Stephen G Matthews

Summary

Affiliation: University of Toronto
Country: Canada

Publications

  1. ncbi request reprint Foetal experience: lifelong consequences
    Stephen G Matthews
    Department of Physiology, Faculty of Medicine, University of Toronto, Ontario, Canada
    J Neuroendocrinol 19:73-4. 2007
  2. pmc Prenatal synthetic glucocorticoid treatment changes DNA methylation states in male organ systems: multigenerational effects
    Ariann Crudo
    Department Pharmacology and Therapeutics, McGill University, Montreal, Canada H9X 3V9
    Endocrinology 153:3269-83. 2012
  3. doi request reprint Glucocorticoid programming of the fetal male hippocampal epigenome
    Ariann Crudo
    Department Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada H3G1Y6
    Endocrinology 154:1168-80. 2013
  4. doi request reprint Transgenerational inheritance of stress pathology
    Stephen G Matthews
    Department of Physiology, Faculty of Medicine, University of Toronto, Medical Sciences Building, 1 King s College Circle, Toronto, Ontario, M5S 1A8, Canada
    Exp Neurol 233:95-101. 2012
  5. ncbi request reprint Hypothalamic oxytocin in the developing ovine fetus: interaction with pituitary-adrenocortical function
    S G Matthews
    Departments of Physiology and Obstetrics and Gynecology, Faculty of Medicine, University of Toronto, Medical Sciences Building, 1 King s College Circle, Toronto, Ontario, M5S 1A8, Canada
    Brain Res 820:92-100. 1999
  6. ncbi request reprint Dynamic changes in glucocorticoid and mineralocorticoid receptor mRNA in the developing guinea pig brain
    S G Matthews
    Department of Physiology, Faculty of Medicine, University of Toronto, Ontario, Canada
    Brain Res Dev Brain Res 107:123-32. 1998
  7. ncbi request reprint CRH and AVP-induced changes in synthesis and release of ACTH from the ovine fetal pituitary in vitro: negative influences of cortisol
    S G Matthews
    Department of Physiology, Faculty of Medicine, University of Toronto, Ontario, Canada
    Endocrine 6:293-300. 1997
  8. doi request reprint Minireview: transgenerational inheritance of the stress response: a new frontier in stress research
    Stephen G Matthews
    Department of Physiology, Faculty of Medicine, University of Toronto, Medical Sciences Building, 1 King s College Circle, Toronto, Ontario, Canada
    Endocrinology 151:7-13. 2010
  9. ncbi request reprint Fetal glucocorticoid exposure and hypothalamo-pituitary-adrenal (HPA) function after birth
    S G Matthews
    Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
    Endocr Res 30:827-36. 2004
  10. ncbi request reprint Early programming of the hypothalamo-pituitary-adrenal axis
    Stephen G Matthews
    Dept Physiology, Faculty of Medicine, University of Toronto, Medical Sciences Building, 1 King s College Circle, ON, M5S 1A8, Toronto, Canada
    Trends Endocrinol Metab 13:373-80. 2002

Collaborators

Detail Information

Publications91

  1. ncbi request reprint Foetal experience: lifelong consequences
    Stephen G Matthews
    Department of Physiology, Faculty of Medicine, University of Toronto, Ontario, Canada
    J Neuroendocrinol 19:73-4. 2007
    ..Furthermore, these effects can pass across generations. The race is now on to understand the mechanisms involved and to find ways to prevent or reverse the effects of an "adverse" early environment in human populations...
  2. pmc Prenatal synthetic glucocorticoid treatment changes DNA methylation states in male organ systems: multigenerational effects
    Ariann Crudo
    Department Pharmacology and Therapeutics, McGill University, Montreal, Canada H9X 3V9
    Endocrinology 153:3269-83. 2012
    ..These data support the hypothesis that prenatal sGC exposure leads to broad changes in critical components of the epigenetic machinery and that these effects can pass to the next generation...
  3. doi request reprint Glucocorticoid programming of the fetal male hippocampal epigenome
    Ariann Crudo
    Department Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada H3G1Y6
    Endocrinology 154:1168-80. 2013
    ..This is important given the widespread use of sGC in the management of women in preterm labor...
  4. doi request reprint Transgenerational inheritance of stress pathology
    Stephen G Matthews
    Department of Physiology, Faculty of Medicine, University of Toronto, Medical Sciences Building, 1 King s College Circle, Toronto, Ontario, M5S 1A8, Canada
    Exp Neurol 233:95-101. 2012
    ....
  5. ncbi request reprint Hypothalamic oxytocin in the developing ovine fetus: interaction with pituitary-adrenocortical function
    S G Matthews
    Departments of Physiology and Obstetrics and Gynecology, Faculty of Medicine, University of Toronto, Medical Sciences Building, 1 King s College Circle, Toronto, Ontario, M5S 1A8, Canada
    Brain Res 820:92-100. 1999
    ..In conclusion, hypothalamic OT mRNA increases at term and OT can stimulate ACTH output from fetal corticotrophs. Together, these data indicate that OT may be involved in the regulation of ACTH secretion in fetal sheep in late gestation...
  6. ncbi request reprint Dynamic changes in glucocorticoid and mineralocorticoid receptor mRNA in the developing guinea pig brain
    S G Matthews
    Department of Physiology, Faculty of Medicine, University of Toronto, Ontario, Canada
    Brain Res Dev Brain Res 107:123-32. 1998
    ..The decreases in GR mRNA levels in the PVN in late gestation likely facilitate the simultaneous increases in ACTH and cortisol that occur near term, and which are critical for the delivery of viable young...
  7. ncbi request reprint CRH and AVP-induced changes in synthesis and release of ACTH from the ovine fetal pituitary in vitro: negative influences of cortisol
    S G Matthews
    Department of Physiology, Faculty of Medicine, University of Toronto, Ontario, Canada
    Endocrine 6:293-300. 1997
    ....
  8. doi request reprint Minireview: transgenerational inheritance of the stress response: a new frontier in stress research
    Stephen G Matthews
    Department of Physiology, Faculty of Medicine, University of Toronto, Medical Sciences Building, 1 King s College Circle, Toronto, Ontario, Canada
    Endocrinology 151:7-13. 2010
    ..Understanding these fundamental biological processes will allow for development of intervention strategies that prevent or reverse adverse programming of the stress response...
  9. ncbi request reprint Fetal glucocorticoid exposure and hypothalamo-pituitary-adrenal (HPA) function after birth
    S G Matthews
    Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
    Endocr Res 30:827-36. 2004
    ..Permanent changes in endocrine function will have a long-term impact on health, since elevated cumulative exposure to endogenous glucocorticoid is linked to the premature onset of pathologies associated with aging...
  10. ncbi request reprint Early programming of the hypothalamo-pituitary-adrenal axis
    Stephen G Matthews
    Dept Physiology, Faculty of Medicine, University of Toronto, Medical Sciences Building, 1 King s College Circle, ON, M5S 1A8, Toronto, Canada
    Trends Endocrinol Metab 13:373-80. 2002
    ..Understanding these mechanisms could hold the key to the development of therapeutic interventions aimed at reversing the impact of an adverse intrauterine or neonatal environment...
  11. ncbi request reprint Glucocorticoids, hypothalamo-pituitary-adrenal (HPA) development, and life after birth
    S G Matthews
    Department of Physiology, Faculty of Medicine, University of Toronto, Medical Sciences Building, 1 King s College Circle, Toronto, Ontario, M5S 1A8 Canada
    Endocr Res 28:709-18. 2002
    ..Permanent changes in HPA function will have a long-term impact on health, since elevated cumulative exposure to endogenous glucocorticoid has been linked to the premature onset of pathologies associated with aging...
  12. ncbi request reprint Diabetes impairs hypothalamo-pituitary-adrenal (HPA) responses to hypoglycemia, and insulin treatment normalizes HPA but not epinephrine responses
    Owen Chan
    Department of Physiology, University of Toronto, Toronto, Ontario, Canada
    Diabetes 51:1681-9. 2002
    ..This is important because during severe hypoglycemia, epinephrine is an important counterregulatory hormone...
  13. ncbi request reprint Recurrent intermittent restraint delays fed and fasting hyperglycemia and improves glucose return to baseline levels during glucose tolerance tests in the Zucker diabetic fatty rat--role of food intake and corticosterone
    Holly E Bates
    Department of Physiology, University of Toronto, Toronto, Canada
    Metabolism 56:1065-75. 2007
    ..Paradoxically, these novel investigations suggest some types of occasional stress may limit development of diabetes...
  14. ncbi request reprint Effects of insulin treatment without and with recurrent hypoglycemia on hypoglycemic counterregulation and adrenal catecholamine-synthesizing enzymes in diabetic rats
    Karen E Inouye
    Departments of Physiology, University of Toronto, Ontario, Canada
    Endocrinology 147:1860-70. 2006
    ..Protection against epinephrine defects, both without and with antecedent hypoglycemia, is associated with enhancement of adrenal catecholamine-synthesizing enzyme levels...
  15. ncbi request reprint Hyperglycemia does not increase basal hypothalamo-pituitary-adrenal activity in diabetes but it does impair the HPA response to insulin-induced hypoglycemia
    Owen Chan
    Department of Physiology, 1 King s College Circle, Medical Sciences Bldg Rm 3358, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    Am J Physiol Regul Integr Comp Physiol 289:R235-46. 2005
    ....
  16. doi request reprint Effect of antenatal corticosteroids on fetal growth and gestational age at birth
    Kellie E Murphy
    Department of Obstetrics and Gynaecology and Paediatrics, Mount Sinai Hospital, Toronto, Ontario, Canada
    Obstet Gynecol 119:917-23. 2012
    ....
  17. doi request reprint Effects of maternal dexamethasone treatment in early pregnancy on pituitary-adrenal axis in fetal sheep
    Thorsten Braun
    Department of Physiology and Obstetrics and Gynecology, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    Endocrinology 150:5466-77. 2009
    ..In females, this effect may be attributed, in part, to increased fetal adrenal steroidogenic activity...
  18. ncbi request reprint Changes in basal hypothalamo-pituitary-adrenal activity during exercise training are centrally mediated
    Edward Park
    School of Kinesiology and Health Science, York University, 4700 Keele St, Toronto, Ontario, Canada M3J 1P3
    Am J Physiol Regul Integr Comp Physiol 289:R1360-71. 2005
    ..In contrast, the increase in basal pituitary-adrenal activity with repeated sham exercise appears to be associated with decreases in hippocampal MR and PVN GR mRNA expression...
  19. ncbi request reprint Insulin alone increases hypothalamo-pituitary-adrenal activity, and diabetes lowers peak stress responses
    Owen Chan
    Department of Physiology, University of Toronto, Medical Sciences Building, Room 3240, 1 King s College Circle, Toronto, Ontario, Canada M5S 1A8
    Endocrinology 146:1382-90. 2005
    ..In diabetes, this ability is impaired; hence, maximal HPA activation is greatly diminished. This is a novel observation that may have important implications in the treatment of impaired counterregulatory mechanisms in human diabetes...
  20. pmc Prenatal glucocorticoid exposure alters hypothalamic-pituitary-adrenal function and blood pressure in mature male guinea pigs
    Sonja Banjanin
    Department of Physiology, Faculty of Medicine, University of Toronto, Medical Sciences Building, 1 King s College Circle, Toronto, Ontario, M5S 1A8, Canada
    J Physiol 558:305-18. 2004
    ....
  21. pmc Effects of repeated prenatal glucocorticoid exposure on long-term potentiation in the juvenile guinea-pig hippocampus
    Elaine Setiawan
    Department of Physiology, Faculty of Medicine, University of Toronto, Medical Sciences Building, 1 King s College Circle, Toronto, Ontario M5S 1A8, Canada
    J Physiol 581:1033-42. 2007
    ..This study reveals sex-specific effects of prenatal exposure to sGC on LTP in the presence of elevated cortisol, a situation that would occur in vivo during stress...
  22. doi request reprint The effect of long-term insulin treatment with and without antecedent hypoglycemia on neuropeptide and corticosteroid receptor expression in the brains of diabetic rats
    Karen E Inouye
    University of Toronto Department of Physiology, Medical Sciences Building, 1 King s College Circle, Toronto, ON M5S 1A8, Canada
    Brain Res Bull 77:149-57. 2008
    ....
  23. ncbi request reprint Partial leptin restoration increases hypothalamic-pituitary-adrenal activity while diminishing weight loss and hyperphagia in streptozotocin diabetic rats
    Eitan M Akirav
    Department of Physiology, University of Toronto, Ontraio, Canada
    Metabolism 53:1558-64. 2004
    ....
  24. ncbi request reprint Swim training prevents hyperglycemia in ZDF rats: mechanisms involved in the partial maintenance of beta-cell function
    Michael A Kiraly
    Department of Physiology, University of Toronto, 1 King s College Circle, Toronto, Ontario, Canada
    Am J Physiol Endocrinol Metab 294:E271-83. 2008
    ..In conclusion, improved beta-cell compensation through increased beta-cell function and mass occurs in exercised but not sedentary ZDF rats and may be in part responsible for improved glucoregulation...
  25. doi request reprint Adaptation to mild, intermittent stress delays development of hyperglycemia in the Zucker diabetic Fatty rat independent of food intake: role of habituation of the hypothalamic-pituitary-adrenal axis
    Holly E Bates
    Departments of Physiology, Medical Sciences Building, University of Toronto, Toronto, Ontario, Canada M5S 1A8
    Endocrinology 149:2990-3001. 2008
    ..In contrast, 24-h catecholamines were unaltered. Thus, rather than playing a causal role, intermittent stress delayed deteriorations in glycemia and ameliorated HPA hyperactivity in the ZDF rat...
  26. doi request reprint Adaptation to intermittent stress promotes maintenance of beta-cell compensation: comparison with food restriction
    Holly E Bates
    Department of Physiology, University of Toronto, Toronto, Ontario, Canada
    Am J Physiol Endocrinol Metab 295:E947-58. 2008
    ..Thus, preservation of beta-cell mass with adaptation to intermittent stress is related to beta-cell hyperplasia, maintenance of insulin responses to glucose, and reductions in alpha-cell mass that do not occur with food restriction...
  27. ncbi request reprint Maternal glucocorticoid treatment programs HPA regulation in adult offspring: sex-specific effects
    L Liu
    Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    Am J Physiol Endocrinol Metab 280:E729-39. 2001
    ..In conclusion, repeated antenatal glucocorticoid treatment programs HPA function in a sex-specific manner, and these changes are associated with modification of corticosteroid receptor expression in the adult brain and pituitary...
  28. ncbi request reprint Effects of diabetes and recurrent hypoglycemia on the regulation of the sympathoadrenal system and hypothalamo-pituitary-adrenal axis
    Karen E Inouye
    Department of Physiology, University of Toronto, Medical Sciences Bldg, Rm 3358, 1 King s College Circle, Toronto, Ontario, Canada M5S 1A8
    Am J Physiol Endocrinol Metab 288:E422-9. 2005
    ..Furthermore, impaired epinephrine counterregulation in diabetes is associated with reduced adrenal TH mRNA, whereas the additional epinephrine defect after recurrent hypoglycemia is associated with decreases in both TH and PNMT mRNA...
  29. doi request reprint Multiple courses of antenatal corticosteroids for preterm birth study: 2-year outcomes
    Elizabeth V Asztalos
    Department of Newborn and Developmental Paediatrics, Centre for Mother, Infant, and Child Research, Sunnybrook Health Sciences Centre, M4 233 2075 Bayview Ave Toronto, Ontario, M4N 3M5, Canada
    Pediatrics 126:e1045-55. 2010
    ....
  30. ncbi request reprint Glucocorticoids do not alter developmental expression of hippocampal or pituitary steroid receptor coactivator-1 and -2 in the late gestation fetal guinea pig
    Elaine Setiawan
    Department of Physiology, Faculty of Medicine, University of Toronto, Medical Sciences Building, Toronto, Ontario, Canada M5S 1A8
    Endocrinology 145:3796-803. 2004
    ..Developmental changes in limbic SRC-1 expression probably have important consequences on steroid receptor signaling, which is known to be critical for brain maturation in late gestation...
  31. doi request reprint Prenatal stress modifies behavior and hypothalamic-pituitary-adrenal function in female guinea pig offspring: effects of timing of prenatal stress and stage of reproductive cycle
    Amita Kapoor
    Department of Physiology, Faculty of Medicine, University of Toronto, Medical Sciences Building, 1 King s College Circle, Toronto, Ontario, Canada M5S 1A8
    Endocrinology 149:6406-15. 2008
    ....
  32. ncbi request reprint Attenuation of type 2 diabetes mellitus in the male Zucker diabetic fatty rat: the effects of stress and non-volitional exercise
    Michael A Kiraly
    Department of Physiology, Medical Sciences Building, University of Toronto, Toronto, Ontario, Canada
    Metabolism 56:732-44. 2007
    ..In summary, both exercise and sham treatment delay the progression of type 2 diabetes mellitus in the male ZDF rat by distinct mechanisms related to pancreatic function and improvements in peripheral glucose disposal...
  33. doi request reprint Multidrug resistance phosphoglycoprotein (ABCB1) expression in the guinea pig placenta: developmental changes and regulation by betamethasone
    Grazyna M Kalabis
    Department of Physiology, University of Toronto, Medical Sciences Building, 1 King s College Circle, Toronto, ON M5S 1A8, Canada
    Can J Physiol Pharmacol 87:973-8. 2009
    ..No sex differences were observed. Understanding the regulation of ABCB1 function will facilitate the development of treatment strategies for human fetal protection against maternally derived endobiotics and xenobiotics...
  34. pmc Transgenerational effects of prenatal synthetic glucocorticoids on hypothalamic-pituitary-adrenal function
    Majid Iqbal
    Department of Physiology, Faculty of Medicine, University of Toronto, 1 King s College Circle, Toronto, Ontario, Canada M5S 1A8
    Endocrinology 153:3295-307. 2012
    ..These data have clinical implication given the widespread use of repeat course glucocorticoid therapy in the management of preterm labour...
  35. ncbi request reprint Developmental regulation of 5-HT1A receptor mRNA in the fetal limbic system: response to antenatal glucocorticoid
    Marcus H Andrews
    Department of Physiology, Faculty of Medicine, University of Toronto, Medical Sciences Building, rm 3240, 1 King s College Circle, Toronto, Ontario, Canada M5S1A8
    Brain Res Dev Brain Res 149:39-44. 2004
    ....
  36. pmc Molecular regulation of the hypothalamic-pituitary-adrenal axis in adult male guinea pigs after prenatal stress at different stages of gestation
    Amita Kapoor
    Department of Physiology, Faculty of Medicine, University of Toronto, Medical Sciences Building, 1 King s College Circle, Toronto, Ontario, Canada, M5S 1A8
    J Physiol 586:4317-26. 2008
    ..Further, these changes are dependent on the timing of the maternal stressor, a pattern that is emerging in human studies...
  37. pmc Fetal programming of hypothalamo-pituitary-adrenal function: prenatal stress and glucocorticoids
    Amita Kapoor
    Department of Physiology, Faculty of Medicine, University of Toronto, Medical Sciences Building, 1 King s College Circle, Toronto, Ontario, Canada
    J Physiol 572:31-44. 2006
    ..Permanent changes in endocrine function will ultimately impact on health in both human and animal populations...
  38. doi request reprint Developmental expression of multidrug resistance phosphoglycoprotein (P-gp) in the mouse fetal brain and glucocorticoid regulation
    Sophie Petropoulos
    Department of Physiology, University of Toronto, Medical Sciences Building, 1 King s College Circle, Toronto, Ontario, Canada
    Brain Res 1357:9-18. 2010
    ..Synthetic glucocorticoid exposure can modify expression and function of multidrug-resistance in the fetal brain, and this will likely have clinical implication given the extensive use of synthetic glucocorticoid in the management of PTL...
  39. ncbi request reprint Prenatal glucocorticoid modifies hypothalamo-pituitary-adrenal regulation in prepubertal guinea pigs
    F Dean
    Departments of Physiology and Obstetrics and Gynecology, Faculty of Medicine, University of Toronto, Ont. M5S 1A8, Canada
    Neuroendocrinology 73:194-202. 2001
    ..In conclusion, prenatal glucocorticoid exposure affects growth and HPA function as well as limbic and hypothalamic GR expression in juvenile offspring, and these effects are highly sex-specific...
  40. ncbi request reprint Regulation of N-methyl-D-aspartate receptor subunit expression in the fetal guinea pig brain
    Dawn Owen
    Department of Physiology, Faculty of Medicine, University of Toronto, 1 King s College Circle, Ontario, Canada M5S 1A8
    Biol Reprod 71:676-83. 2004
    ..It is possible that these alter NMDA-dependent signaling at this time. Prenatal exposure to exogenous glucocorticoids modifies the trajectory of NMDAR subunit expression in females but not in males...
  41. pmc Repeated maternal glucocorticoid treatment affects activity and hippocampal NMDA receptor expression in juvenile guinea pigs
    Dawn Owen
    Department of Physiology, Faculty of Medicine, University of Toronto, Medical Sciences Building, 1 King s College Circle, Toronto, Ontario, Canada M5S 1A8
    J Physiol 578:249-57. 2007
    ....
  42. doi request reprint Exercise maintains euglycemia in association with decreased activation of c-Jun NH2-terminal kinase and serine phosphorylation of IRS-1 in the liver of ZDF rats
    Michael A Kiraly
    Dept of Physiology, Univ of Toronto, ON, Canada
    Am J Physiol Endocrinol Metab 298:E671-82. 2010
    ..These changes in oxidative stress markers and inflammation are associated with decreased hyperglycemia and insulin resistance and reduced expression of the main gluconeogenic enzyme phosphoenolpyruvate carboxykinase...
  43. pmc Prenatal synthetic glucocorticoid exposure alters hypothalamic-pituitary-adrenal regulation and pregnancy outcomes in mature female guinea pigs
    Elizabeth Dunn
    Department of Physiology, Faculty of Medicine, University of Toronto, Medical Sciences Building, Toronto, Ontario, Canada
    J Physiol 588:887-99. 2010
    ..Furthermore, we have shown there are considerable difference in phenotypes between the Beta- and Dex-exposed females and the specific endocrine and maternal outcome is contingent on the specific sGCs administered during pregnancy...
  44. pmc Developmental regulation of the 5-HT7 serotonin receptor and transcription factor NGFI-A in the fetal guinea-pig limbic system: influence of GCs
    Marcus H Andrews
    Department of Physiology, Faculty of Medicine, University of Toronto, 1 King s College Circle, Toronto, Ontario M5S1A8, Canada
    J Physiol 555:659-70. 2004
    ....
  45. ncbi request reprint Prenatal glucocorticoid exposure alters hypothalamic-pituitary-adrenal function in juvenile guinea pigs
    D Owen
    Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
    J Neuroendocrinol 19:172-80. 2007
    ..Furthermore, juvenile males appear to be more vulnerable to the effects of prenatal glucocorticoid exposure than females...
  46. ncbi request reprint Repeated antenatal glucocorticoid treatment decreases hypothalamic corticotropin releasing hormone mRNA but not corticosteroid receptor mRNA expression in the fetal guinea-pig brain
    L McCabe
    Department of Physiology, Faculty of Medicine, University of Toronto, Ontario, Canada
    J Neuroendocrinol 13:425-31. 2001
    ..The latter likely reflects removal of circulating endogenous ligand (cortisol). These alterations may form the basis for permanently modified HPA activity in later life...
  47. ncbi request reprint Chronic prenatal ethanol exposure increases glucocorticoid-induced glutamate release in the hippocampus of the near-term foetal guinea pig
    U Iqbal
    Department of Pharmacology and Toxicology, Queen s University, Kingston, Ontario, Canada
    J Neuroendocrinol 18:826-34. 2006
    ..These effects of CPEE, coupled with increased glutamate release and increased NMDA receptor expression, may predispose the near-term foetal hippocampus to GR and Glu-NMDA receptor-mediated neurodevelopmental toxicity...
  48. ncbi request reprint Central regulation of the hypothalamic-pituitary-adrenal axis during fetal development in the Guinea-pig
    D Owen
    Department of Physiology, Facult of Medicine, University of Toronto, Medical Sciences Building, Toronto, Ontario, Canada
    J Neuroendocrinol 17:220-6. 2005
    ..These findings show that the foetal HPA axis remains highly sensitive to glucocorticoid feedback even as plasma adrenocorticotropic hormone and cortisol levels are elevated at the end of gestation...
  49. pmc Short periods of prenatal stress affect growth, behaviour and hypothalamo-pituitary-adrenal axis activity in male guinea pig offspring
    Amita Kapoor
    Department of Physiology, Faculty of Medicine, University of Toronto, Medical Sciences Building, 1 King s College Circle, Toronto, Ontario, M5S 1A8 Canada
    J Physiol 566:967-77. 2005
    ..Further, the nature of the effect is dependant on the timing of the maternal stress during pregnancy...
  50. doi request reprint Chronic maternal stress affects growth, behaviour and hypothalamo-pituitary-adrenal function in juvenile offspring
    Jeff Emack
    CIHR program in Maternal Adversity Vulnerability and Neurodevelopment MAVAN, University of Toronto, 1 King s College Circle, Toronto, Ontario, Canada
    Horm Behav 54:514-20. 2008
    ..In conclusion, CMS leads to modification of growth trajectory, locomotor activity and adrenocortical responses to stress in juvenile offspring. Further, males appear considerably more vulnerable to these effects than females...
  51. ncbi request reprint Glucocorticoids and sex-dependent development of brain glucocorticoid and mineralocorticoid receptors
    Dawn Owen
    Department of Physiology, Faculty of Medicine, University of Toronto, 1 King s College Circle, Toronto, Ontario, Canada M5S 1A8
    Endocrinology 144:2775-84. 2003
    ..The sex differences in the pattern of GR and MR expression during development may indicate different windows of vulnerability to prenatal glucocorticoid exposure in fetal life...
  52. doi request reprint Glucocorticoid regulation of placental breast cancer resistance protein (Bcrp1) in the mouse
    Sophie Petropoulos
    Department of Physiology, University of Toronto, Toronto, Ontario, Canada
    Reprod Sci 18:631-9. 2011
    ..Further, it appears that, at the level of Abcg2 gene expression, the female-derived placentae are more susceptible to the effects of DEX than male placentae...
  53. ncbi request reprint A short period of maternal nutrient restriction in late gestation modifies pituitary-adrenal function in adult guinea pig offspring
    R I Lingas
    Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ont, Canada
    Neuroendocrinology 73:302-11. 2001
    ..In conclusion, 48 h of maternal nutrient restriction during pregnancy has a long-term effect on HPA function in adult offspring, and this effect is highly sex specific, but does not result in alteration of blood pressure...
  54. doi request reprint The effects of prenatal stress on learning in adult offspring is dependent on the timing of the stressor
    Amita Kapoor
    Department of Physiology, Faculty of Medicine, University of Toronto, Medical Sciences Building, 1 King s College Circle, Toronto, Ontario, M5S 1A8 Canada
    Behav Brain Res 197:144-9. 2009
    ..This model will allow us to determine the mechanisms that underlie the association between prenatal stress and altered learning strategy and ability...
  55. ncbi request reprint Effects of recurrent hyperinsulinemia with and without hypoglycemia on counterregulation in diabetic rats
    Karen Inouye
    Department of Physiology, University of Toronto, Toronto, Ontario, Canada, M5S 1A8
    Am J Physiol Endocrinol Metab 282:E1369-79. 2002
    ..We conclude that 1) recurrent hypoglycemia may increase the risk of subsequent hypoglycemia by increasing insulin sensitivity, and 2) epinephrine counterregulation is particularly sensitive to impairment by recurrent hypoglycemia...
  56. ncbi request reprint Fetal programming of hypothalamic-pituitary-adrenal (HPA) axis function and behavior by synthetic glucocorticoids
    Amita Kapoor
    Department of Physiology, Faculty of Medicine, University of Toronto, Medical Sciences Building, 1 King s College Circle, Toronto, Ontario, Canada M5S 1A8
    Brain Res Rev 57:586-95. 2008
    ..A comprehensive understanding of the acute and long-term impact of sGC exposure in utero is necessary to begin to develop recommendations and treatment options for pregnant women at risk of preterm delivery...
  57. ncbi request reprint Functional changes of mouse placental multidrug resistance phosphoglycoprotein (ABCB1) with advancing gestation and regulation by progesterone
    Sophie Petropoulos
    Department of Physiology, University of Toronto, Toronto, ON, Canada
    Reprod Sci 14:321-8. 2007
    ....
  58. ncbi request reprint Glucocorticoids and serotonin alter glucocorticoid receptor (GR) but not mineralocorticoid receptor (MR) mRNA levels in fetal mouse hippocampal neurons, in vitro
    P Erdeljan
    Department of Physiology, Faculty of Medicine, University of Toronto, Medical Sciences Building, 1 Kings College Circle, Ontario, M5S 1A8, Toronto, Canada
    Brain Res 896:130-6. 2001
    ..We conclude that synthetic and endogenous glucocorticoids, as well as serotonin, can influence neuronal levels of GR mRNA during hippocampal development. However, whether these effects are permanent remains to be determined...
  59. ncbi request reprint Chronic prenatal ethanol exposure alters glucocorticoid signalling in the hippocampus of the postnatal Guinea pig
    U Iqbal
    Department of Pharmacology and Toxicology, Queen s University, Kingston, Ontario, Canada
    J Neuroendocrinol 17:600-8. 2005
    ....
  60. ncbi request reprint Glucocorticoids and serotonin alter glucocorticoid receptor mRNA levels in fetal guinea-pig hippocampal neurons, in vitro
    P Erdeljan
    Department of Physiology, Faculty of Medicine, University of Toronto, Medical Sciences Building, ON, Canada
    Reprod Fertil Dev 17:743-9. 2005
    ..We conclude that synthetic and endogenous glucocorticoids, as well as serotonin, can influence GR expression during hippocampal development and in this way may act to permanently programme HPA function...
  61. doi request reprint Effects of chronic maternal stress on hypothalamo-pituitary-adrenal (HPA) function and behavior: no reversal by environmental enrichment
    Jeff Emack
    Department of Physiology, Faculty of Medicine, University of Toronto, 1 King s College Circle, Toronto, Ontario, Canada M5S 1A8
    Horm Behav 60:589-98. 2011
    ....
  62. pmc Testosterone is involved in mediating the effects of prenatal stress in male guinea pig offspring
    Amita Kapoor
    Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
    J Physiol 589:755-66. 2011
    ..This study provides new information to begin to address the mechanism underlying the interplay between prenatal stress, gonadal steroids and postnatal behaviours...
  63. ncbi request reprint Maternal adversity, glucocorticoids and programming of neuroendocrine function and behaviour
    Dawn Owen
    Department of Physiology, Faculty of Medicine, University of Toronto, Medical Sciences Building, 1 King s College Circle, Toronto, Ont, Canada M5S 1A8
    Neurosci Biobehav Rev 29:209-26. 2005
    ..Permanent changes in endocrine function will impact on health, since elevated cumulative exposure to endogenous glucocorticoid is linked to the premature onset of pathologies associated with aging...
  64. ncbi request reprint Multidrug resistance phosphoglycoprotein (ABCB1) in the mouse placenta: fetal protection
    Grazyna M Kalabis
    Department of Physiology, University of Toronto, Ontario, Canada
    Biol Reprod 73:591-7. 2005
    ....
  65. doi request reprint Breast cancer-resistance protein (BCRP1) in the fetal mouse brain: development and glucocorticoid regulation
    Sophie Petropoulos
    Department of Physiology, University of Toronto, Toronto, Ontario, Canada
    Biol Reprod 84:783-9. 2011
    ..Furthermore, there is a dose-, sex-, and age-dependent effect of DEX on Abcg2 mRNA in the fetal brain in vivo, indicating a complex regulatory role of glucocorticoid during development...
  66. ncbi request reprint Decreased CRH mRNA expression in the fetal guinea pig hypothalamus following maternal nutrient restriction
    K S Go
    Department of Physiology, Faculty of Medicine, University of Toronto, Medical Sciences Building, 1 King's College Circle, Ont, M5S 1A8, Toronto, Canada
    Brain Res 896:179-82. 2001
    ..In conclusion, we have successfully sequenced the coding sequence of the guinea pig CRH gene, and have shown that a short period (48 h) of maternal nutrient restriction inhibits CRH mRNA expression in the fetal hypothalamus...
  67. pmc Prenatal endotoxemia and placental drug transport in the mouse: placental size-specific effects
    Enrrico Bloise
    Department of Physiology, University of Toronto, Toronto, Ontario, Canada
    PLoS ONE 8:e65728. 2013
    ..Collectively, we demonstrate that acute sub-lethal LPS exposure during pregnancy impairs fetal protection against potentially harmful xenobiotics in the maternal circulation...
  68. doi request reprint Corticosteroid regulation of P-glycoprotein in the developing blood-brain barrier
    Majid Iqbal
    Department of Physiology, Faculty of Medicine, University of Toronto, Medical Sciences Building, 1 King s College Circle, Toronto, Ontario, Canada M5S 1A8
    Endocrinology 152:1067-79. 2011
    ..Further, synthetic GCs (administered to pregnant women at risk of preterm delivery) may increase the protective capacity of the developing fetal blood-brain barrier, depending on the timing of GC exposure...
  69. doi request reprint Sertraline alters multidrug resistance phosphoglycoprotein activity in the mouse placenta and fetal blood-brain barrier
    Manzerul Bhuiyan
    Department of Physiology, University of Toronto, Toronto, Canada
    Reprod Sci 19:407-15. 2012
    ..This suggests that P-gp regulation by sertraline is tissue specific. These findings have important clinical implications with respect to fetal protection during maternal drug therapy in pregnancy...
  70. pmc Pro-inflammatory cytokine regulation of P-glycoprotein in the developing blood-brain barrier
    Majid Iqbal
    Department of Physiology, University of Toronto, Toronto, Ontario, Canada
    PLoS ONE 7:e43022. 2012
    ..Thus, women who experience infection and take prescription medication during pregnancy may expose the developing fetal brain to greater amounts of exogenous compounds - many of which are considered potentially teratogenic...
  71. doi request reprint Antenatal dexamethasone treatment in midgestation reduces system A-mediated transport in the late-gestation murine placenta
    Melanie C Audette
    Department of Physiology, University of Toronto, 1 Kings College Circle, Medical Sciences Building Room 3360, Toronto, Ontario, Canada M5S 1A8
    Endocrinology 152:3561-70. 2011
    ....
  72. ncbi request reprint Hyperactivation of the hypothalamo-pituitary-adrenocortical axis in streptozotocin-diabetes is associated with reduced stress responsiveness and decreased pituitary and adrenal sensitivity
    Owen Chan
    Department of Physiology, University of Toronto, Toronto, Ontario, Canada M5S 1A8
    Endocrinology 143:1761-8. 2002
    ....
  73. doi request reprint Dexamethasone stimulates placental system A transport and trophoblast differentiation in term villous explants
    M C Audette
    Department of Physiology, University of Toronto, Toronto, ON, Canada
    Placenta 31:97-105. 2010
    ..05 for all)) markers of syncytiotrophoblast differentiation. These findings suggest that DEX stimulates system A activity and promotes syncytiotrophoblast differentiation and maturation...
  74. ncbi request reprint Endocrine and paracrine regulation of birth at term and preterm
    - Challis JRG
    Department of Physiology University of Toronto, Ontario, Canada
    Endocr Rev 21:514-50. 2000
    ....
  75. doi request reprint Effect of glucocorticoids on regulation of placental multidrug resistance phosphoglycoprotein (P-gp) in the mouse
    S Petropoulos
    Department of Physiology, Faculty of Medicine, University of Toronto, Medical Sciences Building, 1 King s College Circle, Toronto, Ontario M5S 1A8, Canada
    Placenta 31:803-10. 2010
    ..While the latter is somewhat reassuring with respect to antenatal use of glucocorticoids for management of preterm labour, further studies are required to understand regulation of these important drug transporters in the placenta...
  76. ncbi request reprint The effect of estradiol on output of adrenocorticotropin and prolactin by fetal sheep anterior pituitary cells
    S Wang
    Department of Physiology, University of Toronto, Ontario, Canada
    Can J Physiol Pharmacol 76:843-9. 1998
    ..We conclude that E2 may affect CRH-stimulated fetal sheep pituitary corticotroph function late in gestation, but only within a narrow, physiological range of concentration...
  77. ncbi request reprint Antenatal glucocorticoids and the developing brain: mechanisms of action
    S G Matthews
    Department of Physiology, Faculty of Medicine, University of Toronto, Medical Sciences Building, 1 King s College Circle, Toronto, Ontario, Canada
    Semin Neonatol 6:309-17. 2001
    ..Notwithstanding, the data reviewed below indicate that caution should be exercised in the use of multiple course glucocorticoid therapy during pregnancy...
  78. ncbi request reprint The fetal placental hypothalamic-pituitary-adrenal (HPA) axis, parturition and post natal health
    J R Challis
    Department of Physiology, University of Toronto, 1 King s College Circle, Med Sciences, Building MSB 3205 7, Toronto, Ontario, Canada M5S 1A8
    Mol Cell Endocrinol 185:135-44. 2001
    ..Thus, the level of fetal HPA activity is crucial not only for determining gestation length, but may also predict pathophysiologic adjustments in later life...
  79. ncbi request reprint The effects of estradiol-17 beta infusion into fetal sheep in late gestation
    S Wang
    Department of Physiology, University of Toronto, Ontario, Canada
    Endocrine 6:271-8. 1997
    ....
  80. doi request reprint Multiple courses of antenatal corticosteroids for preterm birth (MACS): a randomised controlled trial
    Kellie E Murphy
    Department of Obstetrics and Gynaecology, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada
    Lancet 372:2143-51. 2008
    ..We aimed to find out whether multiple courses of antenatal corticosteroids would reduce neonatal morbidity and mortality without adversely affecting fetal growth...
  81. ncbi request reprint Programming of the hypothalamo-pituitary-adrenal axis: serotonergic involvement
    Marcus H Andrews
    Department of Physiology, University of Toronto, Medical Sciences Building, Toronto, Ont, Cananda
    Stress 7:15-27. 2004
    ..Understanding the mechanisms involved in neuroendocrine programming will facilitate the development of interventions aimed at reversing or ameliorating the impact of an adverse intrauterine environment...
  82. ncbi request reprint Molecular regulation of the hypothalamo-pituitary-adrenal axis in streptozotocin-induced diabetes: effects of insulin treatment
    O Chan
    Department of Physiology, University of Toronto, Toronto, Ontario, Canada M5S 1A8
    Endocrinology 142:4872-9. 2001
    ..Thus, insulin apparently restored HPA activity at and below the pituitary but, surprisingly, not above it...
  83. ncbi request reprint Mechanisms of impaired hypothalamic-pituitary-adrenal (HPA) function in diabetes: reduced counterregulatory responsiveness to hypoglycaemia
    K Inouye
    Department of Physiology, University of Toronto, Toronto, Ontario, Canada
    Diabetes Nutr Metab 15:348-55; discussion 355-6, 362. 2002
    ..Further investigations are essential for understanding poor counterregulation in insulin-treated diabetes and may lead to new strategies for preventing hypoglycaemia...
  84. ncbi request reprint Diabetes and the hypothalamo-pituitary-adrenal (HPA) axis
    O Chan
    Departments of Physiology, University of Toronto, Toronto, Ontario, Canada
    Minerva Endocrinol 28:87-102. 2003
    ..A better understanding of these mechanisms may be important in developing new treatment modalities for patients with diabetes mellitus...
  85. doi request reprint Placental P-glycoprotein and breast cancer resistance protein: influence of polymorphisms on fetal drug exposure and physiology
    J R Hutson
    Insitute of Medical Sciences, University of Toronto, 1 King s College Circle, Toronto, Ontario M5S 1A8, Canada
    Placenta 31:351-7. 2010
    ....
  86. ncbi request reprint Effects of antecedent hypoglycemia, hyperinsulinemia, and excess corticosterone on hypoglycemic counterregulation
    K Shum
    Department of Physiology, Faculty of Medicine, University of Toronto, 1 King's College Circle, Toronto, Ontario, Canada M5S 1A8
    Am J Physiol Endocrinol Metab 281:E455-65. 2001
    ....
  87. ncbi request reprint Breast cancer resistance protein (Bcrp1/Abcg2) in mouse placenta and yolk sac: ontogeny and its regulation by progesterone
    G M Kalabis
    Department of Physiology, Faculty of Medicine, University of Toronto, Medical Sciences Building, 1 King s College Circle, Toronto, ON M5S 1A8, Canada
    Placenta 28:1073-81. 2007
    ....
  88. pmc Maternal nutrient deprivation induces sex-specific changes in thyroid hormone receptor and deiodinase expression in the fetal guinea pig brain
    Shiao Y Chan
    Division of Reproductive and Child Health, University of Birmingham, Birmingham Women s Hospital, Edgbaston, Birmingham B15 2TG, UK
    J Physiol 566:467-80. 2005
    ..These changes may represent a protective mechanism to maintain appropriate thyroid hormone action in the face of fetal hypothyroxinaemia in order to optimize brain development...
  89. pmc Transgenerational effects of prenatal nutrient restriction on cardiovascular and hypothalamic-pituitary-adrenal function
    Caroline Bertram
    1Centre for Developmental Origins of Health and Disease, Princess Anne Hospital, Coxford Road, Southampton SO16 5YA, UK
    J Physiol 586:2217-29. 2008
    ..In conclusion, moderate maternal undernutrition profoundly modifies heart structure and HPA function in adult male offspring for two generations...
  90. ncbi request reprint Overexposure to antenatal corticosteroids: a global concern
    Steven V Koenen
    J Obstet Gynaecol Can 29:879. 2007
  91. doi request reprint Fetal mechanisms in neurodevelopmental disorders
    Susan L Connors
    Department of Neurology and Developmental Medicine, Kennedy Krieger Institute, 707 North Broadway, Baltimore, MD 21205, USA
    Pediatr Neurol 38:163-76. 2008
    ..This research emphasizes the diversity of such prenatal mechanisms and the need to expand our understanding of how, when altered, they may lead to disordered development, the signs of which may not appear until long after birth...