Research Topics
| Larry D LyndSummaryAffiliation: University of British Columbia Country: Canada Publications
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Detail Information
Publications
Economic burden of asthma: a systematic reviewKatayoun Bahadori
Centre for Clinical Epidemiology and Evaluation C2E2, UBC, Vancouver, BC, Canada
BMC Pulm Med 9:24. 2009..It is also associated with the loss of future potential earnings related to both morbidity and mortality. The objective of the study is to determine the burden of disease costs associated with asthma...
A probabilistic cost-effectiveness analysis of enoxaparin versus unfractionated heparin for the prophylaxis of deep-vein thrombosis following major traumaLarry D Lynd
Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada
Can J Clin Pharmacol 14:e215-26. 2007..g. enoxaparin) as thromboprophylaxis for the prevention of deep vein thrombosis (DVT)...- A probabilistic cost-effectiveness analysis of enoxaparin versus unfractionated heparin for the prophylaxis of deep-vein thrombosis following major traumaLarry D Lynd
Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada
Can J Clin Pharmacol 14:e215-26. 2007..g. enoxaparin) as thromboprophylaxis for the prevention of deep vein thrombosis (DVT)... - Antiviral agents for influenza: a comparison of cost-effectiveness dataLarry D Lynd
Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, Canada
Pharmacoeconomics 23:1083-106. 2005.... - Prescription to over-the-counter deregulation in Canada: are we ready for it, or do we need to be?Larry D Lynd
Faculty of Pharmaceutical Sciences, University of British Columbia and the Centre for Clinical Epidemiology and Evaluation, Vancouver Coastal Health Research Institute, Vancouver, BC
CMAJ 173:775-7. 2005 - A probabilistic cost-effectiveness analysis of enoxaparin versus unfractionated heparin for the prophylaxis of deep-vein thrombosis following major traumaLarry D Lynd
Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada
Can J Clin Pharmacol 14:e215-26. 2007..g. enoxaparin) as thromboprophylaxis for the prevention of deep vein thrombosis (DVT)... 
Using the incremental net benefit framework for quantitative benefit-risk analysis in regulatory decision-making--a case study of alosetron in irritable bowel syndromeLarry D Lynd
Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada
Value Health 13:411-7. 2010....- An evaluation of the osmole gap as a screening test for toxic alcohol poisoningLarry D Lynd
Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada
BMC Emerg Med 8:5. 2008.... - Risk of gastrointestinal events in patients with rheumatoid arthritis after withdrawal of rofecoxibCarlo A Marra
Faculty of Pharmaceutical Sciences, University of British Columbia UBC, Vancouver, Canada
J Rheumatol 39:910-5. 2012..To examine the incidence of gastrointestinal (GI) events in patients with rheumatoid arthritis (RA) after the removal of rofecoxib from the market... - Cost-effectiveness of self-managed versus physician-managed oral anticoagulation therapyDean A Regier
Collaboration for Outcomes Research and Evaluation, Centre for Clinical Epidemiology and Evaluation, Vancouver Coastal Health Research Institute, University of British Columbia, Vancouver, BC
CMAJ 174:1847-52. 2006..INTERPRETATION: This model suggests that self-management is a cost-effective strategy for those receiving long-term oral anticoagulation therapy for atrial fibrillation or for a mechanical heart valve... - An evaluation of patients' willingness to trade symptom-free days for asthma-related treatment risks: a discrete choice experimentHelen M McTaggart-Cowan
Department of Health Care and Epidemiology, University of British Columbia, Vancouver, British Columbia, Canada
J Asthma 45:630-8. 2008..The objective of this study was to quantify these preferences, in terms of risk-benefits trade-offs, for six asthma treatment attributes using a discrete choice experiment (DCE)... - Effects of prescription adaptation by pharmacistsMichael R Law
Centre for Health Services and Policy Research, School of Population and Public Health, The University of British Columbia, 201 2206 East Mall, Vancouver, BC, V6T 1Z3, Canada
BMC Health Serv Res 10:313. 2010..We hypothesize this policy increased drug utilization and drug costs, increased patient adherence to medication, and reduced total healthcare resource use... - Health economic evaluation: a primer for the practicing rheumatologistMichael C Y Tan
Vancouver Coastal Health Research Institute, Vancouver, British Columbia, Canada
Arthritis Rheum 55:648-56. 2006 - The irrationality of the present use of the osmole gap: applicable physical chemistry principles and recommendations to improve the validity of current practicesYoshikata Koga
Department of Chemistry, University of British Columbia, Vancouver, British Columbia, Canada
Toxicol Rev 23:203-11. 2004..This correction should be applied before the evaluation of the osmolar gap as a screening test for other low molecular weight substances proceeds... - Antibiotic consumption in children prior to diagnosis of asthmaFawziah Marra
University of British Columbia, BC, Canada
BMC Pulm Med 11:32. 2011..Asthma is difficult to diagnose in children and at times misdiagnosis of an infection can occur. However, little is known about the magnitude and patterns of antibiotic consumption in children with asthma relative to those without asthma... - Antibiotic use in children is associated with increased risk of asthmaFawziah Marra
University of British Columbia, Faculty of Pharmaceutical Sciences, Centre for Health Evaluation and Outcomes Sciences, St Paul s Hospital, 620 1081 Burrard St, Vancouver, British Columbia, Canada
Pediatrics 123:1003-10. 2009..Antibiotic exposure in early childhood is a possible contributor to the increasing asthma prevalence in industrialized countries. Although a number of published studies have tested this hypothesis, the results have been conflicting... - Evaluating societal preferences for human papillomavirus vaccine and cervical smear test screening programmeBridgette Oteng
Faculty of Pharmaceutical Sciences, University of British Columbia, 2146 East Mall, Vancouver V5Z163, British Columbia, Canada
Sex Transm Infect 87:52-7. 2011..Public preferences for HPV vaccines and smear test screening were determined using a discrete choice experiment... - Predicting response to day treatment for personality disorderJohn S Ogrodniczuk
Department of Psychiatry, University of British Columbia, Vancouver, British Columbia
Can J Psychiatry 56:110-7. 2011..Efforts to improve the effectiveness of day treatment should attend to factors that influence treatment response. Our prospective study identified predictors of response to day treatment for personality disorder (PD)... - Pharmacists' preferences for providing patient-centered services: a discrete choice experiment to guide health policyKelly A Grindrod
University of British Columbia, Vancouver, Canada
Ann Pharmacother 44:1554-64. 2010..In Canada, most pharmacists are not paid to provide patient-centered services. In other areas of the world these services have suffered from poor adoption by pharmacists... - Agreement between aggregate and individual-level measures of income and education: a comparison across three patient groupsCarlo A Marra
Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada
BMC Health Serv Res 11:69. 2011..The purpose of this study was to determine the level of agreement between aggregate-level and individual-level measures of income and education among three distinct patient groups, specifically asthma, diabetes, and rheumatoid patients... - Trends in asthma-related direct medical costs from 2002 to 2007 in British Columbia, Canada: a population based-cohort studyPierrick Bedouch
Collaboration for Outcomes Research and Evaluation, Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, British Columbia, Canada
PLoS ONE 7:e50949. 2012..The objective of this work was to analyze direct asthma-related medical costs, and trends in total and per-patient costs of hospitalizations, physician visits, and medications... - Barriers to integrating personalized medicine into clinical practice: a best-worst scaling choice experimentMehdi Najafzadeh
Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, British Columbia, Canada
Genet Med 14:520-6. 2012..The objective of this study was to elicit the preferences of physicians about regarding applying personalized medicine in their clinical practice as these strategies become available... - The validity of generic and condition-specific preference-based instruments: the ability to discriminate asthma control statusHelen M McTaggart-Cowan
Centre for Clinical Epidemiology and Evaluation, Vancouver Coastal Health Research Institute, 7th Floor, 828 West 10th Avenue, Vancouver, BC, Canada, V5Z 1L8
Qual Life Res 17:453-62. 2008..The objective of this study was to evaluate the validity of generic and condition-specific preference-based instruments, in terms of their ability to distinguish asthma control... - The use of the osmole gap as a screening test for the presence of exogenous substancesRoy A Purssell
Division of Emergency Medicine, University of British Columbia, Vancouver, British Columbia, Canada
Toxicol Rev 23:189-202. 2004.... - A quantitative evaluation of the regulatory assessment of the benefits and risks of rofecoxib relative to naproxen: an application of the incremental net-benefit frameworkLarry D Lynd
Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada
Pharmacoepidemiol Drug Saf 19:1172-80. 2010.... - Randomized controlled trial evaluating pictogram augmentation of HIV medication informationKyle Wilby
University of British Columbia, Vancouver, British Columbia, Canada
Ann Pharmacother 45:1378-83. 2011..The use of pictograms on medication vials as a means of improving patients' understanding of medication information has been shown to positively influence understanding and adherence compared to those using text alone... - Inadequate statistical power to detect clinically significant differences in adverse event rates in randomized controlled trialsRuth Tsang
Vancouver General Hospital, Vancouver, British Columbia, Canada
J Clin Epidemiol 62:609-16. 2009..To determine the statistical power to detect potentially clinically significant differences in serious adverse events between drug therapies reported in a sample of randomized controlled trials (RCTs)... - Predictors of premature termination of day treatment for personality disorderJohn S Ogrodniczuk
Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada
Psychother Psychosom 77:365-71. 2008..Efforts to improve compliance should begin by recognising risk factors for premature termination. This prospective study identified predictors of premature termination from a day treatment program for personality disorder... - Approval process and access to prescription drugs in CanadaCarlo A Marra
University of British Columbia, Arthritis Research Centre of Canada, Centre for Clinical Epidemiology and Evaluation, 717-828 West 10th Avenue, Vancouver, British Columbia V5Z 1L8, Canada
Arthritis Rheum 55:9-11. 2006 - The effects of long-acting bronchodilators on total mortality in patients with stable chronic obstructive pulmonary diseaseAgnes Kliber
Department of Medicine Respiratory Division, University of British Columbia, 6040 Iona Drive, Vancouver, V6T 2E8, Canada
Respir Res 11:56. 2010..We performed a comprehensive systematic review and meta-analysis to evaluate the effects of long-acting bronchodilators on total mortality in stable COPD... - Reconcilable differences: a cross-sectional study of the relationship between socioeconomic status and the magnitude of short-acting beta-agonist use in asthmaLarry D Lynd
Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada
Chest 126:1161-8. 2004..Results were consistent for neighborhood unemployment rate. CONCLUSIONS: The social gradient in asthma-related outcomes may be at least partially attributable to poorer asthma control in lower-SES asthmatics... - Using administrative healthcare data to recruit study subjects: experience with 'camouflaged sampling'Larry D Lynd
Department of Health Care and Epidemiology, Faculty of Medicine University of British Columbia, Centre for Health Evaluation and Outcomes Sciences, Vancouver, BC, Canada
Eur J Epidemiol 19:517-25. 2004..To recruit a sample of asthmatics heterogeneous for short-acting (SA) beta-agonist use while protecting their privacy, and to compare participants recruited via 'camouflaged sampling' to those recruited through media advertising... - Patterns of inhaled asthma medication use: a 3-year longitudinal analysis of prescription claims data from British Columbia, CanadaLarry D Lynd
Department of Health Care and Epidemiology, University of British Columbia, Vancouver, BC, Canada V6Z 1Y6
Chest 122:1973-81. 2002..An unexpected trend toward decreasing ICS utilization was identified. Receiving social assistance was a risk factor for increasing SA beta-agonist use, independent of baseline utilization... - Advances in risk-benefit evaluation using probabilistic simulation methods: an application to the prophylaxis of deep vein thrombosisLarry D Lynd
Centre for Evaluation of Medicines, St Joseph s Hospital, Hamilton, Ontario, Canada
J Clin Epidemiol 57:795-803. 2004..Published data are used to introduce the risk-benefit acceptability curve as a novel method of illustrating risk-benefit analysis... - Cost-effectiveness of the implantable cardioverter defibrillator: a review of current evidenceLarry D Lynd
Centre for Evaluation of Medicines, Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
J Cardiovasc Electrophysiol 14:S99-103. 2003..Further research on patient selection criteria and the measurement of health-related quality of life is required...