G B Mancini
Affiliation: University of British Columbia
- Coronary angiographic changes in patients with cardiac events in the Prospective Randomized Evaluation of the Vascular Effects of Norvasc Trial (PREVENT)G B John Mancini
University of British Columbia, Vancouver, British Columbia, Canada
Am J Cardiol 90:776-8. 2002
- Coronary stent restenosis in patients treated with cilostazolJohn S Douglas
Emory University School of Medicine, Atlanta, GA, USA
Circulation 112:2826-32. 2005..We undertook a randomized, double-blind, placebo-controlled trial to determine whether cilostazol, a drug that suppresses intimal proliferation, would reduce renarrowing in patients after stent implantation in native coronary arteries...
- Statins but not fibrates improve the atherogenic to anti-atherogenic lipoprotein particle ratio: a randomized crossover studySammy Y Chan
Division of Cardiology, Department of Medicine, University of British Columbia, Vancouver, Canada
BMC Clin Pharmacol 8:10. 2008..We treated subjects with hyperlipidemia sequentially with statins and fibrates, the 2 main classes of lipid lowering therapy and studied changes in NMR lipoprotein subclasses...
- Reduction of morbidity and mortality by statins, angiotensin-converting enzyme inhibitors, and angiotensin receptor blockers in patients with chronic obstructive pulmonary diseaseG B John Mancini
Division of Cardiology, Vancouver Hospital, Jack Bell Research Centre, University of British Columbia, Vancouver, British Columbia, Canada
J Am Coll Cardiol 47:2554-60. 2006....
- Validation of a new ultrasound method for the measurement of carotid artery intima medial thickness and plaque dimensionsG B John Mancini
Cardiovascular Imaging Research Core Laboratory, Vancouver Hospital, and University of British Columbia, Vancouver, Canada
Can J Cardiol 20:1355-9. 2004..Carotid ultrasound is an accepted method for the detection of subclinical atherosclerosis. Valid methods that allow quantitation of carotid atheroma burden may be useful for stratifying risk...
- Quantitative results of baseline angiography and percutaneous coronary intervention in the COURAGE trialG B John Mancini
Vancouver Hospital, Cardiovascular Imaging Research Core Laboratory, University of British Columbia, Vancouver, Canada
Circ Cardiovasc Qual Outcomes 2:320-7. 2009..COURAGE compared outcomes in stable coronary patients randomized to optimal medical therapy plus percutaneous coronary intervention (PCI) versus optimal medical therapy alone...
- The 'double dip' hypothesis: simultaneous prevention of cardiovascular and pulmonary morbidity and mortality using angiotensin II type 1 receptor blockersG B John Mancini
Division of Cardiology, University of British Columbia, Vancouver, Canada
Can J Cardiol 21:519-23. 2005..Moreover, angiotensin II is also a direct mediator of lung injury; interruption of this mechanism of injury might simultaneously prevent both cardiovascular and pulmonary morbidity and mortality in patients with chronic lung disease...
- Angiotensin II type 1 receptor blocker inhibits pulmonary injuryG B John Mancini
Department of Medicine, Division of Cardiology, University of British Columbia and Vancouver Coastal Research Institute, Vancouver, Canada
Clin Invest Med 28:118-26. 2005..The purpose of this study was to evaluate the effects of an angiotensin II type 1 receptor blocker, valsartan, on systemic, cellular, and fibrotic consequences of pulmonary injury induced by the anti-neoplastic antibiotic, bleomycin...
- Emerging role of angiotensin II type 1 receptor blockers for the treatment of endothelial dysfunction and vascular inflammationG B John Mancini
Vancouver Hospital and Health Sciences Centre, University of British Columbia, Canada
Can J Cardiol 18:1309-16. 2002..ACEIs have been shown to improve endothelial dysfunction in many clinical settings...
- Antiatherosclerotic effects of calcium channel blockersG B John Mancini
Department of Medicine, The University of British Columbia, Vancouver, Canada
Prog Cardiovasc Dis 45:1-20. 2002..This article reviews the currently available evidence of antiatherosclerotic effects of CCBs in animal models and in clinical trials...
- Post hoc analysis of coronary findings from the prospective randomized evaluation of the vascular effects of the Norvasc trial (PREVENT)G B John Mancini
Vancouver Hospital, Vancouver, BC, Canada
Am J Cardiol 89:1414-6. 2002
- Association of skin cholesterol content, measured by a noninvasive method, with markers of inflammation and Framingham risk predictionG B John Mancini
Lipid Clinic/Healthy Heart Program and the Atherosclerosis Reversal Clinic, St. Paul's Hospital and Jack Bell Research Centre, University of British Columbia, Vancouver, British Columbia, Canada
Am J Cardiol 89:1313-6. 2002
- Redefining the normal angiogram using population-derived ranges for coronary size and shape: validation using intravascular ultrasound and applications in diverse patient cohortsG B John Mancini
Cardiovascular Imaging Research Core Laboratory, Division of Cardiology, University of British Columbia, Vancouver Hospital, 10209 2775 Laurel Street, Vancouver, BC, Canada, V5Z 1M9
Int J Cardiovasc Imaging 23:441-53. 2007..To develop a method for quantitating coronary angiographic abnormalities of segmental size and shape (tapering) in comparison to gender- and segment-specific, population derived, normal values...
- Why were the results of the Heart Outcomes Prevention Evaluation (HOPE) trial so astounding?G B Mancini
Department of Medicine, University of British Columbia and Vancouver General Hospital, Vancouver, Canada
Can J Cardiol 17:15A-7A. 2001..The benefits of ACE inhibitor therapy that were observed were likely due to a variety of mechanisms, not just a reduction in blood pressure...
- Diagnosis, prevention, and management of statin adverse effects and intolerance: proceedings of a Canadian Working Group Consensus ConferenceG B John Mancini
Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada
Can J Cardiol 27:635-62. 2011..The ultimate goal is to ensure that patients who warrant cardiovascular risk reduction can be treated optimally, safely, and confidently with statin medications or alternatives when warranted...
- Validation of an automated method for assessing brachial artery endothelial dysfunctionG B John Mancini
Cardiac Imaging Research Laboratory, Jack Bell Research Centre, Atherosclerosis Reversal Clinic, St Paul s Hospital, University of British Columbia, Vancouver
Can J Cardiol 18:259-62. 2002..Automated image analysis of the ultrasound images would facilitate implementation of such measurements in high throughput clinics and/or large clinical trials...
- Angiographic and clinical outcomes of drug-eluting versus bare metal stent deployment in the Occluded Artery TrialVladimir Dzavik
Division of Cardiology, Peter Munk Cardiac Centre, University Health Network, Toronto, Ontario, Canada
Catheter Cardiovasc Interv 73:771-9. 2009..We aimed to determine if stenting of the target occlusion in OAT with drug-eluting stents (DES) was associated with more favorable angiographic results and clinical outcome when compared with treatment with BMS...
- Assessment of novel risk factors in patients at low risk for cardiovascular events based on Framingham risk stratificationJasmine Grewal
Department of Medicine, University of British Columbia, St. Paul's Hospital, Vancouver, BC
Clin Invest Med 26:158-65. 2003....
- Carotid intima-media thickness as a measure of vascular target organ damageG B Mancini
Vancouver Hospital and Health Sciences Centre, 3300 950 West 10th Avenue, Vancouver, BC V5E 4Z3, Canada
Curr Hypertens Rep 2:71-7. 2000..The method appears highly suited to the goal of detecting asymptomatic vascular target organ damage, which may greatly assist with assessment of risk and selection of appropriate, preventive, strategies for management of disease...
- Long-term use of angiotensin-converting enzyme inhibitors to modify endothelial dysfunction: a review of clinical investigationsG B Mancini
Department of Medicine, University of British Columbia, Vancouver Hospital and Health Sciences Centre
Clin Invest Med 23:144-61. 2000..The purpose of this paper is to review clinical studies assessing the effect of long-term, oral ACE inhibition on endothelial dysfunction in specific disease syndromes and to identify areas requiring further research...
- Overview of the prospective randomized evaluation of the vascular effects of Norvasc (amlodipine) trial: PREVENTG B Mancini
Vancouver Hospital and Health Sciences Centre, Vancouver, Canada
Can J Cardiol 16:5D-7D. 2000..This brief report provides an overview and assessment of the implications of these findings...
- Dietary measures and exercise training contribute to improvement of endothelial function and atherosclerosis even in patients given intensive pharmacologic therapySammy Y Chan
Division of Cardiology, Department of Medicine, University of British Columbia, Canada
J Cardiopulm Rehabil 26:288-93. 2006..Atherosclerosis contributes to cardiovascular mortality and morbidity even with aggressive lipid management. Our objective is to determine whether a combined pharmacological and lifestyle intervention can improve atherosclerosis...
- Percutaneous coronary intervention in the Occluded Artery Trial: procedural success, hazard, and outcomes over 5 yearsChristopher E Buller
Vancouver General Hospital, Vancouver, British Columbia, Canada
Am Heart J 158:408-15. 2009..The influence of PCI failure, procedural hazard, and crossover on trial results has not been reported...
- Coronary atherosclerosis in anorexia nervosaCarl Laird Birmingham
Eating Disorders Program, St Paul s Hospital, University of British Columbia, Vancouver, Canada
Int J Eat Disord 34:375-7. 2003..Chest pain is a common complaint in patients with anorexia nervosa (AN). Of those who experience chest pain, about 20% meet the diagnostic criteria for typical or atypical angina...
- Subclinical atherosclerosis in subjects with family history of premature coronary artery diseaseCatalin Taraboanta
Faculty of Medicine, Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada
Am Heart J 155:1020-1026.e1. 2008....
- The effects of aspirin and clopidogrel response on myonecrosis after percutaneous coronary intervention: a BRIEF-PCI (Brief Infusion of Intravenous Eptifibatide Following Successful Percutaneous Coronary Intervention) trial substudyJacqueline Saw
Division of Cardiology, Vancouver General Hospital, University of British Columbia, Vancouver, British Columbia, Canada
JACC Cardiovasc Interv 1:654-9. 2008..The purpose of this study was to evaluate the effects of aspirin and clopidogrel response on myonecrosis after percutaneous coronary intervention (PCI) with glycoprotein (GP) IIb/IIIa blockade...
- Adaptive statistical iterative reconstruction: assessment of image noise and image quality in coronary CT angiographyJonathon Leipsic
Department of Radiology and Department of Medicine, Division of Cardiology, University of British Columbia, St Paul s Hospital, 1081 Burrard St, Vancouver, BC V6N 2N7, Canada
AJR Am J Roentgenol 195:649-54. 2010..The purpose of our study was to determine the effect of Adaptive Statistical Iterative Reconstruction (ASIR) on cardiac CT angiography (CTA) signal, noise, and image quality...
- The prognostic importance of endothelial dysfunction and carotid atheroma burden in patients with coronary artery diseaseSammy Y Chan
Division of Cardiology, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada
J Am Coll Cardiol 42:1037-43. 2003..Preserved endothelial function attenuates the risk of future events associated with a high plaque burden...
- Estimated radiation dose reduction using adaptive statistical iterative reconstruction in coronary CT angiography: the ERASIR studyJonathon Leipsic
Department of Radiology and Department of Medicine, Division of Cardiology, University of British Columbia, Vancouver, BC, Canada
AJR Am J Roentgenol 195:655-60. 2010..The objective of our study was to assess the impact of Adaptive Statistical Iterative Reconstruction (ASIR) on radiation dose and study quality for coronary CT angiography (CTA)...
- Ankle brachial index screening for occult vascular disease is not useful in HIV-positive patientsKevin Johns
University of British Columbia, Vancouver, BC, Canada
AIDS Res Hum Retroviruses 26:955-9. 2010..ABI was not useful in detecting occult vascular disease in HIV-positive patients and offers no additional information to that derived from cardiovascular risk stratification...
- An update on lipid-lowering therapyJ D Barth
Division of Cardiology, Vancouver Hospital and Health Sciences Centre, University of British Columbia, Canada
Curr Opin Lipidol 6:32-7. 1995..More widespread implementation of screening programmes to identify suitable patients for lipid-lowering therapy may help prevent the excess utilization of health care resources...
- A comparison of quantitative coronary angiography systems using a unique set of in vivo coronary stenosis imagesG B Mancini
University of British Columbia, Vancouver Hospital and Health Sciences Centre, Vancouver, Canada
Can J Cardiol 17:785-91. 2001..To compare the accuracy and precision of measurements of minimum lumen diameter (MLD) among two existing, and one new, quantitative coronary angiography systems...
- Retrieval and analysis of particulate debris after saphenous vein graft interventionJ G Webb
St Paul s Hospital, University of British Columbia, Vancouver, Canada
J Am Coll Cardiol 34:468-75. 1999..This study was designed to evaluate the composition and quantity of particulate debris resulting from vein graft intervention...
- Immigration presents a potential increased risk for atherosclerosisScott A Lear
Simon Fraser University, British Columbia, Canada
Atherosclerosis 205:584-9. 2009..The purpose of this study was to determine the independent association of time since immigration with sub-clinical atherosclerosis in immigrants of Chinese, European and South Asian origin...
- Normal angiographic tapering of the coronary arteriesMohammad Zubaid
Vancouver Hospital and Health Sciences Centre, University of British Columbia, Vancouver, Canada
Can J Cardiol 18:973-80. 2002..Similar tapering results were obtained in men. CONCLUSIONS: The estimation of an expected magnitude of tapering of coronary arteries may identify diseased segments that are not angiographically stenotic...
- Initial experience with a novel coronary rinsing and thrombectomy system: "Rinspiration"John Webb
Cardiology Department of St. Paul's Hospital, Vancouver, British Columbia, Canada
J Invasive Cardiol 18:188-92. 2006..CONCLUSIONS: The Rinspiration system appears capable of safely removing intracoronary thrombus and warrants further evaluation...
- Can combining different risk interventions into a single formulation contribute to improved cardiovascular disease risk reduction? Rationale and design for an international, open-label program to assess the effectiveness of a single pill (amlodipine/atorvF D Richard Hobbs
Primary Care Clinical Sciences Building, University of Birmingham, Edgbaston, UK
Int J Cardiol 110:242-50. 2006..The JEWEL study program will investigate the use of single-pill amlodipine/atorvastatin as a strategy to improve management of these patients...
- Effect of PCI on quality of life in patients with stable coronary diseaseWilliam S Weintraub
Christiana Care Health System, Newark, DE 19718, USA
N Engl J Med 359:677-87. 2008..It has not been clearly established whether percutaneous coronary intervention (PCI) can provide an incremental benefit in quality of life over that provided by optimal medical therapy among patients with chronic coronary artery disease...
- Vascular structure versus function: is endothelial dysfunction of independent prognostic importance or not?G B John Mancini
J Am Coll Cardiol 43:624-8. 2004
- The number needed to harm: is it too optimistic?G B John Mancini
Can J Cardiol 20:1375; author reply 1376. 2004
- Optimal medical therapy with or without percutaneous coronary intervention to reduce ischemic burden: results from the Clinical Outcomes Utilizing Revascularization and Aggressive Drug Evaluation (COURAGE) trial nuclear substudyLeslee J Shaw
Emory University School of Medicine, Atlanta, GA 30306, USA
Circulation 117:1283-91. 2008....
- The relationship of three common definitions of the metabolic syndrome with sub-clinical carotid atherosclerosisErica Paras
School of Kinesiology, Simon Fraser University, Harbour Centre Campus, 515 West Hastings St Vancouver, British Columbia, Canada V6B 5K3
Atherosclerosis 198:228-36. 2008....
- Statin therapy and the management of acute coronary syndromesAnatoly Langer
Canadian Heart Research Centre and St Michael s Hospital, University of Toronto, Toronto, Canada
Can J Cardiol 19:921-7. 2003....
- Clarion call for trials assessing "cardiopulmonary" agents to reduce morbidity and mortality in inflammatory lung diseasesG B John Mancini
Chest 131:950-1. 2007
- Optimal medical therapy with or without PCI for stable coronary diseaseWilliam E Boden
Western New York Veterans Affairs Healthcare Network and Buffalo General Hospital SUNY, Buffalo, NY 14203, USA
N Engl J Med 356:1503-16. 2007....
- Reporting measures of endothelial dysfunction independent of baseline arterial diameterG B John Mancini
Am J Cardiol 94:1222-3. 2004
- Surrogate markers for cardiovascular disease: structural markersG B John Mancini
Cardiovascular Division, Department of Medicine, University of Minnesota Medical School, Minneapolis, Minn 55455, USA
Circulation 109:IV22-30. 2004
- Adjunctive use of the Rinspiration system for fluidic thrombectomy during primary angioplasty: the Rinspiration international registryMarco De Carlo
Cardiothoracic and Vascular Department, University of Pisa, Pisa, Italy
Catheter Cardiovasc Interv 72:196-203. 2008..The aim of this study was to investigate the safety and efficacy of an innovative thrombectomy device, the Rinspiration System, which simultaneously "rinses" the vessel with turbulent flow and aspirates thrombus...
- ACE inhibitors: back to prime time?Milan Gupta
Heart 93:1015-6. 2007
- The evolving pattern of symptomatic coronary artery disease in the United States and Canada: baseline characteristics of the Clinical Outcomes Utilizing Revascularization and Aggressive DruG Evaluation (COURAGE) trialWilliam E Boden
VA Connecticut Healthcare System, West Haven, Connecticut, USA
Am J Cardiol 99:208-12. 2007....
- Randomized trial of percutaneous coronary intervention for subacute infarct-related coronary artery occlusion to achieve long-term patency and improve ventricular function: the Total Occlusion Study of Canada (TOSCA)-2 trialVladimir Dzavik
University Health Network, University of Toronto, Toronto, Ontario, Canada
Circulation 114:2449-57. 2006....
- Design and rationale of the Clinical Outcomes Utilizing Revascularization and Aggressive DruG Evaluation (COURAGE) trial Veterans Affairs Cooperative Studies Program no. 424William E Boden
VA Connecticut Healthcare System, West Haven, CT, USA
Am Heart J 151:1173-9. 2006....