A K Malla

Summary

Affiliation: University of Western Ontario
Country: Canada

Publications

  1. ncbi request reprint Early signs in schizophrenia spectrum disorders
    Ross M G Norman
    Department of Psychiatry, University of Western Ontario, Room 114A, WMCH Building, 392 South Street, London, Ontario, Canada N6A 4G5
    J Nerv Ment Dis 193:17-23. 2005
  2. ncbi request reprint Delay in treatment for psychosis : its relation to family history
    Ross M G Norman
    Dept of Psychiatry, University of Western Ontario, London ON, Canada
    Soc Psychiatry Psychiatr Epidemiol 42:507-12. 2007
  3. pmc Computed tomography of the brain morphology of patients with first-episode schizophrenic psychosis
    Ashok K Malla
    Department of Psychiatry, University of Western Ontario, London Health Sciences Centre, Victoria Campus, 392 South St, London, ON N6A 4G5
    J Psychiatry Neurosci 27:350-8. 2002
  4. ncbi request reprint Negative symptoms in first episode non-affective psychosis
    Ashok K Malla
    Department of Psychiatry, University of Western Ontario, Ontario, Canada
    Acta Psychiatr Scand 105:431-9. 2002
  5. ncbi request reprint Status of patients with first-episode psychosis after one year of phase-specific community-oriented treatment
    Ashok K Malla
    University of Western Ontario, Victoria Campus, London, Ontario, Canada
    Psychiatr Serv 53:458-63. 2002
  6. ncbi request reprint A comparison of long-term outcome in first-episode schizophrenia following treatment with risperidone or a typical antipsychotic
    A K Malla
    London Health Sciences Centre, University of Western Ontario, Canada
    J Clin Psychiatry 62:179-84. 2001
  7. ncbi request reprint An integrated medical and psychosocial treatment program for psychotic disorders: patient characteristics and outcome
    A K Malla
    Department of Psychiatry, University of Western Ontario, London
    Can J Psychiatry 43:698-705. 1998
  8. ncbi request reprint Premorbid adjustment in first episode schizophrenia and schizoaffective disorders: a comparison of social and academic domains
    R M G Norman
    Department of Psychiatry, University of Western Ontario, London Health Sciences Centre, Canada
    Acta Psychiatr Scand 112:30-9. 2005
  9. ncbi request reprint Symptoms and cognition as predictors of community functioning: a prospective analysis
    R M Norman
    Department of Psychiatry, London Health Sciences Centre, Ont, Canada
    Am J Psychiatry 156:400-5. 1999
  10. ncbi request reprint Duration of untreated psychosis and cognitive functioning in first-episode patients
    R M Norman
    Prevention and Early Intervention Program, 392 South Street, London, Ontario N6A 4G5, Canada
    Br J Psychiatry 179:340-5. 2001

Collaborators

Detail Information

Publications37

  1. ncbi request reprint Early signs in schizophrenia spectrum disorders
    Ross M G Norman
    Department of Psychiatry, University of Western Ontario, Room 114A, WMCH Building, 392 South Street, London, Ontario, Canada N6A 4G5
    J Nerv Ment Dis 193:17-23. 2005
    ..The latter findings may indicate that patients with more profound indications of affective disturbance or stress have a better prognosis...
  2. ncbi request reprint Delay in treatment for psychosis : its relation to family history
    Ross M G Norman
    Dept of Psychiatry, University of Western Ontario, London ON, Canada
    Soc Psychiatry Psychiatr Epidemiol 42:507-12. 2007
    ..Data were derived from 169 patients who presented for treatment to a first episode psychotic disorders program. Information was collected concerning family history, DUP, DUI and the timing of family recognition of the need for help...
  3. pmc Computed tomography of the brain morphology of patients with first-episode schizophrenic psychosis
    Ashok K Malla
    Department of Psychiatry, University of Western Ontario, London Health Sciences Centre, Victoria Campus, 392 South St, London, ON N6A 4G5
    J Psychiatry Neurosci 27:350-8. 2002
    ....
  4. ncbi request reprint Negative symptoms in first episode non-affective psychosis
    Ashok K Malla
    Department of Psychiatry, University of Western Ontario, Ontario, Canada
    Acta Psychiatr Scand 105:431-9. 2002
    ....
  5. ncbi request reprint Status of patients with first-episode psychosis after one year of phase-specific community-oriented treatment
    Ashok K Malla
    University of Western Ontario, Victoria Campus, London, Ontario, Canada
    Psychiatr Serv 53:458-63. 2002
    ..One-year status is reported for a consecutive sample of patients with nonaffective mostly schizophrenic first-episode psychosis who were receiving treatment in this program...
  6. ncbi request reprint A comparison of long-term outcome in first-episode schizophrenia following treatment with risperidone or a typical antipsychotic
    A K Malla
    London Health Sciences Centre, University of Western Ontario, Canada
    J Clin Psychiatry 62:179-84. 2001
    ..The present study examines the relative effectiveness of risperidone and typical antipsychotics in patients being treated for their first episode of schizophrenia...
  7. ncbi request reprint An integrated medical and psychosocial treatment program for psychotic disorders: patient characteristics and outcome
    A K Malla
    Department of Psychiatry, University of Western Ontario, London
    Can J Psychiatry 43:698-705. 1998
    ....
  8. ncbi request reprint Premorbid adjustment in first episode schizophrenia and schizoaffective disorders: a comparison of social and academic domains
    R M G Norman
    Department of Psychiatry, University of Western Ontario, London Health Sciences Centre, Canada
    Acta Psychiatr Scand 112:30-9. 2005
    ..In this paper, we examine the correlates of and prognostic significance of social and academic premorbid adjustment in a sample of 113 patients...
  9. ncbi request reprint Symptoms and cognition as predictors of community functioning: a prospective analysis
    R M Norman
    Department of Psychiatry, London Health Sciences Centre, Ont, Canada
    Am J Psychiatry 156:400-5. 1999
    ..In the current study, the authors used symptom and neurocognitive data to predict subsequent level of functioning in the community...
  10. ncbi request reprint Duration of untreated psychosis and cognitive functioning in first-episode patients
    R M Norman
    Prevention and Early Intervention Program, 392 South Street, London, Ontario N6A 4G5, Canada
    Br J Psychiatry 179:340-5. 2001
    ..The "toxicity" model of duration of untreated psychosis (DUP) suggests that longer DUP will be associated with poorer performance on cognitive tests in first-episode patients...
  11. ncbi request reprint Predictors of service use and social conditions in patients with psychotic disorders
    A K Malla
    Department of Psychiatry, University of Western Ontario, London
    Can J Psychiatry 45:269-73. 2000
    ..To determine independent predictors of outcome on 3 separate dimensions--namely, relapse and service use, employment, and living conditions--in patients with psychotic disorders...
  12. ncbi request reprint Cognitive functioning in stabilized first-episode psychosis patients
    L A Townsend
    Prevention and Early Intervention Program for Psychoses, London Health Science Center, and Department of Psychiatry, University of Western Ontario, 392 South St, London, Ontario, Canada N6A 4G5
    Psychiatry Res 104:119-31. 2001
    ..The most severe deficits reported were on measures of speeded information processing, and level of performance did not distinguish between patients demographically or clinically...
  13. pmc Computed tomographic findings in schizophrenia: relation with symptom dimensions and sex differences
    A K Malla
    Department of Psychiatry, University of Western Ontario, London
    J Psychiatry Neurosci 24:131-8. 1999
    ..This study was conducted to determine the extent and region of brain atrophy in schizophrenia and its relation to symptom syndromes and to patient sex...
  14. ncbi request reprint Impact of phase-specific treatment of first episode of psychosis on Wisconsin Quality of Life Index (client version)
    A K Malla
    Prevention and Early Intervention Psychosis Program, London Health Sciences Centre and University of Western Ontario, London, Ontario, Canada
    Acta Psychiatr Scand 103:355-61. 2001
    ..CONCLUSION: Patients with a first episode of predominantly schizophrenia spectrum psychosis show a highly significant improvement in subjectively assessed quality of life following a year of phase-specific comprehensive treatment...
  15. ncbi request reprint Family history of schizophrenia and the relationship of stress to symptoms: preliminary findings
    R M Norman
    Department of Psychiatry, University of Western Ontario, Ontario, Canada
    Aust N Z J Psychiatry 35:217-23. 2001
    ..In the past this hypothesis has only been tested through manipulations of negative affect in laboratory settings. In this paper we test this hypothesis using longitudinal clinical data...
  16. ncbi request reprint Exploring the longitudinal course of psychotic illness: a case-study approach
    L Cortese
    Department of Psychiatry, University of Western Ontario, London Health Sciences Centre
    Can J Psychiatry 44:881-6. 1999
    ....
  17. ncbi request reprint Duration of untreated psychosis: a critical examination of the concept and its importance
    R M Norman
    Department of Psychiatry, University of Western Ontario, London, Canada
    Psychol Med 31:381-400. 2001
    ..CONCLUSIONS: It is important that there should be more thorough investigations of DUP, its correlates, and the extent to which it does mediate any advantages of earlier intervention...
  18. ncbi request reprint The treatment of negative symptoms: a clinical and methodological study
    Y D Lapierre
    Department of Psychiatry, Royal Ottawa Hospital, Ontario, Canada
    Int Clin Psychopharmacol 14:101-12. 1999
    ..In addition, the design of the study provides a methodology that is appropriate to the study of primary negative symptoms in schizophrenia...
  19. ncbi request reprint Understanding delay in treatment for first-episode psychosis
    R M G Norman
    Department of Psychiatry, University of Western Ontario, London, Ontario, Canada
    Psychol Med 34:255-66. 2004
    ..In this paper we examine the extent to which this represents a delay in individuals contacting health professionals or a delay in receiving treatment once such contact is made...
  20. ncbi request reprint Symptoms, cognition, treatment adherence and functional outcome in first-episode psychosis
    A K Malla
    London Health Sciences Centre, University of Western Ontario, Canada
    Psychol Med 32:1109-19. 2002
    ..The differential strength of correlation between symptoms, cognition and other patient characteristics with community functioning in first-episode psychosis has not been fully investigated...
  21. ncbi request reprint Early premorbid adjustment as a moderator of the impact of duration of untreated psychosis
    Ross M G Norman
    University of Western Ontario and Prevention and Early Intervention Program for Psychoses, WMCH Building, 392 South Street, London, Ontario, Canada N6A 4G5
    Schizophr Res 95:111-4. 2007
    ..Shorter duration of untreated psychosis (DUP) is often correlated with a poorer response to treatment. In this paper we test the hypothesis that the importance of DUP is moderated by early premorbid adjustment...
  22. ncbi request reprint Social support and three-year symptom and admission outcomes for first episode psychosis
    Ross M G Norman
    University of Western Ontario and Prevention and Early Intervention Program for Psychoses, London Health Sciences Centre, Room 114A, WMCH Building, 392 South Street, London, Ontario, Canada
    Schizophr Res 80:227-34. 2005
    ..The relationship of social support to follow-up symptoms and hospitalization was independent of other potential predictors such as gender, age, premorbid adjustment and duration of untreated illness...
  23. ncbi request reprint Persistent psychoses in first episode patients
    Rahul Manchanda
    Prevention and Early Intervention Program for Psychoses PEPP, London Health Sciences Centre, 392 South Street, London, Ontario, Canada N6A 4G5
    Schizophr Res 80:113-6. 2005
    ..Duration of untreated psychoses or untreated illness did not discriminate between the groups...
  24. ncbi request reprint First-episode psychosis, early intervention, and outcome: what have we learned?
    Ashok K Malla
    Department of Psychiatry, McGill University, Montreal, Quebec
    Can J Psychiatry 50:881-91. 2005
    ..This study's objective was to examine the concept of early intervention and the evidence that currently exists to support such a shift in the delivery of care...
  25. ncbi request reprint Social cognitive impairments in first episode psychosis
    Marie Claude Bertrand
    Department of Psychology, University of Montreal, 90 Vincent d Indy Avenue, Montreal, Quebec, Canada H2V 2S9
    Schizophr Res 95:124-33. 2007
    ..However, most have focused on a single aspect of social cognition, namely "theory of mind" and/or included patients with long standing illness...
  26. ncbi request reprint Relationship of neuromotor disturbances to psychosis symptoms in first-episode neuroleptic-naive schizophrenia patients
    Leonardo Cortese
    The University of Western Ontario and Windsor Regional Hospital, Windsor Ontario, Canada
    Schizophr Res 75:65-75. 2005
    ....
  27. ncbi request reprint Duration of untreated psychosis vs. N-acetylaspartate and choline in first episode schizophrenia: a 1H magnetic resonance spectroscopy study at 4.0 Tesla
    Jean Théberge
    Department of Medical Biophysics, University of Western Ontario, London, ON, Canada
    Psychiatry Res 131:107-14. 2004
    ..Increased choline is associated with longer duration of untreated psychosis and could indicate that psychosis-related membrane alterations precede the appearance of NAA reductions observed by studies of chronic schizophrenia...
  28. ncbi request reprint One year outcome in first episode psychosis: influence of DUP and other predictors
    Ashok K Malla
    University of Western Ontario and London Health Sciences Centre, WMCH Building, 375 South Street, London, N6A 4G5, Ontario, Canada
    Schizophr Res 54:231-42. 2002
    ....
  29. ncbi request reprint Examining adherence to medication and substance use as possible confounds of duration of untreated psychosis
    Ross M G Norman
    Department of Psychiatry, London Health Sciences Centre, University of Western Ontario, 392 South Street, London, Ontario N6A 4G5, Canada
    J Nerv Ment Dis 190:331-4. 2002
  30. ncbi request reprint The significance of family history in first-episode schizophrenia spectrum disorder
    Ross M G Norman
    University of Western Ontario, Prevention and Early Intervention Program for Psychosis, London, Ontario, Canada
    J Nerv Ment Dis 195:846-52. 2007
    ..The findings provide evidence that presence of a positive family history in first-episode patients is associated with a more pernicious form of illness...
  31. ncbi request reprint An evaluation of a stress management program for individuals with schizophrenia
    Ross M G Norman
    Department of Psychiatry, University of Western Ontario, London, Ontario, Canada
    Schizophr Res 58:293-303. 2002
    ..It was concluded that training in stress management may provide patients with skills for coping with acute stressors and reduce the likelihood of subsequent acute exacerbation of symptoms with need for hospitalization...
  32. ncbi request reprint Changes in cognitive functioning following comprehensive treatment for first episode patients with schizophrenia spectrum disorders
    Laurel A Townsend
    Department of Psychiatry, University of Western Ontario, 392 South Street, London, Ontario, Canada, N6A 4G5
    Psychiatry Res 113:69-81. 2002
    ..Neither gender nor duration of untreated psychosis were related to the degree of change in cognitive functioning for this sample. The implications of these findings and the impact of early intervention with this population are discussed...
  33. ncbi request reprint Removing barriers to treatment of first-episode psychotic disorders
    Derek J Scholten
    Department of Psychiatry, University of Western Ontario, London, Ontario
    Can J Psychiatry 48:561-5. 2003
    ....
  34. ncbi request reprint Can patients at risk for persistent negative symptoms be identified during their first episode of psychosis?
    Ashok K Malla
    McGill University, Montreal, Quebec, Canada
    J Nerv Ment Dis 192:455-63. 2004
    ..It may therefore be possible to distinguish a subgroup of FEP patients whose primary negative symptoms are likely to persist on the basis of characteristics shown at initial presentation for treatment...
  35. ncbi request reprint Selective abnormal modulation of hippocampal activity during memory formation in first-episode psychosis
    Amelie M Achim
    Brain Imaging Group, Douglas Hospital Research Centre FBC1, 6875 Boul LaSalle, Verdun, QC H4H 1R3, Canada
    Arch Gen Psychiatry 64:999-1014. 2007
    ..Memory is one of the cognitive functions most affected in schizophrenia, with deficits observed from the first episode of psychosis (FEP). Previous studies have indicated that some memory processes may be more affected than others...
  36. ncbi request reprint Longitudinal grey-matter and glutamatergic losses in first-episode schizophrenia
    Jean Théberge
    St Joseph s Health Care, Nuclear Medicine and MR, Room B5 233, 268 Grosvenor Street, London, Ontario N6A 4V2, Canada
    Br J Psychiatry 191:325-34. 2007
    ..Progressive volumetric changes in the brains of people with schizophrenia have been attributed to a number of factors...
  37. ncbi request reprint An interstitial deletion of the long arm of chromosome 21 in a case of a first episode of psychosis
    J Takhar
    Department of Psychiatry, University of Western Ontario, London Health Sciences Centre, London, Ontario, Canada
    Acta Psychiatr Scand 106:71-4; discussion 74-5. 2002
    ..Case of an interstitial deletion of the long arm of chromosome 21 presenting with first episode of psychosis...