Research Topics
| Vivian Charles McAlisterSummaryAffiliation: University of Western Ontario Country: Canada Publications
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Detail Information
Publications
New immunosuppressants in clinical trialVivian C McAlister
Department of Surgery, University of Western Ontario, London, Ontario, Canada
Curr Drug Targets Cardiovasc Haematol Disord 2:73-7. 2002..Trials of steroid immunotherapy have focused on steroid elimination but trial of newer locally active steroids may be beneficial...
Origins of the Canadian school of surgeryVivian Charles McAlister
Department of Surgery, University of Western Ontario, London, Ont
Can J Surg 50:357-63. 2007..quot; Because no comprehensive history of surgery in this country has yet been written, these articles may provide its basis...
The life of John Wishart (1850-1926): study of an academic surgical career prior to the Flexner ReportEmily Claydon
Department of Surgery, University of Toronto, Toronto, ON, Canada
World J Surg 36:684-8. 2012..To understand the contribution of educators in this earlier period, we investigated the forgotten career of John Wishart, founding Professor of Surgery at Western University, London Ontario...
Influence of local provision of specialty health care service on patient access to careVivian C McAlister
Department of Surgery, University of Western Ontario, London, Ont, Canada
Can J Surg 50:124-8. 2007..The impact of local provision of specialty service on patients' access to care was studied in Canada's 13 health care jurisdictions where distance may be a barrier limiting access...
Control of coagulation: a gift of Canadian agricultureVivian McAlister
Department of Surgery, University of Western Ontario, London, Ontario, Canada
Clin Invest Med 29:373-7. 2006..The roles and the careers of Canadian coagulation research pioneers are briefly presented in this review, which shows how clinical medicine benefited by the systematic development of agricultural science in Guelph, Ontario...
Cyclosporin versus tacrolimus as primary immunosuppressant after liver transplantation: a meta-analysisV C McAlister
Department of Surgery, University of Western Ontario, Canada
Am J Transplant 6:1578-85. 2006....
Orthotopic liver transplantation using low-dose tacrolimus and sirolimusV C McAlister
Atlantic Canada Liver Transplantation Program, Dalhousie University, Halifax, Nova Scotia, Canada
Liver Transpl 7:701-8. 2001..A low-dose combination of SRL and TAC should be compared with conventional immunosuppression in a multicenter, randomized, controlled trial...
Sacred disease of our times: failure of the infectious disease model of spongiform encephalopathyVivian McAlister
Department of Surgery, University of Western Ontario, London, Ontario, Canada
Clin Invest Med 28:101-4. 2005..Inconsistencies of the infectious disease model as it applies to the spongiform encephalopathies may result in failure of these policies...
Duodenal dearterialization and stapling for severe hemorrhage from duodenal varices with portal vein thrombosisVivian C McAlister
Department of Surgery, 4TU 44, University Hospital, London, Ontario, Canada N6A 5A5
Am J Surg 189:49-52. 2005..Hemorrhage from duodenal varices is a rare but frequently fatal cause of gastrointestinal bleeding. Portal vein thrombosis may worsen the bleeding and prevent access for reduction of variceal pressure...
Maimonides's cooling period and organ retrievalVivian McAlister
Department of Surgery, University of Western Ontario, London, Ont
Can J Surg 47:8-9. 2004
A clinical pharmacokinetic study of tacrolimus and sirolimus combination immunosuppression comparing simultaneous to separated administrationVivian C McAlister
Department of Surgery, Dalhousie University, Halifax, Nova Scotia, Canada
Ther Drug Monit 24:346-50. 2002..These data confirm that simultaneous dosing of TAC and SRL after transplantation is safe and that trough level monitoring is adequate to control therapy...
Transplantation in Canada: report of the Canadian Organ Replacement RegisterV C McAlister
Canadian Organ Replacement Register, Canadian Institute of Health Information, Toronto, Ontario, Canada
Transplant Proc 35:2428-30. 2003..5 PMP) and the United States (22.6 PMP) but above Australia (9.3 PMP). As a result the annual gap between transplants performed and the waiting list has grown from 927 in 1992 to 2230 in 2001, representing an annual increase of 8.3%...
Perfusion of renal allografts with verapamil improves graft functionChris Y Nguan
Multi Organ Transplant Program, London Health Sciences Center, London, ON, Canada
Transplantation 86:1463-7. 2008..Additionally, rates of hypotension during graft reperfusion and other adverse reactions were similar in both groups. In conclusion, verapamil supplemented perfusate significantly improved renal function posttransplantation...
Liposomal formulations of tacrolimus and rapamycin increase graft survival and fiber outgrowth of dopaminergic graftsAylin Y Alemdar
Department of Anatomy and Neurobiology, Dalhousie University, Halifax, Nova Scotia, Canada B3H 4H7
Cell Transplant 13:263-71. 2004..These compounds may play an important role in optimizing graft survival and host reinnervation in cell-mediated brain repair strategies for the treatment of neurological conditions...
A prospective 3-yr evaluation of tacrolimus-based immunosuppressive therapy in immunological high risk renal allograft recipientsJeffrey S Zaltzman
St Michael s Hospital, Toronto, Ontario, Canada
Clin Transplant 19:26-32. 2005..We therefore undertook a prospective study to systematically assess outcomes using these agents as part of an aggressive immunosuppressive regimen...
Clinical kidney transplantation: a 50th anniversary review of the first reported seriesVivian Charles McAlister
Department of Surgery, University of Western Ontario, London, Ontario, Canada N6A 5A5
Am J Surg 190:485-8. 2005..CONCLUSIONS: Modern renal transplantation is founded on many of the principles expounded by Gordon Murray 50 years ago...
Liposomal encapsulation significantly enchances the immunosuppressive effect of tacrolimus in a discordant islet xenotransplant modelHua Yang
Department of Pathology, IWK Health Centre, Halifax, Nova Scotia, B3H 1V7 Canada
Transplantation 73:710-3. 2002..CONCLUSIONS: LTAC is the most potent immunosuppressive compound we have tested in our discordant fish-to-mouse islet xenograft model; however, toxicity is an issue at high doses...
The role of recombinant factor VIIa in on-pump cardiac surgery: proceedings of the Canadian Consensus ConferenceKeyvan Karkouti
University Health Network, Toronto General Hospital, Department of Anesthesia, Toronto, Ontario, Canada
Can J Anaesth 54:573-82. 2007..A Canadian Consensus Conference was convened to generate recommendations for rFVIIa use in on-pump cardiac surgery...
Endoscopic fenestration of a duodenal duplication cyst to resolve recurrent pancreatitisMarie Antoinette J Rockx
Department of Medicine, London Health Sciences Centre, London, Canada
JOP 8:795-8. 2007..Free emptying of bile and pancreatic juice from the cyst has resulted in elimination of the patient's persistent epigastric discomfort and attacks of pancreatitis...
Protective anti-donor IgM production after crossmatch positive liver-kidney transplantationChloe C McAlister
Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
Liver Transpl 10:315-9. 2004..We report a crossmatch-positive LKT where posttransplantation production of IgM DSA, which failed to fix complement, appeared to protect the grafts...
Waiting for liver transplantation in Canada: waitlist history 2000--2004 and sensitivity analysis for the futureDavid A Stanford
Department of Statistical and Actuarial Sciences, University of Western Ontario, London, Ontario, Canada
Health Care Manag Sci 11:184-95. 2008..The results can be used by relevant authorities, together with information on success rates for publicity campaigns and living donor matching campaigns, to assess where further efforts should be made to reduce waiting times...
Immunoglobulin-G subclass antidonor reactivity in transplant recipientsZu-hua Gao
Department of Surgery, Dalhousie University, Halifax, Nova Scotia, Canada
Liver Transpl 10:1055-9. 2004..A late rise in antidonor IgG4 is consistent with decreased antidonor reactivity thought to occur late after transplantation...
Use of recombinant activated factor VII in patients without hemophilia: a meta-analysis of randomized control trialsCyrus C Hsia
Division of General Surgery, University of Western Ontario, London, Ontario, Canada
Ann Surg 248:61-8. 2008..Benefits of recombinant activated factor VII (rFVIIa) in hemorrhage may be lost because of thromboembolic events (TAE)...
Prospective comparison of magnetic resonance angiography with selective renal angiography for living kidney donor assessmentChristopher Neville
Division of Urology, London Health Sciences Centre, The University of Western Ontario, London, Ontario, Canada
Urology 71:385-9. 2008..Because of the potential morbidity associated with SRA, we prospectively evaluated magnetic resonance angiography (MRA) in the assessment of renal donors...
Re-exposure to mismatched HLA class I is a significant risk factor for graft loss: multivariable analysis of 259 kidney retransplantsAndrew A House
Multi Organ Transplant Program, London Health Sciences Centre, University of Western Ontario, London, Ontario, Canada
Transplantation 84:722-8. 2007..Conflicting publications have assessed this risk, so to examine our experience 259 kidney retransplants were analyzed...
Metabolic syndrome in liver transplant recipients: prevalence and association with major vascular eventsMarie Laryea
Multi Organ Transplant Program, Capital District Health Authority, Queen Elizabeth II Health Sciences Center, Halifax, Nova Scotia, Canada
Liver Transpl 13:1109-14. 2007..Metabolic syndrome appears to be associated with an increased risk of major vascular events in our liver transplant population...
The role of prophylactic cholecystectomy versus deferral in the care of patients after endoscopic sphincterotomyJason D Archibald
Department of Surgery, Dalhousie University, Halifax, NS, Canada
Can J Surg 50:19-23. 2007..Other studies suggest the cholecystectomy rate to be as low as 8%...
Use of a pelvic kidney for living transplantation: case report and review of the literaturePatrick P W Luke
Departments of Surgery and Medicine, London Health Sciences Center, The Multi Organ Transplant Program, The University of Western Ontario, London, Ontario, Canada
Am J Transplant 3:235-8. 2003..Therefore, careful radiologic and functional evaluation of these kidneys must be performed prior to procurement for transplantation. We report the successful use of a pelvic kidney for living-related transplantation...
Intravenous immunoglobulin as a treatment for BK virus associated nephropathy: one-year follow-up of renal allograft recipientsAlp Sener
Department of Surgery, Division of Urology, London Health Sciences Center, London, Ontario, Canada
Transplantation 81:117-20. 2006..The benefit of concomitant IVIG and reduction of immunosuppressive therapy in BKVAN needs to be further addressed in randomized, multicentered trials...
Modification of xenoantigens on porcine erythrocytes for xenotransfusionJay Doucet
Department of Surgery, Dalhousie University, Halifax, Nova Scotia, Canada
Surgery 135:178-86. 2004..CONCLUSIONS: These data suggest that strategies to remove or mask xenoantigens on PRBCs reduce antigenicity sufficiently to allow in vitro cross-match compatibility to human sera...
Association of recanalization of the left umbilical vein with umbilical hernia in patients with liver diseaseEran Shlomovitz
Department of Surgery, University of Western Ontario, University Hospital, London, Ontario, Canada
Liver Transpl 11:1298-9. 2005
