Heidi M McBride

Summary

Affiliation: University of Ottawa Heart Institute
Country: Canada

Publications

  1. pmc Parkin mitochondria in the autophagosome
    Heidi M McBride
    University of Ottawa Heart Institute, Ottawa, Ontario K1Y 4W7, Canada
    J Cell Biol 183:757-9. 2008
  2. ncbi request reprint Mitochondria: more than just a powerhouse
    Heidi M McBride
    University of Ottawa Heart Institute, Canada
    Curr Biol 16:R551-60. 2006
  3. ncbi request reprint Mitofusin 2 protects cerebellar granule neurons against injury-induced cell death
    Arezu Jahani-Asl
    Department of Cellular and Molecular Medicine, University of Ottawa, Neurosciences Program, Ottawa Health Research Institute, Ottawa, Ontario K1H 8M5, Canada
    J Biol Chem 282:23788-98. 2007
  4. doi request reprint Cargo-selected transport from the mitochondria to peroxisomes is mediated by vesicular carriers
    Margaret Neuspiel
    Lipoproteins and Atherosclerosis Group, University of Ottawa Heart Institute, 40 Ruskin St, Ottawa, Ontario K1Y 4W7, Canada
    Curr Biol 18:102-8. 2008
  5. pmc Bax/Bak promote sumoylation of DRP1 and its stable association with mitochondria during apoptotic cell death
    Sylwia Wasiak
    University of Ottawa Heart Institute, Ottawa, Ontario, Canada
    J Cell Biol 177:439-50. 2007
  6. pmc Mitochondria and the culture of the Borg: understanding the integration of mitochondrial function within the reticulum, the cell, and the organism
    Emelie Braschi
    University of Ottawa Heart Institute, Ottawa, Ontario, Canada
    Bioessays 32:958-66. 2010
  7. pmc Translocation of SenP5 from the nucleoli to the mitochondria modulates DRP1-dependent fission during mitosis
    Rodolfo Zunino
    University of Ottawa Heart Institute, Ottawa, Ontario K1Y 4W7, Canada
    J Biol Chem 284:17783-95. 2009
  8. doi request reprint A vesicular transport pathway shuttles cargo from mitochondria to lysosomes
    Vincent Soubannier
    Lipoproteins and Atherosclerosis Group, University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, ON K1Y 1V1, Canada
    Curr Biol 22:135-41. 2012
  9. pmc The mitochondrial inner membrane GTPase, optic atrophy 1 (Opa1), restores mitochondrial morphology and promotes neuronal survival following excitotoxicity
    Arezu Jahani-Asl
    Department of Cellular and Molecular Medicine, University of Ottawa Heart Institute, University of Ottawa, Ontario K1H 8M5, Canada
    J Biol Chem 286:4772-82. 2011
  10. ncbi request reprint The SUMO protease SENP5 is required to maintain mitochondrial morphology and function
    Rodolfo Zunino
    University of Ottawa Heart Institute, Rm H445A, 40 Ruskin Street, Ottawa, Ontario, K1Y 4W7, Canada
    J Cell Sci 120:1178-88. 2007

Collaborators

Detail Information

Publications28

  1. pmc Parkin mitochondria in the autophagosome
    Heidi M McBride
    University of Ottawa Heart Institute, Ottawa, Ontario K1Y 4W7, Canada
    J Cell Biol 183:757-9. 2008
    ..This work significantly increases our understanding of PD and provides a new framework for the development of therapeutic interventions...
  2. ncbi request reprint Mitochondria: more than just a powerhouse
    Heidi M McBride
    University of Ottawa Heart Institute, Canada
    Curr Biol 16:R551-60. 2006
    ..In this review we will highlight the emerging evidence that provides molecular definition to mitochondria as a central platform in the execution of diverse cellular events...
  3. ncbi request reprint Mitofusin 2 protects cerebellar granule neurons against injury-induced cell death
    Arezu Jahani-Asl
    Department of Cellular and Molecular Medicine, University of Ottawa, Neurosciences Program, Ottawa Health Research Institute, Ottawa, Ontario K1H 8M5, Canada
    J Biol Chem 282:23788-98. 2007
    ..These findings highlight a signaling role for Mfn2 in the regulation of apoptosis that extends beyond its role in mitochondrial fusion...
  4. doi request reprint Cargo-selected transport from the mitochondria to peroxisomes is mediated by vesicular carriers
    Margaret Neuspiel
    Lipoproteins and Atherosclerosis Group, University of Ottawa Heart Institute, 40 Ruskin St, Ottawa, Ontario K1Y 4W7, Canada
    Curr Biol 18:102-8. 2008
    ..These data are the first to identify MAPL, describe and characterize MDVs, and define a new intracellular transport route between mitochondria and peroxisomes...
  5. pmc Bax/Bak promote sumoylation of DRP1 and its stable association with mitochondria during apoptotic cell death
    Sylwia Wasiak
    University of Ottawa Heart Institute, Ottawa, Ontario, Canada
    J Cell Biol 177:439-50. 2007
    ..Altogether, these data demonstrate that the apoptotic machinery regulates the biochemical properties of DRP1 during cell death...
  6. pmc Mitochondria and the culture of the Borg: understanding the integration of mitochondrial function within the reticulum, the cell, and the organism
    Emelie Braschi
    University of Ottawa Heart Institute, Ottawa, Ontario, Canada
    Bioessays 32:958-66. 2010
    ..Decisions within the subspace domain couple signaling pathways involved in the functional integration of mitochondria with complex cellular transitions, including developmental cues, mitosis, and apoptosis...
  7. pmc Translocation of SenP5 from the nucleoli to the mitochondria modulates DRP1-dependent fission during mitosis
    Rodolfo Zunino
    University of Ottawa Heart Institute, Ottawa, Ontario K1Y 4W7, Canada
    J Biol Chem 284:17783-95. 2009
    ..The altered intracellular localization of SenP5 represents the first example of the mitochondrial recruitment of a SUMO protease and provides new insights into the mechanisms of interorganellar communication during the cell cycle...
  8. doi request reprint A vesicular transport pathway shuttles cargo from mitochondria to lysosomes
    Vincent Soubannier
    Lipoproteins and Atherosclerosis Group, University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, ON K1Y 1V1, Canada
    Curr Biol 22:135-41. 2012
    ..These data characterize a novel vesicle transport route between the mitochondria and lysosomes, providing insights into the basic mechanisms of mitochondrial quality control...
  9. pmc The mitochondrial inner membrane GTPase, optic atrophy 1 (Opa1), restores mitochondrial morphology and promotes neuronal survival following excitotoxicity
    Arezu Jahani-Asl
    Department of Cellular and Molecular Medicine, University of Ottawa Heart Institute, University of Ottawa, Ontario K1H 8M5, Canada
    J Biol Chem 286:4772-82. 2011
    ..These studies suggest Opa1 as a potential therapeutic target to promote neuronal survival following acute brain damage and neurodegenerative diseases...
  10. ncbi request reprint The SUMO protease SENP5 is required to maintain mitochondrial morphology and function
    Rodolfo Zunino
    University of Ottawa Heart Institute, Rm H445A, 40 Ruskin Street, Ottawa, Ontario, K1Y 4W7, Canada
    J Cell Sci 120:1178-88. 2007
    ..These data demonstrate the importance of SENP5 as a new regulator of SUMO1 proteolysis from mitochondrial targets, impacting mitochondrial morphology and metabolism...
  11. doi request reprint Vps35 mediates vesicle transport between the mitochondria and peroxisomes
    Emelie Braschi
    University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, ON K1Y 4W7, Canada
    Curr Biol 20:1310-5. 2010
    ..Silencing of Vps35 or Vps26A leads to a significant reduction in the delivery of MAPL to peroxisomes, placing the retromer within a novel intracellular trafficking route and providing insight into the formation of MAPL-positive MDVs...
  12. pmc MAPL is a new mitochondrial SUMO E3 ligase that regulates mitochondrial fission
    Emelie Braschi
    University of Ottawa Heart Institute, Ottawa, Ontario, Canada
    EMBO Rep 10:748-54. 2009
    ..Importantly, the large number of unidentified mitochondrial SUMO targets suggests a global role for SUMOylation in mitochondrial function, placing MAPL as a crucial component in the regulation of multiple conjugation events...
  13. pmc A novel cell-free mitochondrial fusion assay amenable for high-throughput screenings of fusion modulators
    Astrid C Schauss
    University of Ottawa Heart Institute, 40 Ruskin St, Ottawa, ON, USA
    BMC Biol 8:100. 2010
    ..In terms of mitochondrial fusion, the field currently relies upon on semi-quantitative assays which, even under optimal conditions, are labour-intensive, low-throughput and require complex imaging techniques...
  14. doi request reprint Positioning mitochondrial plasticity within cellular signaling cascades
    Vincent Soubannier
    University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, ON, Canada K1Y 4W7
    Biochim Biophys Acta 1793:154-70. 2009
    ..This review focuses on the molecular switches that control mitochondrial dynamics and the integration of mitochondrial morphology within cellular signaling cascades...
  15. ncbi request reprint Mitochondrial dynamics in the regulation of neuronal cell death
    Eric C C Cheung
    University of Ottawa, Department of Cellular Molecular Medicine, Ottawa Health Research Institute, 451 Smyth Road, Ottawa, Ontario, Canada
    Apoptosis 12:979-92. 2007
    ..We will discuss how this uniqueness presents special challenges in the cellular response to neurotoxic stresses, and how this affects the mitochondrial dynamics in the regulation of cell death in neurons...
  16. pmc Mitochondrial hyperfusion during oxidative stress is coupled to a dysregulation in calcium handling within a C2C12 cell model
    Calum J Redpath
    Cellular Electrophysiology Laboratory, University of Ottawa Heart Institute, University of Ottawa, Ottawa, ON, Canada
    PLoS ONE 8:e69165. 2013
    ..We believe that the MAM merits further investigation as a therapeutic target in AF-induced remodelling. ..
  17. pmc The intracellular redox state is a core determinant of mitochondrial fusion
    Timothy Shutt
    University of Ottawa Heart Institute, Ottawa, Ontario, Canada
    EMBO Rep 13:909-15. 2012
    ..Our data outline the molecular events that prime the fusion machinery, providing new insights into the coupling of mitochondrial fusion with the cellular stress response...
  18. pmc Dissociating the dual roles of apoptosis-inducing factor in maintaining mitochondrial structure and apoptosis
    Eric C C Cheung
    Ottawa Health Research Institute, Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada
    EMBO J 25:4061-73. 2006
    ..Cell death induced by AIF is through its proapoptotic activity once it is translocated to the nucleus, not due to the loss of AIF from the mitochondria...
  19. doi request reprint Processing-dependent trafficking of Sonic hedgehog to the regulated secretory pathway in neurons
    Shawn T Beug
    Vision Program, Ottawa Hospital Research Institute, 501 Smyth Road, Ottawa, Ontario, Canada
    Mol Cell Neurosci 46:583-96. 2011
    ....
  20. doi request reprint ROMO1 is an essential redox-dependent regulator of mitochondrial dynamics
    Matthew Norton
    1Children s Hospital of Eastern Ontario Research Institute, 401 Smyth Road, Ottawa, Ontario K1H 8L1, Canada
    Sci Signal 7:ra10. 2014
    ..Together, our data identify ROMO1 as a critical molecular switch that couples metabolic stress and mitochondrial morphology, linking mitochondrial fusion to cell survival. ..
  21. ncbi request reprint Different cellular traffic of LDL-cholesterol and acetylated LDL-cholesterol leads to distinct reverse cholesterol transport pathways
    Ming dong Wang
    Lipoprotein and Atherosclerosis Research Group, University of Ottawa Heart Institute, and Department of Biochemistry, University of Ottawa, Ottawa, Ontario, Canada
    J Lipid Res 48:633-45. 2007
    ..This indicates a greater efficiency of HDL than lipid-poor apoA-I in interstitial fluid in controlling in vivo RCT. These assays, taken together, emphasize the importance of mediators of diffusional cholesterol efflux in RCT...
  22. ncbi request reprint Mitochondrial fission: a non-nuclear role for Num1p
    Astrid C Schauss
    University of Ottawa Heart Institute, Rm H445A, 40 Ruskin St, Ottawa, Ontario, K1Y 4W7 Canada
    Curr Biol 17:R467-70. 2007
    ..A recent study by Rob Jensen and coworkers provides a new link between a protein required for the inheritance of nuclei in yeast with the positioning and morphology of the mitochondria...
  23. ncbi request reprint SR-BI undergoes cholesterol-stimulated transcytosis to the bile canaliculus in polarized WIF-B cells
    Christopher J Harder
    Lipoprotein and Atherosclerosis Group, University of Ottawa Heart Institute, Ottawa, Ontario K1Y 4W7, Canada
    J Biol Chem 282:1445-55. 2007
    ..Taken together, these data demonstrate that hepatic SR-BI transcytosis is regulated by cholesterol and suggest that SR-BI has a stationary function on the bile canaliculus...
  24. ncbi request reprint The lipoprotein receptor-related protein-1 (LRP) adapter protein GULP mediates trafficking of the LRP ligand prosaposin, leading to sphingolipid and free cholesterol accumulation in late endosomes and impaired efflux
    Robert S Kiss
    Lipoprotein and Atherosclerosis Research Group, Department of Pathology and Laboratory Medicine, University of Ottawa Heart Institute, Ottawa K1Y 4W7, Canada
    J Biol Chem 281:12081-92. 2006
    ..Taken together, these data reveal that GULP/LRP/ABCA1 represents a triad of molecules involved in engulfment and cellular lipid homeostasis...
  25. pmc The PINK1/Parkin pathway regulates mitochondrial morphology
    Angela C Poole
    Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 105:1638-43. 2008
    ..Our studies suggest that the PINK1/Parkin pathway promotes mitochondrial fission and that the loss of mitochondrial and tissue integrity in PINK1 and parkin mutants derives from reduced mitochondrial fission...
  26. pmc Phosphorylation and cleavage of presenilin-associated rhomboid-like protein (PARL) promotes changes in mitochondrial morphology
    Danny V Jeyaraju
    Centre de Recherche Universite Laval Robert Giffard, 2601 Ch de la Canardiere, Quebec City, QC, Canada G1J 2G3
    Proc Natl Acad Sci U S A 103:18562-7. 2006
    ..Our findings reveal that PARL phosphorylation and cleavage impact mitochondrial dynamics, providing a blueprint to study the molecular evolution of mitochondrial morphology...
  27. pmc Mammalian polynucleotide phosphorylase is an intermembrane space RNase that maintains mitochondrial homeostasis
    Hsiao Wen Chen
    Department of Pathology and Laboratory Medicine, UCLA David Geffen School of Medicine, Los Angeles, CA 90095, USA
    Mol Cell Biol 26:8475-87. 2006
    ..Combined, the data demonstrate an unexpected IMS localization and a key role for PNPase in maintaining mitochondrial homeostasis...
  28. pmc Endoplasmic reticulum BIK initiates DRP1-regulated remodelling of mitochondrial cristae during apoptosis
    Marc Germain
    Department of Biochemistry, McGill University, Montreal, QC, Canada
    EMBO J 24:1546-56. 2005
    ..When expressed together, BIK and NOXA cause rapid release of mobilized cytochrome c and activation of caspases...