Karen Madsen

Summary

Affiliation: University of Alberta
Country: Canada

Publications

  1. ncbi request reprint Probiotics and the immune response
    Karen Madsen
    University of Alberta, 6146 Dentistry Pharmacy Building, Edmonton, AL, Canada T6G 2C2
    J Clin Gastroenterol 40:232-4. 2006
  2. ncbi request reprint VSL#3 probiotic-mixture induces remission in patients with active ulcerative colitis
    Rodrigo Bibiloni
    Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alberta, Canada
    Am J Gastroenterol 100:1539-46. 2005
  3. doi request reprint Alleviating intestinal ischemia-reperfusion injury in an in vivo large animal model: developing an organ-specific preservation solution
    Payam Salehi
    Department of Surgery, Division of Transplantation, University of Illinois, Chicago, IL, USA
    Transplantation 85:878-84. 2008
  4. ncbi request reprint Probiotic bacteria enhance murine and human intestinal epithelial barrier function
    K Madsen
    Division of Gastroenterology, University of Alberta, Edmonton, Alberta, Canada
    Gastroenterology 121:580-91. 2001
  5. doi request reprint The International Scientific Conference on Probiotics and Prebiotics
    Karen Madsen
    Division of Gastroenterology, Department of Medicine, University of Alberta, 7 142 Katz Group Center, Edmonton, AB T6G 2N1, Canada
    Expert Rev Gastroenterol Hepatol 5:571-3. 2011
  6. doi request reprint Probiotics in critically ill patients
    Karen Madsen
    Department of Medicine, Division of Gastroenterology, University of Alberta, Edmonton, Alberta, Canada
    J Clin Gastroenterol 42:S116-8. 2008
  7. ncbi request reprint Normal Breast Milk Limits the Development of Colitis in IL-10-Deficient Mice
    Karen L Madsen
    Department of Medicine, University of Alberta, Edmonton, Canada
    Inflamm Bowel Dis 8:390-8. 2002
  8. ncbi request reprint The use of probiotics in gastrointestinal disease
    K L Madsen
    University of Alberta, Edmonton, Alberta, Canada
    Can J Gastroenterol 15:817-22. 2001
  9. ncbi request reprint Probiotic bacteria prevent hepatic damage and maintain colonic barrier function in a mouse model of sepsis
    Julia Ewaschuk
    Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    Hepatology 46:841-50. 2007
  10. doi request reprint Small bowel fibrosis and systemic inflammatory response after ileocolonic anastomosis in IL-10 null mice
    Anna M Borowiec
    Department of Surgery, University of Alberta, 2 14A Zeidler Building, Edmonton, T6G 2X8 Alberta, Canada
    J Surg Res 178:147-54. 2012

Collaborators

Detail Information

Publications38

  1. ncbi request reprint Probiotics and the immune response
    Karen Madsen
    University of Alberta, 6146 Dentistry Pharmacy Building, Edmonton, AL, Canada T6G 2C2
    J Clin Gastroenterol 40:232-4. 2006
    ..Both innate and adaptive immune responses can be modulated by probiotic bacteria...
  2. ncbi request reprint VSL#3 probiotic-mixture induces remission in patients with active ulcerative colitis
    Rodrigo Bibiloni
    Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alberta, Canada
    Am J Gastroenterol 100:1539-46. 2005
    ..We evaluated the safety and efficacy of VSL#3 and the components, and the composition of the biopsy-associated microbiota in patients with active mild to moderate ulcerative colitis (UC)...
  3. doi request reprint Alleviating intestinal ischemia-reperfusion injury in an in vivo large animal model: developing an organ-specific preservation solution
    Payam Salehi
    Department of Surgery, Division of Transplantation, University of Illinois, Chicago, IL, USA
    Transplantation 85:878-84. 2008
    ..This study investigated the role of a novel nutrient-rich preservation solution in alleviating intestinal ischemia-reperfusion (IR) injury in a large animal model...
  4. ncbi request reprint Probiotic bacteria enhance murine and human intestinal epithelial barrier function
    K Madsen
    Division of Gastroenterology, University of Alberta, Edmonton, Alberta, Canada
    Gastroenterology 121:580-91. 2001
    ..The aim of this study was to determine the efficacy of VSL#3 as a primary therapy in the treatment of colitis in the interleukin (IL)-10 gene-deficient mouse. Mechanisms of action of VSL#3 were investigated in T(84) monolayers...
  5. doi request reprint The International Scientific Conference on Probiotics and Prebiotics
    Karen Madsen
    Division of Gastroenterology, Department of Medicine, University of Alberta, 7 142 Katz Group Center, Edmonton, AB T6G 2N1, Canada
    Expert Rev Gastroenterol Hepatol 5:571-3. 2011
    ....
  6. doi request reprint Probiotics in critically ill patients
    Karen Madsen
    Department of Medicine, Division of Gastroenterology, University of Alberta, Edmonton, Alberta, Canada
    J Clin Gastroenterol 42:S116-8. 2008
    ..Results from these clinical trials are encouraging, and warrant further investigation to clarify which probiotic bacterial strains are of most benefit to this population...
  7. ncbi request reprint Normal Breast Milk Limits the Development of Colitis in IL-10-Deficient Mice
    Karen L Madsen
    Department of Medicine, University of Alberta, Edmonton, Canada
    Inflamm Bowel Dis 8:390-8. 2002
    ..This study examined the role of breast milk in neonatal bacterial colonization of the colon and disease progression in IL-10-deficient mice...
  8. ncbi request reprint The use of probiotics in gastrointestinal disease
    K L Madsen
    University of Alberta, Edmonton, Alberta, Canada
    Can J Gastroenterol 15:817-22. 2001
    ..In addition, well planned and controlled clinical studies are necessary to delineate fully the potential for probiotic compounds...
  9. ncbi request reprint Probiotic bacteria prevent hepatic damage and maintain colonic barrier function in a mouse model of sepsis
    Julia Ewaschuk
    Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    Hepatology 46:841-50. 2007
    ..The inhibition of PPARgamma with GW9662 abrogated the protection induced by probiotics. CONCLUSION: Orally administered probiotics prevented liver and intestinal damage in a mouse model of sepsis through a PPARgamma-dependent mechanism...
  10. doi request reprint Small bowel fibrosis and systemic inflammatory response after ileocolonic anastomosis in IL-10 null mice
    Anna M Borowiec
    Department of Surgery, University of Alberta, 2 14A Zeidler Building, Edmonton, T6G 2X8 Alberta, Canada
    J Surg Res 178:147-54. 2012
    ..The purpose of this study was to examine the bacterial, local, and systemic immune changes that follow ileocolonic anastomosis in a rodent model of Crohn's disease, the interleukin-10 gene-deficient (IL-10 null) mice...
  11. ncbi request reprint DNA from probiotic bacteria modulates murine and human epithelial and immune function
    Humberto Jijon
    Division of Gastroenterology, University of Alberta, Edmonton, Alberta, Canada T6G 2N8
    Gastroenterology 126:1358-73. 2004
    ..The intestinal epithelium must discriminate between pathogenic and nonpathogenic bacteria and respond accordingly. The aim of this study was to examine whether bacterial DNA can serve as the molecular basis for bacterial recognition...
  12. doi request reprint Probiotic preparation VSL#3 induces remission in children with mild to moderate acute ulcerative colitis: a pilot study
    Hien Q Huynh
    Division of Pediatric Gastroenterology and Nutrition, Department of Pediatrics, University of Alberta, Stollery Children s Hospital, Edmonton, Alberta, Canada
    Inflamm Bowel Dis 15:760-8. 2009
    ..We evaluated the clinical efficacy and safety profile of probiotic preparation VSL#3 in the treatment of mild to moderate acute UC in the pediatric population...
  13. doi request reprint Effects of probiotic therapy on portal pressure in patients with cirrhosis: a pilot study
    Puneeta Tandon
    Department of Medicine, University of Alberta, Edmonton, AB, Canada
    Liver Int 29:1110-5. 2009
    ..The objective of this study was to determine whether the probiotic VSL#3 would reduce portal pressure in patients with cirrhosis...
  14. ncbi request reprint MAP kinases contribute to IL-8 secretion by intestinal epithelial cells via a posttranscriptional mechanism
    Humberto B Jijon
    Gastrointestinal Research Group, University of Calgary, Calgary T2N 4N1, Canada T6G 2C2
    Am J Physiol Cell Physiol 283:C31-41. 2002
    ....
  15. ncbi request reprint Serum amyloid A activates NF-kappaB and proinflammatory gene expression in human and murine intestinal epithelial cells
    Humberto B Jijon
    Gastrointestinal Research Unit, University of Alberta, Edmonton, Canada
    Eur J Immunol 35:718-26. 2005
    ..This indicates that SAA potentially participate in the inflammatory process by virtue of its ability to activate proinflammatory signaling in IEC...
  16. ncbi request reprint Probiotics and the management of inflammatory bowel disease
    Richard N Fedorak
    Division of Gastroenterology, University of Alberta, Edmonton, Alberta, Canada
    Inflamm Bowel Dis 10:286-99. 2004
    ....
  17. doi request reprint Mind the gaps: confocal endomicroscopy showed increased density of small bowel epithelial gaps in inflammatory bowel disease
    Julia J Liu
    Department of Medicine, Division of Gastroenterology, University of Alberta, Edmonton, Canada
    J Clin Gastroenterol 45:240-5. 2011
    ..We also determined the density of epithelial gaps in a mouse model of inflammatory bowel disease-interleukin-10-deficient (IL-10) mice, versus the background strain using rigid probe confocal endomicroscopy...
  18. pmc cis-Urocanic acid attenuates acute dextran sodium sulphate-induced intestinal inflammation
    Eric Albert
    Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    PLoS ONE 5:e13676. 2010
    ..This provides further evidence for a possible role for sunlight exposure in modulating inflammatory disorders...
  19. pmc Inflammation and epithelial cell injury in AIDS enteropathy: involvement of endoplasmic reticulum stress
    Ferdinand Maingat
    Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    FASEB J 25:2211-20. 2011
    ..Lentivirus infections cause gut inflammation and ensuing damage to intestinal epithelial cells, likely through induction of ER stress pathways, resulting in disruption of gut functional integrity...
  20. ncbi request reprint Effects of probiotic therapy in critically ill patients: a randomized, double-blind, placebo-controlled trial
    Cathy Alberda
    Royal Alexandra Hospital, Edmonton, Canada, University of Alberta, Edmonton, Canada
    Am J Clin Nutr 85:816-23. 2007
    ..A breakdown in gut barrier function and immune dysfunction are associated with the onset of MODS. Probiotic bacteria have been shown to modulate intestinal barrier and immune function...
  21. ncbi request reprint The role of antibiotic and probiotic therapies in current and future management of inflammatory bowel disease
    Julia B Ewaschuk
    Division of Gastroenterology, Zeidler Family Gastrointestinal Health and Research Centre, Zeidler Ledcor Building, 130 University Campus, Edmonton, AB, Canada T6G 2C8
    Curr Gastroenterol Rep 8:486-98. 2006
    ..This article summarizes studies evaluating the efficacy of antibiotics and probiotics in the induction and maintenance of remission of ulcerative colitis, Crohn's disease, and pouchitis...
  22. ncbi request reprint Antisense oligonucleotides to poly(ADP-ribose) polymerase-2 ameliorate colitis in interleukin-10-deficient mice
    Ian Popoff
    Division of Gastroenterology, University of Alberta, Edmonton, Alberta, Canada
    J Pharmacol Exp Ther 303:1145-54. 2002
    ..Our data demonstrate that selective inhibition of PARP-2 activity results in a marked improvement of colonic inflammatory disease in a mouse model of chronic colitis and a normalization of colonic function...
  23. ncbi request reprint Activation of AMP-activated protein kinase reduces cAMP-mediated epithelial chloride secretion
    John Walker
    Univ of Alberta, 6146 Dentistry Pharmacy Bldg, Edmonton, AB, Canada T6G 2C2
    Am J Physiol Gastrointest Liver Physiol 285:G850-60. 2003
    ..In conclusion, AMPK activation is linked with reductions in cAMP-mediated epithelial chloride flux and may be a contributing factor to the hyporesponsiveness seen under conditions of chronic inflammation...
  24. ncbi request reprint Citrobacter rodentium infection causes both mitochondrial dysfunction and intestinal epithelial barrier disruption in vivo: role of mitochondrial associated protein (Map)
    Caixia Ma
    Division of Gastroenterology, BC s Children s Hospital, Vancouver, BC, Canada
    Cell Microbiol 8:1669-86. 2006
    ..rodentium...
  25. ncbi request reprint The role of enteric microflora in inflammatory bowel disease: human and animal studies with probiotics and prebiotics
    Kevin P Rioux
    Department of Medicine, Division of Gastroenterology, University of Alberta, Edmonton, Alberta T6G 2C8, Canada
    Gastroenterol Clin North Am 34:465-82, ix. 2005
  26. doi request reprint Secreted bioactive factors from Bifidobacterium infantis enhance epithelial cell barrier function
    Julia B Ewaschuk
    Univ of Alberta, Edmonton, Alberta, Canada T6G 2N8
    Am J Physiol Gastrointest Liver Physiol 295:G1025-34. 2008
    ..The effects of BiCM are mediated in part by changes in MAP kinases and tight junction proteins...
  27. ncbi request reprint Adenosine is a negative regulator of NF-kappaB and MAPK signaling in human intestinal epithelial cells
    Humberto B Jijon
    Gastrointestinal Research Unit, University of Alberta, Edmonton, Alberta, Canada T6G 2N8
    Cell Immunol 237:86-95. 2005
    ..The observed effects in this study occurred independently of known surface adenosine receptors. This study identifies adenosine as a potent negative regulator of pro-inflammatory signaling in intestinal epithelial cells...
  28. pmc Surface expression of Toll-like receptor 9 is upregulated on intestinal epithelial cells in response to pathogenic bacterial DNA
    Julia B Ewaschuk
    Division of Gastroenterology, University of Alberta, Edmonton, Alberta T6G 2N8, Canada
    Infect Immun 75:2572-9. 2007
    ....
  29. ncbi request reprint Control of oxidative stress in small bowel: relevance to organ preservation
    Payam Salehi
    Surgical Medical Research Institute, 1074 Dentistry Pharmacy Building, University of Alberta, Edmonton, Alberta, Canada T6G 2N8
    Surgery 139:317-23. 2006
    ..We hypothesized that oxidative catabolism facilitated by a proven amino acid-based (AA) storage solution promotes oxidative stress; furthermore, there is an important role for antioxidant supplementation during cold storage...
  30. ncbi request reprint Probiotics and nutraceuticals: non-medicinal treatments of gastrointestinal diseases
    Robert Penner
    Division of Gastroenterology, University of Alberta, 6146 Dentistry Pharmacy, Edmonton, Alberta T6G 2N8, Canada
    Curr Opin Pharmacol 5:596-603. 2005
    ..Scientific studies are providing mechanisms of action to explain the therapeutic effects, and randomized controlled trials are providing the necessary evidence for their incorporation into the therapeutic armamentarium...
  31. pmc 5-aminoimidazole-4-carboxamide riboside (AICAR) enhances GLUT2-dependent jejunal glucose transport: a possible role for AMPK
    John Walker
    Division of Gastroenterology, University of Alberta, 6146 Dentistry Pharmacy Building, Edmonton, Alberta, Canada T6G 2C2
    Biochem J 385:485-91. 2005
    ..We conclude that the activation of AMPK results in an up-regulation of non-energy requiring glucose uptake by GLUT2 and a concurrent down-regulation of sodium-dependent glucose transport...
  32. ncbi request reprint Postoperative Crohn's disease
    Robert M Penner
    Division of Gastroenterology, Department of Medicine, University of Alberta, Edmonton, Canada
    Inflamm Bowel Dis 11:765-77. 2005
    ..Despite the many limitations in current knowledge of postoperative CD, it is an exciting field because new developments have improved patient care, and ongoing research has the potential for further gains...
  33. ncbi request reprint Bioproduction of conjugated linoleic acid by probiotic bacteria occurs in vitro and in vivo in mice
    Julia B Ewaschuk
    Division of Gastroenterology, University of Alberta, Edmonton, Alberta, Canada
    J Nutr 136:1483-7. 2006
    ..This study supports a role for supplemental probiotics as a strategy both for attenuating inflammation and for preventing colon cancer...
  34. doi request reprint Estrogen receptor-β signaling modulates epithelial barrier function
    Mirjam Looijer-van Langen
    Division of Gastroenterology, Department of Medicine, University of Alberta, Edmonton, Canada
    Am J Physiol Gastrointest Liver Physiol 300:G621-6. 2011
    ..This study suggests a potential role for ERβ signaling in the modulation of epithelial permeability and demonstrates reduced ERβ mRNA in animal models of colitis and colon of patients with inflammatory bowel disease...
  35. ncbi request reprint Human small bowel storage: the role for luminal preservation solutions
    David W Olson
    Surgical Medical Research Institute, University of Alberta, Edmonton, Alberta, Canada
    Transplantation 76:709-14. 2003
    ..We investigated the role for the luminal administration of preservation solutions in a small animal model, documenting significantly improved graft quality. The current study addresses direct clinical applicability using human SB...
  36. ncbi request reprint Defining the role of a tailored luminal solution for small bowel preservation
    Yasuhiro Fujimoto
    Surgical Medical Research Institute, University of Alberta, Edmonton, Canada
    Am J Transplant 2:229-36. 2002
    ..This study documents that a luminal-delivered solution, formulated on physiologic SB requirements, provides targeted preservation of the SB mucosa...
  37. ncbi request reprint Intestinal decontamination using povidone-iodine compromises small bowel storage quality
    David W Olson
    Surgical Medical Research Institute, University of Alberta, Edmonton, Canada
    Transplantation 75:1460-2. 2003
    ..Povidone-iodine (PI) (Betadine, Purdue Fredrick Co., Norwalk, CT) is used during pancreas transplantation to provide duodenal decontamination without any intestinal complications...
  38. ncbi request reprint The bacteriology of biopsies differs between newly diagnosed, untreated, Crohn's disease and ulcerative colitis patients
    Rodrigo Bibiloni
    Department of Agricultural, Food and Nutritional Science, University of Otago, PO Box 56, Dunedin, New Zealand
    J Med Microbiol 55:1141-9. 2006
    ..The observations made in this study should permit targeting of specific bacteriological abnormalities in investigations of the pathogenesis of inflammatory bowel diseases and provide targets for medical interventions...