Andres M Lozano

Summary

Affiliation: University of Toronto
Country: Canada

Publications

  1. ncbi request reprint The future of deep brain stimulation
    Andres M Lozano
    Division of Neurosurgery, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada
    J Clin Neurophysiol 21:68-9. 2004
  2. ncbi request reprint New movement in Parkinson's
    Andres M Lozano
    Toronto Western Hospital, University of Toronto
    Sci Am 293:68-75. 2005
  3. ncbi request reprint Firing rates of pallidal neurons are similar in Huntington's and Parkinson's disease patients
    Joyce K H Tang
    Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada, M5S 1A8
    Exp Brain Res 166:230-6. 2005
  4. doi request reprint Dopamine-dependent high-frequency oscillatory activity in thalamus and subthalamic nucleus of patients with Parkinson's disease
    Abdoul Kane
    Department of Physiology, University of Toronto, Toronto, Ontario, Canada
    Neuroreport 20:1549-53. 2009
  5. ncbi request reprint Vim thalamic stimulation for tremor
    A M Lozano
    Division of Neurosurgery, University of Toronto, The Toronto Hospital, Western Division, Toronto, Ontario, Canada
    Arch Med Res 31:266-9. 2000
  6. doi request reprint Basal ganglia physiology and deep brain stimulation
    Andres M Lozano
    Division of Neurosurgery, Toronto Western Hospital, University of Toronto, UHN, Toronto, Ontario, Canada
    Mov Disord 25:S71-5. 2010
  7. doi request reprint Deep brain stimulation for parkinsonian gait disorders
    Andres M Lozano
    Division of Neurosurgery, Toronto Western Hospital, University of Toronto, UHN, 399 Bathurst Street WW 4 447, Toronto, ON, M5T2S8, Canada
    J Neurol 255:30-1. 2008
  8. doi request reprint Subcallosal cingulate gyrus deep brain stimulation for treatment-resistant depression
    Andres M Lozano
    Division of Neurosurgery, University of Toronto, Toronto, Canada
    Biol Psychiatry 64:461-7. 2008
  9. ncbi request reprint Physiologic studies in the human brain in movement disorders
    Andres M Lozano
    Division of Neurosurgery, Department of Surgery, The Toronto Western Hospital, Toronto Western Hospital Research Institute, Suite 2 433 McL, 399 Bathurst St, M5T 2S8, Toronto, Ont, Canada
    Parkinsonism Relat Disord 8:455-8. 2002
  10. ncbi request reprint Deep brain stimulation for Parkinson's disease: disrupting the disruption
    Andres M Lozano
    Toronto Western Hospital Research Institute, and Department of Surgery, University of Toronto, ON, Canada
    Lancet Neurol 1:225-31. 2002

Detail Information

Publications109 found, 100 shown here

  1. ncbi request reprint The future of deep brain stimulation
    Andres M Lozano
    Division of Neurosurgery, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada
    J Clin Neurophysiol 21:68-9. 2004
    ..This will act as a driving force to increase the efforts to improve the technology applied to design and manufacture new hardware...
  2. ncbi request reprint New movement in Parkinson's
    Andres M Lozano
    Toronto Western Hospital, University of Toronto
    Sci Am 293:68-75. 2005
  3. ncbi request reprint Firing rates of pallidal neurons are similar in Huntington's and Parkinson's disease patients
    Joyce K H Tang
    Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada, M5S 1A8
    Exp Brain Res 166:230-6. 2005
    ..Furthermore, the findings did reveal a difference between firing patterns in the HD and PD groups, thereby supporting the role of altered firing patterns in the pathophysiology of these diseases...
  4. doi request reprint Dopamine-dependent high-frequency oscillatory activity in thalamus and subthalamic nucleus of patients with Parkinson's disease
    Abdoul Kane
    Department of Physiology, University of Toronto, Toronto, Ontario, Canada
    Neuroreport 20:1549-53. 2009
    ..These findings confirm and extend earlier findings suggesting that in PD there are marked changes in basal ganglia oscillatory activity and that these can be reversed after dopaminergic therapy...
  5. ncbi request reprint Vim thalamic stimulation for tremor
    A M Lozano
    Division of Neurosurgery, University of Toronto, The Toronto Hospital, Western Division, Toronto, Ontario, Canada
    Arch Med Res 31:266-9. 2000
    ..The mechanism of action of thalamic DBS is not understood and remains a research priority...
  6. doi request reprint Basal ganglia physiology and deep brain stimulation
    Andres M Lozano
    Division of Neurosurgery, Toronto Western Hospital, University of Toronto, UHN, Toronto, Ontario, Canada
    Mov Disord 25:S71-5. 2010
    ..In addition we review the recent work on pedunculopontine nucleus neurophysiology and trials of deep brain stimulation in that region for gait disturbances in Parkinson's disease...
  7. doi request reprint Deep brain stimulation for parkinsonian gait disorders
    Andres M Lozano
    Division of Neurosurgery, Toronto Western Hospital, University of Toronto, UHN, 399 Bathurst Street WW 4 447, Toronto, ON, M5T2S8, Canada
    J Neurol 255:30-1. 2008
    ..We review the rationale behind this treatment and the status of the current trials...
  8. doi request reprint Subcallosal cingulate gyrus deep brain stimulation for treatment-resistant depression
    Andres M Lozano
    Division of Neurosurgery, University of Toronto, Toronto, Canada
    Biol Psychiatry 64:461-7. 2008
    ..We now report the results of these and an additional 14 patients with extended follow-up...
  9. ncbi request reprint Physiologic studies in the human brain in movement disorders
    Andres M Lozano
    Division of Neurosurgery, Department of Surgery, The Toronto Western Hospital, Toronto Western Hospital Research Institute, Suite 2 433 McL, 399 Bathurst St, M5T 2S8, Toronto, Ont, Canada
    Parkinsonism Relat Disord 8:455-8. 2002
    ....
  10. ncbi request reprint Deep brain stimulation for Parkinson's disease: disrupting the disruption
    Andres M Lozano
    Toronto Western Hospital Research Institute, and Department of Surgery, University of Toronto, ON, Canada
    Lancet Neurol 1:225-31. 2002
    ..Current research is aimed at elucidating how DBS works and using this information to develop better treatments for patients with PD and other neurological disorders...
  11. ncbi request reprint Deep brain stimulation surgery for Parkinson's disease: mechanisms and consequences
    Andres M Lozano
    Division of Neurosurgery, Department of Surgery, The Toronto Western Hospital Research Institute, 399 Bathurst Street, Toronto, Ont, Canada M5T 2S8
    Parkinsonism Relat Disord 10:S49-57. 2004
    ..High frequency stimulation has similar effects to ablative surgery, and is generally preferred. The clinical effects and possible mechanisms of action of deep brain stimulation of the subthalamic nucleus and globus pallidus are reviewed...
  12. ncbi request reprint Microelectrode recordings in the pallidum
    Andres M Lozano
    Division of Neurosurgery, University of Toronto, The Toronto Hospital, Western Division, Toronto, Ontario, Canada
    Mov Disord 17:S150-4. 2002
    ..Because the clinical features of movement disorders can be differentially affected as a function of location within the pallidal complex, further refinements in intraoperative targeting may become important...
  13. ncbi request reprint How does DBS work?
    Andres M Lozano
    Toronto Western Hospital, Division of Neurosurgery, Toronto, Ontario, Canada
    Suppl Clin Neurophysiol 57:733-6. 2004
    ..This simplistic proposal has supporting and detracting evidence. In the present work we consider the mechanism of action of DBS and provide arguments for and against the stimulation or inhibition of target neural structures...
  14. ncbi request reprint Beta oscillatory activity in the subthalamic nucleus and its relation to dopaminergic response in Parkinson's disease
    Moran Weinberger
    Department of Physiology, Med Sci Building 3302, 1 King s College Circle, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    J Neurophysiol 96:3248-56. 2006
    ..The study also suggests that LFP beta oscillatory activity is generated largely within the dorsal portion of the STN and can produce synchronous oscillatory activity of the local neuronal population...
  15. ncbi request reprint Pedunculopontine nucleus microelectrode recordings in movement disorder patients
    Moran Weinberger
    Department of Physiology, University of Toronto, Med Sci Bldg 3302, 1 King s College Circle, M5S 1A8, Toronto, ON, Canada
    Exp Brain Res 188:165-74. 2008
    ..It remains to be seen to what extent the physiological characteristics of the neurons and the stimulation-evoked effects will permit reliable identification of PPN and determination of the optimal target for DBS therapy...
  16. doi request reprint Functional convergence of developmentally and adult-generated granule cells in dentate gyrus circuits supporting hippocampus-dependent memory
    Scellig S D Stone
    Program in Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, Ontario, Canada
    Hippocampus 21:1348-62. 2011
    ....
  17. pmc Stimulation of the subthalamic nucleus and impulsivity: release your horses
    Benedicte Ballanger
    Division of Brain, Imaging and Behaviour Systems Neuroscience, Toronto Western Research Institute, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Ann Neurol 66:817-24. 2009
    ....
  18. doi request reprint A phase I trial of deep brain stimulation of memory circuits in Alzheimer's disease
    Adrian W Laxton
    Division of Neurosurgery, University of Toronto, Toronto, Ontario, Canada
    Ann Neurol 68:521-34. 2010
    ..We hypothesized that fornix/hypothalamus deep brain stimulation (DBS) could modulate neurophysiological activity in these pathological circuits and possibly produce clinical benefits...
  19. ncbi request reprint Involvement of human thalamus in the preparation of self-paced movement
    Guillermo Paradiso
    The Krembil Neuroscience Centre and Toronto Western Research Institute, Toronto, Ontario, Canada
    Brain 127:2717-31. 2004
    ..Different cortico-subcortical circuits may mediate alpha and beta oscillations. During movement preparation, the motor thalamus and the supplementary motor area predominantly interact in the beta band...
  20. doi request reprint Modulation of Beta oscillations in the subthalamic nucleus with prosaccades and antisaccades in Parkinson's disease
    Akihiro Yugeta
    Division of Neurology, Toronto Western Research Institute, and the Edmond J Safra Program in Parkinson s Disease, University of Toronto, Toronto, Ontario M5T 2S8, Canada
    J Neurosci 33:6895-904. 2013
    ..Beta-band desynchronization in the STN may reflect the additional processes associated with suppression of reflexive responses and volitional execution of saccades in the opposite direction...
  21. doi request reprint Cerebral blood flow changes induced by pedunculopontine nucleus stimulation in patients with advanced Parkinson's disease: a [(15)O] H2O PET study
    Benedicte Ballanger
    Toronto Western Research Institute Division of Brain, Imaging and Behaviour Systems Neuroscience, UHN, University of Toronto, Toronto, Ontario, Canada
    Hum Brain Mapp 30:3901-9. 2009
    ..Whether these findings are associated with the DBS-PPN clinical effect remains to be proven. However, they suggest that PPN modulation may induce functional changes in neural networks associated with the control of lower limb movements...
  22. doi request reprint High-frequency microstimulation in human globus pallidus and substantia nigra
    Myriam Lafreniere-Roula
    Department of Physiology, University of Toronto, Medical Sciences Building Room 3302, 1 King s College Circle, Toronto, ON, M5S 1A8, Canada
    Exp Brain Res 205:251-61. 2010
    ..The findings suggest that high-frequency microstimulation of the GPi and SNr depresses local neuronal activity and synaptic transmission, and such mechanisms may contribute to the therapeutic effects of DBS...
  23. ncbi request reprint Neuronal firing rates and patterns in the globus pallidus internus of patients with cervical dystonia differ from those with Parkinson's disease
    Joyce K H Tang
    Department of Physiology, University of Toronto, Toronto, ON, Canada
    J Neurophysiol 98:720-9. 2007
    ..These findings suggest that alterations in both firing rate and firing pattern may underlie the differing motor symptoms associated with these two movement disorders...
  24. ncbi request reprint Neuronal coding of implicit emotion categories in the subcallosal cortex in patients with depression
    Adrian W Laxton
    Department of Neurosurgery, Wake Forest Baptist Medical Center, Winston Salem, North Carolina Department of Surgery, Toronto Western Hospital, Institute of Medical Science, University of Toronto, Toronto, Canada Electronic address
    Biol Psychiatry 74:714-9. 2013
    ..On the basis of imaging studies, it is unclear whether the SCC predominantly processes 1) negatively valenced affective content, 2) affective arousal, or 3) category-specific affective information...
  25. doi request reprint Movement related potentials and oscillatory activities in the human internal globus pallidus during voluntary movements
    Eric W Tsang
    Division of Brain Imaging and Behaviour Systems Neuroscience, Toronto Western Research Institute, University Health Network, Toronto, Canada
    J Neurol Neurosurg Psychiatry 83:91-7. 2012
    ..To study internal globus pallidus (GPi) activities and the interactions among the bilateral GPi and motor cortical areas during voluntary movements...
  26. ncbi request reprint Subthalamic nucleus deep brain stimulation for parkinson's disease after successful pallidotomy: clinical and electrophysiological observations
    Galit Kleiner-Fisman
    Division of Neurology, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada
    Mov Disord 19:1209-14. 2004
    ..017, 0.005). There were no side-to-side differences clinically or in the STN neuronal firing rates and patterns. Bilateral STN DBS is safe and efficacious in improving motor symptoms in patients with prior pallidotomy...
  27. doi request reprint Unilateral subdural motor cortex stimulation improves essential tremor but not Parkinson's disease
    Elena Moro
    Movement Disorders Centre, Division of Neurology, Department of Medicine, University of Toronto, Toronto Western Hospital, University Health Network, Toronto, ON M5T2S8, Canada
    Brain 134:2096-105. 2011
    ..These findings suggest that unilateral subdural motor cortex stimulation may be useful for contralateral hand tremor in selected patients with essential tremor but was not effective in improving parkinsonian signs in our series...
  28. ncbi request reprint Bursting activity of neurons in the human anterior thalamic nucleus
    Mojgan Hodaie
    Division of Neurosurgery, University of Toronto, Toronto, ON M5S 1A8, Canada
    Brain Res 1115:1-8. 2006
    ..This study describes for the first time the properties of this nucleus in humans and may be important in furthering our knowledge of thalamic mechanisms of epileptogenesis...
  29. doi request reprint Event-related desynchronization of motor cortical oscillations in patients with multiple system atrophy
    Ron Levy
    Division of Neurosurgery, Department of Clinical Neuroscience, Faculty of Medicine, University of Calgary, Foothills Medical Centre, Calgary, AB, T2N 2T9, Canada
    Exp Brain Res 206:1-13. 2010
    ....
  30. doi request reprint The nature and time course of cortical activation following subthalamic stimulation in Parkinson's disease
    Renju Kuriakose
    Division of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada M5T 2S8
    Cereb Cortex 20:1926-36. 2010
    ..Cortical activation may be related to the clinical effects of STN DBS in PD...
  31. ncbi request reprint Changes in cortical and pallidal oscillatory activity during the execution of a sensory trick in patients with cervical dystonia
    Joyce K H Tang
    Department of Physiology, Med Sci Bldg 3302, 1 King s College Circle, University of Toronto, Toronto, Ontario, Canada M5S 1A8
    Exp Neurol 204:845-8. 2007
    ..These preliminary findings suggest a role for 4-8 Hz frequency synchronization in the pathophysiology of dystonia...
  32. doi request reprint Neural stimulation successfully treats depression in patients with prior ablative cingulotomy
    Joseph S Neimat
    Toronto Western Hospital, 399 Bathurst St, WW4 425, Toronto, Ontario M5T 2S8, Canada
    Am J Psychiatry 165:687-93. 2008
  33. doi request reprint Pedunculopontine nucleus evoked potentials from subthalamic nucleus stimulation in Parkinson's disease
    Bogdan Neagu
    Toronto Western Research Institute, University Health Network, University of Toronto, Canada
    Exp Neurol 250:221-7. 2013
    ..These results demonstrate a functional connection between the STN and the PPNR. It likely involves direct projections between the STN and PPNR or polysynaptic pathways with thalamic or cortical relays. ..
  34. ncbi request reprint Involvement of the basal ganglia and cerebellar motor pathways in the preparation of self-initiated and externally triggered movements in humans
    Jamie Purzner
    The Krembil Neuroscience Centre and Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada M5T 2S8
    J Neurosci 27:6029-36. 2007
    ..The CTC pathway is involved in the preparation of self-paced but not externally cued movements, although the pathway may still be involved in the execution of these movements...
  35. doi request reprint Frequency-dependent effects of electrical stimulation in the globus pallidus of dystonia patients
    Liu D Liu
    Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
    J Neurophysiol 108:5-17. 2012
    ....
  36. ncbi request reprint Stimulation-induced inhibition of neuronal firing in human subthalamic nucleus
    Mohammed Filali
    Department of Physiology, Rm 3305 Medical Sciences Building, University of Toronto, University Health Network, 1 King s College Circle, M5S 1A8, Toronto, Ontario, Canada
    Exp Brain Res 156:274-81. 2004
    ..Therefore, the overall effects of DBS stimulation in STN are likely to be inhibition of intrinsic and synaptically mediated activity, and its replacement by regular high-frequency firing...
  37. ncbi request reprint Dependence of subthalamic nucleus oscillations on movement and dopamine in Parkinson's disease
    Ron Levy
    Department of Physiology, University of Toronto, Toronto, Canada
    Brain 125:1196-209. 2002
    ....
  38. ncbi request reprint Somatosensory evoked potentials (SEPs) recorded from deep brain stimulation (DBS) electrodes in the thalamus and subthalamic nucleus (STN)
    Ritsuko Hanajima
    Toronto Western Research Institute, Toronto Western Hospital, 399 Bathurst St, Toronto, ON M5T 2S8, Canada
    Clin Neurophysiol 115:424-34. 2004
    ..To examine the location of deep brain stimulation (DBS) electrode somatosensory evoked potentials (SEPs) and determine the generators of the median nerve SEPs recorded in thalamus and subthalamic nucleus (STN)...
  39. doi request reprint Selective enhancement of rapid eye movement sleep by deep brain stimulation of the human pons
    Andrew S Lim
    Division of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    Ann Neurol 66:110-4. 2009
    ..This represents the first demonstration that DBS can selectively modulate human sleep, and it supports an important role for the pedunculopontine nucleus region in modulating human REM sleep. Ann Neurol 2009;66:110-114...
  40. ncbi request reprint Neuronal activity in the globus pallidus of multiple system atrophy patients
    Luiz C M Pereira
    Department of Surgery, Division of Neurosurgery, University of Toronto, Toronto, Ontario, Canada
    Mov Disord 19:1485-92. 2004
    ....
  41. ncbi request reprint Eye movement-related responses of neurons in human subthalamic nucleus
    Adrian P Fawcett
    Dept of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, M5S 1A8, Canada
    Exp Brain Res 162:357-65. 2005
    ....
  42. doi request reprint Spatial extent of β oscillatory activity in and between the subthalamic nucleus and substantia nigra pars reticulata of Parkinson's disease patients
    Mahan Alavi
    Department of Physiology, University of Toronto, Toronto, ON, Canada
    Exp Neurol 245:60-71. 2013
    ....
  43. doi request reprint A multicenter pilot study of subcallosal cingulate area deep brain stimulation for treatment-resistant depression
    Andres M Lozano
    Division of Neurosurgery, University of Toronto, Canada
    J Neurosurg 116:315-22. 2012
    ..They conducted a 3-center prospective open-label trial of SCG DBS for 12 months in patients with treatment-resistant depression...
  44. pmc Direct demonstration of inhibitory interactions between long interval intracortical inhibition and short interval intracortical inhibition
    Zhen Ni
    7MC 411, Toronto Western Hospital, 399 Bathurst Street, Toronto, Ontario, M5T 2S8, Canada
    J Physiol 589:2955-62. 2011
    ..We conclude that decreased SICI in the presence of LICI is not due to changes in I-wave content induced by LICI and is caused by their interactions at the cortical level...
  45. ncbi request reprint Levodopa response in long-term bilateral subthalamic stimulation for Parkinson's disease
    Panida Piboolnurak
    Movement Disorders Center, Division of Neurology, University of Toronto, Toronto Western Hospital, Toronto, Ontario, Canada
    Mov Disord 22:990-7. 2007
    ..1% at 3 years and 19.2% at 5 years). Anti-PD drugs were significantly reduced by 47.9% at 3 years and 39.8% at 5 years. However, the magnitude of the preoperative response to levodopa did not predict DBS benefit at 3 and 5 years...
  46. ncbi request reprint Dual microelectrode technique for deep brain stereotactic surgery in humans
    Ron Levy
    Department of Physiology, University of Toronto, Toronto, Canada
    Neurosurgery 60:277-83; discussion 283-4. 2007
    ..To improve functional stereotactic microelectrode localization of small deep brain structures by developing and evaluating a recording system with two closely separated independently controlled microelectrodes...
  47. doi request reprint Somatosensory evoked potentials recorded from the human pedunculopontine nucleus region
    I Jin Yeh
    Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada
    Mov Disord 25:2076-83. 2010
    ..Among the 10 recordings with HFOs, only 1 had possible phase reversal in the bipolar derivation. Our results suggest that there are direct somatosensory inputs to the PPNR. The slow components and HFOs of the SEP have different origins...
  48. ncbi request reprint Very fast oscillations evoked by median nerve stimulation in the human thalamus and subthalamic nucleus
    Ritsuko Hanajima
    Toronto Western Research Institute, University Health Network, University of Toronto, Ontario, Canada
    J Neurophysiol 92:3171-82. 2004
    ..The VFOs from STN probably represent volume conduction, possibly from the medial lemniscus. We conclude that the thalamic VFOs are generated within Vc and that they induce time-locked firing in a network of neurons...
  49. ncbi request reprint Subdural motor cortex stimulation in Parkinson's disease does not modify movement-related rCBF pattern
    Antonio P Strafella
    Movement Disorders Center, Division of Neurology, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada
    Mov Disord 22:2113-6. 2007
    ..We conclude that while MCS may be a simpler and safer surgical procedure than DBS of STN, it failed to provide evidence of clear effect on motor performance and movement-related activation pattern in patients with advanced PD...
  50. ncbi request reprint Deep brain stimulation of the anterior nucleus of the thalamus: effects of electrical stimulation on pilocarpine-induced seizures and status epilepticus
    Clement Hamani
    Division of Neurosurgery, Toronto Western Hospital and University Health Network, University of Toronto, Toronto, Ontario, Canada
    Epilepsy Res 78:117-23. 2008
    ..As the optimal stimulation settings remain elusive, we studied the effects of different stimulation parameters against pilocarpine induced seizures and status epilepticus (SE)...
  51. ncbi request reprint Correspondence of microelectrode mapping with magnetic resonance imaging for subthalamic nucleus procedures
    Clement Hamani
    Division of Neurosurgery, University of Toronto, Toronto, ON M5T 2S8, Canada
    Surg Neurol 63:249-53; discussion 253. 2005
    ..Little is known about the correlation between the position of the STN as seen on MRI and that as determined by MER mapping. We compared these in 10 patients with Parkinson's disease...
  52. ncbi request reprint Neurosurgical treatment of anorexia nervosa: review of the literature from leucotomy to deep brain stimulation
    Nir Lipsman
    Division of Neurosurgery, University Health Network, University of Toronto, Toronto, ON, Canada
    Eur Eat Disord Rev 21:428-35. 2013
    ..This has translated into the development of novel, focused therapeutic options for patients with treatment-refractory AN...
  53. doi request reprint Oscillatory activity in the globus pallidus internus: comparison between Parkinson's disease and dystonia
    Moran Weinberger
    Department of Physiology, University of Toronto, Toronto, ON, Canada
    Clin Neurophysiol 123:358-68. 2012
    ....
  54. doi request reprint Unilateral pedunculopontine stimulation improves falls in Parkinson's disease
    Elena Moro
    Division of Neurosurgery, 4 447 Toronto Western Hospital, 399 Bathurst Street, Toronto, ON, M5T 2S8 Canada
    Brain 133:215-24. 2010
    ..Our results suggest that pedunculopontine nucleus deep-brain stimulation may be effective in preventing falls in patients with advanced Parkinson's disease but that further evaluation of this procedure is required...
  55. doi request reprint Effects of different stimulation parameters on the antidepressant-like response of medial prefrontal cortex deep brain stimulation in rats
    Clement Hamani
    Neuroimaging Research Section, Centre for Addiction and Mental Health, 250 College Street, Toronto, ON, Canada M5T 1R8
    J Psychiatr Res 44:683-7. 2010
    ..In summary, vmPFC DBS at high frequency and moderate intensity led to a maximal response in the FST...
  56. doi request reprint rCBF changes associated with PPN stimulation in a patient with Parkinson's disease: a PET study
    Antonio P Strafella
    Movement Disorders Center, Toronto Western Hospital, Division of Neurology, University of Toronto, Toronto, Ontario, Canada
    Mov Disord 23:1051-4. 2008
    ....
  57. doi request reprint Microstimulation-induced inhibition as a tool to aid targeting the ventral border of the subthalamic nucleus
    Myriam Lafreniere-Roula
    Department of Physiology, University of Toronto, Ontario, Canada
    J Neurosurg 111:724-8. 2009
    ..The presence of inhibition in the SNr but not in the STN could be used as an additional criterion to help identify the location of the border between the STN and SNr...
  58. doi request reprint Enhanced synchronization of thalamic theta band local field potentials in patients with essential tremor
    Abdoul Kane
    Department of Physiology, University of Toronto, Toronto, ON, Canada
    Exp Neurol 217:171-6. 2009
    ....
  59. ncbi request reprint Mesial temporal inhibition in a patient with deep brain stimulation of the anterior thalamus for epilepsy
    Dominik Zumsteg
    Krembil Neuroscience Centre, Toronto Western Hospital, University of Toronto, Toronto, Canada
    Epilepsia 47:1958-62. 2006
    ..The hippocampal inhibition was clearly related to the voltage (> or =7 V) and frequency (> or =70 Hz) of the thalamic stimulus and occurred with a delay of approximately 60 s after stimulus onset...
  60. ncbi request reprint Saccade-related potentials recorded from human subthalamic nucleus
    Adrian P Fawcett
    Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ont, Canada
    Clin Neurophysiol 118:155-63. 2007
    ..To investigate an ocular motor role for the STN in Parkinson's disease (PD) patients...
  61. ncbi request reprint Dissociation of thalamic high frequency oscillations and slow component of sensory evoked potentials following damage to ascending pathways
    Ritsuko Hanajima
    Toronto Western Research Institute, University Health Network, University of Toronto, Toronto, ONT Canada
    Clin Neurophysiol 117:906-11. 2006
    ..In this study, we examined how lesions in the sensory afferent pathway affect these components...
  62. ncbi request reprint Psychiatric symptoms following surgery for Parkinson's disease with an emphasis on subthalamic stimulation
    Valerie Voon
    Department of Psychiatry, Toronto Western Hospital, UHN, Toronto, Canada
    Adv Neurol 96:130-47. 2005
    ..The paucity of the literature underscores the need for well-designed studies on psychiatric issues investigating both pathophysiology and clinical outcomes...
  63. doi request reprint Clinicopathological study in progressive supranuclear palsy with pedunculopontine stimulation
    Lili Naz Hazrati
    Department of Pathology, University of Toronto, University Health Network, Toronto, Ontario, Canada
    Mov Disord 27:1304-7. 2012
    ..However, targeting this nucleus can be challenging. We report on the first neuropathological analyses after PPN-DBS surgery in advanced progressive supranuclear palsy (PSP)...
  64. ncbi request reprint Subthalamic nucleus stimulation: improvements in outcome with reprogramming
    Elena Moro
    Movement Disorders Center and Department of Neurosurgery, Toronto Western Hospital, University Health Network, University of Toronto, 399 Bathurst Street, Toronto, Ontario
    Arch Neurol 63:1266-72. 2006
    ..Even when the electrode is well positioned in the target, the optimization of clinical results depends on careful programming of electrical parameters and changes in antiparkinsonian drug dosages...
  65. ncbi request reprint Intracranial volume conduction of cortical spikes and sleep potentials recorded with deep brain stimulating electrodes
    Richard A Wennberg
    Krembil Neuroscience Centre, Toronto Western Hospital, University of Toronto, 399 Bathurst Street, 5W444, Toronto, Ontario, Canada M5T 2S8
    Clin Neurophysiol 114:1403-18. 2003
    ....
  66. ncbi request reprint Comparison of 2-dimensional magnetic resonance imaging and 3-planar reconstruction methods for targeting the subthalamic nucleus in Parkinson disease
    Yuri M Andrade-Souza
    Division of Neurosurgery, Department of Surgery, University of Toronto and University Health Network, Toronto, Ontario, M5T 2S8, Canada
    Surg Neurol 63:357-62; discussion 362-3. 2005
    ....
  67. ncbi request reprint Comparison of three methods of targeting the subthalamic nucleus for chronic stimulation in Parkinson's disease
    Yuri M Andrade-Souza
    Division of Neurosurgery, University of Toronto, Toronto, Ontario, Canada
    Neurosurgery 56:360-8; discussion 360-8. 2005
    ....
  68. doi request reprint Deep brain stimulation of the subcallosal cingulate gyrus for depression: anatomical location of active contacts in clinical responders and a suggested guideline for targeting
    Clement Hamani
    Division of Neurosurgery, Toronto Western Hospital, 399 Bathurst Street, WW 4 447 Toronto, Ontario M5T2S8 Canada
    J Neurosurg 111:1209-15. 2009
    ..Based on the location of the active contacts used for long-term stimulation in responders, the authors suggest a standardized method of targeting the SCG in patients with MDD...
  69. doi request reprint The regulation of adult rodent hippocampal neurogenesis by deep brain stimulation
    Hiroki Toda
    Division of Neurosurgery, Toronto Western Hospital, Ontario, Canada
    J Neurosurg 108:132-8. 2008
    ..To examine the influence of deep brain stimulation on hippocampal neurogenesis in an adult rodent model...
  70. ncbi request reprint Movement-related neurons of the subthalamic nucleus in patients with Parkinson disease
    Aviva Abosch
    Department of Surgery, Division of Neurosurgery, Toronto Western Hospital, Toronto Western Research Institute, Ontario, Canada
    J Neurosurg 97:1167-72. 2002
    ..The authors' goal was to examine the distribution of movement-related neurons within the STN of humans by using microelectrode recording to identify neuronal receptive fields...
  71. ncbi request reprint Human anterior cingulate cortex neurons encode cognitive and emotional demands
    Karen D Davis
    Toronto Western Research Institute, University of Toronto, Toronto, Ontario, M5T 2S8, Canada
    J Neurosci 25:8402-6. 2005
    ....
  72. doi request reprint Deep brain stimulation of the ventral intermediate nucleus of the thalamus for tremor in patients with multiple sclerosis
    Cristina V Torres
    Division of Neurosurgery, Department of Surgery, Toronto Western Hospital, University of Toronto, University Health Network, Toronto, Ontario, Canada
    Neurosurgery 67:646-51; discussion 651. 2010
    ..Tremor is an important cause of disability in patients with multiple sclerosis (MS). Deep brain stimulation (DBS) in the ventral intermediate nucleus (VIM) of the thalamus is said to be beneficial for MS tremor...
  73. ncbi request reprint Cortical activation with deep brain stimulation of the anterior thalamus for epilepsy
    Dominik Zumsteg
    Krembil Neuroscience Centre, Toronto Western Hospital, University of Toronto, 399 Bathurst Street, Toronto, Ont, Canada M5T 2S8
    Clin Neurophysiol 117:192-207. 2006
    ....
  74. ncbi request reprint Depth electrode recorded cerebral responses with deep brain stimulation of the anterior thalamus for epilepsy
    Dominik Zumsteg
    Krembil Neuroscience Centre, Toronto Western Hospital, University of Toronto, 399 Bathurst Street, Toronto, Ont, Canada M5T 2S8
    Clin Neurophysiol 117:1602-9. 2006
    ....
  75. doi request reprint Deep brain stimulation for treatment-resistant depression: follow-up after 3 to 6 years
    Sidney H Kennedy
    Department of Psychiatry, Division of Neurosurgery, University Health Network, Toronto, Canada
    Am J Psychiatry 168:502-10. 2011
    ..This report represents an extended follow-up of 20 patients with treatment-resistant depression who received DBS to the subcallosal cingulate gyrus (Brodmann's area 25)...
  76. ncbi request reprint Synchronized neuronal discharge in the basal ganglia of parkinsonian patients is limited to oscillatory activity
    Ron Levy
    Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada M5S 1A8
    J Neurosci 22:2855-61. 2002
    ..These results also suggest that overt neuronal synchronization, which may be attributable to an increase in direct synaptic connections or common collateral afferent inputs, is not present in the basal ganglia of patients with PD...
  77. ncbi request reprint Bilateral anterior thalamic nucleus lesions and high-frequency stimulation are protective against pilocarpine-induced seizures and status epilepticus
    Clement Hamani
    Division of Neurosurgery, University of Toronto, Toronto, Ontario, Canada
    Neurosurgery 54:191-5; discussion 195-7. 2004
    ..The aim of the present study was to investigate the influence of anterior thalamic nucleus lesions and high-frequency stimulation in the pilocarpine model of secondarily generalized seizures in rats...
  78. ncbi request reprint Pallidal stimulation for dystonia
    Andres M Lozano
    Division of Neurosurgery, Toronto Western Hospital, Toronto, Ontario, Canada
    Adv Neurol 94:301-8. 2004
    ..There is now increasing experience in the use of DBS to treat various forms of dystonia. The initial results suggest that certain primary dystonias can show a strong improvement with GPi DBS...
  79. ncbi request reprint Neonatal ablation of the nigrostriatal dopamine pathway does not influence limb development in rats
    Matthew O Hebb
    Division of Neurosurgery, University of Toronto, Toronto, Ontario, M5T 2S8, Canada
    Exp Neurol 177:547-56. 2002
    ..The results of this study indicate that early skeletal development in rats is not affected by loss of nigrostriatal dopamine per se, but is markedly attenuated by corticospinal lesions sustained during the neonatal period...
  80. doi request reprint Current and future indications for deep brain stimulation in pediatric populations
    Nir Lipsman
    Division of Neurosurgery, Toronto Western Hospital, University of Toronto, Ontario, Canada
    Neurosurg Focus 29:E2. 2010
    ..The authors conclude that DBS in children can and should be considered a valid and effective treatment option, albeit in highly specific and carefully selected cases...
  81. ncbi request reprint Special lecture: Brain stimulation: perspectives for the future
    Clement Hamani
    Division of Neurosurgery, Toronto Western Hospital, Ontario, Canada
    Clin Neurosurg 51:271-4. 2004
  82. ncbi request reprint Bilateral globus pallidus stimulation for Huntington's disease
    Elena Moro
    Movement Disorders Center, Toronto Western Hospital, Toronto, Ontario, Canada
    Ann Neurol 56:290-4. 2004
    ..Adjustment of stimulation parameters in GPi DBS may have the potential to optimize the motor response in HD, improving chorea without aggravating bradykinesia...
  83. doi request reprint Criteria for the ethical conduct of psychiatric neurosurgery clinical trials
    Nir Lipsman
    Division of Neurosurgery, Toronto Western Hospital, University Health Network, University of Toronto, Canada
    Neurosurg Focus 29:E9. 2010
    ..Ethical criteria, such as the ones proposed here, need to be established now and applied in earnest if the field is to move forward and if patients with no other therapeutic options are to receive much-needed treatment...
  84. ncbi request reprint The globus pallidus, deep brain stimulation, and Parkinson's disease
    Jonathan O Dostrovsky
    Department of Physiology, Faculty of Medicine, University of Toronto, Ontario, Canada
    Neuroscientist 8:284-90. 2002
    ....
  85. ncbi request reprint Chronic anterior thalamus stimulation for intractable epilepsy
    Mojgan Hodaie
    Division of Neurosurgery, University of Toronto, ON, Canada
    Epilepsia 43:603-8. 2002
    ..We investigated neuromodulation of the anterior thalamus by using deep-brain stimulation (DBS) in patients with intractable seizures...
  86. doi request reprint Neurosurgical treatment of bipolar depression: defining treatment resistance and identifying surgical targets
    Nir Lipsman
    Division of Neurosurgery, University Health Network Department of Psychiatry, University of Toronto, University Health Network, 399 Bathurst Street, Toronto, Ontario, Canada
    Bipolar Disord 12:691-701. 2010
    ..Herein, we provide the rationale for employing DBS as an alternative treatment avenue in individuals with bipolar depression...
  87. pmc Ubiquitinylation of α-synuclein by carboxyl terminus Hsp70-interacting protein (CHIP) is regulated by Bcl-2-associated athanogene 5 (BAG5)
    Lorraine V Kalia
    Department of Neurology, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, United States of America
    PLoS ONE 6:e14695. 2011
    ..Thus, our results identify CHIP as an E3 ubiquitin ligase of α-syn and suggest a novel function for BAG5 as a modulator of CHIP E3 ubiquitin ligase activity with implications for CHIP-mediated regulation of α-syn oligomerization...
  88. ncbi request reprint Rhythmic cortical EEG synchronization with low frequency stimulation of the anterior and medial thalamus for epilepsy
    Dominik Zumsteg
    Krembil Neuroscience Centre, University of Toronto, Toronto Western Hospital, Toronto, Canada
    Clin Neurophysiol 117:2272-8. 2006
    ..To investigate the neurophysiological characteristics and prognostic impact of EEG synchronization with low frequency thalamic stimulation in patients with intractable epilepsy...
  89. ncbi request reprint Mechanisms of deep brain stimulation
    Jonathan O Dostrovsky
    Department of Physiology and Division of Neurosurgery, University of Toronto, Toronto, Ontario, Canada
    Mov Disord 17:S63-8. 2002
    ....
  90. ncbi request reprint Pallidal neuronal activity: implications for models of dystonia
    William D Hutchison
    Department of Surgery, Division of Neurosurgery and Toronto Western Research Institute, Toronto Western Hospital and Faculty of Medicine, University of Toronto, Ontario, Canada
    Ann Neurol 53:480-8. 2003
    ..The widely accepted pathophysiological models of dystonia that propose global decreases in basal ganglia output need to be viewed with caution in light of these findings...
  91. doi request reprint Bilateral anterior thalamic nucleus lesions are not protective against seizures in chronic pilocarpine epileptic rats
    Clement Hamani
    Departamentode Fisiologia, Escola Paulista de Medicina, Universidade Federal de Sao Paulo, Sao Paulo, Brazil
    Stereotact Funct Neurosurg 87:143-7. 2009
    ..To investigate whether anterior thalamic nucleus (AN) lesions are protective against spontaneous recurrent seizures in the chronic phase of the pilocarpine model of epilepsy...
  92. ncbi request reprint Stimulation of the subthalamic nucleus in Parkinson's disease does not produce striatal dopamine release
    Aviva Abosch
    Department of Surgery, Morton and Gloria Shulman Movement Disorders Centre, Toronto Western Hospital, and University Health Network, University of Toronto, Toronto, Ontario, Canada
    Neurosurgery 53:1095-102; discussion 1102-5. 2003
    ..We sought to determine whether STN stimulation could release endogenous striatal dopamine...
  93. ncbi request reprint Localization of clinically effective stimulating electrodes in the human subthalamic nucleus on magnetic resonance imaging
    Jean A Saint-Cyr
    Department of Surgery, Division of Neurosurgery, University of Toronto and University Health Network, Toronto, Ontario, Canada
    J Neurosurg 97:1152-66. 2002
    ..The authors sought to determine the location of deep brain stimulation (DBS) electrodes that were most effective in treating Parkinson disease (PD)...
  94. ncbi request reprint Deep brain stimulation for treatment-resistant depression
    Helen S Mayberg
    Rotman Research Institute at Baycrest Centre, and Departments of Psychiatry and Neurology, University of Toronto, Toronto, Ontario, M6A 2E1, Canada
    Neuron 45:651-60. 2005
    ....
  95. doi request reprint Bilateral pallidal stimulation for x-linked dystonia parkinsonism
    Pettarusp M Wadia
    Movement Disorders Centre, Toronto Western Hospital, 399 Bathurst St, McL7 402, Toronto, Ontario, Canada, M5T 2S8
    Arch Neurol 67:1012-5. 2010
    ..To report the clinical benefits of bilateral deep brain stimulation (DBS) of the globus pallidus internus (GPi) in a patient with X-linked dystonia parkinsonism (XDP)...
  96. ncbi request reprint Bilateral subthalamic nucleus stimulation for Parkinson's disease: a systematic review of the clinical literature
    Clement Hamani
    Division of Neurosurgery, University of Toronto, Toronto Western Hospital, Toronto, Ontario, Canada
    Neurosurgery 56:1313-21; discussion 1321-4. 2005
    ..To evaluate the benefits and adverse effects of bilateral subthalamic nucleus stimulation in the treatment of Parkinson's disease (PD) by systematically reviewing the published literature...
  97. ncbi request reprint Single pulse stimulation of the human subthalamic nucleus facilitates the motor cortex at short intervals
    Ritsuko Hanajima
    Dept of Neurology, University of Tokyo Hospital, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    J Neurophysiol 92:1937-43. 2004
    ..Single pulse STN stimulation facilitates the M1 at short latencies. The possible mechanisms include antidromic excitation of the cortico-STN fibers or transmission through the basal ganglia-thalamocortical pathway...
  98. ncbi request reprint Tremor cells in the human thalamus: differences among neurological disorders
    Jason A Brodkey
    Division of Neurosurgery, Toronto Western Hospital, Ontario, Canada
    J Neurosurg 101:43-7. 2004
    ....
  99. ncbi request reprint Long-term follow up of bilateral deep brain stimulation of the subthalamic nucleus in patients with advanced Parkinson disease
    Galit Kleiner-Fisman
    Division of Neurology and Neurosurgery, Toronto Western Hospital, University of Toronto, Ontario, Canada
    J Neurosurg 99:489-95. 2003
    ..The authors present the long-term results of a cohort of 25 individuals who underwent bilateral DBS of the STN between 1996 and 2001 and were followed up for 1 year or longer after implantation of the stimulator...
  100. ncbi request reprint Long-term follow-up of thalamic deep brain stimulation for essential and parkinsonian tremor
    Rajeev Kumar
    Division of Neurology, Faculty of Medicine, University of Toronto, Canada
    Neurology 61:1601-4. 2003
    ..Two of five patients with essential tremor had contralateral tremor improvement after ongoing stimulation for 2 years; two developed marked tolerance to DBS...
  101. ncbi request reprint To serve and protect? Interventions in the subthalamic nucleus for Parkinson's disease. Commentary on "Ablation of the subthalamic nucleus protects dopaminergic phenotype but not cell survival in a rat model of Parkinson's disease"
    Suneil K Kalia
    Division of Applied and Interventional Research, The Toronto Western Hospital Research Institute, Toronto ON, Canada M5T 2S8
    Exp Neurol 185:201-3. 2004