Mary Pat McAndrews
Affiliation: University of Toronto
- Understanding medial temporal activation in memory tasks: evidence from fMRI of encoding and recognition in a case of transient global amnesiaRobyn Westmacott
Toronto Western Research Institute, Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada
Hippocampus 18:317-25. 2008..Furthermore, the strong hippocampal activation during unsuccessful retrieval highlights important issues in interpreting memory-related activations, particularly in dysfunctional systems...
- Cognitive effects of long-term benzodiazepine use in older adultsMary Pat McAndrews
Department of Psychology, Toronto Western Hospital and University of Toronto, Canada
Hum Psychopharmacol 18:51-7. 2003..However, the magnitude of these effects is quite small and may be of little clinical significance in the healthy elderly...
- Prevalence and significance of neurocognitive dysfunction in hepatitis C in the absence of correlated risk factorsMary Pat McAndrews
Divisions of Psychology, University Health Network, Toronto, Ontario, Canada
Hepatology 41:801-8. 2005....
- Self-reported depressive symptoms and memory complaints in survivors five years after ARDSNeill K J Adhikari
Interdepartmental Division of Critical Care, University of Toronto, Toronto, ON, Canada
Chest 140:1484-93. 2011..Survivors of ARDS report depressive symptoms and memory complaints, the prevalence of which after 5 years is unknown...
- A phase I trial of deep brain stimulation of memory circuits in Alzheimer's diseaseAdrian W Laxton
Division of Neurosurgery, University of Toronto, Toronto, Ontario, Canada
Ann Neurol 68:521-34. 2010..We hypothesized that fornix/hypothalamus deep brain stimulation (DBS) could modulate neurophysiological activity in these pathological circuits and possibly produce clinical benefits...
- Default mode network connectivity indicates episodic memory capacity in mesial temporal lobe epilepsyCornelia McCormick
Krembil Neuroscience Center and Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada
Epilepsia 54:809-18. 2013....
- Visuospatial associative memory and hippocampal functioning in congenital hypothyroidismSarah M Wheeler
Neuroscience and Mental Health Research Program, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada
J Int Neuropsychol Soc 18:49-56. 2012..These results suggest that perinatal deprivation of thyroid hormone has longstanding effects on hippocampal function and may account for memory problems experienced by adolescents with congenital hypothyroidism...
- Network interactions explain effective encoding in the context of medial temporal damage in MCIAndrea B Protzner
Krembil Neuroscience Centre, University Health Network, Toronto, Ontario, Canada
Hum Brain Mapp 32:1277-89. 2011..Our findings suggest that understanding brain-behavior relationships in neurological disorders requires examination of large-scale networks, even when dysfunction is relatively focal as in MCI...
- Consequences of hippocampal damage across the autobiographical memory network in left temporal lobe epilepsyDonna Rose Addis
Toronto Western Research Institute, Toronto, ON, Canada
Brain 130:2327-42. 2007....
- Functional neuroanatomy of remote episodic, semantic and spatial memory: a unified account based on multiple trace theoryMorris Moscovitch
Department of Psychology, University of Toronto and Rotman Research Institute Baycrest Centre, Ontario, Canada
J Anat 207:35-66. 2005....
- Influence of hepatitis C virus on neurocognitive function in patients free from other risk factors: validation from therapeutic outcomesVenessa Pattullo
Department of Medicine, University Health Network, Toronto Western Hospital, University of Toronto, Toronto, ON, Canada
Liver Int 31:1028-38. 2011..This longitudinal study aimed to quantify these abnormalities in a cohort of patients free from correlated risk factors and determine whether treatment-induced viral clearance abolished these abnormalities...
- Memory enhancement induced by hypothalamic/fornix deep brain stimulationClement Hamani
Division of Neurosurgery, Toronto Western Hospital and Research Institute, University of Toronto, Toronto, Ontario, Canada
Ann Neurol 63:119-23. 2008..This shows that hypothalamic stimulation in this patient modulates limbic activity and improves certain memory functions...
- fMRI differences in encoding and retrieval of pictures due to encoding strategy in the elderlyJennifer L Mandzia
Cognitive Neurology Unit and Imaging Research, Sunnybrook and Women s College Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada
Hum Brain Mapp 21:1-14. 2004..Focusing on the medial temporal lobe (MTL) region, our results suggest a greater involvement of both anterior MTL and prefrontal regions in retrieval compared to encoding...
- Characterizing spatial and temporal features of autobiographical memory retrieval networks: a partial least squares approachDonna Rose Addis
Toronto Western Research Institute, Toronto, Ontario, Canada
Neuroimage 23:1460-71. 2004....
- Network alterations supporting word retrieval in patients with medial temporal lobe epilepsyAndrea B Protzner
Department of Neuropsychology, Krembil Neuroscience Centre, University Health Network, 399 Bathurst St, Toronto, ON, Canada
J Cogn Neurosci 23:2605-19. 2011..This strategy of correlating network changes and off-line behavior may provide a powerful tool for predicting a postoperative decline in language performance...
- Recollective qualities modulate hippocampal activation during autobiographical memory retrievalDonna Rose Addis
Department of Psychology, University of Toronto, Toronto, Ontario, Canada
Hippocampus 14:752-62. 2004..These findings are consistent with theories of hippocampal function that emphasize its role in the recollection of multifaceted autobiographical experiences...
- Characterizing functional integrity: intraindividual brain signal variability predicts memory performance in patients with medial temporal lobe epilepsyAndrea B Protzner
Department of Psychology, University of Calgary, Alberta, Canada
J Neurosci 33:9855-65. 2013..Furthermore, this measure can be characterized as a robust biomarker in this clinical setting because it reveals the same pattern regardless of cognitive challenge or task engagement during scanning...
- Characterizing the normal developmental trajectory of expressive language lateralization using magnetoencephalographyDarren S Kadis
Division of Neurology, Hospital for Sick Children, Toronto, Ontario, Canada
J Int Neuropsychol Soc 17:896-904. 2011..Findings suggest that adult-typical left hemisphere lateralization emerges from an early bilateral language network, which may explain the pediatric advantage for interhemispheric plasticity of language...
- Recollection versus strength as the primary determinant of hippocampal engagement at retrievalMelanie Cohn
Krembil Neuroscience Centre, University Health Network, Fell Pavilion, Toronto, Ontario, Canada
Proc Natl Acad Sci U S A 106:22451-5. 2009..Together, our results support the notion that it is recollection of context, rather than memory strength, that underlies hippocampal engagement at retrieval...
- The immediacy of recollection: the use of the historical present in narratives of autobiographical episodes by patients with unilateral temporal lobe epilepsyLillian Park
Rotman Research Institute, Baycrest, Toronto, Ontario M6A 2E1, Canada
Neuropsychologia 49:1171-6. 2011..We provide the first empirical evidence that a linguistic construct can be used to assess the conscious experience that accompanies recollection...
- Associative reinstatement: a novel approach to assessing associative memory in patients with unilateral temporal lobe excisionsMelanie Cohn
Krembil Neuroscience Centre, University Health Network, Canada
Neuropsychologia 47:2989-94. 2009..We propose that associative reinstatement provides a sensitive measure of relational memory that is less dependent on strategic processing and therefore more appropriate for evaluating MTL function in patients...
- Determinants of autobiographical memory in patients with unilateral temporal lobe epilepsy or excisionsMarie St-Laurent
Krembil Neuroscience Center, University Health Network, Canada
Neuropsychologia 47:2211-21. 2009..The similarity of the impairment between the event-specific and the generic memory conditions also suggests that temporal specificity is not a key determinant of hippocampal engagement in autobiographical retrieval...
- Self-reported symptoms of depression and memory dysfunction in survivors of ARDSNeill K J Adhikari
Department of Critical Care Medicine, Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Toronto, Ontario, Canada
Chest 135:678-87. 2009..Survivors of ARDS have well documented physical limitations, but psychological effects are less clear. We determined the prevalence of self-reported depression and memory dysfunction in ARDS survivors...
- Hippocampal size and memory functioning in children and adolescents with congenital hypothyroidismSarah M Wheeler
The Hospital for Sick Children, Toronto, Ontario, Canada
J Clin Endocrinol Metab 96:E1427-34. 2011..One area of particular weakness is memory, especially on tasks known to be mediated by the hippocampus. However, the hippocampus has not been directly studied in this population...
- Visual-spatial ability and fMRI cortical activation in surgery residentsKyle R Wanzel
Department of Surgery, University of Toronto, Toronto, Ontario, Canada
Am J Surg 193:507-10. 2007..In the current study, we used functional magnetic resonance imaging (fMRI) to identify patterns of cortical activation associated with mental rotation ability in those same residents...
- Memory for famous people in patients with unilateral temporal lobe epilepsy and excisionsIndre V Viskontas
Department of Psychology, University of Toronto, Ontario, Canada
Neuropsychology 16:472-80. 2002..These findings suggest the integrity of temporal structures in both hemispheres is critical for retrieval of detailed semantic information about famous individuals...
- Material-specific deficits in "remembering" in patients with unilateral temporal lobe epilepsy and excisionsDavid A Moscovitch
Department of Psychology, University of Toronto, Toronto, Canada
Neuropsychologia 40:1335-42. 2002..We offer this as a novel interpretation of the "remember-know" literature...
- Altered resting state brain dynamics in temporal lobe epilepsy can be observed in spectral power, functional connectivity and graph theory metricsMaher A Quraan
Krembil Neuroscience Center and Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada
PLoS ONE 8:e68609. 2013..To our knowledge, this is the only study to encompass power, connectivity and graph theory metrics to investigate the reorganization of resting state functional networks in LTLE patients. ..
- Episodic memory processes mediated by the medial temporal lobes contribute to open-ended problem solvingSigny Sheldon
Department of Psychology, University of Toronto, Toronto, ON, Canada
Neuropsychologia 49:2439-47. 2011....
- The sign of the cross as a learned ictal automatism?Richard Wennberg
Krembil Neuroscience Centre, Toronto Western Hospital, University of Toronto, Toronto, Ont, Canada
Epilepsy Behav 15:394-8. 2009....
- Effects of early thyroid hormone deficiency on children's autobiographical memory performanceKaren A Willoughby
Neuroscience and Mental Health Research Program, The Hospital for Sick Children, Toronto, Ontario
J Int Neuropsychol Soc 19:419-29. 2013..Furthermore, the present study indicates that the CAI is an effective tool for investigating episodic AM impairment in clinical pediatric populations...
- Efficacy and tolerability of the modified Atkins diet in adults with pharmacoresistant epilepsy: a prospective observational studyMara Smith
Schulich School of Medicine, University of Western Ontario, London, Ontario, Canada
Epilepsia 52:775-80. 2011..Recent evidence suggests that a Modified Atkins Diet may be a beneficial form of cotherapy for adult patients with pharmacoresistant epilepsy...
- Intrahemispheric reorganization of language in children with medically intractable epilepsy of the left hemisphereDarren S Kadis
Department of Psychology, University of Toronto, Toronto, Ontario, CanadaDepartment of Psychology, Hospital for Sick Children, Toronto, Ontario, Canada
J Int Neuropsychol Soc 13:505-16. 2007..Findings suggest that left hemisphere insult in young children may result in anterior displacement of language within the frontal cortex...
- Well-being in informal caregivers of survivors of acute respiratory distress syndromeJill I Cameron
University Health Network, Women s Health Program, Toronto, ON
Crit Care Med 34:81-6. 2006....
- Tremor cells in the human thalamus: differences among neurological disordersJason A Brodkey
Division of Neurosurgery, Toronto Western Hospital, Ontario, Canada
J Neurosurg 101:43-7. 2004....
- Intact perceptual and conceptual priming in temporal lobe epilepsy: neuroanatomical and methodological implicationsRebecca L Billingsley
Department of Psychology, University of Toronto and The Hospital for Sick Children, Ontario, Canada
Neuropsychology 16:92-101. 2002..Thus, intact left temporal cortex does not appear to be necessary for normal implicit memory performance, even when conceptual processing is emphasized at study or test...
- Prefrontal and hippocampal contributions to the generation and binding of semantic associations during successful encodingDonna Rose Addis
Department of Psychology, Harvard University, William James Hall, Rm 854, 33 Kirkland Street, Cambridge, MA 02138, USA
Neuroimage 33:1194-206. 2006..Our findings illustrate that modulation of components in a memory network can be independent of patterns of mutual connectivity among those components in mediating successful encoding...