J F MacDonald

Summary

Affiliation: University of Toronto
Country: Canada

Publications

  1. ncbi request reprint Insulin increases the potency of glycine at ionotropic glycine receptors
    Valerie B Caraiscos
    Institute of Medical Science, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada
    Mol Pharmacol 71:1277-87. 2007
  2. ncbi request reprint Weighted least squares fitting with multiple templates for detection of small spontaneous signals
    Guo Hua Li
    School of Life Sciences, Heilongjiang University, Harbin, China
    J Neurosci Methods 164:139-48. 2007
  3. pmc Recent advances in basic neurosciences and brain disease: from synapses to behavior
    Guo Qiang Bi
    Department of Neurobiology, University of Pittsburgh, Pittsburgh, USA
    Mol Pain 2:38. 2006
  4. pmc The modulation of TRPM7 currents by nafamostat mesilate depends directly upon extracellular concentrations of divalent cations
    Xuanmao Chen
    Department of Physiology, University of Toronto, Canada
    Mol Brain 3:38. 2010
  5. ncbi request reprint Gadolinium reduces AMPA receptor desensitization and deactivation in hippocampal neurons
    S Lei
    Department of Physiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    J Neurophysiol 86:173-82. 2001
  6. ncbi request reprint G protein-coupled receptors control NMDARs and metaplasticity in the hippocampus
    John F MacDonald
    Department of Physiology, University of Toronto, Toronto, ON, Canada
    Biochim Biophys Acta 1768:941-51. 2007
  7. ncbi request reprint Hippocampal long-term synaptic plasticity and signal amplification of NMDA receptors
    John F MacDonald
    Department of Physiology, Medical Sciences Building, 1 King s College, University of Toronto, Toronto Ontario M5S1A8, Canada
    Crit Rev Neurobiol 18:71-84. 2006
  8. ncbi request reprint Paradox of Ca2+ signaling, cell death and stroke
    John F MacDonald
    Department of Physiology, University of Toronto, 1 King s College Circle, Toronto, Ontario M5S 1A8, Canada
    Trends Neurosci 29:75-81. 2006
  9. ncbi request reprint Cyclic GMP-dependent feedback inhibition of AMPA receptors is independent of PKG
    S Lei
    Departments of Physiology and Pharmacology, University of Toronto, Medical Sciences Bldg, 1 King s College Circle, Toronto, Ontario M5S 1A8, Canada
    Nat Neurosci 3:559-65. 2000
  10. ncbi request reprint Positive allosteric modulators of AMPA receptors reduce proton-induced receptor desensitization in rat hippocampal neurons
    S Lei
    Departments of Physiology and Pharmacology and Anaesthesia, University of Toronto, Toronto M5S 1A8, Ontario K7L 3N6, Canada
    J Neurophysiol 85:2030-8. 2001

Detail Information

Publications61

  1. ncbi request reprint Insulin increases the potency of glycine at ionotropic glycine receptors
    Valerie B Caraiscos
    Institute of Medical Science, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada
    Mol Pharmacol 71:1277-87. 2007
    ..Together, these results show that insulin has a novel regulatory action on the potency of glycine for ionotropic glycine receptors...
  2. ncbi request reprint Weighted least squares fitting with multiple templates for detection of small spontaneous signals
    Guo Hua Li
    School of Life Sciences, Heilongjiang University, Harbin, China
    J Neurosci Methods 164:139-48. 2007
    ..An important outcome of the weighted template technique is that the detection rate is not as sensitive to the length of templates and this technique is capable of detection overlapping events reliably...
  3. pmc Recent advances in basic neurosciences and brain disease: from synapses to behavior
    Guo Qiang Bi
    Department of Neurobiology, University of Pittsburgh, Pittsburgh, USA
    Mol Pain 2:38. 2006
    ..The second international meeting on Neurons and Brain Disease will be held in Toronto (August 29-31, 2007)...
  4. pmc The modulation of TRPM7 currents by nafamostat mesilate depends directly upon extracellular concentrations of divalent cations
    Xuanmao Chen
    Department of Physiology, University of Toronto, Canada
    Mol Brain 3:38. 2010
    ..NM thus provides a molecular template for the design of putative modulators of TRPM7...
  5. ncbi request reprint Gadolinium reduces AMPA receptor desensitization and deactivation in hippocampal neurons
    S Lei
    Department of Physiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    J Neurophysiol 86:173-82. 2001
    ..These results demonstrate that Gd(3+) potently reduces AMPA receptor desensitization and mimics a number of the properties of the positive modulators of AMPA receptor desensitization such as cyclothiazide...
  6. ncbi request reprint G protein-coupled receptors control NMDARs and metaplasticity in the hippocampus
    John F MacDonald
    Department of Physiology, University of Toronto, Toronto, ON, Canada
    Biochim Biophys Acta 1768:941-51. 2007
    ..We discuss the protein kinase signal cascades stimulated by Galphaq and Galphas coupled GPCRs and describe how control of NMDAR activity shifts the threshold for the induction of LTP...
  7. ncbi request reprint Hippocampal long-term synaptic plasticity and signal amplification of NMDA receptors
    John F MacDonald
    Department of Physiology, Medical Sciences Building, 1 King s College, University of Toronto, Toronto Ontario M5S1A8, Canada
    Crit Rev Neurobiol 18:71-84. 2006
    ....
  8. ncbi request reprint Paradox of Ca2+ signaling, cell death and stroke
    John F MacDonald
    Department of Physiology, University of Toronto, 1 King s College Circle, Toronto, Ontario M5S 1A8, Canada
    Trends Neurosci 29:75-81. 2006
    ..Here, we discuss how several transient receptor potential (TRP) channels are likely to contribute to both the Ca2+ paradox and the delayed death of neurons following an ischemic stroke...
  9. ncbi request reprint Cyclic GMP-dependent feedback inhibition of AMPA receptors is independent of PKG
    S Lei
    Departments of Physiology and Pharmacology, University of Toronto, Medical Sciences Bldg, 1 King s College Circle, Toronto, Ontario M5S 1A8, Canada
    Nat Neurosci 3:559-65. 2000
    ..Our findings demonstrate that cGMP's modulation of excitatory transmission may involve a coupling of AMPA channel activity to levels of cGMP...
  10. ncbi request reprint Positive allosteric modulators of AMPA receptors reduce proton-induced receptor desensitization in rat hippocampal neurons
    S Lei
    Departments of Physiology and Pharmacology and Anaesthesia, University of Toronto, Toronto M5S 1A8, Ontario K7L 3N6, Canada
    J Neurophysiol 85:2030-8. 2001
    ..These results demonstrate that a reduction in the proton sensitivity of receptor desensitization contributes to the mechanism of action of some positive modulators of AMPA receptors...
  11. ncbi request reprint In CA1 pyramidal neurons of the hippocampus protein kinase C regulates calcium-dependent inactivation of NMDA receptors
    W Y Lu
    Department of Physiology, University of Toronto, Toronto, Ontario M5S 1A8 Canada
    J Neurosci 20:4452-61. 2000
    ....
  12. ncbi request reprint Distinct functional and pharmacological properties of tonic and quantal inhibitory postsynaptic currents mediated by gamma-aminobutyric acid(A) receptors in hippocampal neurons
    D Bai
    Department of Physiology, University of Toronto, Toronto, Ontario, Canada
    Mol Pharmacol 59:814-24. 2001
    ..In summary, the receptors underlying the tonic current are functionally and pharmacologically distinct from quantally activated synaptic receptors and these receptors represent a novel target for neurodepressive drugs...
  13. ncbi request reprint Regulation of NMDA receptor activity by F-actin and myosin light chain kinase
    S Lei
    Canadian Institutes of Health Research Group The Synapse, Departments of Physiology and Pharmacology, University of Toronto, Toronto M5S 1A8, Canada
    J Neurosci 21:8464-72. 2001
    ..Our results suggest that MLCK enhances actomyosin contractility to either increase the membrane tension on NMDARs or to alter physical relationships between the actin cytoskeleton and the linker proteins of NMDARs...
  14. ncbi request reprint Modulation of AMPA receptors by a novel organic nitrate
    S Toong
    Department of Physiology, University of Toronto, ON, Canada
    Can J Physiol Pharmacol 79:422-9. 2001
    ..With respect to alteration of the excitatory synaptic transmission, GT-005 delayed the decay and increased the frequency of spontaneous miniature excitatory postsynaptic currents (mepsc) recorded in cultured hippocampal neurons...
  15. ncbi request reprint Glucocorticoids and serotonin alter glucocorticoid receptor (GR) but not mineralocorticoid receptor (MR) mRNA levels in fetal mouse hippocampal neurons, in vitro
    P Erdeljan
    Department of Physiology, Faculty of Medicine, University of Toronto, Medical Sciences Building, 1 Kings College Circle, Ontario, M5S 1A8, Toronto, Canada
    Brain Res 896:130-6. 2001
    ..We conclude that synthetic and endogenous glucocorticoids, as well as serotonin, can influence neuronal levels of GR mRNA during hippocampal development. However, whether these effects are permanent remains to be determined...
  16. ncbi request reprint Co-stimulation of mGluR5 and N-methyl-D-aspartate receptors is required for potentiation of excitatory synaptic transmission in hippocampal neurons
    Suhas A Kotecha
    Department of Physiology, Faculty of Medicine, University of Toronto, Mt Sinai Hospital, Toronto, Ontario M5S 1A8, Canada
    J Biol Chem 278:27742-9. 2003
    ....
  17. ncbi request reprint Blockade of AMPA receptors and volatile anesthetics: reduced anesthetic requirements in GluR2 null mutant mice for loss of the righting reflex and antinociception but not minimum alveolar concentration
    D T Joo
    Department of Anesthesia, University of Toronto, Ontario, Canada
    Anesthesiology 94:478-88. 2001
    ..To determine if interactions between anesthetics and AMPA receptors account for the increased sensitivity of (-/-) mice, the effects of volatile anesthetics that do not directly inhibit AMPA receptors were examined...
  18. ncbi request reprint Modulation of NMDA receptors by pituitary adenylate cyclase activating peptide in CA1 neurons requires G alpha q, protein kinase C, and activation of Src
    D S MacDonald
    Department of Pharmacology, Faculty of Medicine, University of Toronto, Mount Sinai Hospital, Toronto, Ontario, M5S 1A8, Canada
    J Neurosci 25:11374-84. 2005
    ..RACK1 serves as a hub for PKC, Fyn, and Src and facilitates the regulation of basal NMDAR activity in CA1 hippocampal neurons...
  19. pmc Tyrosine kinases enhance the function of glycine receptors in rat hippocampal neurons and human alpha(1)beta glycine receptors
    Valerie B Caraiscos
    Department of Physiology, University of Toronto, Canada
    J Physiol 539:495-502. 2002
    ..Together, these findings indicate that GlyR function is upregulated by PTKs and this modulation is dependent on the tyrosine-413 residue of the beta subunit...
  20. ncbi request reprint CAKbeta/Pyk2 kinase is a signaling link for induction of long-term potentiation in CA1 hippocampus
    Y Huang
    Programmes in Brain and, Behaviour and Cell Biology, Hospital for Sick Children, Ontario, M5G 1X8, Toronto, Canada
    Neuron 29:485-96. 2001
    ..Thus, activating CAKbeta/Pyk2 is required for inducing LTP and may depend upon downstream activation of Src to upregulate NMDA receptors...
  21. ncbi request reprint LTP in a culture dish
    J F MacDonald
    Department of Physiology, University of Toronto, Canada
    ScientificWorldJournal 1:213-5. 2001
    ..Understanding how the human brain encodes and stores information becomes critical in designing required therapeutic strategies...
  22. ncbi request reprint A D2 class dopamine receptor transactivates a receptor tyrosine kinase to inhibit NMDA receptor transmission
    Suhas A Kotecha
    Department of Physiology, Faculty of Medicine, University of Toronto, Ontario, Canada
    Neuron 35:1111-22. 2002
    ....
  23. ncbi request reprint Activation of PI3-kinase is required for AMPA receptor insertion during LTP of mEPSCs in cultured hippocampal neurons
    Heng Ye Man
    Brain and Behavior Program and Department of Pathology, Research Institute of the Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada M5S 1A8
    Neuron 38:611-24. 2003
    ....
  24. ncbi request reprint Gabapentin increases a tonic inhibitory conductance in hippocampal pyramidal neurons
    Victor Y Cheng
    Institute of Medical Science, University of Toronto, Ontario, Canada
    Anesthesiology 105:325-33. 2006
    ..As a positive control, the effects of vigabatrin, which irreversibly inhibits GABA transaminase, were also examined...
  25. ncbi request reprint Blockade of glutamate receptors and barbiturate anesthesia: increased sensitivity to pentobarbital-induced anesthesia despite reduced inhibition of AMPA receptors in GluR2 null mutant mice
    D T Joo
    Department of Anaesthesia, University of Toronto, Ontario, Canada
    Anesthesiology 91:1329-41. 1999
    ....
  26. ncbi request reprint Prostaglandin F2alpha potentiates cortisol production by stimulating 11beta-hydroxysteroid dehydrogenase 1: a novel feedback loop that may contribute to human labor
    N Alfaidy
    CIHR Group in Fetal and Neonatal Health and Development, University of Toronto, Toronto, Ontario, Canada M5S 1A8
    J Clin Endocrinol Metab 86:5585-92. 2001
    ....
  27. ncbi request reprint Convergence of PKC-dependent kinase signal cascades on NMDA receptors
    J F MacDonald
    Canadian Institutes of Health Research Group, The Synapse, Department of Physiology, University of Toronto, Canada
    Curr Drug Targets 2:299-312. 2001
    ..In CAI neurons, PKC provides a point of convergence of control of NMDARs and synaptic plasticity for a wide variety of G-protein coupled and growth factor receptors...
  28. pmc Platelet-derived growth factor selectively inhibits NR2B-containing N-methyl-D-aspartate receptors in CA1 hippocampal neurons
    Michael A Beazely
    Department of Physiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    J Biol Chem 284:8054-63. 2009
    ..We conclude that PDGFbetaR signaling, by preferentially targeting NR2B receptors, provides an important mechanism for neuroprotection by growth factors in the central nervous system...
  29. pmc Vasoactive intestinal peptide acts via multiple signal pathways to regulate hippocampal NMDA receptors and synaptic transmission
    Kai Yang
    Department of Physiology, University of Toronto, Toronto, Ontario, Canada
    Hippocampus 19:779-89. 2009
    ..g., 100 nM) was mediated by PAC1-R as well as by Src kinase. Overall, these results show that VIP can regulate NMDA receptors through different receptors and signaling pathways...
  30. pmc Effects of repeated prenatal glucocorticoid exposure on long-term potentiation in the juvenile guinea-pig hippocampus
    Elaine Setiawan
    Department of Physiology, Faculty of Medicine, University of Toronto, Medical Sciences Building, 1 King s College Circle, Toronto, Ontario M5S 1A8, Canada
    J Physiol 581:1033-42. 2007
    ..This study reveals sex-specific effects of prenatal exposure to sGC on LTP in the presence of elevated cortisol, a situation that would occur in vivo during stress...
  31. ncbi request reprint General anaesthetics and their effects on GABA(A) receptor desensitization
    B A Orser
    The Anaesthesia Research Laboratory, University of Toronto, Ont, Canada
    Toxicol Lett 100:217-24. 1998
    ..6. Here, we discuss the effects of intravenous general anaesthetic on desensitization of the GABA(A) receptor...
  32. ncbi request reprint Enhanced calcium transients in glial cells in neonatal cerebellar cultures derived from S100B null mice
    Z Xiong
    Department of Physiology, University of Toronto, Toronto, Ontario, M5S 1A8, Canada
    Exp Cell Res 257:281-9. 2000
    ..These results demonstrate a specific decrease in Ca(2+)-handling capacity in astrocytes derived from S100B null mice and suggest that S100B plays a role in the maintenance of Ca(2+) homeostasis in astrocytes...
  33. doi request reprint Design and screening of ASIC inhibitors based on aromatic diamidines for combating neurological disorders
    Xuanmao Chen
    Department of Physiology, University of Toronto, Canada
    Eur J Pharmacol 648:15-23. 2010
    ..Further studies may lead to a drug with therapeutic value and extend the therapeutic scope of aromatic diamidines to combat neurological diseases...
  34. ncbi request reprint D2-class dopamine receptor inhibition of NMDA currents in prefrontal cortical neurons is platelet-derived growth factor receptor-dependent
    Michael A Beazely
    Department of Physiology, University of Toronto, Toronto, Ontario, Canada
    J Neurochem 98:1657-63. 2006
    ....
  35. doi request reprint Suppression of hippocampal TRPM7 protein prevents delayed neuronal death in brain ischemia
    Hong Shuo Sun
    Toronto Western Hospital Research Institute, Toronto, Ontario, Canada
    Nat Neurosci 12:1300-7. 2009
    ..Thus, regional suppression of TRPM7 is feasible, well tolerated and inhibits delayed neuronal death in vivo...
  36. pmc Control of excitatory synaptic transmission by C-terminal Src kinase
    Jindong Xu
    Faculty of Dentistry, University of Toronto, Toronto, Ontario M5G 1G6, Canada
    J Biol Chem 283:17503-14. 2008
    ..Thus, Csk serves to maintain the constancy of baseline excitatory synaptic transmission by inhibiting Src kinase-dependent synaptic plasticity in the hippocampus...
  37. ncbi request reprint Protein kinase C enhances glycine-insensitive desensitization of NMDA receptors independently of previously identified protein kinase C sites
    Michael F Jackson
    Department of Physiology, University of Toronto, Ontario, Canada
    J Neurochem 96:1509-18. 2006
    ..We conclude that activation of PKC increases NMDAR glycine-insensitive desensitization independently of previously identified sites located within the NR1 C-terminus and distal segment of the NR2A C-terminus...
  38. doi request reprint Distinct properties of murine alpha 5 gamma-aminobutyric acid type a receptors revealed by biochemical fractionation and mass spectroscopy
    Young H Ju
    Department of Physiology, University of Toronto, Toronto, Ontario, Canada
    J Neurosci Res 87:1737-47. 2009
    ..Mass spectroscopy now offers a method for detecting and characterizing factors that confer the unique detergent solubility and possibly cellular location of alpha 5 GABA(A)Rs in hippocampal neurons...
  39. ncbi request reprint Desensitization of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors facilitates use-dependent inhibition by pentobarbital
    Michael F Jackson
    Department of Physiology, Medical Sciences Bldg, University of Toronto, 1 King s College Circle, Toronto, ON M5S 1A8, Canada
    Mol Pharmacol 64:395-406. 2003
    ..Our results suggest that PB does not act as an open channel blocker of AMPARs. Rather, the sensitivity, use dependence, and trapping of inhibition by PB are determined by AMPARs desensitization...
  40. ncbi request reprint Multiple mechanisms of ketamine blockade of N-methyl-D-aspartate receptors
    B A Orser
    Anaesthesia Research Laboratory, University of Toronto, Ontario, Canada
    Anesthesiology 86:903-17. 1997
    ..Previous studies suggest that ketamine occludes the open channel by binding to a site located within the channel pore. This hypothesis was examined by investigating the effects of ketamine on single-channel currents from NMDA receptors...
  41. ncbi request reprint Specific coupling of NMDA receptor activation to nitric oxide neurotoxicity by PSD-95 protein
    R Sattler
    Toronto Western Hospital, University of Toronto, Lab 11 416, 399 Bathurst Street, Toronto, Ontario M5T 2S8, Canada
    Science 284:1845-8. 1999
    ..Thus, PSD-95 is required for efficient coupling of NMDAR activity to nitric oxide toxicity, and imparts specificity to excitotoxic Ca2+ signaling...
  42. ncbi request reprint Alpha5GABAA receptors regulate the intrinsic excitability of mouse hippocampal pyramidal neurons
    Robert P Bonin
    Department of Physiology, University of Toronto, Toronto, ON, Canada
    J Neurophysiol 98:2244-54. 2007
    ..We conclude that shunting inhibition mediated by alpha5GABA(A) receptors regulates the firing of action potentials and may synchronize network activity that underlies hippocampal-dependent behavior...
  43. doi request reprint Alpha5GABAA receptor activity sets the threshold for long-term potentiation and constrains hippocampus-dependent memory
    Loren J Martin
    Department of Physiology, Institute of Medical Science, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    J Neurosci 30:5269-82. 2010
    ..Thus, under specific conditions, alpha5GABA(A)R activity predominates over synaptic inhibition in modifying the strength of both synaptic plasticity in vitro and certain forms of memory in vivo...
  44. pmc TRPM7 channels in hippocampal neurons detect levels of extracellular divalent cations
    Wen Li Wei
    Department of Physiology, University of Toronto, 1 King s College Circle, Toronto, ON, Canada M5S 1A8
    Proc Natl Acad Sci U S A 104:16323-8. 2007
    ....
  45. ncbi request reprint Signaling molecules and receptor transduction cascades that regulate NMDA receptor-mediated synaptic transmission
    Suhas A Kotecha
    Department of Physiology, Faculty of Medicine, University of Toronto, Canadian Institute of Health Research Group, The Synapse, Toronto, Ontario, Canada M5S 1A8
    Int Rev Neurobiol 54:51-106. 2003
  46. doi request reprint Nonsteroidal anti-inflammatory drugs upregulate function of wild-type and mutant CFTR
    J Li
    Research Building S104, Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Toronto, ON M4N3M5, Canada
    Eur Respir J 32:334-43. 2008
    ....
  47. ncbi request reprint Glucocorticoids and serotonin alter glucocorticoid receptor mRNA levels in fetal guinea-pig hippocampal neurons, in vitro
    P Erdeljan
    Department of Physiology, Faculty of Medicine, University of Toronto, Medical Sciences Building, ON, Canada
    Reprod Fertil Dev 17:743-9. 2005
    ..We conclude that synthetic and endogenous glucocorticoids, as well as serotonin, can influence GR expression during hippocampal development and in this way may act to permanently programme HPA function...
  48. ncbi request reprint Enhanced vulnerability to NMDA toxicity in sublethal traumatic neuronal injury in vitro
    Mark Arundine
    Toronto Western Hospital Research Institute, Toronto, Ontario, Canada
    J Neurotrauma 20:1377-95. 2003
    ..Our data illustrate that sublethal in vitro stretch injury triggers distinct signaling pathways that lead to secondary injury, rather than causing a generalized increase in vulnerability to secondary insults...
  49. ncbi request reprint Selective enhancement of tonic GABAergic inhibition in murine hippocampal neurons by low concentrations of the volatile anesthetic isoflurane
    Valerie B Caraiscos
    Institute of Medical Science, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    J Neurosci 24:8454-8. 2004
    ..These studies suggest that an increased tonic inhibition in the hippocampus may contribute to amnestic properties of volatile anesthetics...
  50. ncbi request reprint Tonically activated GABAA receptors in hippocampal neurons are high-affinity, low-conductance sensors for extracellular GABA
    Jacky Y T Yeung
    Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada
    Mol Pharmacol 63:2-8. 2003
    ..The receptors underlying tonic and phasic inhibitory conductances in hippocampal neurons are pharmacologically and biophysically distinct, suggesting that they serve different physiological roles...
  51. pmc Ca2+-dependent induction of TRPM2 currents in hippocampal neurons
    Michelle E Olah
    Robarts Research Institute, Molecular Brain Research Group, University of Western Ontario, 100 Perth Drive, London, ON, Canada, N6A 5K8
    J Physiol 587:965-79. 2009
    ..Taken together, these results indicate that hippocampal pyramidal neurons possess functional TRPM2 channels whose activation by ADPR is functionally coupled to VDCCs and NMDARs through a rise in [Ca(2+)](i)...
  52. ncbi request reprint Alpha5GABAA receptors mediate the amnestic but not sedative-hypnotic effects of the general anesthetic etomidate
    Victor Y Cheng
    Institute of Medical Science, Division of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario, M5S 1A8, Canada
    J Neurosci 26:3713-20. 2006
    ..Thus, the amnestic and sedative-hypnotic properties of etomidate can be dissociated on the basis of GABAAR subtype pharmacology...
  53. doi request reprint Diarylamidines: high potency inhibitors of acid-sensing ion channels
    Xuanmao Chen
    Department of Physiology, University of Toronto, Canada
    Neuropharmacology 58:1045-53. 2010
    ..This study indicates diarylamidines constitute a novel class of non-amiloride ASIC blockers and suggests that diarylamidines may be developed as therapeutic agents in treatment of ASIC-involved diseases...
  54. doi request reprint Neural stem/progenitor cells differentiate in vitro to neurons by the combined action of dibutyryl cAMP and interferon-gamma
    Tasneem Zahir
    Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada
    Stem Cells Dev 18:1423-32. 2009
    ..These NSPC-derived neurons may be promising for neural regenerative strategies in the CNS...
  55. pmc Tonic inhibition in mouse hippocampal CA1 pyramidal neurons is mediated by alpha5 subunit-containing gamma-aminobutyric acid type A receptors
    Valerie B Caraiscos
    Institute of Medical Science, Department of Anesthesia, University of Toronto, Toronto, ON, Canada M5S 1A8
    Proc Natl Acad Sci U S A 101:3662-7. 2004
    ....
  56. ncbi request reprint Transient receptor potential channels of the melastatin family and ischemic responses of central neurons
    John F MacDonald
    Department of Physiology, University of Toronto, Toronto, Ontario, Canada
    Stroke 38:665-9. 2007
    ..The more-delayed activation of these channels offers the tantalizing possibility that drugs targeting selected members of this family may possess a wider therapeutic window for preventing the debilitating consequences after stroke onset...
  57. ncbi request reprint A transmembrane model for an ionotropic glutamate receptor predicted on the basis of the location of asparagine-linked oligosaccharides
    F A Taverna
    Medical Research Council Group on Nerve Cells and Synapses, University of Toronto, Ontario, Canada
    J Biol Chem 269:14159-64. 1994
    ..Based on these findings, we propose a model for the transmembrane topology of GluR6...
  58. ncbi request reprint Neuroprotection in ischemia: blocking calcium-permeable acid-sensing ion channels
    Zhi Gang Xiong
    Robert S Dow Neurobiology Laboratories, Legacy Research, Portland, OR 97232, USA
    Cell 118:687-98. 2004
    ..Thus, acidosis injures the brain via membrane receptor-based mechanisms with resultant toxicity of [Ca2+]i, disclosing new potential therapeutic targets for stroke...
  59. ncbi request reprint Abnormal spine morphology and enhanced LTP in LIMK-1 knockout mice
    Yanghong Meng
    Program in Brain and Behavior, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada M5G 1X8
    Neuron 35:121-33. 2002
    ..The knockout mice also showed altered fear responses and spatial learning. These results indicate that LIMK-1 plays a critical role in dendritic spine morphogenesis and brain function...
  60. pmc Acidosis decreases low Ca(2+)-induced neuronal excitation by inhibiting the activity of calcium-sensing cation channels in cultured mouse hippocampal neurons
    Xiang Ping Chu
    Robert S Dow Neurobiology Laboratories, Legacy Research, Portland, OR 97232, USA
    J Physiol 550:385-99. 2003
    ..Both the extracellular and the intracellular sites are involved in the proton modulation of the csNSC channels...
  61. ncbi request reprint A key role for TRPM7 channels in anoxic neuronal death
    Michelle Aarts
    Toronto Western Hospital Research Institute, 11 416 MC PAV, 399 Bathurst Street, Toronto, Ontario M5T 2S8 Canada
    Cell 115:863-77. 2003
    ..Thus, excitotoxicity is a subset of a greater overall anoxic cell death mechanism, in which TRPM7 channels play a key role...