Stephen G Lomber

Summary

Affiliation: University of Western Ontario
Country: Canada

Publications

  1. doi request reprint Double dissociation of 'what' and 'where' processing in auditory cortex
    Stephen G Lomber
    Centre for Brain and Mind, Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, Middlesex Road, London, Ontario N6A 5K8, Canada
    Nat Neurosci 11:609-16. 2008
  2. ncbi request reprint Acoustic motion processing in auditory cortex
    STEPHEN LOMBER
    The Brain and Mind Institute, The University of Western Ontario, London, Ontario, Canada
    J Acoust Soc Am 131:3441. 2012
  3. doi request reprint Cross-modal plasticity in specific auditory cortices underlies visual compensations in the deaf
    Stephen G Lomber
    Centre for Brain and Mind, Department of Physiology and Pharmacology, University of Western Ontario, London, Ontario, Canada
    Nat Neurosci 13:1421-7. 2010
  4. ncbi request reprint Relocation of specific visual functions following damage of mature posterior parietal cortex
    Stephen G Lomber
    School of Behavioral and Brain Sciences, The University of Texas at Dallas, Richardson, TX 75080, USA
    Prog Brain Res 157:157-72. 2006
  5. doi request reprint Adaptive crossmodal plasticity in deaf auditory cortex: areal and laminar contributions to supranormal vision in the deaf
    Stephen G Lomber
    Department of Physiology and Pharmacology, Centre for Brain and Mind, The University of Western Ontario, London, Ontario, Canada
    Prog Brain Res 191:251-70. 2011
  6. ncbi request reprint Restoration of acoustic orienting into a cortically deaf hemifield by reversible deactivation of the contralesional superior colliculus: the acoustic "Sprague Effect"
    Stephen G Lomber
    Centre for Brain and Mind, Robarts Research Institute, University of Western Ontario, 100 Perth Drive, London, Ontario N6A 5K8, Canada
    J Neurophysiol 97:979-93. 2007
  7. ncbi request reprint Functional specialization in non-primary auditory cortex of the cat: areal and laminar contributions to sound localization
    Stephen G Lomber
    Centre for Brain and Mind, Department of Physiology and Pharmacology, University of Western Ontario, London, ON, Canada
    Hear Res 229:31-45. 2007
  8. ncbi request reprint Sound localization during homotopic and heterotopic bilateral cooling deactivation of primary and nonprimary auditory cortical areas in the cat
    Shveta Malhotra
    School of Behavioral and Brain Sciences, The University of Texas at Dallas, Richardson, TX, USA
    J Neurophysiol 97:26-43. 2007
  9. doi request reprint Cerebral origins of the auditory projection to the superior colliculus of the cat
    Nicole Chabot
    Cerebral Systems Laboratory, Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario N6A 5K8, Canada
    Hear Res 300:33-45. 2013
  10. doi request reprint Reciprocal modulatory influences between tonotopic and nontonotopic cortical fields in the cat
    Andres Carrasco
    Graduate Program in Neuroscience, University of Western Ontario, London, Ontario N6A 5B8, Canada
    J Neurosci 30:1476-87. 2010

Research Grants

Collaborators

Detail Information

Publications37

  1. doi request reprint Double dissociation of 'what' and 'where' processing in auditory cortex
    Stephen G Lomber
    Centre for Brain and Mind, Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, Middlesex Road, London, Ontario N6A 5K8, Canada
    Nat Neurosci 11:609-16. 2008
    ..These findings support a model of cortical organization that proposes that identifying an acoustic stimulus ('what') and its spatial location ('where') are processed in separate streams in auditory cortex...
  2. ncbi request reprint Acoustic motion processing in auditory cortex
    STEPHEN LOMBER
    The Brain and Mind Institute, The University of Western Ontario, London, Ontario, Canada
    J Acoust Soc Am 131:3441. 2012
    ..Supported by the Canadian Institutes of Health Research and the Natural Sciences and Engineering Research Council of Canada...
  3. doi request reprint Cross-modal plasticity in specific auditory cortices underlies visual compensations in the deaf
    Stephen G Lomber
    Centre for Brain and Mind, Department of Physiology and Pharmacology, University of Western Ontario, London, Ontario, Canada
    Nat Neurosci 13:1421-7. 2010
    ....
  4. ncbi request reprint Relocation of specific visual functions following damage of mature posterior parietal cortex
    Stephen G Lomber
    School of Behavioral and Brain Sciences, The University of Texas at Dallas, Richardson, TX 75080, USA
    Prog Brain Res 157:157-72. 2006
    ..Overall, this series of experiments demonstrates that certain visual functions may relocate to specific cortical loci following damage to discrete areas within posterior parietal cortex...
  5. doi request reprint Adaptive crossmodal plasticity in deaf auditory cortex: areal and laminar contributions to supranormal vision in the deaf
    Stephen G Lomber
    Department of Physiology and Pharmacology, Centre for Brain and Mind, The University of Western Ontario, London, Ontario, Canada
    Prog Brain Res 191:251-70. 2011
    ....
  6. ncbi request reprint Restoration of acoustic orienting into a cortically deaf hemifield by reversible deactivation of the contralesional superior colliculus: the acoustic "Sprague Effect"
    Stephen G Lomber
    Centre for Brain and Mind, Robarts Research Institute, University of Western Ontario, 100 Perth Drive, London, Ontario N6A 5K8, Canada
    J Neurophysiol 97:979-93. 2007
    ..Thus the "Sprague Effect" is not unique to a particular sensory system and deactivation of the contralesional SC can restore either visual or acoustic orienting responses into an impaired hemifield after cortical damage...
  7. ncbi request reprint Functional specialization in non-primary auditory cortex of the cat: areal and laminar contributions to sound localization
    Stephen G Lomber
    Centre for Brain and Mind, Department of Physiology and Pharmacology, University of Western Ontario, London, ON, Canada
    Hear Res 229:31-45. 2007
    ..Therefore, we propose that sound localization signals processed in primary and non-primary auditory cortex are transmitted to the superior colliculus by means of the auditory field of the AES...
  8. ncbi request reprint Sound localization during homotopic and heterotopic bilateral cooling deactivation of primary and nonprimary auditory cortical areas in the cat
    Shveta Malhotra
    School of Behavioral and Brain Sciences, The University of Texas at Dallas, Richardson, TX, USA
    J Neurophysiol 97:26-43. 2007
    ..Neither unilateral nor bilateral deactivation of AI/DZ, PAF, or AES affected the accurate localization of a visual target. The results suggest that hemispheric deactivations contribute independently to sound localization deficits...
  9. doi request reprint Cerebral origins of the auditory projection to the superior colliculus of the cat
    Nicole Chabot
    Cerebral Systems Laboratory, Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario N6A 5K8, Canada
    Hear Res 300:33-45. 2013
    ..Sound localization signals processed in primary (A1) and other non-primary (PAF and DZ) auditory cortices may be transmitted to the SC via a multi-synaptic corticotectal network...
  10. doi request reprint Reciprocal modulatory influences between tonotopic and nontonotopic cortical fields in the cat
    Andres Carrasco
    Graduate Program in Neuroscience, University of Western Ontario, London, Ontario N6A 5B8, Canada
    J Neurosci 30:1476-87. 2010
    ....
  11. doi request reprint Evidence for hierarchical processing in cat auditory cortex: nonreciprocal influence of primary auditory cortex on the posterior auditory field
    Andres Carrasco
    Graduate Program in Neuroscience, University of Western Ontario, London, Ontario N6A 5B8, Canada
    J Neurosci 29:14323-33. 2009
    ..In comparison, we did not identify any significant changes in A1 neuronal responses during deactivation of PAF neurons. These findings support proposed models of hierarchal processing in cat auditory cortex...
  12. doi request reprint Influence of core auditory cortical areas on acoustically evoked activity in contralateral primary auditory cortex
    Andres Carrasco
    Brain and Mind Institute, Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario N6A 5C1, Canada
    J Neurosci 33:776-89. 2013
    ..These findings demonstrate that during periods of acoustic exposure, callosal projections emanating from core auditory areas modulate A1 neuronal activity via excitatory inputs...
  13. doi request reprint Sound localization deficits during reversible deactivation of primary auditory cortex and/or the dorsal zone
    Shveta Malhotra
    Department of Physiology and Pharmacology, University of Western Ontario, London, Ontario, Canada
    J Neurophysiol 99:1628-42. 2008
    ....
  14. ncbi request reprint Cortical control of sound localization in the cat: unilateral cooling deactivation of 19 cerebral areas
    Shveta Malhotra
    Cerebral Systems Laboratory, School of Behavioral and Brain Sciences, The University of Texas at Dallas, 2601 N Floyd Road, GR41, Richardson, TX 75080, USA
    J Neurophysiol 92:1625-43. 2004
    ..Overall, three regions in auditory cortex (AI, PAF, AES) are critical for accurate sound localization as assessed by orienting...
  15. doi request reprint Neuronal activation times to simple, complex, and natural sounds in cat primary and nonprimary auditory cortex
    Andres Carrasco
    Centre for Brain and Mind, Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada
    J Neurophysiol 106:1166-78. 2011
    ..Collectively, these results demonstrate that acoustic signals, regardless of complexity, induce a directional pattern of activation in auditory cortex...
  16. doi request reprint Prefrontal cortex deactivation in macaques alters activity in the superior colliculus and impairs voluntary control of saccades
    Michael J Koval
    Graduate Program in Neuroscience, University of Western Ontario, London, Ontario N6A 3K7, Canada
    J Neurosci 31:8659-68. 2011
    ..The results suggest that the dlPFC participates in the cognitive control of gaze by suppressing stimulus-evoked automatic saccade programs...
  17. ncbi request reprint Cerebral areas mediating visual redirection of gaze: cooling deactivation of 15 loci in the cat
    Stephen G Lomber
    Cerebral Systems Laboratory, School of Behavioral and Brain Sciences, The University of Texas at Dallas, Richardson, Texas 75080, USA
    J Comp Neurol 474:190-208. 2004
    ..These loci have several features in common with cortical fields in monkey and human brains that contribute to the visually guided redirection of the head and eyes...
  18. doi request reprint Influence of inter-field communication on neuronal response synchrony across auditory cortex
    Andres Carrasco
    Cerebral Systems Laboratory, University of Western Ontario, London, ON N6A 5C1, Canada Department of Physiology and Pharmacology, University of Western Ontario, London, ON N6A 5C1, Canada
    Hear Res 304:57-69. 2013
    ..Collectively, the results of the present investigation demonstrate that cortical neurons participate in the modulation of response synchrony levels across neuronal assemblies of primary and non-primary auditory fields. ..
  19. doi request reprint There's more than one way to scan a cat: imaging cat auditory cortex with high-field fMRI using continuous or sparse sampling
    Amee J Hall
    Department of Anatomy and Cell Biology, University of Western Ontario, London, Ontario N6A 5C2, Canada Cerebral Systems Laboratory, University of Western Ontario, London, Ontario N6A 5C2, Canada
    J Neurosci Methods 224:96-106. 2014
    ..Also, choice of method for future investigations of midbrain activity should be driven by other experimental factors, such as stimulus intensity and task performance during scanning...
  20. ncbi request reprint Differential modulatory influences between primary auditory cortex and the anterior auditory field
    Andres Carrasco
    Graduate Program in Neuroscience, University of Western Ontario, London, Ontario N6A 5B8, Canada
    J Neurosci 29:8350-62. 2009
    ..Collectively, these results suggest that the modulation of acoustic information between A1 and AAF in cat auditory cortex is dominated by a unidirectional AAF to A1 pathway...
  21. doi request reprint Auditory cortex projections target the peripheral field representation of primary visual cortex
    Amee J Hall
    Graduate Program in Neuroscience, University of Western Ontario, London, ON, Canada
    Exp Brain Res 190:413-30. 2008
    ..Therefore, direct projections can be identified from tonotopically organized auditory cortex to the earliest stages of visual cortical processing...
  22. doi request reprint Characterization of the blood-oxygen level-dependent (BOLD) response in cat auditory cortex using high-field fMRI
    Trecia A Brown
    Department of Physiology and Pharmacology, University of Western Ontario, London, ON, Canada N6A 3K7
    Neuroimage 64:458-65. 2013
    ..The results of this study will provide a foundation for future auditory fMRI studies in the cat to incorporate these hemodynamic response properties into appropriate analyses of cat auditory cortex...
  23. doi request reprint Areas of cat auditory cortex as defined by neurofilament proteins expressing SMI-32
    Jeffrey G Mellott
    Centre for Brain and Mind, Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, The University of Western Ontario, Medical Sciences Building, Room 216, 1151 Richmond Street North, London, Ontario N6A 5C1, Canada
    Hear Res 267:119-36. 2010
    ..The ability to distinguish auditory areas with SMI-32 is valuable for the identification of auditory cerebral areas in electrophysiological, anatomical, and/or behavioral investigations...
  24. pmc Learning to see the trees before the forest: reversible deactivation of the superior colliculus during learning of local and global visual features
    Stephen G Lomber
    Cerebral Systems Laboratory, School of Human Development, University of Texas at Dallas, Richardson, TX 75083 0688, USA
    Proc Natl Acad Sci U S A 99:4049-54. 2002
    ..Therefore, deactivation of the superficial layers of the SC during pattern discrimination learning reverses the precedence for global visual features that is typical of normal learning...
  25. ncbi request reprint Effects of unilateral deactivations of dorsolateral prefrontal cortex and anterior cingulate cortex on saccadic eye movements
    Michael J Koval
    Graduate Program in Neuroscience, University of Western Ontario, London, Ontario, Canada
    J Neurophysiol 111:787-803. 2014
    ..We suggest that the dlPFC plays a more prominent role in the preparation of pro- and antisaccades than the ACC. ..
  26. ncbi request reprint Macaque Dorsolateral Prefrontal Cortex Does not Suppress Saccade-Related Activity in the Superior Colliculus
    Kevin Johnston
    Brain and Mind Institute, London, ON, Canada
    Cereb Cortex 24:1373-88. 2014
    ..These data challenge the inhibitory model and suggest instead that the primary influence of the DLPFC on the SC is excitatory. ..
  27. ncbi request reprint Cross-modal reorganization of cortical afferents to dorsal auditory cortex following early- and late-onset deafness
    Melanie A Kok
    Graduate Program in Neuroscience, University of Western Ontario, London, Ontario, N6A 5C1, Canada Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, N6A 5C1, Canada Cerebral Systems Laboratory, University of Western Ontario, London, Ontario, N6A 5C1, Canada
    J Comp Neurol 522:654-75. 2014
    ....
  28. ncbi request reprint Cancellation of visuoparietal lesion-induced spatial neglect
    Bertram R Payne
    Cerebral Dynamics, Department of Anatomy and Neurobiology, Boston University School of Medicine, 700 Albany Street, Boston, MA 02118, USA
    Exp Brain Res 150:395-8. 2003
    ....
  29. ncbi request reprint Restoration of visual orienting into a cortically blind hemifield by reversible deactivation of posterior parietal cortex or the superior colliculus
    Stephen G Lomber
    Laboratory for Visual Perception and Cognition, Department of Anatomy and Neurobiology, Boston University School of Medicine, 700 Albany Street, Boston, MA 02118, USA
    Exp Brain Res 142:463-74. 2002
    ..The results are discussed in terms of excitation and disinhibition of visual circuits...
  30. ncbi request reprint Impact of repetitive transcranial magnetic stimulation of the parietal cortex on metabolic brain activity: a 14C-2DG tracing study in the cat
    Antoni Valero-Cabre
    Cerebral Dynamics, Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA 02118, USA
    Exp Brain Res 163:1-12. 2005
    ..Thus, in the anesthetized animal, the impact of rTMS is upon a distributed network of structures connected to the primary site of application...
  31. ncbi request reprint Functional impact of primary visual cortex deactivation on subcortical target structures in the thalamus and midbrain
    R Jarrett Rushmore
    Cerebral Dynamics and Neural Plasticity, Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Comp Neurol 488:414-26. 2005
    ..We discuss these findings in terms of neural circuits and in terms of drivers and modulators...
  32. ncbi request reprint Functional circuitry underlying visual neglect
    R Jarrett Rushmore
    Laboratory of Cerebral Dynamics, Plasticity and Rehabilitation Department of Anatomy and Neurobiology, Boston University School of Medicine Boston, MA 02118, USA
    Brain 129:1803-21. 2006
    ..These results suggest that the most effective therapies for visual neglect will be those that act to decrease neural activity in the intermediate layers of the SC contralateral to the brain damage...
  33. ncbi request reprint Cooling produces minimal neuropathology in neocortex and hippocampus
    Xiao Feng Yang
    Department of Neurology Box 8111, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Neurobiol Dis 23:637-43. 2006
    ..While there may be biochemical and functional alterations in brain cooled as low as 5 degrees C, the neuropathological consequences of brain cooling appear to be insignificant...
  34. ncbi request reprint Pattern motion selectivity in population responses of area 18
    Kerstin E Schmidt
    Max Planck Institute for Brain Research, Deutschordenstrasse 46, 60528 Frankfurt, Germany
    Eur J Neurosci 24:2363-74. 2006
    ....
  35. pmc Integrating motion and depth via parallel pathways
    Carlos R Ponce
    Harvard MIT Division of Health Sciences and Technology, Harvard Medical School, 260 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nat Neurosci 11:216-23. 2008
    ....
  36. pmc The role of feedback in shaping neural representations in cat visual cortex
    Ralf A W Galuske
    Department of Neurophysiology, Max Planck Institute for Brain Research, 60528 Frankfurt am Main, Germany Europe
    Proc Natl Acad Sci U S A 99:17083-8. 2002
    ..Thus we propose that higher cortical areas have significant influence over fundamental neuronal properties as they emerge in lower areas...
  37. ncbi request reprint Quantitative analyses of principal and secondary compound parieto-occipital feedback pathways in cat
    Bertram R Payne
    Cerebral Dynamics, Center for Advanced Biomedical Research, Boston University School of Medicine, 700 Albany Street, Boston, MA 02118, USA
    Exp Brain Res 152:420-33. 2003
    ..MS cortex in the contralateral hemisphere also innervates area 18 directly. These data are important for interpreting the impact of deactivating feedback projections from visuoparietal cortex on occipital cortex...

Research Grants2

  1. DEVELOPMENT OF fMRI COMPATIBLE REVERSIBLE DEACTIVATION
    STEPHEN LOMBER; Fiscal Year: 2005
    ..Such a development should have wide appeal and will greatly advance our ability to dissect functional circuits with fMRI. ..
  2. CEREBRAL ORGANIZATION FOLLOWING COCHLEAR IMPLANT
    STEPHEN LOMBER; Fiscal Year: 2005
    ..The results from these studies will be directly applicable to clinical situations concerning the functional outcomes of cochlear implants in young children. ..