of Psychology and Neuroscience, University of Lethbridge, Lethbridge, AB, Canada T1K 3M4
    Exp Brain Res 177:509-19. 2007
    ..These and other results from a transfer test suggest that the medial prefrontal cortex participates in the behavioral effects of a context-specific inhibitory association acquired during visual discrimination learning...
  8. ncbi request reprint A dissociation of dorso-lateral striatum and amygdala function on the same stimulus-response habit task
    R J McDonald
    Department of Psychology, University of Toronto, Toronto, Ontario, Canada M5S 3G3
    Neuroscience 124:507-13. 2004
    ..This pattern of results represents a dissociation of learning and memory functions of the dorsal striatum and amygdala on the same task...
  9. ncbi request reprint Empirical tests of the functional significance of amygdala-based modulation of hippocampal representations: evidence for multiple memory consolidation pathways
    Robert J McDonald
    Canadian Centre for Behavioral Neuroscience, Department of Neuroscience, University of Lethbridge, Lethbridge, Alberta, Canada
    Eur J Neurosci 25:1568-80. 2007
    ..Arguments for an alternative view are presented suggesting that there are multiple memory consolidation pathways, one of which may depend on amygdala neural circuitry...
  10. ncbi request reprint Multiple memory systems: the power of interactions
    Robert J McDonald
    Department of Psychology and Neuroscience, Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, AB T1K 3M4, Canada
    Neurobiol Learn Mem 82:333-46. 2004
    ....
  11. ncbi request reprint Incidental information acquired by the amygdala during acquisition of a stimulus-response habit task
    Robert J McDonald
    Canadian Centre for Behavioural Neuroscience, Department of Psychology and Neuroscience, University of Lethbridge, 4401 University Drive, Lethbridge, AB, T1K 3M4, Canada
    Exp Brain Res 159:72-83. 2004
    ..The nature of the association acquired in this learning paradigm, and the implications of this finding for theories dealing with the organization and functions of mammalian learning and memory are discussed...
  12. ncbi request reprint The challenges of understanding mammalian cognition and memory-based behaviours: an interactive learning and memory systems approach
    Robert J McDonald
    Department of Psychology and Neuroscience, Canadian Centre for Behavioural Neuroscience, University of Lethbridge, 4401 University Drive, Lethbridge, Alta, Canada AB T1K 3M4
    Neurosci Biobehav Rev 28:719-45. 2004
    ..Empirical and theoretical work directed at understanding the cognitive and non-cognitive processes associated with place learning in the water task and context conditioning during aversive events is also presented...
  13. doi request reprint Enhanced cell death in hippocampus and emergence of cognitive impairments following a localized mini-stroke in hippocampus if preceded by a previous episode of acute stress
    Robert J McDonald
    Canadian Centre for Behavioral Neuroscience, Department of Neuroscience, University of Lethbridge, Lethbridge, AB, Canada
    Eur J Neurosci 27:2197-209. 2008
    ..This vulnerability might be due to the actions of stress hormones, like the glucocorticoids, that have been previously shown to endanger hippocampal neurons...
  14. ncbi request reprint The etiology of age-related dementia is more complicated than we think
    Robert J McDonald
    Canadian Centre for Behavioural Neuroscience, Department of Neuroscience, University of Lethbridge Lethbridge, AB, Canada
    Behav Brain Res 214:3-11. 2010
    ..Various proof of principle experiments are presented and the mechanistic and treatment implications of this view are discussed...
  15. doi request reprint Expression of a conditioned place preference or spatial navigation task following muscimol-induced inactivations of the amygdala or dorsal hippocampus: A double dissociation in the retrograde direction
    Robert J McDonald
    Canadian Centre for Behavioural Neuroscience, Department of Neuroscience, University of Lethbridge, AB, Canada
    Brain Res Bull 83:29-37. 2010
    ..Taken together, the results showed a functional dissociation between the, effects of amygdala or hippocampal dysfunction on the expression of these different classes of tasks...
  16. doi request reprint Selective lesion of medial septal cholinergic neurons followed by a mini-stroke impairs spatial learning in rats
    Laura A Craig
    Department of Neuroscience, Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, AB, Canada
    Exp Brain Res 193:29-42. 2009
    ..This suggests an association between the cholinergic depletion observed during aging and the potential for functional recovery following stroke...
  17. doi request reprint Cholinergic depletion of the medial septum followed by phase shifting does not impair memory or rest-activity rhythms measured under standard light/dark conditions in rats
    Laura A Craig
    Canadian Centre for Behavioural Neuroscience, Department of Neuroscience, University of Lethbridge, 4401 University Drive West, Lethbridge, AB, Canada T1K 3M4
    Brain Res Bull 79:53-62. 2009
    ....
  18. pmc Making context memories independent of the hippocampus
    Hugo Lehmann
    Psychology Department, Trent University, Peterborough, Ontario, Canada
    Learn Mem 16:417-20. 2009
    ..The latter provides a new account for patterns of hippocampal retrograde amnesia and how memories may become independent of the hippocampus...
  19. doi request reprint Chronic disruption of circadian rhythms impairs hippocampal memory in the rat
    Laura A Craig
    Canadian Centre for Behavioural Neuroscience, Department of Neuroscience, University of Lethbridge, 4401 University Drive, Lethbridge, AB, Canada
    Brain Res Bull 76:141-51. 2008
    ..We propose that chronic circadian disruption may play a role in the development of age-related cognitive deficits and dementia in the elderly...
  20. doi request reprint Reduced cholinergic status in hippocampus produces spatial memory deficits when combined with kainic acid induced seizures
    Laura A Craig
    Department of Neuroscience, Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, Alberta, Canada
    Hippocampus 18:1112-21. 2008
    ..This result could not be explained by seizure severity or the extent of hippocampal damage, suggesting a more subtle interaction between these two risk factors in the development of a hippocampal based memory impairment...
  21. doi request reprint Persistent impairments in hippocampal, dorsal striatal, and prefrontal cortical function following repeated photoperiod shifts in rats
    Erin L Zelinski
    Department of Neuroscience, Canadian Centre for Behavioural Neuroscience, University of Lethbridge, 4401 University Drive, Lethbridge, AB T1K 3M4, Canada
    Exp Brain Res 224:125-39. 2013
    ....
  22. doi request reprint Emergence of spatial impairment in rats following specific cholinergic depletion of the medial septum combined with chronic stress
    Laura A Craig
    Canadian Centre for Behavioural Neuroscience, Department of Neuroscience, University of Lethbridge, Lethbridge, AB, Canada
    Eur J Neurosci 27:2262-71. 2008
    ..These findings support our theory that cholinergic depletion of the medial septum increases hippocampal vulnerability to further insults such as stress...
  23. ncbi request reprint Post-training intra-amygdala amphetamine injections given during acquisition of a stimulus-response (S-R) habit task enhance the expression of stimulus-reward learning: further evidence for incidental amygdala learning
    Matthew R Holahan
    Department of Psychology, University of Toronto, Toronto, Ont, M5S 3G3, Canada
    Brain Res Bull 66:222-8. 2005
    ..This suggests that post-training amphetamine strengthened a stimulus-reward association that did not immediately affect behavioral output. This association may reflect a mnemonic representation stored in an ensemble of amygdala neurons...
  24. doi request reprint Prefrontal cortical contributions during discriminative fear conditioning, extinction, and spontaneous recovery in rats
    Erin L Zelinski
    Department of Neuroscience, Canadian Centre for Behavioural Neuroscience, University of Lethbridge, 4401 University Drive, Lethbridge, AB, T1K 3M4, Canada
    Exp Brain Res 203:285-97. 2010
    ..These results further implicate OPFC and I/P PFC in the pathology underlying generalized anxiety disorder...
  25. ncbi request reprint Blunted cortisol rhythm is associated with learning impairment in aged hamsters
    Sean W Cain
    Department of Psychology, University of Toronto, 100 St George Street, Room 4020, Ontario, Canada M5S 3G3
    Physiol Behav 82:339-44. 2004
    ..These data suggest that age-related cognitive decline may be related more to a loss of hormone rhythmicity than to a loss of behavioral rhythmicity or an increase in hormone level...
  26. ncbi request reprint Differential involvement of amygdala and hippocampus in responding to novel objects and contexts
    Sandra N Moses
    Department of Psychology, University of Toronto, Ont, Toronto, Canada
    Brain Res Bull 58:517-27. 2002
    ..To the extent that we tap implicit and explicit knowledge using this paradigm, we suggest that in the rat, the amygdala and hippocampal systems are necessary for at least some types of explicit knowledge...
  27. ncbi request reprint How does a specific learning and memory system in the mammalian brain gain control of behavior?
    Robert J McDonald
    Department of Neuroscience, Canadian Centre for Behavioral Neuroscience, University of Lethbridge, Lethbridge, Alberta, Canada
    Hippocampus 23:1084-102. 2013
    ..The outcome of this work, in combination with other approaches, might improve understanding of the mechanisms of volition in human and non-human animals...
  28. ncbi request reprint The significance of circadian phase for performance on a reward-based learning task in hamsters
    Martin R Ralph
    Department of Psychology and Zoology, University of Toronto, 100 St George Street, ON, Canada M5S 3G3
    Behav Brain Res 136:179-84. 2002
    ..Timing is not an explicit discriminative cue in these experiments. Hence, the learning mechanism must be predisposed to register circadian time as an attribute during context learning...
  29. ncbi request reprint Attenuation of context-specific inhibition on reversal learning of a stimulus-response task in rats with neurotoxic hippocampal damage
    Robert J McDonald
    Department of Psychology, University of Toronto, 100 St George Street, Ont, Canada M5S 3G3
    Behav Brain Res 136:113-26. 2002
    ..Taken together these results suggest that rats with hippocampal lesions do not acquire normal context-specific inhibition during discrimination learning...
  30. ncbi request reprint Enhanced cell death and learning deficits after a mini-stroke in aged hippocampus
    Ira Driscoll
    Department of Neuroscience, Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, Alta, Canada
    Neurobiol Aging 29:1847-58. 2008
    ..Overall, our pattern of results suggest that the aged hippocampus is more vulnerable to the same insult that has little or no effect on the young hippocampus...
  31. ncbi request reprint Time stamp in conditioned place avoidance can be set to different circadian phases
    Sean W Cain
    Centre for Biological Timing and Cognition, Department of Psychology, University of Toronto, 100 St George Street, Room 4020, Toronto, Ont, Canada M5S 3G3
    Neurobiol Learn Mem 89:591-4. 2008
    ..Such an ability may allow animals in nature to predict the recurrence of 24h events, regardless of the time of day the event was encountered...
  32. ncbi request reprint Lesions of the dorsolateral striatum impair the acquisition of a simplified stimulus-response dependent conditional discrimination task
    R E Featherstone
    Department of Psychology, University of Toronto, 100 St George Street, Toronto, Ontario, Canada, M5S 3G3
    Neuroscience 136:387-95. 2005
    ..Animals with lesions of the dorsolateral striatum showed marked impairments in learning this task, a finding that is in agreement with the notion that the dorsolateral striatum is necessary for stimulus-response learning...
  33. ncbi request reprint Dorsal striatum and stimulus-response learning: lesions of the dorsolateral, but not dorsomedial, striatum impair acquisition of a stimulus-response-based instrumental discrimination task, while sparing conditioned place preference learning
    R E Featherstone
    Department of Psychology, University of Toronto, 100 St George Street, Toronto, Ontario, Canada M5S 3G3
    Neuroscience 124:23-31. 2004
    ..These results suggest that the dorsolateral striatum is necessary for the successful acquisition of tasks that place a demand upon stimulus-response learning, while the dorsomedial striatum is not involved in this type of learning...
  34. doi request reprint Revisiting the cholinergic hypothesis in the development of Alzheimer's disease
    Laura A Craig
    Canadian Centre for Behavioural Neuroscience, Department of Neuroscience, University of Lethbridge 4401 University Drive, Lethbridge, AB, Canada
    Neurosci Biobehav Rev 35:1397-409. 2011
    ..Finally we will discuss some of the implications for treatment that arise from this model and present directions for future study...
  35. ncbi request reprint Learning-induced alterations in prefrontal cortical dendritic morphology
    Wendy L Comeau
    Canadian Center for Behavioral Neuroscience, University of Lethbridge, Lethbridge, T1K 3M4, Canada
    Behav Brain Res 214:91-101. 2010
    ..In addition to demonstrating learning-specific modifications in dendritic connectivity within the PFC, the results illustrate varying patterns of change that likely reflect task-dependent requirements on the PFC...
  36. ncbi request reprint Dorsal/ventral hippocampus, fornix, and conditioned place preference
    J Ferbinteanu
    Department of Psychology, University of Toronto, Ontario, Canada
    Hippocampus 11:187-200. 2001
    ..To explain the complex pattern of results presently obtained, we propose a novel hypothesis regarding behavioral functions of HPC neural circuits. Implications regarding the interaction between memory systems are also considered...
  37. doi request reprint Retrograde amnesia for fear-potentiated startle in rats after complete, but not partial, hippocampal damage
    H Lehmann
    Department of Psychology, Trent University, Peterborough, ON, Canada
    Neuroscience 167:974-84. 2010
    ..Thus, the hippocampus normally has a critical and long-lasting role enabling recall of fear conditioning to a discrete visual stimulus. In the absence of the hippocampus other memory systems support new learning...
  38. ncbi request reprint A role for adult neurogenesis in spatial long-term memory
    J S Snyder
    Department of Physiology, University of Toronto, 1 King s College Circle, Room 3214, Toronto, Ontario, Canada M5S 1A8
    Neuroscience 130:843-52. 2005
    ..These results suggest a new role for adult neurogenesis in the formation and/or consolidation of long-term, hippocampus-dependent, spatial memories...
  39. ncbi request reprint Lesions of the medial or lateral perforant path have different effects on hippocampal contributions to place learning and on fear conditioning to context
    J Ferbinteanu
    Department of Psychology, University of Toronto, ON, Canada
    Behav Brain Res 101:65-84. 1999
    ..The context discrimination results can be explained by either a dissociation of sensory information that reaches the MEC and LEC, or alternatively, by a dissociation between the limbic nature of the MEC and the sensory nature of the LEC...
  40. doi request reprint Intact intracortical microstimulation (ICMS) representations of rostral and caudal forelimb areas in rats with quinolinic acid lesions of the medial or lateral caudate-putamen in an animal model of Huntington's disease
    Jenni M Karl
    Department of Neuroscience, Canadian Centre for Behavioural Neuroscience, University of Lethbridge, 4401 University Drive, Lethbridge, AB T1K 3M4, Canada
    Brain Res Bull 77:42-8. 2008
    ..Therefore, the impairments that follow striatal cell loss are due either to alterations in circuitry that is independent of motor cortex or to alterations in circuitry afferent to the motor cortex projections...
  41. ncbi request reprint Multiple parallel memory systems in the brain of the rat
    Norman M White
    Department of Psychology, McGill University, Montreal, Canada
    Neurobiol Learn Mem 77:125-84. 2002
    ..These interactions can be cooperative (leading to similar behaviors) or competitive (leading to different behaviors). Experimental findings consistent with these ideas, mostly from experiments with rats, are reviewed...
  42. ncbi request reprint Neurotoxic lesions of the caudate-putamen on a reaching for food task in the rat: acute sensorimotor neglect and chronic qualitative motor impairment follow lateral lesions and improved success follows medial lesions
    I Q Whishaw
    Department of Neuroscience, Canadian Centre for Behavioural Neuroscience, University of Lethbridge, 4401 University Drive, Lethbridge, Alberta, Canada T1K 3M4
    Neuroscience 146:86-97. 2007
    ....
  43. ncbi request reprint Rats with hippocampal damage are impaired on place learning in the water task when overtrained under constrained conditions
    R J McDonald
    Department of Psychology, University of Toronto, Ontario, Canada
    Hippocampus 10:153-61. 2000
    ..Overall, the results of the present study do not support the idea that the hippocampus is not specifically involved in acquisition of place information in the water task...
  44. doi request reprint Post-training CB1 cannabinoid receptor agonist activation disrupts long-term consolidation of spatial memories in the hippocampus
    T T Yim
    Canadian Centre for Behavioural Neuroscience, Department of Psychology and Neuroscience, University of Lethbridge, 4401 University Drive, Lethbridge, AB, Canada T1K 3M4
    Neuroscience 151:929-36. 2008
    ..Plausible pharmacological interactions between cannabinoids and other neurotransmitter systems and associated plasticity mechanisms are discussed...
  45. ncbi request reprint Dorsal striatum and stimulus-response learning: lesions of the dorsolateral, but not dorsomedial, striatum impair acquisition of a simple discrimination task
    R E Featherstone
    Department of Psychology, University of Toronto, 100 St George Street, Toronto, Canada M5S3G3
    Behav Brain Res 150:15-23. 2004
    ....
  46. ncbi request reprint Lesions of the dorsolateral or dorsomedial striatum impair performance of a previously acquired simple discrimination task
    R E Featherstone
    Department of Psychology, University of Toronto, Toronto, Canada
    Neurobiol Learn Mem 84:159-67. 2005
    ..Possible explanations for the differences between the role of the dorsomedial striatum in acquisition and expression of the simple discrimination task are proposed...
  47. ncbi request reprint Context-specific interference on reversal learning of a stimulus-response habit
    R J McDonald
    Department of Psychology, University of Toronto, 100 St. George Street, Toronto, ON, Canada M5S-3G3
    Behav Brain Res 121:149-65. 2001
    ..Animals that were reversed in a different context showed a renewal effect to the initial S-R when brought back to the original training context...
  48. ncbi request reprint Amygdala, hippocampus and discriminative fear conditioning to context
    E A Antoniadis
    Department of Psychology, University of Toronto, Ont, Canada
    Behav Brain Res 108:1-19. 2000
    ..The proposed view ascribes an equal role in fear conditioning to both the amygdala and the hippocampus...
  49. ncbi request reprint Amygdala, hippocampus, and unconditioned fear
    E A Antoniadis
    Department of Psychology, University of Toronto, 100 St George St, Toronto, Ontario M5S 3G3, Canada
    Exp Brain Res 138:200-9. 2001
    ....
  50. doi request reprint The trouble with circadian clock dysfunction: multiple deleterious effects on the brain and body
    Erin L Zelinski
    Canadian Centre for Behavioural Neuroscience, Department of Neuroscience, University of Lethbridge, Lethbridge, AB, Canada Electronic address
    Neurosci Biobehav Rev 40:80-101. 2014
    ..Subsequently, experimental support for these largely correlational human studies conducted in non-human animal models will be described. ..
  51. doi request reprint Persistent impairments in hippocampal function following a brief series of photoperiod shifts in rats
    Erin L Zelinski
    Department of Neuroscience, Canadian Centre for Behavioural Neuroscience, University of Lethbridge, 4401 University Drive, Lethbridge, AB, T1K 6W4, Canada
    Anim Cogn 17:127-41. 2014
    ..Effects were limited to a hippocampus-dependent task, indicating that impairments are specific, not global. ..
  52. ncbi request reprint Aging effects on spatial tuning of hippocampal place cells in mice
    Jun Yan
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, 600 University Avenue, ON M5G 1X5, Toronto, Canada
    Exp Brain Res 150:184-93. 2003
    ..Furthermore, we speculate that the age-related impairment in hippocampal inhibition system may be involved in the impaired spatial representation of hippocampal CA1 place cells in old mice...
  53. ncbi request reprint Circadian rhythms, aging and memory
    E A Antoniadis
    Departments of Psychology and Zoology, University of Toronto, 100 St George Street, Ont, M5S 3G3, Toronto, Canada
    Behav Brain Res 114:221-33. 2000
    ..The degree of preference was also correlated with activity amplitude. These results support the notion that age-related rhythm fragmentation contributes to the age-related memory decline...
  54. ncbi request reprint Discriminative fear conditioning to context expressed by multiple measures of fear in the rat
    E A Antoniadis
    Department of Psychology, University of Toronto, Ontario, Canada
    Behav Brain Res 101:1-13. 1999
    ..In general these findings also suggest that there are different learning parameters for the measures of fear examined in this paradigm...
  55. ncbi request reprint Finding a goal on dry land and in the water: differential effects of disorientation on spatial learning
    B M Gibson
    Department of Psychology, University of Toronto, 100 St George Street, Toronto, Ontario, Canada M5S 3G3
    Behav Brain Res 123:103-11. 2001
    ..The results constrain theoretical explanations for the differential effects of disorientation on different spatial tasks...
  56. ncbi request reprint Lesions of dorsal striatum eliminate lose-switch responding but not mixed-response strategies in rats
    Ivan Skelin
    Department of Neuroscience, Canadian Centre for Behavioural Neuroscience, University of Lethbridge, 4401 University Dr W, T1K 3M4, Lethbridge, AB, Canada
    Eur J Neurosci 39:1655-63. 2014
    ..These results provide further evidence that the rodent DLS is involved in rapid response adaptation that is more sophisticated than that embodied by the classic notion of habit formation driven by gradual stimulus-response learning. ..
  57. ncbi request reprint The effects of chronic photoperiod shifting on the physiology of female Long-Evans rats
    Scott H Deibel
    Canadian Centre for Behavioural Neuroscience, Department of Neuroscience, University of Lethbridge, Lethbridge, AB, Canada Electronic address
    Brain Res Bull 103:72-81. 2014
    ..This study demonstrates that chronic photoperiod shifting elicits weight gain when exposed to a stressful event and impairs glucose tolerance in the same individual. ..
  58. ncbi request reprint Role of epigenetic effectors in maintenance of the long-term persistent bystander effect in spleen in vivo
    Igor Koturbash
    Department of Biological Sciences, University of Lethbridge, Alberta, T1K 3M4, Canada
    Carcinogenesis 28:1831-8. 2007
    ....
  59. ncbi request reprint Circadian rhythms, aging and memory
    E A Antoniadis
    Departments of Psychology and Zoology, University of Toronto, 100 St George Street, Ont, M5S 3G3, Toronto, Canada
    Behav Brain Res 111:25-37. 2000
    ..The degree of preference was also correlated with activity amplitude. These results support the notion that age-related rhythm fragmentation contributes to the age-related memory decline...
  60. ncbi request reprint Partial reinforcement across trials impairs escape performance but spares place learning in the water maze
    Bryan D Devan
    Krasnow Institute for Advanced Study, George Mason University, Mail Stop 2A1, Fairfax, VA 22030 4444, USA
    Behav Brain Res 141:91-104. 2003
    ..We conclude that across-trial partial reinforcement procedures may promote response competition and mask evidence of place learning in addition to weakening escape performance late in training...
  61. ncbi request reprint Both dorsal and ventral hippocampus contribute to spatial learning in Long-Evans rats
    Janina Ferbinteanu
    Department of Neurobiology, Mt Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Neurosci Lett 345:131-5. 2003
    ..The acquisition deficit diminishes with training in both lesion groups. The data thus suggest that the entire HPC axis is involved in acquisition of spatial information...
  62. ncbi request reprint Place-cell impairment in glutamate receptor 2 mutant mice
    Jun Yan
    Department of Physiology and Biophysics, University of Calgary, Calgary, T2N 4NI Canada
    J Neurosci 22:RC204. 2002
    ..Our data suggest that place cells of GluR2 knock-out mice did not form robust place fields, and that enhanced non-Hebbian LTP might play a negative role in their formation...
  63. ncbi request reprint Fornix, medial prefrontal cortex, nucleus accumbens, and mediodorsal thalamic nucleus: roles in a fear-based context discrimination task
    Elena A Antoniadis
    California National Primate Research Center, University of California, Davis, CA 95616, USA
    Neurobiol Learn Mem 85:71-85. 2006
    ....
  64. pmc Defective place cell activity in nociceptin receptor knockout mice with elevated NMDA receptor-dependent long-term potentiation
    Franco A Taverna
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue Toronto, Ontario, Canada M5G 1X5
    J Physiol 565:579-91. 2005
    ..The data have important clinical implications on development of strategies to improve cognitive function...
  65. ncbi request reprint Impairment in long-term retention but not short-term performance on a water maze reversal task following hippocampal or mediodorsal striatal N-methyl-D-aspartate receptor blockade
    Matthew R Holahan
    Mount Sinai Hospital and University of Toronto, ON, Canada
    Behav Neurosci 119:1563-71. 2005
    ..Therefore, blocking dorsal hippocampal or mediodorsal striatal NMDA receptors selectively blocked long-term spatial retention without producing short-term performance deficits...
  66. ncbi request reprint Multiple combinations of co-factors produce variants of age-related cognitive decline: a theory
    Robert J McDonald
    University of Toronto
    Can J Exp Psychol 56:221-39. 2002
    ..The co-factors in the present model include genes, neurotransmitter changes, vascular abnormalities, stress hormones, circadian rhythms, head trauma, and seizures...