R H Martin

Summary

Affiliation: University of Calgary
Country: Canada

Publications

  1. pmc Is there a relationship between sperm chromosome abnormalities and sperm morphology?
    Fei Sun
    Department of Medical Genetics, Faculty of Medicine, University of Calgary, Calgary, Alberta T2N 4N1, Canada
    Reprod Biol Endocrinol 4:1. 2006
  2. ncbi request reprint Mechanisms of nondisjunction in human spermatogenesis
    R H Martin
    Department of Medical Genetics, University of Calgary, Alberta Children s Hospital, Calgary, Alberta, Canada
    Cytogenet Genome Res 111:245-9. 2005
  3. ncbi request reprint Meiotic chromosome abnormalities in human spermatogenesis
    Renee H Martin
    Department of Medical Genetics, University of Calgary, Calgary, Alta, Canada
    Reprod Toxicol 22:142-7. 2006
  4. ncbi request reprint Studying meiosis: a review of FISH and M-FISH techniques used in the analysis of meiotic processes in humans
    M Oliver-Bonet
    Department of Medical Genetics, University of Calgary, Calgary, Canada
    Cytogenet Genome Res 114:312-8. 2006
  5. ncbi request reprint Chromosome abnormalities in human sperm
    Renee H Martin
    Department of Medical Genetics, University of Calgary, Calgary, Alberta, Canada
    Adv Exp Med Biol 518:181-8. 2003
  6. ncbi request reprint Sperm chromosome aneuploidy analysis in a man with globozoospermia
    Renee H Martin
    Department of Medical Genetics, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada
    Fertil Steril 79:1662-4. 2003
  7. ncbi request reprint A comparison of the frequency of sperm chromosome abnormalities in men with mild, moderate, and severe oligozoospermia
    Renee H Martin
    Department of Medical Genetics, University of Calgary, Calgary, Alberta, Canada T4N 4N1
    Biol Reprod 69:535-9. 2003
  8. ncbi request reprint Recombination in the pseudoautosomal region in a 47,XYY male
    R H Martin
    Department of Medical Genetics, Alberta Children s Hospital, 1820 Richmond Road SW, Calgary, Alberta T2T 5C7, Canada
    Hum Genet 109:143-5. 2001
  9. pmc Analysis of aneuploidy frequencies in sperm from patients with hereditary nonpolyposis colon cancer and an hMSH2 mutation
    R H Martin
    Department of Medical Genetics, Alberta Children s Hospital, Calgary, AB Canada T2T 5C7
    Am J Hum Genet 66:1149-52. 2000
  10. ncbi request reprint Meiotic errors in human oogenesis and spermatogenesis
    Renee H Martin
    University of Calgary, Department of Medical Genetics, 3330 Hospital Drive NW, Calgary, Alberta, Canada T2N 4N1
    Reprod Biomed Online 16:523-31. 2008

Detail Information

Publications31

  1. pmc Is there a relationship between sperm chromosome abnormalities and sperm morphology?
    Fei Sun
    Department of Medical Genetics, Faculty of Medicine, University of Calgary, Calgary, Alberta T2N 4N1, Canada
    Reprod Biol Endocrinol 4:1. 2006
    ..Thus, there may be an association between sperm morphology and aneuploidy in infertile men with specific abnormalities...
  2. ncbi request reprint Mechanisms of nondisjunction in human spermatogenesis
    R H Martin
    Department of Medical Genetics, University of Calgary, Alberta Children s Hospital, Calgary, Alberta, Canada
    Cytogenet Genome Res 111:245-9. 2005
    ..These men have an increased risk of aneuploidy in sperm that have been surgically removed from the testes. Thus, evidence is starting to accumulate that reduced recombination has a marked effect on the generation of aneuploid sperm...
  3. ncbi request reprint Meiotic chromosome abnormalities in human spermatogenesis
    Renee H Martin
    Department of Medical Genetics, University of Calgary, Calgary, Alta, Canada
    Reprod Toxicol 22:142-7. 2006
    ..Such errors make these cells susceptible to meiotic arrest and the production of aneuploid gametes...
  4. ncbi request reprint Studying meiosis: a review of FISH and M-FISH techniques used in the analysis of meiotic processes in humans
    M Oliver-Bonet
    Department of Medical Genetics, University of Calgary, Calgary, Canada
    Cytogenet Genome Res 114:312-8. 2006
    ..In this paper, we review the different FISH and M-FISH techniques that have been used on human meiotic cells in both men and women...
  5. ncbi request reprint Chromosome abnormalities in human sperm
    Renee H Martin
    Department of Medical Genetics, University of Calgary, Calgary, Alberta, Canada
    Adv Exp Med Biol 518:181-8. 2003
  6. ncbi request reprint Sperm chromosome aneuploidy analysis in a man with globozoospermia
    Renee H Martin
    Department of Medical Genetics, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada
    Fertil Steril 79:1662-4. 2003
    ..To determine the frequencies of chromosome aneuploidy and diploidy in sperm from a male with globozoospermia...
  7. ncbi request reprint A comparison of the frequency of sperm chromosome abnormalities in men with mild, moderate, and severe oligozoospermia
    Renee H Martin
    Department of Medical Genetics, University of Calgary, Calgary, Alberta, Canada T4N 4N1
    Biol Reprod 69:535-9. 2003
    ..These results demonstrate that men with severe oligozoospermia have an elevated risk for chromosome abnormalities in their sperm, particularly sex chromosome abnormalities...
  8. ncbi request reprint Recombination in the pseudoautosomal region in a 47,XYY male
    R H Martin
    Department of Medical Genetics, Alberta Children s Hospital, 1820 Richmond Road SW, Calgary, Alberta T2T 5C7, Canada
    Hum Genet 109:143-5. 2001
    ....
  9. pmc Analysis of aneuploidy frequencies in sperm from patients with hereditary nonpolyposis colon cancer and an hMSH2 mutation
    R H Martin
    Department of Medical Genetics, Alberta Children s Hospital, Calgary, AB Canada T2T 5C7
    Am J Hum Genet 66:1149-52. 2000
    ..There was a significantly increased frequency of disomy 13, disomy 21, XX, and diploidy in mutation carriers compared with control men. These results suggest that the hMSH2 mutation may affect meiosis in humans...
  10. ncbi request reprint Meiotic errors in human oogenesis and spermatogenesis
    Renee H Martin
    University of Calgary, Department of Medical Genetics, 3330 Hospital Drive NW, Calgary, Alberta, Canada T2N 4N1
    Reprod Biomed Online 16:523-31. 2008
    ..There is a link between infertility and the genesis of chromosome abnormalities. Future studies will unravel more of the underlying causal factors...
  11. pmc Cytogenetic determinants of male fertility
    R H Martin
    Department of Medical Genetics, University of Calgary, Room 287, Heritage Medical Research Building, 3330 Hospital Drive NW, Calgary, Alberta, Canada T2N 4N1
    Hum Reprod Update 14:379-90. 2008
    ..Cytogenetic abnormalities have been known to be important causes of male infertility for decades...
  12. ncbi request reprint Discontinuities and unsynapsed regions in meiotic chromosomes have a trans effect on meiotic recombination of some chromosomes in human males
    F Sun
    Department of Medical Genetics, University of Calgary, Canada
    Cytogenet Genome Res 119:27-32. 2007
    ..The positioning of MLH1 foci on other SCs in cells with gapped/split SC 9 was not altered. These studies suggest that gaps and splits not only have a cis effect, but may also have a trans effect on meiotic recombination in humans...
  13. ncbi request reprint Analysis of non-crossover bivalents in pachytene cells from 10 normal men
    Fei Sun
    Department of Medical Genetics, University of Calgary, Alberta, Canada
    Hum Reprod 21:2335-9. 2006
    ..Bivalents with no recombination foci (possible achiasmates) are unable to orient properly on the metaphase plate or to segregate chromosomes to daughter cells. Non-crossover bivalents are known to cause meiotic arrest in various organisms...
  14. ncbi request reprint Chromosomal abnormalities in sperm from testicular cancer patients before and after chemotherapy
    R H Martin
    Department of Genetics, Alberta Children s Hospital, Calgary, Canada
    Hum Genet 99:214-8. 1997
    ..None of the values in the cancer patients differed significantly from 10 normal control donors. Thus our study suggests that BEP chemotherapy does not increase the risk of numerical chromosomal abnormalities in human sperm...
  15. pmc Reduced meiotic recombination on the XY bivalent is correlated with an increased incidence of sex chromosome aneuploidy in men with non-obstructive azoospermia
    F Sun
    Department of Medical Genetics, University of Calgary, 3330 Hospital Drive NW, Calgary, AB, Canada
    Mol Hum Reprod 14:399-404. 2008
    ..004) and YY (0.12% versus 0.03%, P = 0.04). There was a significant correlation between meiotic cells with zero MLH1 foci in the sex body and total sex chromosome disomy (XX + YY + XY) in sperm from men with NOA (r = 0.79, P = 0.036)...
  16. doi request reprint The relationship between meiotic recombination in human spermatocytes and aneuploidy in sperm
    F Sun
    Department of Medical Genetics, University of Calgary, 3330 Hospital Dr, NW, Calgary, AB, Canada
    Hum Reprod 23:1691-7. 2008
    ..This study's aim was to determine the relationship between recombination frequency in human pachytene spermatocytes and aneuploidy frequencies in individual chromosomes in sperm from the same men...
  17. ncbi request reprint Single sperm typing demonstrates that reduced recombination is associated with the production of aneuploid 24,XY human sperm
    Q Shi
    Department of Medical Genetics, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada
    Am J Med Genet 99:34-8. 2001
    ..7, P = 0.001). This direct analysis of human sperm indicates that lack of recombination in the pseudoautosomal region is a significant cause of XY nondisjunction and thus Klinefelter syndrome...
  18. ncbi request reprint Multicolor fluorescence in situ hybridization analysis of aneuploidy and diploidy frequencies in 225,846 sperm from 10 normal men
    R H Martin
    Department of Medical Genetics, University of Calgary, Alberta, Canada
    Biol Reprod 54:394-8. 1996
    ..This powerful technology may be useful for future studies of potential environmental and occupational mutagens...
  19. ncbi request reprint Temporal progression of recombination in human males
    M Oliver-Bonet
    Department of Medical Genetics, University of Calgary, Calgary, Alberta, Canada T2N 4N1
    Mol Hum Reprod 11:517-22. 2005
    ..We discuss a possible role for MSH4 in synapsis initiation and/or maintenance...
  20. ncbi request reprint Immunofluorescent synaptonemal complex analysis in azoospermic men
    F Sun
    Department of Medical Genetics, University of Calgary, Calgary, Canada
    Cytogenet Genome Res 111:366-70. 2005
    ..Defects in chromosome pairing and decreased recombination during meiotic prophase may have led to spermatogenesis arrest and contributed in part to this unexplained infertility...
  21. ncbi request reprint Meiotic studies in two human reciprocal translocations and their association with spermatogenic failure
    M Oliver-Bonet
    University of Calgary, Department of Obstetrics and Gynecology, Faculty of Medicine, University of Calgary, Calgary T2N 4N1, Canada
    Hum Reprod 20:683-8. 2005
    ..Reciprocal translocations are often associated with infertility in male carriers. However, some carriers present normal semen profiles and are identified because of repetitive pregnancy failures...
  22. ncbi request reprint Aneuploidy in human spermatozoa: FISH analysis in men with constitutional chromosomal abnormalities, and in infertile men
    Q Shi
    Department of Medical Genetics, Faculty of Medicine, University of Calgary; and Genetics Department, Alberta Children's Hospital, Calgary, Alberta, T2T 5C7 Canada
    Reproduction 121:655-66. 2001
    ..An increased risk of sperm aneuploidy was not observed in infertile men with poor sperm motility or in those with a normal karyotype and normal semen parameters...
  23. ncbi request reprint Meiotic studies in an azoospermic human translocation (Y;1) carrier
    F Sun
    Department of Medical Genetics, University of Calgary, Calgary, Canada T2N 4N1
    Mol Hum Reprod 11:361-4. 2005
    ....
  24. ncbi request reprint The effect of cold storage on recombination frequencies in human male testicular cells
    F Sun
    Department of Medical Genetics, University of Calgary, Calgary, Alberta, Canada
    Cytogenet Genome Res 106:39-42. 2004
    ..These results demonstrate that testicular specimens may be shipped on ice without compromising data on chromosome pairing and recombination in early meiosis...
  25. ncbi request reprint Analysis of human sperm karyotypes in testicular cancer patients before and after chemotherapy
    R H Martin
    Department of Genetics, Alberta Children s Hospital, Calgary, Canada
    Cytogenet Cell Genet 78:120-3. 1997
    ..Together, these two studies suggest that the sperm of men receiving BEP chemotherapy are not at increased risk of chromosomal abnormalities two or more years after treatment...
  26. ncbi request reprint Male infertility in reciprocal translocation carriers: the sex body affair
    M Oliver-Bonet
    Department of Medical Genetics, University of Calgary, Calgary, Canada
    Cytogenet Genome Res 111:343-6. 2005
    ....
  27. ncbi request reprint Nondisjunction in human sperm: comparison of frequencies in acrocentric chromosomes
    R H Martin
    Department of Medical Genetics, University of Calgary, Alberta Children s Hospital, Calgary, Alberta, Canada
    Cytogenet Cell Genet 86:43-5. 1999
    ..chromosomes 13 and 15; 0.15%) (P < 0.001, Mantel-Haenszel chi(2) test) and other autosomes (chromosomes 1, 2, 4, 9, 12, 13, 15, 16, 18, and 20; 0. 13%) studied in the same men (P < 0.001, Mantel-Haenszel chi(2) test)...
  28. ncbi request reprint Analysis of aneuploidy for chromosomes 13, 21, X and Y by multicolour fluorescence in situ hybridisation (FISH) in a 47,XYY male
    R H Martin
    Department of Genetics, Alberta Children s Hospital, Calgary, Canada
    Zygote 7:131-4. 1999
    ..Our results suggest that the extra Y chromosome is eliminated during spermatogenesis in the majority of cells but that there may be a small but significant increase in the frequency of aneuploid sperm in these men...
  29. ncbi request reprint Analysis of replication protein A (RPA) in human spermatogenesis
    Maria Oliver-Bonet
    Department of Medical Genetics, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta, Canada
    Mol Hum Reprod 13:837-44. 2007
    ..These observations strengthen the original pre-synaptic model, although the visualization of post-synaptic RPA foci may indicate the presence of a different role for this protein during homologous recombination...
  30. ncbi request reprint Sperm aneuploidy frequencies analysed before and after chemotherapy in testicular cancer and Hodgkin's lymphoma patients
    H G Tempest
    Department of Medical Genetics, University of Calgary, 3330 Hospital Drive NW, Calgary, AB, Canada T2 N 4N1
    Hum Reprod 23:251-8. 2008
    ....
  31. ncbi request reprint Meiotic defects in a man with non-obstructive azoospermia: case report
    F Sun
    Department of Medical Genetics, University of Calgary, Calgary, Alberta T2N 4N1, Canada
    Hum Reprod 19:1770-3. 2004
    ..This is the first demonstration of dramatic pachytene-stage abnormalities in an infertile man using these powerful new immunocytogenetic techniques...