Research Topics
Species | R H MartinSummaryAffiliation: University of Calgary Country: Canada Publications
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Publications
Is there a relationship between sperm chromosome abnormalities and sperm morphology?Fei Sun
Department of Medical Genetics, Faculty of Medicine, University of Calgary, Calgary, Alberta T2N 4N1, Canada
Reprod Biol Endocrinol 4:1. 2006..Thus, there may be an association between sperm morphology and aneuploidy in infertile men with specific abnormalities...
Mechanisms of nondisjunction in human spermatogenesisR H Martin
Department of Medical Genetics, University of Calgary, Alberta Children s Hospital, Calgary, Alberta, Canada
Cytogenet Genome Res 111:245-9. 2005..These men have an increased risk of aneuploidy in sperm that have been surgically removed from the testes. Thus, evidence is starting to accumulate that reduced recombination has a marked effect on the generation of aneuploid sperm...- Meiotic chromosome abnormalities in human spermatogenesisRenee H Martin
Department of Medical Genetics, University of Calgary, Calgary, Alta, Canada
Reprod Toxicol 22:142-7. 2006..Such errors make these cells susceptible to meiotic arrest and the production of aneuploid gametes... - Studying meiosis: a review of FISH and M-FISH techniques used in the analysis of meiotic processes in humansM Oliver-Bonet
Department of Medical Genetics, University of Calgary, Calgary, Canada
Cytogenet Genome Res 114:312-8. 2006..In this paper, we review the different FISH and M-FISH techniques that have been used on human meiotic cells in both men and women... - Chromosome abnormalities in human spermRenee H Martin
Department of Medical Genetics, University of Calgary, Calgary, Alberta, Canada
Adv Exp Med Biol 518:181-8. 2003 - Sperm chromosome aneuploidy analysis in a man with globozoospermiaRenee H Martin
Department of Medical Genetics, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada
Fertil Steril 79:1662-4. 2003..To determine the frequencies of chromosome aneuploidy and diploidy in sperm from a male with globozoospermia... - A comparison of the frequency of sperm chromosome abnormalities in men with mild, moderate, and severe oligozoospermiaRenee H Martin
Department of Medical Genetics, University of Calgary, Calgary, Alberta, Canada T4N 4N1
Biol Reprod 69:535-9. 2003..These results demonstrate that men with severe oligozoospermia have an elevated risk for chromosome abnormalities in their sperm, particularly sex chromosome abnormalities... - Recombination in the pseudoautosomal region in a 47,XYY maleR H Martin
Department of Medical Genetics, Alberta Children s Hospital, 1820 Richmond Road SW, Calgary, Alberta T2T 5C7, Canada
Hum Genet 109:143-5. 2001.... 
Analysis of aneuploidy frequencies in sperm from patients with hereditary nonpolyposis colon cancer and an hMSH2 mutationR H Martin
Department of Medical Genetics, Alberta Children s Hospital, Calgary, AB Canada T2T 5C7
Am J Hum Genet 66:1149-52. 2000..There was a significantly increased frequency of disomy 13, disomy 21, XX, and diploidy in mutation carriers compared with control men. These results suggest that the hMSH2 mutation may affect meiosis in humans...- Meiotic errors in human oogenesis and spermatogenesisRenee H Martin
University of Calgary, Department of Medical Genetics, 3330 Hospital Drive NW, Calgary, Alberta, Canada T2N 4N1
Reprod Biomed Online 16:523-31. 2008..There is a link between infertility and the genesis of chromosome abnormalities. Future studies will unravel more of the underlying causal factors... - Cytogenetic determinants of male fertilityR H Martin
Department of Medical Genetics, University of Calgary, Room 287, Heritage Medical Research Building, 3330 Hospital Drive NW, Calgary, Alberta, Canada T2N 4N1
Hum Reprod Update 14:379-90. 2008..Cytogenetic abnormalities have been known to be important causes of male infertility for decades... - Discontinuities and unsynapsed regions in meiotic chromosomes have a trans effect on meiotic recombination of some chromosomes in human malesF Sun
Department of Medical Genetics, University of Calgary, Canada
Cytogenet Genome Res 119:27-32. 2007..The positioning of MLH1 foci on other SCs in cells with gapped/split SC 9 was not altered. These studies suggest that gaps and splits not only have a cis effect, but may also have a trans effect on meiotic recombination in humans... - Analysis of non-crossover bivalents in pachytene cells from 10 normal menFei Sun
Department of Medical Genetics, University of Calgary, Alberta, Canada
Hum Reprod 21:2335-9. 2006.... - Chromosomal abnormalities in sperm from testicular cancer patients before and after chemotherapyR H Martin
Department of Genetics, Alberta Children s Hospital, Calgary, Canada
Hum Genet 99:214-8. 1997..None of the values in the cancer patients differed significantly from 10 normal control donors. Thus our study suggests that BEP chemotherapy does not increase the risk of numerical chromosomal abnormalities in human sperm... - Reduced meiotic recombination on the XY bivalent is correlated with an increased incidence of sex chromosome aneuploidy in men with non-obstructive azoospermiaF Sun
Department of Medical Genetics, University of Calgary, 3330 Hospital Drive NW, Calgary, AB, Canada
Mol Hum Reprod 14:399-404. 2008..004) and YY (0.12% versus 0.03%, P = 0.04). There was a significant correlation between meiotic cells with zero MLH1 foci in the sex body and total sex chromosome disomy (XX + YY + XY) in sperm from men with NOA (r = 0.79, P = 0.036)... 
The relationship between meiotic recombination in human spermatocytes and aneuploidy in spermF Sun
Department of Medical Genetics, University of Calgary, 3330 Hospital Dr, NW, Calgary, AB, Canada
Hum Reprod 23:1691-7. 2008..This study's aim was to determine the relationship between recombination frequency in human pachytene spermatocytes and aneuploidy frequencies in individual chromosomes in sperm from the same men...- Single sperm typing demonstrates that reduced recombination is associated with the production of aneuploid 24,XY human spermQ Shi
Department of Medical Genetics, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada
Am J Med Genet 99:34-8. 2001..7, P = 0.001). This direct analysis of human sperm indicates that lack of recombination in the pseudoautosomal region is a significant cause of XY nondisjunction and thus Klinefelter syndrome... - Multicolor fluorescence in situ hybridization analysis of aneuploidy and diploidy frequencies in 225,846 sperm from 10 normal menR H Martin
Department of Medical Genetics, University of Calgary, Alberta, Canada
Biol Reprod 54:394-8. 1996..This powerful technology may be useful for future studies of potential environmental and occupational mutagens... - Temporal progression of recombination in human malesM Oliver-Bonet
Department of Medical Genetics, University of Calgary, Calgary, Alberta, Canada T2N 4N1
Mol Hum Reprod 11:517-22. 2005..We discuss a possible role for MSH4 in synapsis initiation and/or maintenance... - Immunofluorescent synaptonemal complex analysis in azoospermic menF Sun
Department of Medical Genetics, University of Calgary, Calgary, Canada
Cytogenet Genome Res 111:366-70. 2005..Defects in chromosome pairing and decreased recombination during meiotic prophase may have led to spermatogenesis arrest and contributed in part to this unexplained infertility... - Meiotic studies in two human reciprocal translocations and their association with spermatogenic failureM Oliver-Bonet
University of Calgary, Department of Obstetrics and Gynecology, Faculty of Medicine, University of Calgary, Calgary T2N 4N1, Canada
Hum Reprod 20:683-8. 2005..CONCLUSIONS: By comparing these two different translocation carriers with different fertility outcomes, we discuss the possible mechanisms by which translocations might cause the spermatogenesis process to fail... - Aneuploidy in human spermatozoa: FISH analysis in men with constitutional chromosomal abnormalities, and in infertile menQ Shi
Department of Medical Genetics, Faculty of Medicine, University of Calgary; and Genetics Department, Alberta Children's Hospital, Calgary, Alberta, T2T 5C7 Canada
Reproduction 121:655-66. 2001..An increased risk of sperm aneuploidy was not observed in infertile men with poor sperm motility or in those with a normal karyotype and normal semen parameters... - Meiotic studies in an azoospermic human translocation (Y;1) carrierF Sun
Department of Medical Genetics, University of Calgary, Calgary, Canada T2N 4N1
Mol Hum Reprod 11:361-4. 2005.... - The effect of cold storage on recombination frequencies in human male testicular cellsF Sun
Department of Medical Genetics, University of Calgary, Calgary, Alberta, Canada
Cytogenet Genome Res 106:39-42. 2004..These results demonstrate that testicular specimens may be shipped on ice without compromising data on chromosome pairing and recombination in early meiosis... - Analysis of human sperm karyotypes in testicular cancer patients before and after chemotherapyR H Martin
Department of Genetics, Alberta Children s Hospital, Calgary, Canada
Cytogenet Cell Genet 78:120-3. 1997..Together, these two studies suggest that the sperm of men receiving BEP chemotherapy are not at increased risk of chromosomal abnormalities two or more years after treatment... - Male infertility in reciprocal translocation carriers: the sex body affairM Oliver-Bonet
Department of Medical Genetics, University of Calgary, Calgary, Canada
Cytogenet Genome Res 111:343-6. 2005.... - Nondisjunction in human sperm: comparison of frequencies in acrocentric chromosomesR H Martin
Department of Medical Genetics, University of Calgary, Alberta Children s Hospital, Calgary, Alberta, Canada
Cytogenet Cell Genet 86:43-5. 1999..chromosomes 13 and 15; 0.15%) (P < 0.001, Mantel-Haenszel chi(2) test) and other autosomes (chromosomes 1, 2, 4, 9, 12, 13, 15, 16, 18, and 20; 0. 13%) studied in the same men (P < 0.001, Mantel-Haenszel chi(2) test)... - Analysis of aneuploidy for chromosomes 13, 21, X and Y by multicolour fluorescence in situ hybridisation (FISH) in a 47,XYY maleR H Martin
Department of Genetics, Alberta Children s Hospital, Calgary, Canada
Zygote 7:131-4. 1999..Our results suggest that the extra Y chromosome is eliminated during spermatogenesis in the majority of cells but that there may be a small but significant increase in the frequency of aneuploid sperm in these men... - Analysis of replication protein A (RPA) in human spermatogenesisMaria Oliver-Bonet
Department of Medical Genetics, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta, Canada
Mol Hum Reprod 13:837-44. 2007..These observations strengthen the original pre-synaptic model, although the visualization of post-synaptic RPA foci may indicate the presence of a different role for this protein during homologous recombination... - Sperm aneuploidy frequencies analysed before and after chemotherapy in testicular cancer and Hodgkin's lymphoma patientsH G Tempest
Department of Medical Genetics, University of Calgary, 3330 Hospital Drive NW, Calgary, AB, Canada T2 N 4N1
Hum Reprod 23:251-8. 2008.... - Meiotic defects in a man with non-obstructive azoospermia: case reportF Sun
Department of Medical Genetics, University of Calgary, Calgary, Alberta T2N 4N1, Canada
Hum Reprod 19:1770-3. 2004..This is the first demonstration of dramatic pachytene-stage abnormalities in an infertile man using these powerful new immunocytogenetic techniques...