Research Topics
| Nizar N MahomedSummaryAffiliation: University of Toronto Country: Canada Publications
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Detail Information
Publications
Improving the postmarket surveillance of total joint arthroplasty devicesNizar N Mahomed
Division of Orthopaedic Surgery, Toronto Western Hospital, University Health Network, University of Toronto, 399 Bathurst St, ECW 1 002, Toronto, Ontario, Canada M5T 2S8 Clinical Epidemiology and Health Care Research Program, Department of Health Administration, University of Toronto, Canada
Open Rheumatol J 2:7-12. 2008..To evaluate the FDA's approval process and postmarket surveillance strategies for THR devices...
Rates and outcomes of primary and revision total hip replacement in the United States medicare populationNizar N Mahomed
Toronto Western Hospital, ON, Canada
J Bone Joint Surg Am 85:27-32. 2003..The objective of this study was to characterize the rates and immediate postoperative outcomes of primary and revision total hip replacement in persons sixty-five years of age and older residing in the United States...
Patients' gender affected physicians' clinical decisions when presented with standardized patients but not for matching paper patientsCornelia M Borkhoff
Centre for Global Health, Institute of Population Health, University of Ottawa, Ontario, Canada
J Clin Epidemiol 62:527-41. 2009..To compare physicians' treatment and referral decisions for total knee arthroplasty (TKA) for standardized patients with matching paper patients...
Asian ethnicity and the prevalence of metabolic syndrome in the osteoarthritic total knee arthroplasty populationRajiv Gandhi
Division of Orthopedic Surgery, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada
J Arthroplasty 25:416-9. 2010..1-3.8; P = .03) times greater odds of MS as compared with those of other ethnicity. Metabolic syndrome is a risk factor for OA, and Asians demonstrate a greater prevalence of MS as compared with whites and blacks in this population...
Relationship between self-reported and performance-based tests in a hip and knee joint replacement populationRajiv Gandhi
Division of Orthopaedic Surgery, University Health Network Department of Surgery, University of Toronto, Toronto, ON, Canada
Clin Rheumatol 28:253-7. 2009..004) and preoperative TUG scores (p < 0.0001). Given low-to-moderate relationship between self-reported and performance-based tools, both tests are needed to assess the true level of patient disability...
Relationship between body habitus and joint leptin levels in a knee osteoarthritis populationRajiv Gandhi
Division of Orthopaedic Surgery, Toronto Western Hospital, University Health Network, 399 Bathurst Street, East Wing 1 439, Toronto, Ontario M5T 2S8, Canada
J Orthop Res 28:329-33. 2010..05). WC may be a more accurate measure of body habitus than BMI in the relationship between the metabolic effects of adipose tissue and OA...
Willingness to go through surgery again validated the WOMAC clinically important difference from THR/TKR surgeryBert M Chesworth
School of Physical Therapy, Faculty of Health Sciences, University of Western Ontario, Elborn College, 1201 Western Road, London, Ontario, Canada
J Clin Epidemiol 61:907-18. 2008..The objective was to determine the clinically important difference (CID) from primary total hip replacement (THR) and total knee replacement (TKR) surgeries using the Western Ontario McMaster University (WOMAC) osteoarthritis index...
The relation between body mass index and waist-hip ratio in knee osteoarthritisRajiv Gandhi
the Division of Orthopaedic Surgery, University Health Network and the Department of Surgery, University of Toronto, Toronto, Ont, Canada
Can J Surg 53:151-4. 2010..Our intent was to examine the relation between waist-hip ratio (WHR) and body mass index (BMI) as a measurement of body habitus in patients with end-stage knee osteoarthritis (OA)...
Quantifying the pain experience in hip and knee osteoarthritisRajiv Gandhi
Division of Orthopedic Surgery, University of Toronto, Toronto, Ontario, Canada
Pain Res Manag 15:224-8. 2010..Furthermore, the impact that mental health symptoms and catastrophizing had on these scales was investigated...
Metabolic syndrome and the incidence of symptomatic deep vein thrombosis following total knee arthroplastyRajiv Gandhi
Division of Orthopedic Surgery, University of Toronto, Toronto, ON, Canada
J Rheumatol 36:2298-301. 2009..We asked if patients with metabolic syndrome undergoing total knee replacement (TKR) have an increased risk for symptomatic deep vein thrombosis (DVT) at 3 months followup...
Antibiotic bone cement and the incidence of deep infection after total knee arthroplastyRajiv Gandhi
Division of Orthopedic Surgery, University of Toronto, Toronto, ON, Canada
J Arthroplasty 24:1015-8. 2009..84). Antibiotic-laden bone cement did not reduce the incidence of deep infection following primary total knee arthroplasty at 1-year follow-up...
Waiting for hip revision surgery: the impact on patient disabilityAileen M Davis
Outcomes and Population Health, Arthritis Community Research and Evaluation Unit, University Health Network, Toronto Western Hospital, University of Toronto, Canada
Can J Surg 51:92-6. 2008..Additionally, the number of patients requiring revision of their initial TJA is increasing. The purpose of this study was to evaluate the wait times and impact of waiting for revision TJA...
Greater perceived helplessness in osteoarthritis predicts outcome of joint replacement surgeryRajiv Gandhi
Division of Orthopedic Surgery, University of Toronto, Toronto, Ontario, Canada
J Rheumatol 36:1507-11. 2009....
Ethnicity and patient's perception of risk in joint replacement surgeryRajiv Gandhi
Division of Orthopedic Surgery, University of Toronto, Toronto, Ontario, Canada
J Rheumatol 35:1664-7. 2008..Despite much evidence showing racial disparities in the use of surgical procedures, it is unknown whether ethnicity affects perception of surgical risk...
Effect of sex and living arrangement on the timing and outcome of joint replacement surgeryRajiv Gandhi
Department of Surgery, University of Toronto, Toronto, Ont
Can J Surg 53:37-41. 2010..We investigated the impact living status (alone or with another person) and sex on the timing and outcomes of hip and knee replacement surgery...
The synovial fluid adiponectin-leptin ratio predicts pain with knee osteoarthritisRajiv Gandhi
Division of Orthopaedic Surgery, Toronto Western Hospital, University Health Network, Department of Surgery, University of Toronto, 399 Bathurst Street, East Wing 1 439, Toronto, ON, M5T 2S8, Canada
Clin Rheumatol 29:1223-8. 2010..03) but not the WOMAC pain scale (p=0.77). A greater A/L ratio was associated with less pain with severe knee OA and this metabolic pathway may represent a target for novel therapeutics...
BMI independently predicts younger age at hip and knee replacementRajiv Gandhi
Division of Orthopaedic Surgery, University Health Network, Toronto, Ontario, Canada
Obesity (Silver Spring) 18:2362-6. 2010..05). Our study indicates that obese patients, especially those with a BMI ≥ 35 kg/m(2), presented for and underwent joint replacement surgery at a younger age as compared to nonobese patients...
Variability in physician opinions about the indications for knee arthroplastyJames G Wright
The Hospital for Sick Children, 555 University Avenue, Toronto, ON, M5G1X8, Canada
J Arthroplasty 26:569-575.e1. 2011..49). Although surgeons and referring physicians vary in their opinion, half of the variability could be attributed to individual physician inconsistency...
Meta-analysis and systematic review of clinical outcomes comparing mobile bearing and fixed bearing total knee arthroplastyHolly Smith
Division of Orthopaedic Surgery, Department of Surgery, University Health Network, University of Toronto, Toronto, Ontario, Canada
J Arthroplasty 26:1205-13. 2011..902, and P = .426 respectively). Similarly, the pooled data for ROM showed no difference between groups (P = .265). The results of this study found no significant differences between clinical outcomes of MB and FB TKA...
Microarray analysis of the infrapatellar fat pad in knee osteoarthritis: relationship with joint inflammationRajiv Gandhi
Toronto Western Hospital, East Wing 1 439, 399 Bathurst Street, Toronto, Ontario M5T 2S8, Canada
J Rheumatol 38:1966-72. 2011..To examine differences in genes involved in fat metabolism, energy homeostasis, adipogenesis, and inflammation between endstage and early-stage knee osteoarthritis (OA) infrapatellar fat pads (IFP)...
Comparison of published orthopaedic trauma trials following registration in Clinicaltrials.govRajiv Gandhi
Toronto Western Hospital EW 1 439, 399 Bathurst Street, Toronto, ON M5T 2S8, Canada
BMC Musculoskelet Disord 12:278. 2011..Our primary objective was to determine publication rates for orthopaedic trauma trials registered with ClinicalTrials.gov. We further evaluated methodological consistency between registration and publication...
Comparison of arthroplasty trial publications after registration in ClinicalTrials.govHolly N Smith
Toronto Western Hospital EW 1 433, Toronto, Ontario, Canada
J Arthroplasty 27:1283-8. 2012..Registration of arthroplasty trials in CTG does not consistently result in publication or disclosure of results. In addition, changes are frequently made to the final presentation of the data that are not reflected in the trial registry...
Metabolic syndrome and the functional outcomes of hip and knee arthroplastyRajiv Gandhi
Division of Orthopedic Surgery, University of Toronto, Toronto, Canada
J Rheumatol 37:1917-22. 2010..We investigated the influence of risk factors of metabolic syndrome (MetS) on patient function before and after hip and knee replacement surgery...
Predicting the longer-term outcomes of total hip replacementRajiv Gandhi
Division of Orthopedic Surgery, University of Toronto, Toronto, Ontario, Canada
J Rheumatol 37:2573-7. 2010..The objective of this study was to identify the patient-level predictors (age, sex, body mass index, mental health, and comorbidity) for a sustained functional outcome at a minimum 1 year of followup after total hip replacement (THR)...
Epidemiology of total knee replacement in the United States Medicare populationNizar N Mahomed
Musculoskeletal Health and Arthritis Program, Toronto Western Hospital, University Health Network, 399 Bathurst Street, University of Toronto, Toronto, Ontario M5T 2S8, Canada
J Bone Joint Surg Am 87:1222-8. 2005..In the United States, blacks and individuals with low income undergo total knee replacement less frequently and generally have higher rates of adverse outcomes following primary knee replacement...
High-flexion implants in primary total knee arthroplasty: a meta-analysisRajiv Gandhi
Division of Orthopedic Surgery, University of Toronto, Canada
Knee 16:14-7. 2009..We asked whether a high-flexion design implant improves patient functional outcomes or range of motion (ROM) after primary knee arthroplasty...
Ethnic differences in the relationship between obesity and joint pain and function in a joint arthroplasty populationRajiv Gandhi
Division of Orthopedic Surgery, University of Toronto, Toronto, Canada
J Rheumatol 35:1874-7. 2008..We investigated the influence of obesity on joint pain and function in Asians as compared to Caucasians with degenerative hip and knee arthritis...
A pilot study of computed tomography-detected asymptomatic pulmonary filling defects after hip and knee arthroplastiesRajiv Gandhi
Toronto Western Hospital, Toronto, Ontario, Canada
J Arthroplasty 27:730-5. 2012..Our study demonstrates a high rate of abnormal MDCT early after lower extremity arthroplasty, the clinical importance of which may be benign...
Inpatient compared with home-based rehabilitation following primary unilateral total hip or knee replacement: a randomized controlled trialNizar N Mahomed
Toronto Western Hospital, University Health Network, 399 Bathurst Street, East Wing 1 435, Toronto, ON M5T 2S8, Canada
J Bone Joint Surg Am 90:1673-80. 2008..We evaluated the effectiveness and cost of care of home-based compared with inpatient rehabilitation following primary total hip or knee joint replacement...
Hydroxyapatite coated femoral stems in primary total hip arthroplasty: a meta-analysisRajiv Gandhi
Division of Orthopedic Surgery, University of Toronto, Ontario, Canada
J Arthroplasty 24:38-42. 2009..072 (95% CI: -0.062 to 0.206), P = .293. The results of this study demonstrate that there are no clinical benefits in the use of HA/porous coating over porous coating alone in primary hip arthroplasty...
Complications after minimally invasive total knee arthroplasty as compared with traditional incision techniques: a meta-analysisRajiv Gandhi
Division of Orthopaedic Surgery, Department of Surgery, University Health Network, University of Toronto, Toronto, Canada
J Arthroplasty 26:29-35. 2011..05) and 0.79 (95% confidence interval, 0.34-1.82; P = .58), respectively. The standard difference in means for Knee Society scores was no different between groups. Minimally invasive knee surgery should be approached with caution...
Topical application of tranexamic acid reduces postoperative blood loss in total knee arthroplasty: a randomized, controlled trialJean Wong
Department of Anesthesia, Toronto Western Hospital, University of Toronto, 2MC 434, 399 Bathurst Street, Toronto, ON M5T 2S8, Canada
J Bone Joint Surg Am 92:2503-13. 2010..The objective of the present trial was to assess the efficacy and safety of the topical application of tranexamic acid on postoperative blood loss in patients undergoing primary unilateral total knee arthroplasty with cement...
Predicting patient dissatisfaction following joint replacement surgeryRajiv Gandhi
Division of Orthopedic Surgery, University of Toronto, Toronto, Ontario, Canada
J Rheumatol 35:2415-8. 2008..The incidence of patient-reported dissatisfaction following total joint arthroplasty can be up to 30%. Our aim was to identify the preoperative patient-level predictors of patient dissatisfaction 1 year after surgery...
In the eye of the beholder: preferences of patients, family physicians, and surgeons for lumbar spinal surgeryS Samuel Bederman
Department of Orthopaedic Surgery, University of California, San Francisco, CA 94143, USA
Spine (Phila Pa 1976) 35:108-15. 2010..Survey to all orthopedic and neurosurgeons, a random sample of family physicians (FPs) and patients in Ontario, Canada...
Functional outcome of total knee arthroplasty after high tibial osteotomyBob Karabatsos
Department of Surgery, Toronto East General Hospital, University of Toronto, Ont
Can J Surg 45:116-9. 2002..To evaluate the functional outcome for patients who undergo total knee arthroplasty (TKA) after high tibial osteotomy (HTO)...
Incorrect use of the student t test in randomized trials of bilateral hip and knee arthroplasty patientsRajiv Gandhi
Division of Orthopaedic Surgery, University Health Network, University of Toronto, Toronto, Ontario, Canada
J Arthroplasty 26:811-6. 2011..The extent to which the incorrect use of this statistical test led to misleading conclusions is uncertain; however, our findings highlight the misuse of statistical tests in the arthroplasty literature...
Expectations of recovery from revision knee replacementViji Venkataramanan
Toronto Rehabilitation Institute, 550 University Avenue, Toronto, Ontario, Canada M5G 2A2
Arthritis Rheum 55:314-21. 2006..03), LOT (P = 0.03), and interaction between concerns about surgery and general health were significant predictors. CONCLUSION: Clinicians need to understand and help patients shape appropriate expectations for recovery from revision TKR...
The effect of patients' sex on physicians' recommendations for total knee arthroplastyCornelia M Borkhoff
Child Health Evaluative Sciences, Research Institute, The Hospital for Sick Children, Toronto, Ontario
CMAJ 178:681-7. 2008..The purpose of our study was to determine whether patients' sex affects physicians' decisions to refer a patient for, or to perform, total knee arthroplasty...
Provider volumes and early outcomes of primary total joint replacement in OntarioJ Michael Paterson
The Institute for Clinical Evaluative Sciences, Toronto, Ont, Canada
Can J Surg 53:175-83. 2010..Given the recent increase in TJR, changing patient characteristics and small sizes of previous Ontario studies, we reassessed whether adverse outcomes of TJR are related to hospital and surgeon procedure volumes...
Rehabilitation services following total joint replacement: a qualitative analysis of key processes and structures to decrease length of stay and increase surgical volumes in Ontario, CanadaCarol Fancott
Toronto Rehabilitation Institute and Department of Health Policy, Management, and Evaluation, University of Toronto, Toronto, ON, Canada
J Eval Clin Pract 16:724-30. 2010....
Comparison of early and delayed fixation of subcapital hip fractures in patients sixty years of age or lessRina Jain
University Health Network, Toronto Western Hospital, Ontario, Canada
J Bone Joint Surg Am 84:1605-12. 2002....
The importance of patient expectations in predicting functional outcomes after total joint arthroplastyNizar N Mahomed
Division of Orthopaedic Surgery, Toronto Western Hospital, University of Toronto, ON, Canada
J Rheumatol 29:1273-9. 2002..Greater understanding of the relationship between expectations and outcomes may improve the process of care and outcomes of TJA...
A single group follow-up study of non-surgical patients seen by physiotherapists working in expanded roles in orthopaedic departments: recall of recommendations, change in exercise and self-efficacyCrystal MacKay
Division of Health Care and Outcomes Research and Arthritis Community Research and Evaluation Unit, Toronto Western Research Institute, Toronto, ON, Canada
BMC Res Notes 5:669. 2012....
The role of surgeon volume on patient outcome in total knee arthroplasty: a systematic review of the literatureRick L Lau
Division of Orthopaedics, Department of Surgery Kingston General Hospital, Queen s University, 76 Stuart St, Nickle 3, Rm 9 309, Kingston, ON K7L 2V7, Canada
BMC Musculoskelet Disord 13:250. 2012....
Lumbar paravertebral nerve block in the management of pain after total hip and knee arthroplasty: a randomized controlled clinical trialEarl R Bogoch
Division of Orthopaedic Surgery, Department of Surgery, St. Michael's Hospital, University of Toronto, Ontario, Canada
J Arthroplasty 17:398-401. 2002..Paravertebral nerve block of the lumbar plexus is an invasive procedure with some risk. Considering the added risk and minimal benefits, routine use of this procedure is not supported...
Incidence rates of dislocation, pulmonary embolism, and deep infection during the first six months after elective total hip replacementCharlotte B Phillips
Robert Breck Brigham Multipurpose Arthritis and Musculoskeletal Diseases Center, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA
J Bone Joint Surg Am 85:20-6. 2003..LEVEL OF EVIDENCE: Prognostic study, Level II-1 (retrospective study). See p. 2 for complete description of levels of evidence...
Early failures of total hip replacement: effect of surgeon volumeElena Losina
Department of Biostatistics, Boston University School of Public Health and Robert B Brigham Arthritis and Musculoskeletal Clinical Research Center, Boston, Massachusetts 02118, USA
Arthritis Rheum 50:1338-43. 2004..To determine whether provider volume is associated with early failures following total hip replacement (THR) requiring revision...
The moving target: a qualitative study of elderly patients' decision-making regarding total joint replacement surgeryJocalyn P Clark
BMJ Publishing Group, BMA House, Tavistock Square, London WC1H 9JR, United Kingdom
J Bone Joint Surg Am 86:1366-74. 2004..This process needs to be considered when developing ways to aid decision-making...
Association between hospital and surgeon procedure volume and the outcomes of total knee replacementJeffrey N Katz
Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Boston, MA 02115, USA
J Bone Joint Surg Am 86:1909-16. 2004..The relationship between hospital and surgeon volume and perioperative outcomes following total knee replacement has received little study...
Association of hospital and surgeon volume of total hip replacement with functional status and satisfaction three years following surgeryJeffrey N Katz
Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, 75 Francis Street, B 3, Boston, MA 02115, USA
Arthritis Rheum 48:560-8. 2003..To evaluate whether hospital volume and surgeon volume of total hip replacements (THRs) are associated with patient-reported functional status and satisfaction with surgery 3 years postoperatively...
Bilateral total knee replacement: staging and pulmonary embolismJane Barrett
Department of Medicine, Dartmouth Medical School, 46 Centerra Parkway, Evergreen Building, Suite 300, Lebanon, NH 03766, USA
J Bone Joint Surg Am 88:2146-51. 2006..A greater risk of pulmonary embolism after simultaneous total knee replacement has been reported by some authors, but little national data are available...
Neighborhoods matter: use of hospitals with worse outcomes following total knee replacement by patients from vulnerable populationsElena Losina
Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA
Arch Intern Med 167:182-7. 2007....
Association of hospital and surgeon procedure volume with patient-centered outcomes of total knee replacement in a population-based cohort of patients age 65 years and olderJeffrey N Katz
Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Arthritis Rheum 56:568-74. 2007..To study the association between procedure volume and patient-centered outcomes such as functional status...
Survival following total hip replacementJane Barrett
Department of Medicine, Section of Biostatistics and Epidemiology, Dartmouth Medical School, Evergreen Building, Suite 300, 46 Centerra Parkway, Lebanon, NH 03766, USA
J Bone Joint Surg Am 87:1965-71. 2005..The purpose of our investigation was to assess whether the association had the characteristics of a causal relationship or whether it might appear to be due to comorbidity or other factors...
