Research Topics
| T LouieSummaryAffiliation: University of Calgary Country: Canada Publications
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Publications
How should we respond to the highly toxogenic NAP1/ribotype 027 strain of Clostridium difficile?Thomas J Louie
Infectious Diseases Division, Department of Medicine, University of Calgary, Alta
CMAJ 173:1049-50. 2005
Clostridium difficile infection in hospitals: risk factors and responsesThomas J Louie
Department of Medicine, University of Calgary
CMAJ 171:45-6. 2004
Understanding influenza vaccination attitudes at a Canadian cancer centerManuel W Mah
Infection Prevention and Control Program, Calgary Health Region, The University of Calgary, Canada
Am J Infect Control 33:243-50. 2005..Understanding health care worker perceptions and needs is essential for improving rates of vaccination...
Tolevamer, a novel nonantibiotic polymer, compared with vancomycin in the treatment of mild to moderately severe Clostridium difficile-associated diarrheaThomas J Louie
University of Calgary, Calgary, Alberta, Canada
Clin Infect Dis 43:411-20. 2006..difficile-associated diarrhea, and selection for nosocomial pathogens. Tolevamer, a soluble, high-molecular weight, anionic polymer that binds C. difficile toxins A and B is a unique nonantibiotic treatment option...
Development of a Health-Related Quality of Life Questionnaire (HRQL) for patients with Extremity Soft Tissue Infections (ESTI)Aric J Storck
Department of Emergency Medicine, Calgary Health Region, Calgary, Alberta, Canada
BMC Infect Dis 6:148. 2006..The objective of this study was to develop a health-related quality of life questionnaire (HRQL) for patients with extremity soft tissue infections (ESTI) for future use in clinical trials...
Clinical outcomes, safety, and pharmacokinetics of OPT-80 in a phase 2 trial with patients with Clostridium difficile infectionT Louie
University of Calgary, Calgary, Alberta, Canada
Antimicrob Agents Chemother 53:223-8. 2009....
Systematic review: faecal transplantation for the treatment of Clostridium difficile-associated diseaseB Guo
Institute of Health Economics, Edmonton, Alberta, Canada
Aliment Pharmacol Ther 35:865-75. 2012..Management of recurrent Clostridium difficile-associated disease (CDAD), particularly in elderly patients, remains clinically challenging. Faecal transplantation (FT) may restore normal microbiota and break the cycle of recurrent CDAD...
Molecular analysis of Clostridium difficile PCR ribotype 027 isolates from Eastern and Western CanadaDuncan R MacCannell
Department of Microbiology and Infectious Diseases, University of Calgary, Calgary, Alberta, Canada
J Clin Microbiol 44:2147-52. 2006..PCR ribotype 027 strains appear to be widely distributed, to predate the Montreal outbreak, and to have measurable community presence in Western Canada...
Treatment of first recurrences of Clostridium difficile-associated disease: waiting for new treatment optionsThomas J Louie
Clin Infect Dis 42:765-7. 2006
Population-based epidemiological study of infections caused by carbapenem-resistant Pseudomonas aeruginosa in the Calgary Health Region: importance of metallo-beta-lactamase (MBL)-producing strainsKevin B Laupland
Department of Medicine, University of Calgary, Centre for Anti-microbial Resistance, and Calgary Health Region, Calgary, Alberta, Canada
J Infect Dis 192:1606-12. 2005..aeruginosa strains were associated with a higher case-fatality rate and invasive disease. Our study highlights the potential importance of molecular laboratory techniques in infection control and patient care...
Population-based assessment of intensive care unit-acquired bloodstream infections in adults: Incidence, risk factors, and associated mortality rateKevin B Laupland
Division of Critical Care Medicine, University of Calgary, Calgary Health Region, Alberta, Canada
Crit Care Med 30:2462-7. 2002..In our region, multiple antibiotic-resistant organisms are uncommon causes of bloodstream infections, suggesting that it may be safe to use narrower spectrum empirical treatment regimens than current guidelines recommend...
Incidence and risk factors for acquiring nosocomial urinary tract infection in the critically illKevin B Laupland
Division of Critical Care Medicine, University of Calgary, Calgary Health Region, Canada
J Crit Care 17:50-7. 2002..CONCLUSIONS: Nosocomial UTIs develop commonly in the critically ill and women and those with an extended ICU stay are at increased risk. Although ICU-acquired UTIs are markers of morbidity, they do not significantly increase mortality...
