E Maurer-Spurej

Summary

Affiliation: University of British Columbia
Country: Canada

Publications

  1. ncbi request reprint Factors influencing uptake and retention of amino-containing drugs in large unilamellar vesicles exhibiting transmembrane pH gradients
    E Maurer-Spurej
    University of British Columbia, Department of Biochemistry and Molecular Biology, Faculty of Medicine, 2146 Health Sciences Mall, Vancouver, BC V6T 1Z3, Canada
    Biochim Biophys Acta 1416:1-10. 1999
  2. doi request reprint Erroneous automated optical platelet counts in 1-hour post-transfusion blood samples
    E Maurer-Spurej
    Canadian Blood Services, University of British Columbia, Vancouver, BC, Canada
    Int J Lab Hematol 32:e1-8. 2010
  3. ncbi request reprint Past and future approaches to assess the quality of platelets for transfusion
    Elisabeth Maurer-Spurej
    Canadian Blood Services, Vancouver, BC, Canada
    Transfus Med Rev 21:295-306. 2007
  4. doi request reprint Platelet quality measured with dynamic light scattering correlates with transfusion outcome in hematologic malignancies
    Elisabeth Maurer-Spurej
    Canadian Blood Services, Ottawa, Ontario, Canada
    Transfusion 49:2276-84. 2009
  5. pmc Platelet serotonin levels support depression scores for women with postpartum depression
    Elisabeth Maurer-Spurej
    Canadian Blood Services, Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada
    J Psychiatry Neurosci 32:23-9. 2007
  6. ncbi request reprint Portable dynamic light scattering instrument and method for the measurement of blood platelet suspensions
    Elisabeth Maurer-Spurej
    Canadian Blood Services and Department of Pathology and Laboratory Medicine and Centre for Blood Research, University of British Columbia, Vancouver, BC, Canada
    Phys Med Biol 51:3747-58. 2006
  7. ncbi request reprint Circulating serotonin in vertebrates
    E Maurer-Spurej
    Department of Pathology, University of British Columbia, Vancouver, Canada
    Cell Mol Life Sci 62:1881-9. 2005
  8. ncbi request reprint Serotonin reuptake inhibitors and cardiovascular diseases: a platelet connection
    E Maurer-Spurej
    Department of Pathology, University of British Columbia, 2211 Wesbrook Mall, Vancouver, British Columbia, V6T 2B5, Canada
    Cell Mol Life Sci 62:159-70. 2005
  9. ncbi request reprint The influence of selective serotonin reuptake inhibitors on human platelet serotonin
    Elisabeth Maurer-Spurej
    Canadian Blood Services University of British Columbia Pathology and Laboratory Medicine 2211 Wesbrook Mall Vancouver, BC, V6T 2B5, Canada
    Thromb Haemost 91:119-28. 2004
  10. ncbi request reprint A novel immunocytochemical assay for the detection of serotonin in platelets
    Elisabeth Maurer-Spurej
    Canadian Blood Services, University of British Columbia, Department of Pathology, Vancouver, BC, Canada
    Br J Haematol 116:604-11. 2002

Collaborators

Detail Information

Publications18

  1. ncbi request reprint Factors influencing uptake and retention of amino-containing drugs in large unilamellar vesicles exhibiting transmembrane pH gradients
    E Maurer-Spurej
    University of British Columbia, Department of Biochemistry and Molecular Biology, Faculty of Medicine, 2146 Health Sciences Mall, Vancouver, BC V6T 1Z3, Canada
    Biochim Biophys Acta 1416:1-10. 1999
    ..Taken together these results provide methodology for improving (weak base) drug retention in liposomes and indicate that drugs that can partition into the lipid bilayer exhibit improved uptake and retention characteristics...
  2. doi request reprint Erroneous automated optical platelet counts in 1-hour post-transfusion blood samples
    E Maurer-Spurej
    Canadian Blood Services, University of British Columbia, Vancouver, BC, Canada
    Int J Lab Hematol 32:e1-8. 2010
    ..Transfusion of platelet concentrates containing contaminating particles can lead to unexpectedly high post-transfusion platelet counts and misdiagnosis of thrombocytopenic patients...
  3. ncbi request reprint Past and future approaches to assess the quality of platelets for transfusion
    Elisabeth Maurer-Spurej
    Canadian Blood Services, Vancouver, BC, Canada
    Transfus Med Rev 21:295-306. 2007
    ..Recently, a new test for platelet quality has been introduced that uses dynamic light scattering. The advantages and remaining challenges for dynamic light scattering before it can become a routine platelet quality test are discussed...
  4. doi request reprint Platelet quality measured with dynamic light scattering correlates with transfusion outcome in hematologic malignancies
    Elisabeth Maurer-Spurej
    Canadian Blood Services, Ottawa, Ontario, Canada
    Transfusion 49:2276-84. 2009
    ..The aim of this pilot study was to determine whether a new measure of PLT quality and function based on dynamic light scattering (DLS) correlates with transfusion outcome...
  5. pmc Platelet serotonin levels support depression scores for women with postpartum depression
    Elisabeth Maurer-Spurej
    Canadian Blood Services, Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada
    J Psychiatry Neurosci 32:23-9. 2007
    ..This study examined whether a new measurement for platelet serotonin could aid in the diagnosis of postpartum depression and support the results from questionnaires...
  6. ncbi request reprint Portable dynamic light scattering instrument and method for the measurement of blood platelet suspensions
    Elisabeth Maurer-Spurej
    Canadian Blood Services and Department of Pathology and Laboratory Medicine and Centre for Blood Research, University of British Columbia, Vancouver, BC, Canada
    Phys Med Biol 51:3747-58. 2006
    ..This three-dimensional analysis provides a high degree of confidence for the determination of platelet quality. The experimental data are compared to a matrix and facilitate automated, unbiased quality testing...
  7. ncbi request reprint Circulating serotonin in vertebrates
    E Maurer-Spurej
    Department of Pathology, University of British Columbia, Vancouver, Canada
    Cell Mol Life Sci 62:1881-9. 2005
    ..Phylogenetic comparison of the presence of circulating serotonin indicated an evolutionary divergence within reptilian species that might coincide with the emergence of endothermy...
  8. ncbi request reprint Serotonin reuptake inhibitors and cardiovascular diseases: a platelet connection
    E Maurer-Spurej
    Department of Pathology, University of British Columbia, 2211 Wesbrook Mall, Vancouver, British Columbia, V6T 2B5, Canada
    Cell Mol Life Sci 62:159-70. 2005
    ..In addition, SSRIs inhibit tight clot formation of platelets in vitro, which points to a direct anti-thrombotic or pro-fibrinolytic effect of SSRIs...
  9. ncbi request reprint The influence of selective serotonin reuptake inhibitors on human platelet serotonin
    Elisabeth Maurer-Spurej
    Canadian Blood Services University of British Columbia Pathology and Laboratory Medicine 2211 Wesbrook Mall Vancouver, BC, V6T 2B5, Canada
    Thromb Haemost 91:119-28. 2004
    ..The active inhibition of platelet aggregation by SSRIs might explain their cardiovascular benefit...
  10. ncbi request reprint A novel immunocytochemical assay for the detection of serotonin in platelets
    Elisabeth Maurer-Spurej
    Canadian Blood Services, University of British Columbia, Department of Pathology, Vancouver, BC, Canada
    Br J Haematol 116:604-11. 2002
    ..The new assay was also reliable in cases where the 5-HT content of dense granules was not correlated with the calcium or ATP content, such as in calcium deficiency or in the presence of selective serotonin reuptake inhibitors...
  11. ncbi request reprint Platelet aggregation is not initiated by platelet shape change
    E Maurer-Spurej
    Canadian Blood Services, Vancouver, Canada
    Lab Invest 81:1517-25. 2001
    ..We conclude that platelet aggregation occurs independently of shape change and that shape change is not necessarily followed by aggregation. These observations suggest an alternative role for platelet shape change of single platelets...
  12. ncbi request reprint Room temperature activates human blood platelets
    E Maurer-Spurej
    Canadian Blood Services EM S, DVD, Vancouver
    Lab Invest 81:581-92. 2001
    ..This may contribute to both the functional lesion associated with 22 degrees C storage of platelets for transfusion and the in vivo hemostatic failure after hypothermia...
  13. doi request reprint The value of proteomics for the diagnosis of a platelet-related bleeding disorder
    E Maurer-Spurej
    Canadian Blood Services, Vancouver, BC, Canada
    Platelets 19:342-51. 2008
    ..Diagnosis of rare bleeding disorders has important implications for prophylactic and acute treatment of bleeding patients. This is the first report using proteomics to identify a familial platelet defect...
  14. doi request reprint The ELAPSE (Evaluation of Long-Term Clopidogrel Antiplatelet and Systemic Anti-Inflammatory Effects) study
    Jacqueline Saw
    Division of Cardiology, Vancouver General Hospital, University of British Columbia, Vancouver, British Columbia, Canada
    J Am Coll Cardiol 52:1826-33. 2008
    ..This study was designed to evaluate the effects of long-term clopidogrel and aspirin administration on platelet aggregation, activation, and inflammation...
  15. ncbi request reprint Diagnosing platelet delta-storage pool disease in children by flow cytometry
    Elisabeth Maurer-Spurej
    Canadian Blood Services, University of British Columbia, Vancouver, Canada Centre for Blood Research, University of British Columbia, Vancouver, Canada
    Am J Clin Pathol 127:626-32. 2007
    ..The advantages of this test are small sample volume of fresh or fixed/frozen platelets, availability of objective results within 2 hours of obtaining the blood sample, and automated analysis by flow cytometry...
  16. doi request reprint PEGylation prevents bacteria-induced platelet activation and biofilm formation in platelet concentrates
    C A Greco
    Canadian Blood Services, Ottawa, Ontario, Canada
    Vox Sang 100:336-9. 2011
    ..In the first study of its kind, we demonstrate that PEGylated platelet concentrates inoculated with Staphylococcus epidermidis display a significant reduction in bacterial binding and biofilm formation...
  17. doi request reprint Quebec platelet disorder: features, pathogenesis and treatment
    Maria Diamandis
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
    Blood Coagul Fibrinolysis 19:109-19. 2008
    ..The focus of the present review is to summarize the current state of knowledge on QPD, including the history of this disorder, its clinical and laboratory features, and recommended approaches for its diagnosis and treatment...
  18. doi request reprint Effects of aspirin and clopidogrel in healthy men measured by platelet aggregation and PFA-100
    Esben H Madsen
    Department of Clinical Biochemistry, Centre for Cardiovascular Research, Aalborg Hospital, Aarhus University Hospital, Aalborg, Denmark
    Platelets 19:335-41. 2008
    ..The PFA-100 results varied greatly and low-response was not precisely defined by this method...