I R A Mackenzie

Summary

Affiliation: University of British Columbia
Country: Canada

Publications

  1. ncbi The relationship between extramotor ubiquitin-immunoreactive neuronal inclusions and dementia in motor neuron disease
    Ian R A Mackenzie
    Department of Pathology, University of British Columbia, Vancouver General Hospital, 855 West 12th Avenue, Canada V5Z 1M9
    Acta Neuropathol 105:98-102. 2003
  2. ncbi The neuropathology of frontotemporal lobar degeneration caused by mutations in the progranulin gene
    Ian R A Mackenzie
    Department of Pathology and Laboratory Medicine, University of British Columbia and Vancouver Coastal Health Vancouver, BC, Canada
    Brain 129:3081-90. 2006
  3. ncbi Manson's schistosomiasis presenting as a brain tumor. Case report
    I R Mackenzie
    Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada
    J Neurosurg 89:1052-4. 1998
  4. ncbi Anti-inflammatory drugs and Alzheimer-type pathology in aging
    I R Mackenzie
    Department of Pathology and Laboratory Medicine, Vancouver General Hospital and the University of British Columbia, Canada
    Neurology 54:732-4. 2000
  5. ncbi Postmortem studies of the effect of anti-inflammatory drugs on Alzheimer-type pathology and associated inflammation
    I R Mackenzie
    Department of Pathology and Laboratory Medicine, Vancouver General Hospital and the University of British Columbia, Vancouver, BC, Canada
    Neurobiol Aging 22:819-22. 2001
  6. ncbi Neuronal intranuclear inclusions distinguish familial FTD-MND type from sporadic cases
    Ian R A Mackenzie
    Department of Pathology, Vancouver General Hospital, 855 West 12th Avenue, V5Z 1M9, Vancouver, British Columbia, Canada
    Acta Neuropathol 105:543-8. 2003
  7. ncbi Extrapyramidal features in patients with motor neuron disease and dementia; a clinicopathological correlative study
    Ian R Mackenzie
    Department of Pathology, Vancouver General Hospital and University of British Columbia, 855 West 12th Avenue, V5Z 1M9, Vancouver, British Columbia, Canada
    Acta Neuropathol 107:336-40. 2004
  8. ncbi Neurofilament inclusion body disease with early onset frontotemporal dementia and primary lateral sclerosis
    I R A Mackenzie
    Division of Neuropathology, Department of Pathology, University of British Columbia, Vancouver, Canada
    Clin Neuropathol 23:183-93. 2004
  9. ncbi Neuronal intranuclear inclusions distinguish familial FTD-MND type from sporadic cases
    Ian R A Mackenzie
    Department of Pathology, University of British Columbia, Vancouver, Canada
    Dement Geriatr Cogn Disord 17:333-6. 2004
  10. doi Progranulin expression in the developing and adult murine brain
    Terri L Petkau
    Centre for Molecular Medicine and Therapeutics, Department of Medical Genetics, University of British Columbia, and Children s and Women s Hospital, Vancouver, BC, Canada V5Z 4H4
    J Comp Neurol 518:3931-47. 2010

Detail Information

Publications29

  1. ncbi The relationship between extramotor ubiquitin-immunoreactive neuronal inclusions and dementia in motor neuron disease
    Ian R A Mackenzie
    Department of Pathology, University of British Columbia, Vancouver General Hospital, 855 West 12th Avenue, Canada V5Z 1M9
    Acta Neuropathol 105:98-102. 2003
    ..Such cases may either represent a subclinical stage of pathology or indicate that cognitive dysfunction is an underrecognized complication of MND...
  2. ncbi The neuropathology of frontotemporal lobar degeneration caused by mutations in the progranulin gene
    Ian R A Mackenzie
    Department of Pathology and Laboratory Medicine, University of British Columbia and Vancouver Coastal Health Vancouver, BC, Canada
    Brain 129:3081-90. 2006
    ..These findings suggest that FTD caused by PGRN mutations has a recognizable pathology with the most characteristic feature being ub-ir NII...
  3. ncbi Manson's schistosomiasis presenting as a brain tumor. Case report
    I R Mackenzie
    Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada
    J Neurosurg 89:1052-4. 1998
    ..This case demonstrates that neuroschistosomiasis should be considered when an individual presenting with an intracerebral mass has lived in a region in which this disease is endemic...
  4. ncbi Anti-inflammatory drugs and Alzheimer-type pathology in aging
    I R Mackenzie
    Department of Pathology and Laboratory Medicine, Vancouver General Hospital and the University of British Columbia, Canada
    Neurology 54:732-4. 2000
    ....
  5. ncbi Postmortem studies of the effect of anti-inflammatory drugs on Alzheimer-type pathology and associated inflammation
    I R Mackenzie
    Department of Pathology and Laboratory Medicine, Vancouver General Hospital and the University of British Columbia, Vancouver, BC, Canada
    Neurobiol Aging 22:819-22. 2001
    ..The results of these and future postmortem studies will be invaluable in the development of optimum treatment strategies...
  6. ncbi Neuronal intranuclear inclusions distinguish familial FTD-MND type from sporadic cases
    Ian R A Mackenzie
    Department of Pathology, Vancouver General Hospital, 855 West 12th Avenue, V5Z 1M9, Vancouver, British Columbia, Canada
    Acta Neuropathol 105:543-8. 2003
    ....
  7. ncbi Extrapyramidal features in patients with motor neuron disease and dementia; a clinicopathological correlative study
    Ian R Mackenzie
    Department of Pathology, Vancouver General Hospital and University of British Columbia, 855 West 12th Avenue, V5Z 1M9, Vancouver, British Columbia, Canada
    Acta Neuropathol 107:336-40. 2004
    ..This study illustrates the utility of ubiquitin immunohistochemistry in demonstrating the range of pathology in MND and provides a neuropathological correlate for the extrapyramidal features which may occur in MND with dementia...
  8. ncbi Neurofilament inclusion body disease with early onset frontotemporal dementia and primary lateral sclerosis
    I R A Mackenzie
    Division of Neuropathology, Department of Pathology, University of British Columbia, Vancouver, Canada
    Clin Neuropathol 23:183-93. 2004
    ..In addition, it extends the clinical phenotype of NIBD to include PLS and better defines the anatomical distribution and morphology of the pathological lesions...
  9. ncbi Neuronal intranuclear inclusions distinguish familial FTD-MND type from sporadic cases
    Ian R A Mackenzie
    Department of Pathology, University of British Columbia, Vancouver, Canada
    Dement Geriatr Cogn Disord 17:333-6. 2004
    ....
  10. doi Progranulin expression in the developing and adult murine brain
    Terri L Petkau
    Centre for Molecular Medicine and Therapeutics, Department of Medical Genetics, University of British Columbia, and Children s and Women s Hospital, Vancouver, BC, Canada V5Z 4H4
    J Comp Neurol 518:3931-47. 2010
    ..Our results suggest that progranulin plays distinct roles in neurons and microglia, both of which likely contribute to overall neuronal health and function...
  11. ncbi The molecular genetics and neuropathology of frontotemporal lobar degeneration: recent developments
    Ian R A Mackenzie
    Department of Pathology, Vancouver General Hospital, 855 West 12th Avenue, Vancouver, BC, V5Z 1M9, Canada
    Neurogenetics 8:237-48. 2007
    ..It is anticipated that these discoveries will facilitate the development of new diagnostic tests and therapeutics...
  12. pmc TDP-43 in familial and sporadic frontotemporal lobar degeneration with ubiquitin inclusions
    Nigel J Cairns
    MRCPath, Department of Pathology and Immunology, Washington University School of Medicine, Campus Box 8118, St Louis, MO 63110, USA
    Am J Pathol 171:227-40. 2007
    ....
  13. pmc Neuropathologic diagnostic and nosologic criteria for frontotemporal lobar degeneration: consensus of the Consortium for Frontotemporal Lobar Degeneration
    Nigel J Cairns
    Department of Neurology, Washington University School of Medicine, Campus Box 8118, 660 South Euclid Avenue, St Louis, MO, 63110, USA
    Acta Neuropathol 114:5-22. 2007
    ..These criteria will be of value to the practicing neuropathologist and provide a foundation for clinical, clinico-pathologic, mechanistic studies and in vivo models of pathogenesis of FTLD...
  14. doi Atypical frontotemporal lobar degeneration with ubiquitin-positive, TDP-43-negative neuronal inclusions
    Ian R A Mackenzie
    Department of Pathology, University of British Columbia, Vancouver General Hospital, 855 West 12th Avenue, Vancouver, British Columbia, V5Z 1M9 Canada
    Brain 131:1282-93. 2008
    ..Moreover, the existence of such cases indicates that the designations of 'FTLD-U' and 'TDP-43 proteinopathy' should not be considered to be synonymous...
  15. ncbi Ubiquitinated pathological lesions in frontotemporal lobar degeneration contain the TAR DNA-binding protein, TDP-43
    Yvonne Davidson
    Clinical Neuroscience Research Group, Division of Medicine and Neuroscience, Greater Manchester Neurosciences Centre, Hope Hospital, University of Manchester, Salford, M6 8HD, UK
    Acta Neuropathol 113:521-33. 2007
    ..We conclude that the UBQ-ir lesions of FTLD and MND are defined by the presence of TDP-43, and that these disorders can be subsumed into a single disease entity under the umbrella of TDP-43 proteinopathy...
  16. ncbi Mutations in progranulin explain atypical phenotypes with variants in MAPT
    Stuart M Pickering-Brown
    Brain 129:3124-6. 2006
    ..Here, we demonstrate that the MAPT variants are almost certainly rare benign polymorphisms as all of these cases harbour mutations in Progranulin (PGRN). Mutations in PGRN were recently shown to cause ubiquitin-positive FTDP-17...
  17. ncbi The neuropathology and biochemistry of frontotemporal dementia
    David G Munoz
    Department of Pathology, University of Western Ontario, London, Ontario, Canada
    Ann Neurol 54:S24-8. 2003
  18. pmc Heterogeneity of ubiquitin pathology in frontotemporal lobar degeneration: classification and relation to clinical phenotype
    Ian R A Mackenzie
    Department of Pathology, Vancouver General Hospital, V5Z 1M9, Vancouver, BC, Canada
    Acta Neuropathol 112:539-49. 2006
    ....
  19. ncbi Dementia lacking distinctive histology (DLDH) revisited
    Ian R A Mackenzie
    Department of Pathology, Vancouver General Hospital, Vancouver, BC, Canada
    Acta Neuropathol 112:551-9. 2006
    ..Hence, we conclude that DLDH is a very rare disorder, and that lack of sensitivity for UBQ immunostaining is likely responsible for the failure to disclose this pathology and to provide a diagnosis of FTLD-U...
  20. ncbi Ubiquitin immunohistochemistry suggests classic motor neuron disease, motor neuron disease with dementia, and frontotemporal dementia of the motor neuron disease type represent a clinicopathologic spectrum
    Ian R A Mackenzie
    Division of Neuropathology, University of British Columbia, Vancouver, Canada
    J Neuropathol Exp Neurol 64:730-9. 2005
    ..The only finding restricted to a specific subgroup of patients was the presence of ub-ir neuronal intranuclear inclusions in some cases of familial FTD...
  21. doi TDP-43-negative FTLD-U is a significant new clinico-pathological subtype of FTLD
    Sigrun Roeber
    Center for Neuropathology and Prion Research, Ludwig Maximilians University Munich, Feodor Lynen Str 23, 81377, Munich, Germany
    Acta Neuropathol 116:147-57. 2008
    ..The highly consistent clinical and neuropathological phenotype supports the concept that TDP-43-negative FTLD-U should be considered as a new clinicopathological FTLD entity...
  22. ncbi A reassessment of the neuropathology of frontotemporal dementia linked to chromosome 3
    Ida Elisabeth Holm
    Department of Pathology, Aalborg Hospital, Aarhus University Hospital, Aalborg, Denmark
    J Neuropathol Exp Neurol 66:884-91. 2007
    ....
  23. doi Clinical presentation of prodromal frontotemporal dementia
    Bradley J Hallam
    Division of Neurology, Geriatric Psychiatry Outreach Team, Vancouver Hospital, Vancouver, British Columbia
    Am J Alzheimers Dis Other Demen 22:456-67. 2007
    ....
  24. ncbi The neuropathology of FTD associated With ALS
    Ian R A Mackenzie
    Department of Pathology, University of British Columbia and Vancouver General Hospital, British Columbia, Canada
    Alzheimer Dis Assoc Disord 21:S44-9. 2007
    ..Together, these findings suggest that FTD-ALS is part of a clinicopathologic spectrum of disease, now identified as TDP-43 proteinopathies...
  25. ncbi Pathological TDP-43 distinguishes sporadic amyotrophic lateral sclerosis from amyotrophic lateral sclerosis with SOD1 mutations
    Ian R A Mackenzie
    Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada
    Ann Neurol 61:427-34. 2007
    ..We recently identified TDP-43 as the major pathological protein in sporadic ALS. In this study, we investigated TDP-43 in a larger series of ALS cases (n = 111), including familial cases with and without SOD1 mutations...
  26. ncbi The neuropathology and clinical phenotype of FTD with progranulin mutations
    Ian R A Mackenzie
    Department of Pathology, Vancouver General Hospital, 855 West 12th Avenue, Vancouver, BC, Canada
    Acta Neuropathol 114:49-54. 2007
    ..This degree of clinical variability makes it difficult to predict which cases of familial FTD will turn out to have a PGRN mutation...
  27. pmc Progranulin in frontotemporal lobar degeneration and neuroinflammation
    Zeshan Ahmed
    Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, FL, USA
    J Neuroinflammation 4:7. 2007
    ....
  28. pmc alpha-internexin is present in the pathological inclusions of neuronal intermediate filament inclusion disease
    Nigel J Cairns
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 4283, USA
    Am J Pathol 164:2153-61. 2004
    ..The discovery of alpha-internexin in the cytoplasmic inclusions implicates novel mechanisms of pathogenesis in NIFID and other neurological diseases with pathological accumulations of IFs...
  29. pmc alpha-Internexin aggregates are abundant in neuronal intermediate filament inclusion disease (NIFID) but rare in other neurodegenerative diseases
    Nigel J Cairns
    Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, 3600 Spruce Street, Philadelphia, PA 19104 4283, USA
    Acta Neuropathol 108:213-23. 2004
    ..The discovery of alpha-internexin in neuronal cytoplasmic inclusions implicates novel mechanisms of pathogenesis in NIFID and other neurological diseases with pathological filamentous neuronal inclusions...