Helen J Mackay

Summary

Affiliation: University of Toronto
Country: Canada

Publications

  1. pmc The Emerging Role of PARP Inhibitors in the Treatment of Epithelial Ovarian Cancer
    Lilian T Gien
    Princess Margaret Hospital, University of Toronto, Toronto, ON, Canada M5G 2M9
    J Oncol 2010:151750. 2010
  2. doi request reprint A phase II trial of the Src kinase inhibitor saracatinib (AZD0530) in patients with metastatic or locally advanced gastric or gastro esophageal junction (GEJ) adenocarcinoma: a trial of the PMH phase II consortium
    Helen J Mackay
    Department of Medical Oncology, Princess Margaret Hospital, University of Toronto, Ontario, Canada
    Invest New Drugs 30:1158-63. 2012
  3. pmc Phase II trial of the histone deacetylase inhibitor belinostat in women with platinum resistant epithelial ovarian cancer and micropapillary (LMP) ovarian tumours
    Helen J Mackay
    Princess Margaret Phase II Consortium, Toronto, Canada
    Eur J Cancer 46:1573-9. 2010
  4. doi request reprint Evaluation of pandemic H1N1 (2009) influenza vaccine in adults with solid tumor and hematological malignancies on active systemic treatment
    Helen J Mackay
    Princess Margaret Hospital, 610 University Ave, Toronto, ON M5G 2M9, Canada
    J Clin Virol 50:212-6. 2011
  5. doi request reprint A phase II study of sunitinib in patients with locally advanced or metastatic cervical carcinoma: NCIC CTG Trial IND.184
    Helen J Mackay
    Department of Medical Oncology, Princess Margaret Hospital, University of Toronto, Ontario M5G 2M9, Canada
    Gynecol Oncol 116:163-7. 2010
  6. doi request reprint Other new targets
    Helen J Mackay
    Princess Margaret Hospital, University of Toronto, 610 University Ave, Toronto, Ontario, Canada
    Int J Gynecol Cancer 19:S49-54. 2009
  7. doi request reprint Prognostic value of microsatellite instability (MSI) and PTEN expression in women with endometrial cancer: results from studies of the NCIC Clinical Trials Group (NCIC CTG)
    Helen J Mackay
    Princess Margaret Hospital, Toronto, Ontario, Canada
    Eur J Cancer 46:1365-73. 2010
  8. doi request reprint Prognostic relevance of uncommon ovarian histology in women with stage III/IV epithelial ovarian cancer
    Helen J Mackay
    National Cancer Institute of Canada Clinical Trials Group NCIC CTG, Kingston, Ontario, Canada
    Int J Gynecol Cancer 20:945-52. 2010
  9. ncbi request reprint A multicenter phase II study of "adjuvant" irinotecan following resection of colorectal hepatic metastases
    Helen J Mackay
    Princess Margaret Hospital, Toronto, Canada
    Am J Clin Oncol 28:547-54. 2005
  10. ncbi request reprint Molecular determinants of outcome with mammalian target of rapamycin inhibition in endometrial cancer
    Helen J Mackay
    Princess Margaret Hospital, Toronto, Ontario, Canada
    Cancer 120:603-10. 2014

Detail Information

Publications14

  1. pmc The Emerging Role of PARP Inhibitors in the Treatment of Epithelial Ovarian Cancer
    Lilian T Gien
    Princess Margaret Hospital, University of Toronto, Toronto, ON, Canada M5G 2M9
    J Oncol 2010:151750. 2010
    ..We will then expand on the broader relevance and future directions for PARP inhibition in the clinical setting...
  2. doi request reprint A phase II trial of the Src kinase inhibitor saracatinib (AZD0530) in patients with metastatic or locally advanced gastric or gastro esophageal junction (GEJ) adenocarcinoma: a trial of the PMH phase II consortium
    Helen J Mackay
    Department of Medical Oncology, Princess Margaret Hospital, University of Toronto, Ontario, Canada
    Invest New Drugs 30:1158-63. 2012
    ..We evaluated the activity and safety of saracatinib an oral, anilinoquinazolone, non-receptor tyrosine kinase inhibitor targeting Src kinases, in patients with metastatic or locally advanced gastric carcinoma...
  3. pmc Phase II trial of the histone deacetylase inhibitor belinostat in women with platinum resistant epithelial ovarian cancer and micropapillary (LMP) ovarian tumours
    Helen J Mackay
    Princess Margaret Phase II Consortium, Toronto, Canada
    Eur J Cancer 46:1573-9. 2010
    ..Platinum resistant epithelial ovarian cancer (EOC) has a poor prognosis. The histone deacetylase inhibitor belinostat demonstrated antitumour activity in pre-clinical ovarian cancer models...
  4. doi request reprint Evaluation of pandemic H1N1 (2009) influenza vaccine in adults with solid tumor and hematological malignancies on active systemic treatment
    Helen J Mackay
    Princess Margaret Hospital, 610 University Ave, Toronto, ON M5G 2M9, Canada
    J Clin Virol 50:212-6. 2011
    ..Over 85% of healthy individuals vaccinated with the pandemic H1N1 (pH1N1) vaccine achieve seroprotection...
  5. doi request reprint A phase II study of sunitinib in patients with locally advanced or metastatic cervical carcinoma: NCIC CTG Trial IND.184
    Helen J Mackay
    Department of Medical Oncology, Princess Margaret Hospital, University of Toronto, Ontario M5G 2M9, Canada
    Gynecol Oncol 116:163-7. 2010
    ..This multi-centre phase II study was performed to evaluate the activity of sunitinib in women with locally advanced or metastatic cervical carcinoma who had received up to one prior line of chemotherapy for advanced disease...
  6. doi request reprint Other new targets
    Helen J Mackay
    Princess Margaret Hospital, University of Toronto, 610 University Ave, Toronto, Ontario, Canada
    Int J Gynecol Cancer 19:S49-54. 2009
    ..This review focuses on some of these newer approaches to targeted therapy highlighting the importance of trial design and incorporation of biomarkers as we move forward into the era of personalized medicine...
  7. doi request reprint Prognostic value of microsatellite instability (MSI) and PTEN expression in women with endometrial cancer: results from studies of the NCIC Clinical Trials Group (NCIC CTG)
    Helen J Mackay
    Princess Margaret Hospital, Toronto, Ontario, Canada
    Eur J Cancer 46:1365-73. 2010
    ..The aim of this study was to investigate MSI and PTEN expression in two patient populations using data from NCIC CTG studies...
  8. doi request reprint Prognostic relevance of uncommon ovarian histology in women with stage III/IV epithelial ovarian cancer
    Helen J Mackay
    National Cancer Institute of Canada Clinical Trials Group NCIC CTG, Kingston, Ontario, Canada
    Int J Gynecol Cancer 20:945-52. 2010
    ....
  9. ncbi request reprint A multicenter phase II study of "adjuvant" irinotecan following resection of colorectal hepatic metastases
    Helen J Mackay
    Princess Margaret Hospital, Toronto, Canada
    Am J Clin Oncol 28:547-54. 2005
    ....
  10. ncbi request reprint Molecular determinants of outcome with mammalian target of rapamycin inhibition in endometrial cancer
    Helen J Mackay
    Princess Margaret Hospital, Toronto, Ontario, Canada
    Cancer 120:603-10. 2014
    ..The aim of this study was to identify molecular markers associated with mTOR inhibitor activity in women with metastatic endometrial cancer...
  11. ncbi request reprint Current phase II clinical data for ridaforolimus in cancer
    Anna Spreafico
    Princess Margaret Hospital, Division of Medical Oncology and Hematology, 610 University Avenue, Toronto, Ontario, M5G 2M9, Canada 1 416 846 2253 1 416 946 6546
    Expert Opin Investig Drugs 22:1485-93. 2013
    ..Constitutive activation of this pathway has been demonstrated in many tumor types. Targeting the PI3K/AKT/mTOR pathway is of increasing therapeutic interest...
  12. pmc Phase II study of temsirolimus in women with recurrent or metastatic endometrial cancer: a trial of the NCIC Clinical Trials Group
    Amit M Oza
    Princess Margaret Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada
    J Clin Oncol 29:3278-85. 2011
    ..Temsirolimus, an ester derivative of rapamycin that inhibits mTOR, was evaluated in this setting...
  13. doi request reprint Treatment of rectal cancer metastases to the thyroid gland: report of two cases
    Winson Y Cheung
    Department of Medical Oncology and Hematology, University of Toronto, Princess Margaret Hospital, Ontario, Canada
    Clin Colorectal Cancer 7:280-2. 2008
    ..The favorable survival and symptom benefits observed in these patients suggest that combination chemotherapy should be considered in the management of these very rare cases...
  14. ncbi request reprint Targeting the protein kinase C family: are we there yet?
    Helen J Mackay
    University of Toronto, Department of Medical Oncology and Hematology, Princess Margaret Hospital, 610 University Avenue, Toronto, Ontario, Canada
    Nat Rev Cancer 7:554-62. 2007
    ..PKC isozymes is not new; however, with many of the early PKC inhibitor cytotoxic drug combinations being discarded at the phase II level, and recent phase III studies in non-small-cell lung cancer proving negative, what's going wrong?..