Research Topics
| T K MarrasSummaryAffiliation: University of Toronto Country: Canada Publications
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Detail Information
Publications
Epidemiology of human pulmonary infection with nontuberculous mycobacteriaTheodore K Marras
University of California, San Francisco, UCSF Campus Box 0841, San Francisco, CA 94143-0841, USA
Clin Chest Med 23:553-67. 2002..The rates of NTM infection and disease are increasing, so the problem will likely continue to grow and become a far more important issue than current rates suggest...
Isolation prevalence of pulmonary non-tuberculous mycobacteria in Ontario, 1997 2003Theodore K Marras
Joint Division of Respirology, University Health Network and Mount Sinai Hospital, Department of Medicine, University of Toronto, Toronto, Canada
Thorax 62:661-6. 2007..A study was undertaken of the "isolation prevalence" of pulmonary NTM in Ontario, Canada between 1997 and 2003 and the frequency of pulmonary NTM "disease"...- Hypersensitivity pneumonitis reaction to Mycobacterium avium in household waterTheodore K Marras
Division of Respirology, Toronto Western Hospital, Edith Cavell 4 022, 399 Bathurst St, Toronto, ON, Canada M5T 2S8
Chest 127:664-71. 2005..Hypersensitivity pneumonitis has been described with exposure to aerosolized Mycobacterium avium complex (MAC) in indoor hot tubs (hot tub lung)... - A systematic review of the clinical significance of pulmonary Mycobacterium kansasii isolates in HIV infectionTheodore K Marras
Department of Medicine, Division of Respirology, University of Toronto, Toronto Western Hospital, Ontario, Canada
J Acquir Immune Defic Syndr 36:883-9. 2004..kansasii may exist in the setting of HIV, but published data do not provide adequate information to identify such patients. It is unclear whether unfulfilled diagnostic criteria necessarily imply the absence of disease in this context... - Mortality prediction in pulmonary Mycobacterium kansasii infection and human immunodeficiency virusTheodore K Marras
Department of Medicine Respiratory, University of Toronto, Ontario, Canada
Am J Respir Crit Care Med 170:793-8. 2004..Withholding treatment in HIV-infected patients with respiratory M. kansasii isolates should only be considered with negative smear microscopy, few positive cultures, and mild immunosuppression... - Inpatient care of community-acquired pneumonia: the effect of antimicrobial guidelines on clinical outcomes and drug costs in Canadian teaching hospitalsTheodore K Marras
Department of Medicine, University of Toronto, Canada
Can Respir J 11:131-7. 2004..Evidence supporting antibiotic treatment guidelines and respiratory quinolones (RQs) in community-acquired pneumonia (CAP) is limited... - Efficacy of exclusively oral antibiotic therapy in patients hospitalized with nonsevere community-acquired pneumonia: a retrospective study and meta-analysisTheodore K Marras
Joint Division of Respirology, Department of Medicine, University Health Network, and Mount Sinai Hospital, University of Toronto, Toronto, Canada
Am J Med 116:385-93. 2004..To assess the efficacy of oral antibiotics in patients hospitalized with community-acquired pneumonia and to identify factors precluding oral therapy... - Long-term pulmonary function abnormalities and survival after allogeneic marrow transplantationT K Marras
Joint Division of Respirology, Department of Medicine, University Health Network and Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada
Bone Marrow Transplant 33:509-17. 2004..In summary, after BMT, decreased diffusion capacity is common and benign; obstruction has decreased in frequency, is rare without cGVHD, and is associated with mortality; nonsibling and mismatched donor are risk factors for restriction... - Tuberculosis among Tibetan refugee claimants in Toronto: 1998 to 2000Theodore K Marras
Department of Medicine, University of Toronto, Toronto, Ontario, Canada
Chest 124:915-21. 2003..We reviewed TB-related outcomes in this cohort, to compare our experience with previously published work, and to assess follow-up after a stay in a low-incidence region... 
Nontuberculous mycobacterial lung infections in Ontario, Canada: clinical and microbiological characteristicsTheodore K Marras
Joint Division of Respirology, Department of Medicine, University of Toronto, University Health Network and Mount Sinai Hospital, Toronto, Canada
Lung 188:289-99. 2010..The aim of this study was to determine gender and clinical phenotype frequencies in pulmonary nontuberculous mycobacterial (NTM) infection and the frequency of disease in NTM isolates...- Pulmonary function abnormalities after allogeneic marrow transplantation: a systematic review and assessment of an existing predictive instrumentT K Marras
Joint Division of Respirology, University Health Network and Mount Sinai Hospital, Department of Medicine, University of Toronto, Canada
Bone Marrow Transplant 30:599-607. 2002..We concluded that PFT changes after BMT are common. A published predictive index is not sufficiently accurate to identify high-risk patients for potential preventive or early therapeutic strategies... - Macrolides in the treatment of bronchiolitis obliterans in allograft recipientsN Maimon
Joint Division of Respirology, Department of Medicine, University Health Network and Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada
Bone Marrow Transplant 44:69-73. 2009..The benefit for BO post HSCT was shown only in a small non-randomized trial. Additional in vivo research is needed before developing any firm conclusions... - Nontuberculous mycobacterial sensitization in the United States: national trends over three decadesKamran Khan
Department of Medicine, University of Toronto, Toronto, Canada
Am J Respir Crit Care Med 176:306-13. 2007..Temporal changes in the epidemiology of Mycobacterium intracellulare sensitization may help explain recently observed trends in pulmonary NTM infections... - Pneumonia severity index in the immunocompromisedK M Sanders
Department of Medicine, University of Toronto, Toronto, Canada
Can Respir J 13:89-93. 2006..6). CONCLUSIONS: Patients with CAP and immunosuppression can be divided into low-risk and high-risk groups. The low-risk IP have mortality similar to non-IP and can be risk stratified by using the PSI... - Pulmonary Mycobacterium xenopi infection in non-HIV-infected patients: a systematic reviewR G Varadi
Division of Respirology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada
Int J Tuberc Lung Dis 13:1210-8. 2009..The incidence of Mycobacterium xenopi infections is increasing worldwide. The characteristics and optimal management of patients with pulmonary M. xenopi infections have not been well established... - The cost of medical management of pulmonary nontuberculous mycobacterial disease in Ontario, CanadaA Leber
Dept of Medicine, University Health Network, Mount Sinai Hospital, Toronto Western Hospital, Toronto, ON, M5T 2S8, Canada
Eur Respir J 37:1158-65. 2011..The direct medical costs of NTM infections are substantial. Less expensive alternative therapies might be most helpful for M. abscessus infection and when i.v. antibiotics are deemed necessary... - Aerosolized pentamidine prophylaxis for Pneumocystis carinii pneumonia after allogeneic marrow transplantationT K Marras
Department of Medicine, Toronto General Hospital, 200 Elizabeth Street, Toronto, Ontario M5G 2C4, Canada
Transpl Infect Dis 4:66-74. 2002..However, it should be administered using a well-studied protocol, and only when TMP-SMX is not tolerated... - Hot tub lung mimicking classic acute and chronic hypersensitivity pneumonitis: two case reportsGeetika Verma
Department of Medicine, Division of Respirology, University Health Network, University of Toronto, Toronto, Ontario
Can Respir J 14:354-6. 2007..Both cases exhibited clinical, radiological and pathological findings closely mimicking classic subacute and chronic hypersensitivity pneumonitis... - A 21-year-old man with systemic-onset juvenile rheumatoid arthritis, cough and progressive dyspneaA Leber
Department of Medicine, University Health Network, University of Toronto, Toronto, Ontario, Canada
Can Respir J 17:e42-4. 2010..Multiple treatment regimens were attempted; however, definitive management was only achieved through double-lung transplantation... - Fatal pulmonary Mycobacterium xenopi in a patient with rheumatoid arthritis receiving etanerceptNimrod Maimon
Division of Respirology, University Health Network and Mount Sinai Hospital, Department of Medicine, University of Toronto, Toronto, Canada
Thorax 62:739-40. 2007..Little is known about the association between anti-tumour necrosis factor (TNF)alpha and non-tuberculous mycobacterial infections. The case history is presented of fatal M xenopi infection in a patient receiving anti-TNFalpha treatment... - Pulmonary sarcoidosis developing during infliximab therapyTheodore K Marras
Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada
Arthritis Rheum 55:978-81. 2006 - One-year outcomes and health care utilization in survivors of severe acute respiratory syndromeCatherine M Tansey
Department of Medicine, University Health Network, and Mount Sinai Hospital, Toronto, Ontario, Canada
Arch Intern Med 167:1312-20. 2007..Research conducted during the SARS outbreak may help inform research planning for future public health emergencies. The objective of this study was to evaluate the 1-year outcomes in survivors of SARS and their family caregivers... - Detailed analysis of the radiographic presentation of Mycobacterium kansasii lung disease in patients with HIV infectionAdithya Cattamanchi
University of California San Francisco, San Francisco General Hospital, San Francisco, CA 94110, USA
Chest 133:875-80. 2008..In patients with HIV infection, the radiographic findings of M kansasii lung disease are not well described... - Pharmacodynamic target attainment analysis against Streptococcus pneumoniae using levofloxacin 500 mg, 750 mg and 1000 mg once daily in plasma (P) and epithelial lining fluid (ELF) of hospitalized patients with community acquired pneumonia (CAP)Ayman M Noreddin
Department of Medical Microbiology, Faculty of Medicine, University of Manitoba, Winnipeg, Man, Canada
Int J Antimicrob Agents 24:479-84. 2004..Levofloxacin 750 mg OD results in high probability of pharmacodynamic target attainment and improved bacteriological outcome against S. pneumoniae in patients with CAP... - Pneumococcal vaccination in older adultsTheodore K Marras
N Engl J Med 349:712-4; author reply 712-4. 2003 - Dexamethasone for tuberculous meningitisTheodore K Marras
N Engl J Med 352:628-30; author reply 628-30. 2005