Affiliation: University of Winnipeg
- T(2)-weighted microMRI and evoked potential of the visual system measurements during the development of hypomyelinated transgenic miceMelanie Martin
Department of Physics, University of Winnipeg, 515 Portage Avenue, Winnipeg, Manitoba, Canada, R3B 2E9
Neurochem Res 32:159-65. 2007..Overall these non-invasive techniques are capable of spatially resolving the increase in myelination in the normally developing and developmentally delayed mouse brain...
- Myelin deficiencies visualized in vivo: visually evoked potentials and T2-weighted magnetic resonance images of shiverer mutant and wild-type miceMelanie Martin
Biological Imaging Center, Beckman Institute, Division of Biology, California Institute of Technology, Pasadena, CA, USA
J Neurosci Res 84:1716-26. 2006..These data show the potential of using micro MRI in combination with VEPs to follow changes in both the quality and the quantity of myelin in vivo. These combined methods would be useful for longitudinal studies and therapy testing...
- Comparison of manual and semi-automated segmentation methods to evaluate hippocampus volume in APP and PS1 transgenic mice obtained via in vivo magnetic resonance imagingKerrie Hayes
Department of Biology, University of Winnipeg, 515 Portage Avenue, Winnipeg, MB, Canada R3B 2E9 Electronic address
J Neurosci Methods 221:103-11. 2014..A hallmark pathological feature of Alzheimer's disease is atrophy of the hippocampus, which is an early biomarker of the disease. MRI can be used to detect and monitor this biomarker...
- Neurofibrillary tangles and plaques are not accompanied by white matter pathology in aged triple transgenic-Alzheimer disease miceMarzena Z Kastyak-Ibrahim
Department of Physics, University of Winnipeg, 515 Portage Avenue, Winnipeg, Manitoba, R3B 2E9, Canada Electronic address
Magn Reson Imaging 31:1515-21. 2013..Myelin staining was normal in affected mice. These data suggest that the 3xTg-AD mouse model does not develop MRI detectable white matter changes at the ages we examined. ..
- Digital three-dimensional atlas of quail development using high-resolution MRISeth W Ruffins
California Institute of Technology, Division of Biology, Biological Imaging Center, Beckman Institute, Pasadena, CA, USA
ScientificWorldJournal 7:592-604. 2007..This provides a method for the analysis and examination of the spatial relationships among the different types of information within the context of the entire embryo...
- Quantitative MRI and ultrastructural examination of the cuprizone mouse model of demyelinationJonathan D Thiessen
Department of Physics and Astronomy, University of Manitoba, Winnipeg, MB, Canada Department of Radiology, University of Manitoba, Winnipeg, MB, Canada
NMR Biomed 26:1562-81. 2013..37ƒ - 0.25). Of the calculated MRI metrics, ƒ was the strongest indicator of myelin content, while longitudinal relaxation rates and diffusivity measurements were the strongest indicators of changes in tissue structure...
- Superiority of 3D wavelet-packet denoising in MR microscopyNilesh R Ghugre
Biomedical Electrical Engineering, University of Southern California, Los Angeles, CA, USA
Magn Reson Imaging 21:913-21. 2003..MR microscopy researchers preferred the denoised images to the unprocessed images for their atlas projects...
- Histochemical visualization and diffusion MRI at 7 Tesla in the TgCRND8 transgenic model of Alzheimer's diseaseJonathan D Thiessen
Division of Neurodegenerative Disorders, St Boniface Research Centre, Winnipeg, MB, R2H 2A6, Canada
Brain Struct Funct 215:29-36. 2010....
- Region-specific myelin pathology in mice lacking the golli products of the myelin basic protein geneErin C Jacobs
Neuropsychiatric Institute, University of California Los Angeles School of Medicine, Los Angeles, California 90024, USA
J Neurosci 25:7004-13. 2005..Together, all these findings suggest a role for golli proteins in oligodendrocyte differentiation, migration, and/or myelin elaboration in the brain...